Heterogeneity in Malignant Pleural Mesothelioma

Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular lev...
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Autor*in:	Kathrin Oehl [verfasserIn] Bart Vrugt [verfasserIn] Isabelle Opitz [verfasserIn] Mayura Meerang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	mesothelioma inter-tumor heterogeneity temporal intra-tumor heterogeneity spatial intra-tumor heterogeneity chemoresistance cancer stem cells targeted therapy

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 19(2018), 6, p 1603
Übergeordnetes Werk:	volume:19 ; year:2018 ; number:6, p 1603

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms19061603

Katalog-ID:	DOAJ067574483

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520			\|a Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.
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language	English
source	In International Journal of Molecular Sciences 19(2018), 6, p 1603 volume:19 year:2018 number:6, p 1603
sourceStr	In International Journal of Molecular Sciences 19(2018), 6, p 1603 volume:19 year:2018 number:6, p 1603
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topic_facet	mesothelioma inter-tumor heterogeneity temporal intra-tumor heterogeneity spatial intra-tumor heterogeneity chemoresistance cancer stem cells targeted therapy Biology (General) Chemistry
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callnumber-first	Q - Science
author	Kathrin Oehl
spellingShingle	Kathrin Oehl misc QH301-705.5 misc QD1-999 misc mesothelioma misc inter-tumor heterogeneity misc temporal intra-tumor heterogeneity misc spatial intra-tumor heterogeneity misc chemoresistance misc cancer stem cells misc targeted therapy misc Biology (General) misc Chemistry Heterogeneity in Malignant Pleural Mesothelioma
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topic_title	QH301-705.5 QD1-999 Heterogeneity in Malignant Pleural Mesothelioma mesothelioma inter-tumor heterogeneity temporal intra-tumor heterogeneity spatial intra-tumor heterogeneity chemoresistance cancer stem cells targeted therapy
topic	misc QH301-705.5 misc QD1-999 misc mesothelioma misc inter-tumor heterogeneity misc temporal intra-tumor heterogeneity misc spatial intra-tumor heterogeneity misc chemoresistance misc cancer stem cells misc targeted therapy misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc mesothelioma misc inter-tumor heterogeneity misc temporal intra-tumor heterogeneity misc spatial intra-tumor heterogeneity misc chemoresistance misc cancer stem cells misc targeted therapy misc Biology (General) misc Chemistry
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title	Heterogeneity in Malignant Pleural Mesothelioma
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title_full	Heterogeneity in Malignant Pleural Mesothelioma
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title_sort	heterogeneity in malignant pleural mesothelioma
callnumber	QH301-705.5
title_auth	Heterogeneity in Malignant Pleural Mesothelioma
abstract	Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.
abstractGer	Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.
abstract_unstemmed	Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.
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title_short	Heterogeneity in Malignant Pleural Mesothelioma
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Heterogeneity in Malignant Pleural Mesothelioma

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