Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study

<p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ito Hiroaki [verfasserIn] Inoue Haruhiro [verfasserIn] Odaka Noriko [verfasserIn] Satodate Hitoshi [verfasserIn] Suzuki Michitaka [verfasserIn] Mukai Shumpei [verfasserIn] Takehara Yusuke [verfasserIn] Kida Hiroyuki [verfasserIn] Kudo Shin-ei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Esophagogastric junctional cancer Esophageal cancer Gastric cancer Lymph node metastasis

Übergeordnetes Werk:	In: Journal of Experimental & Clinical Cancer Research - BMC, 2008, 32(2013), 1, p 2
Übergeordnetes Werk:	volume:32 ; year:2013 ; number:1, p 2

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1756-9966-32-2

Katalog-ID:	DOAJ067544754

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allfields	10.1186/1756-9966-32-2 doi (DE-627)DOAJ067544754 (DE-599)DOAJ62b87c66f8de44a98229b4832d14fc1a DE-627 ger DE-627 rakwb eng RC254-282 Ito Hiroaki verfasserin aut Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p< Esophagogastric junctional cancer Esophageal cancer Gastric cancer Lymph node metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Inoue Haruhiro verfasserin aut Odaka Noriko verfasserin aut Satodate Hitoshi verfasserin aut Suzuki Michitaka verfasserin aut Mukai Shumpei verfasserin aut Takehara Yusuke verfasserin aut Kida Hiroyuki verfasserin aut Kudo Shin-ei verfasserin aut In Journal of Experimental & Clinical Cancer Research BMC, 2008 32(2013), 1, p 2 (DE-627)568921380 (DE-600)2430698-8 17569966 nnns volume:32 year:2013 number:1, p 2 https://doi.org/10.1186/1756-9966-32-2 kostenfrei https://doaj.org/article/62b87c66f8de44a98229b4832d14fc1a kostenfrei http://www.jeccr.com/content/32/1/2 kostenfrei https://doaj.org/toc/1756-9966 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2013 1, p 2
spelling	10.1186/1756-9966-32-2 doi (DE-627)DOAJ067544754 (DE-599)DOAJ62b87c66f8de44a98229b4832d14fc1a DE-627 ger DE-627 rakwb eng RC254-282 Ito Hiroaki verfasserin aut Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p< Esophagogastric junctional cancer Esophageal cancer Gastric cancer Lymph node metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Inoue Haruhiro verfasserin aut Odaka Noriko verfasserin aut Satodate Hitoshi verfasserin aut Suzuki Michitaka verfasserin aut Mukai Shumpei verfasserin aut Takehara Yusuke verfasserin aut Kida Hiroyuki verfasserin aut Kudo Shin-ei verfasserin aut In Journal of Experimental & Clinical Cancer Research BMC, 2008 32(2013), 1, p 2 (DE-627)568921380 (DE-600)2430698-8 17569966 nnns volume:32 year:2013 number:1, p 2 https://doi.org/10.1186/1756-9966-32-2 kostenfrei https://doaj.org/article/62b87c66f8de44a98229b4832d14fc1a kostenfrei http://www.jeccr.com/content/32/1/2 kostenfrei https://doaj.org/toc/1756-9966 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2013 1, p 2
allfields_unstemmed	10.1186/1756-9966-32-2 doi (DE-627)DOAJ067544754 (DE-599)DOAJ62b87c66f8de44a98229b4832d14fc1a DE-627 ger DE-627 rakwb eng RC254-282 Ito Hiroaki verfasserin aut Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p< Esophagogastric junctional cancer Esophageal cancer Gastric cancer Lymph node metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Inoue Haruhiro verfasserin aut Odaka Noriko verfasserin aut Satodate Hitoshi verfasserin aut Suzuki Michitaka verfasserin aut Mukai Shumpei verfasserin aut Takehara Yusuke verfasserin aut Kida Hiroyuki verfasserin aut Kudo Shin-ei verfasserin aut In Journal of Experimental & Clinical Cancer Research BMC, 2008 32(2013), 1, p 2 (DE-627)568921380 (DE-600)2430698-8 17569966 nnns volume:32 year:2013 number:1, p 2 https://doi.org/10.1186/1756-9966-32-2 kostenfrei https://doaj.org/article/62b87c66f8de44a98229b4832d14fc1a kostenfrei http://www.jeccr.com/content/32/1/2 kostenfrei https://doaj.org/toc/1756-9966 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2013 1, p 2
allfieldsGer	10.1186/1756-9966-32-2 doi (DE-627)DOAJ067544754 (DE-599)DOAJ62b87c66f8de44a98229b4832d14fc1a DE-627 ger DE-627 rakwb eng RC254-282 Ito Hiroaki verfasserin aut Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p< Esophagogastric junctional cancer Esophageal cancer Gastric cancer Lymph node metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Inoue Haruhiro verfasserin aut Odaka Noriko verfasserin aut Satodate Hitoshi verfasserin aut Suzuki Michitaka verfasserin aut Mukai Shumpei verfasserin aut Takehara Yusuke verfasserin aut Kida Hiroyuki verfasserin aut Kudo Shin-ei verfasserin aut In Journal of Experimental & Clinical Cancer Research BMC, 2008 32(2013), 1, p 2 (DE-627)568921380 (DE-600)2430698-8 17569966 nnns volume:32 year:2013 number:1, p 2 https://doi.org/10.1186/1756-9966-32-2 kostenfrei https://doaj.org/article/62b87c66f8de44a98229b4832d14fc1a kostenfrei http://www.jeccr.com/content/32/1/2 kostenfrei https://doaj.org/toc/1756-9966 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2013 1, p 2
