Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and in vivo by blocking chemotherapy-induced ER stress.

Gespeichert in:

Autor*in:	Alexia Karen Cotte [verfasserIn] Virginie Aires [verfasserIn] Maxime Fredon [verfasserIn] Emeric Limagne [verfasserIn] Valentin Derangère [verfasserIn] Marion Thibaudin [verfasserIn] Etienne Humblin [verfasserIn] Alessandra Scagliarini [verfasserIn] Jean-Paul Pais de Barros [verfasserIn] Patrick Hillon [verfasserIn] François Ghiringhelli [verfasserIn] Dominique Delmas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 16
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-017-02732-5

Katalog-ID:	DOAJ067524982

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author	Alexia Karen Cotte
spellingShingle	Alexia Karen Cotte misc Science misc Q Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
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topic_title	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
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title	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
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title_full	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
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author_browse	Alexia Karen Cotte Virginie Aires Maxime Fredon Emeric Limagne Valentin Derangère Marion Thibaudin Etienne Humblin Alessandra Scagliarini Jean-Paul Pais de Barros Patrick Hillon François Ghiringhelli Dominique Delmas
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title_sort	lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
title_auth	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
abstract	Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and in vivo by blocking chemotherapy-induced ER stress.
abstractGer	Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and in vivo by blocking chemotherapy-induced ER stress.
abstract_unstemmed	Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and in vivo by blocking chemotherapy-induced ER stress.
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title_short	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
url	https://doi.org/10.1038/s41467-017-02732-5 https://doaj.org/article/ebbb44a3f0364d6cb5aecb457ae581a2 https://doaj.org/toc/2041-1723
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Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

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