Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review

Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protec...
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Gespeichert in:

Autor*in:	Daniel J. York [verfasserIn] Anne L. Smazal [verfasserIn] Daniel T. Robinson [verfasserIn] Isabelle G. De Plaen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	necrotizing enterocolitis human milk growth factors Epidermal Growth Factor (EGF) Heparin-Binding EGF-like Growth Factor (HB-EGF) Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2)

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 13(2021), 11, p 3751
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:11, p 3751

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu13113751

Katalog-ID:	DOAJ067581862

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520			\|a Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.
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allfieldsSound	10.3390/nu13113751 doi (DE-627)DOAJ067581862 (DE-599)DOAJ1f9c9a356c7c41799d266b4887a048cb DE-627 ger DE-627 rakwb eng TX341-641 Daniel J. York verfasserin aut Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC. necrotizing enterocolitis human milk growth factors Epidermal Growth Factor (EGF) Heparin-Binding EGF-like Growth Factor (HB-EGF) Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2) Nutrition. Foods and food supply Anne L. Smazal verfasserin aut Daniel T. Robinson verfasserin aut Isabelle G. De Plaen verfasserin aut In Nutrients MDPI AG, 2009 13(2021), 11, p 3751 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:13 year:2021 number:11, p 3751 https://doi.org/10.3390/nu13113751 kostenfrei https://doaj.org/article/1f9c9a356c7c41799d266b4887a048cb kostenfrei https://www.mdpi.com/2072-6643/13/11/3751 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 11, p 3751
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topic_facet	necrotizing enterocolitis human milk growth factors Epidermal Growth Factor (EGF) Heparin-Binding EGF-like Growth Factor (HB-EGF) Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2) Nutrition. Foods and food supply
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callnumber-first	T - Technology
author	Daniel J. York
spellingShingle	Daniel J. York misc TX341-641 misc necrotizing enterocolitis misc human milk misc growth factors misc Epidermal Growth Factor (EGF) misc Heparin-Binding EGF-like Growth Factor (HB-EGF) misc Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2) misc Nutrition. Foods and food supply Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
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topic_title	TX341-641 Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review necrotizing enterocolitis human milk growth factors Epidermal Growth Factor (EGF) Heparin-Binding EGF-like Growth Factor (HB-EGF) Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2)
topic	misc TX341-641 misc necrotizing enterocolitis misc human milk misc growth factors misc Epidermal Growth Factor (EGF) misc Heparin-Binding EGF-like Growth Factor (HB-EGF) misc Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2) misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc necrotizing enterocolitis misc human milk misc growth factors misc Epidermal Growth Factor (EGF) misc Heparin-Binding EGF-like Growth Factor (HB-EGF) misc Insulin-like Growth Factor 1 (IGF-1) Insulin-like Growth Factor 2 (IGF-2) misc Nutrition. Foods and food supply
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title_sort	human milk growth factors and their role in nec prevention: a narrative review
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title_auth	Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
abstract	Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.
abstractGer	Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.
abstract_unstemmed	Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.
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title_short	Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review
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