allfieldsSound	10.1186/1756-9966-32-2 doi (DE-627)DOAJ067544754 (DE-599)DOAJ62b87c66f8de44a98229b4832d14fc1a DE-627 ger DE-627 rakwb eng RC254-282 Ito Hiroaki verfasserin aut Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p< Esophagogastric junctional cancer Esophageal cancer Gastric cancer Lymph node metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Inoue Haruhiro verfasserin aut Odaka Noriko verfasserin aut Satodate Hitoshi verfasserin aut Suzuki Michitaka verfasserin aut Mukai Shumpei verfasserin aut Takehara Yusuke verfasserin aut Kida Hiroyuki verfasserin aut Kudo Shin-ei verfasserin aut In Journal of Experimental & Clinical Cancer Research BMC, 2008 32(2013), 1, p 2 (DE-627)568921380 (DE-600)2430698-8 17569966 nnns volume:32 year:2013 number:1, p 2 https://doi.org/10.1186/1756-9966-32-2 kostenfrei https://doaj.org/article/62b87c66f8de44a98229b4832d14fc1a kostenfrei http://www.jeccr.com/content/32/1/2 kostenfrei https://doaj.org/toc/1756-9966 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2013 1, p 2
language	English
source	In Journal of Experimental & Clinical Cancer Research 32(2013), 1, p 2 volume:32 year:2013 number:1, p 2
sourceStr	In Journal of Experimental & Clinical Cancer Research 32(2013), 1, p 2 volume:32 year:2013 number:1, p 2
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Esophagogastric junctional cancer Esophageal cancer Gastric cancer Lymph node metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Journal of Experimental & Clinical Cancer Research
authorswithroles_txt_mv	Ito Hiroaki @@aut@@ Inoue Haruhiro @@aut@@ Odaka Noriko @@aut@@ Satodate Hitoshi @@aut@@ Suzuki Michitaka @@aut@@ Mukai Shumpei @@aut@@ Takehara Yusuke @@aut@@ Kida Hiroyuki @@aut@@ Kudo Shin-ei @@aut@@
publishDateDaySort_date	2013-01-01T00:00:00Z
hierarchy_top_id	568921380
id	DOAJ067544754
language_de	englisch
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callnumber-first	R - Medicine
author	Ito Hiroaki
spellingShingle	Ito Hiroaki misc RC254-282 misc Esophagogastric junctional cancer misc Esophageal cancer misc Gastric cancer misc Lymph node metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study
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topic_title	RC254-282 Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study Esophagogastric junctional cancer Esophageal cancer Gastric cancer Lymph node metastasis
topic	misc RC254-282 misc Esophagogastric junctional cancer misc Esophageal cancer misc Gastric cancer misc Lymph node metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Esophagogastric junctional cancer misc Esophageal cancer misc Gastric cancer misc Lymph node metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Esophagogastric junctional cancer misc Esophageal cancer misc Gastric cancer misc Lymph node metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study
ctrlnum	(DE-627)DOAJ067544754 (DE-599)DOAJ62b87c66f8de44a98229b4832d14fc1a
title_full	Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study
author_sort	Ito Hiroaki
journal	Journal of Experimental & Clinical Cancer Research
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author_browse	Ito Hiroaki Inoue Haruhiro Odaka Noriko Satodate Hitoshi Suzuki Michitaka Mukai Shumpei Takehara Yusuke Kida Hiroyuki Kudo Shin-ei
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title_sort	clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study
callnumber	RC254-282
title_auth	Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study
abstract	<p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controversial.</p< <p<Methods</p< <p<We conducted a single-center retrospective cohort study of the patients who underwent curative surgery with lymphadenectomy for EGJ cancer. Tumor specimens were categorized by histology and location into four types—centered in the esophagus < 5 cm from EGJ (type E), which were subtyped as (i) squamous-cell carcinoma (SQ) or (ii) adenocarcinoma (AD); (iii) any histological tumor centered in the stomach < 5 cm from EGJ, with EGJ invasion (type Ge); (iv) any histological tumor centered in the stomach < 5 cm from EGJ, without EGJ invasion (type G)—and classified by TNM system; these were compared to patients’ clinicopathological characteristics and survival outcomes.</p< <p<Results</p< <p<A total of 92 EGJ cancer patients were studied. Median follow-up of surviving patients was 35.5 months. Tumors were categorized as 12 type E (SQ), 6 type E (AD), 27 type Ge and 47 type G; of these 7 (58.3%), 3 (50%), 19 (70.4%) and 14 (29.8%) and 23 patients, respectively, had lymph node metastases. No patients with type E (AD) and Ge tumors had cervical lymph node metastasis; those with type G tumors had no nodal metastasis at cervical and mediastinal lymph nodes. Multivariate analysis showed that type E (AD) tumor was an independent prognostic factor.</p< <p<Conclusions</p< <p<We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.</p< <p<Trial registration</p< <p<University Hospital Medical Information Network in Japan, UMIN000008596.</p<
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title_short	Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study
url	https://doi.org/10.1186/1756-9966-32-2 https://doaj.org/article/62b87c66f8de44a98229b4832d14fc1a http://www.jeccr.com/content/32/1/2 https://doaj.org/toc/1756-9966
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Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study

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