Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children
Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The...
Ausführliche Beschreibung
Autor*in: |
Yang Zhou [verfasserIn] Li-Wen Hu [verfasserIn] Zhengmin (Min) Qian [verfasserIn] Sarah Dee Geiger [verfasserIn] Katelyn L. Parrish [verfasserIn] Shyamali C. Dharmage [verfasserIn] Brittany Campbell [verfasserIn] Marjut Roponen [verfasserIn] Pasi Jalava [verfasserIn] Maija-Riitta Hirvonen [verfasserIn] Joachim Heinrich [verfasserIn] Xiao-Wen Zeng [verfasserIn] Bo-Yi Yang [verfasserIn] Xiao-Di Qin [verfasserIn] Yungling Leo Lee [verfasserIn] Guang-Hui Dong [verfasserIn] |
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E-Artikel |
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Englisch |
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2017 |
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Übergeordnetes Werk: |
In: Scientific Reports - Nature Portfolio, 2011, 7(2017), 1, Seite 7 |
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Übergeordnetes Werk: |
volume:7 ; year:2017 ; number:1 ; pages:7 |
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DOI / URN: |
10.1038/s41598-017-01140-5 |
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Katalog-ID: |
DOAJ067528031 |
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520 | |a Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. | ||
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10.1038/s41598-017-01140-5 doi (DE-627)DOAJ067528031 (DE-599)DOAJcdc6d93a68af4031a68e659b458e9448 DE-627 ger DE-627 rakwb eng Yang Zhou verfasserin aut Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. Medicine R Science Q Li-Wen Hu verfasserin aut Zhengmin (Min) Qian verfasserin aut Sarah Dee Geiger verfasserin aut Katelyn L. Parrish verfasserin aut Shyamali C. Dharmage verfasserin aut Brittany Campbell verfasserin aut Marjut Roponen verfasserin aut Pasi Jalava verfasserin aut Maija-Riitta Hirvonen verfasserin aut Joachim Heinrich verfasserin aut Xiao-Wen Zeng verfasserin aut Bo-Yi Yang verfasserin aut Xiao-Di Qin verfasserin aut Yungling Leo Lee verfasserin aut Guang-Hui Dong verfasserin aut In Scientific Reports Nature Portfolio, 2011 7(2017), 1, Seite 7 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:7 year:2017 number:1 pages:7 https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/article/cdc6d93a68af4031a68e659b458e9448 kostenfrei https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 7 |
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10.1038/s41598-017-01140-5 doi (DE-627)DOAJ067528031 (DE-599)DOAJcdc6d93a68af4031a68e659b458e9448 DE-627 ger DE-627 rakwb eng Yang Zhou verfasserin aut Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. Medicine R Science Q Li-Wen Hu verfasserin aut Zhengmin (Min) Qian verfasserin aut Sarah Dee Geiger verfasserin aut Katelyn L. Parrish verfasserin aut Shyamali C. Dharmage verfasserin aut Brittany Campbell verfasserin aut Marjut Roponen verfasserin aut Pasi Jalava verfasserin aut Maija-Riitta Hirvonen verfasserin aut Joachim Heinrich verfasserin aut Xiao-Wen Zeng verfasserin aut Bo-Yi Yang verfasserin aut Xiao-Di Qin verfasserin aut Yungling Leo Lee verfasserin aut Guang-Hui Dong verfasserin aut In Scientific Reports Nature Portfolio, 2011 7(2017), 1, Seite 7 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:7 year:2017 number:1 pages:7 https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/article/cdc6d93a68af4031a68e659b458e9448 kostenfrei https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 7 |
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10.1038/s41598-017-01140-5 doi (DE-627)DOAJ067528031 (DE-599)DOAJcdc6d93a68af4031a68e659b458e9448 DE-627 ger DE-627 rakwb eng Yang Zhou verfasserin aut Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. Medicine R Science Q Li-Wen Hu verfasserin aut Zhengmin (Min) Qian verfasserin aut Sarah Dee Geiger verfasserin aut Katelyn L. Parrish verfasserin aut Shyamali C. Dharmage verfasserin aut Brittany Campbell verfasserin aut Marjut Roponen verfasserin aut Pasi Jalava verfasserin aut Maija-Riitta Hirvonen verfasserin aut Joachim Heinrich verfasserin aut Xiao-Wen Zeng verfasserin aut Bo-Yi Yang verfasserin aut Xiao-Di Qin verfasserin aut Yungling Leo Lee verfasserin aut Guang-Hui Dong verfasserin aut In Scientific Reports Nature Portfolio, 2011 7(2017), 1, Seite 7 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:7 year:2017 number:1 pages:7 https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/article/cdc6d93a68af4031a68e659b458e9448 kostenfrei https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 7 |
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10.1038/s41598-017-01140-5 doi (DE-627)DOAJ067528031 (DE-599)DOAJcdc6d93a68af4031a68e659b458e9448 DE-627 ger DE-627 rakwb eng Yang Zhou verfasserin aut Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. Medicine R Science Q Li-Wen Hu verfasserin aut Zhengmin (Min) Qian verfasserin aut Sarah Dee Geiger verfasserin aut Katelyn L. Parrish verfasserin aut Shyamali C. Dharmage verfasserin aut Brittany Campbell verfasserin aut Marjut Roponen verfasserin aut Pasi Jalava verfasserin aut Maija-Riitta Hirvonen verfasserin aut Joachim Heinrich verfasserin aut Xiao-Wen Zeng verfasserin aut Bo-Yi Yang verfasserin aut Xiao-Di Qin verfasserin aut Yungling Leo Lee verfasserin aut Guang-Hui Dong verfasserin aut In Scientific Reports Nature Portfolio, 2011 7(2017), 1, Seite 7 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:7 year:2017 number:1 pages:7 https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/article/cdc6d93a68af4031a68e659b458e9448 kostenfrei https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 7 |
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10.1038/s41598-017-01140-5 doi (DE-627)DOAJ067528031 (DE-599)DOAJcdc6d93a68af4031a68e659b458e9448 DE-627 ger DE-627 rakwb eng Yang Zhou verfasserin aut Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. Medicine R Science Q Li-Wen Hu verfasserin aut Zhengmin (Min) Qian verfasserin aut Sarah Dee Geiger verfasserin aut Katelyn L. Parrish verfasserin aut Shyamali C. Dharmage verfasserin aut Brittany Campbell verfasserin aut Marjut Roponen verfasserin aut Pasi Jalava verfasserin aut Maija-Riitta Hirvonen verfasserin aut Joachim Heinrich verfasserin aut Xiao-Wen Zeng verfasserin aut Bo-Yi Yang verfasserin aut Xiao-Di Qin verfasserin aut Yungling Leo Lee verfasserin aut Guang-Hui Dong verfasserin aut In Scientific Reports Nature Portfolio, 2011 7(2017), 1, Seite 7 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:7 year:2017 number:1 pages:7 https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/article/cdc6d93a68af4031a68e659b458e9448 kostenfrei https://doi.org/10.1038/s41598-017-01140-5 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 7 |
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interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children |
title_auth |
Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children |
abstract |
Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. |
abstractGer |
Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. |
abstract_unstemmed |
Abstract To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009–2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents. |
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Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children |
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https://doi.org/10.1038/s41598-017-01140-5 https://doaj.org/article/cdc6d93a68af4031a68e659b458e9448 https://doaj.org/toc/2045-2322 |
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Li-Wen Hu Zhengmin (Min) Qian Sarah Dee Geiger Katelyn L. Parrish Shyamali C. Dharmage Brittany Campbell Marjut Roponen Pasi Jalava Maija-Riitta Hirvonen Joachim Heinrich Xiao-Wen Zeng Bo-Yi Yang Xiao-Di Qin Yungling Leo Lee Guang-Hui Dong |
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Li-Wen Hu Zhengmin (Min) Qian Sarah Dee Geiger Katelyn L. Parrish Shyamali C. Dharmage Brittany Campbell Marjut Roponen Pasi Jalava Maija-Riitta Hirvonen Joachim Heinrich Xiao-Wen Zeng Bo-Yi Yang Xiao-Di Qin Yungling Leo Lee Guang-Hui Dong |
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