Phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: An assay through cell culture

Objective: The present study aimed to establish cell lines of fibroblast from human OSF tissues and their response to varying concentrations of arecoline. The various morphological forms of fibroblasts were identified to establish phenotypic change. Materials and Method: Fibroblast cell lines were o...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Abhishek Banerjee [verfasserIn] Mathew O Mampilly [verfasserIn] V V Kamath [verfasserIn] Vijayaraghavan Athreya [verfasserIn] Vijayalakshmi Kotrashetti [verfasserIn] Kumar Chandan Srivastava [verfasserIn] Deepti Shrivastava [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	arecoline cell culture fibroblast phenotype oral submucous fibrosis

Übergeordnetes Werk:	In: Journal of Pharmacy and Bioallied Sciences - Wolters Kluwer Medknow Publications, 2009, 13(2021), 6, Seite 1234-1239
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:6 ; pages:1234-1239

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/jpbs.jpbs_408_21

Katalog-ID:	DOAJ067612180

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callnumber-first	R - Medicine
author	Abhishek Banerjee
spellingShingle	Abhishek Banerjee misc RS1-441 misc QD71-142 misc arecoline misc cell culture misc fibroblast phenotype misc oral submucous fibrosis misc Pharmacy and materia medica misc Analytical chemistry Phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: An assay through cell culture
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topic_title	RS1-441 QD71-142 Phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: An assay through cell culture arecoline cell culture fibroblast phenotype oral submucous fibrosis
topic	misc RS1-441 misc QD71-142 misc arecoline misc cell culture misc fibroblast phenotype misc oral submucous fibrosis misc Pharmacy and materia medica misc Analytical chemistry
topic_unstemmed	misc RS1-441 misc QD71-142 misc arecoline misc cell culture misc fibroblast phenotype misc oral submucous fibrosis misc Pharmacy and materia medica misc Analytical chemistry
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title	Phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: An assay through cell culture
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title_full	Phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: An assay through cell culture
author_sort	Abhishek Banerjee
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author_browse	Abhishek Banerjee Mathew O Mampilly V V Kamath Vijayaraghavan Athreya Vijayalakshmi Kotrashetti Kumar Chandan Srivastava Deepti Shrivastava
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title_sort	phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: an assay through cell culture
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title_auth	Phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: An assay through cell culture
abstract	Objective: The present study aimed to establish cell lines of fibroblast from human OSF tissues and their response to varying concentrations of arecoline. The various morphological forms of fibroblasts were identified to establish phenotypic change. Materials and Method: Fibroblast cell lines were obtained from control samples as well as from OSF cases. The cell lines were treated with 50/100/150/300/500 ug/ml of arecoline and morphology were determined. Results: Three morphological forms were detected; F1 spindle, F2 epitheloid and the F3 stellate. The F3 to F1 ratio was higher in OSF. Arecoline at 50ug/ml was stimulatory and at 150ug/ml cytotoxic to the cell lines. Conclusion: Arecoline seems to enhance proliferation of the fibroblast at lower concentrations but cytotoxic at higher levels. This is probably due to the generation of new cell lines and response of the arecoline receptors indicating phenotypic change.
abstractGer	Objective: The present study aimed to establish cell lines of fibroblast from human OSF tissues and their response to varying concentrations of arecoline. The various morphological forms of fibroblasts were identified to establish phenotypic change. Materials and Method: Fibroblast cell lines were obtained from control samples as well as from OSF cases. The cell lines were treated with 50/100/150/300/500 ug/ml of arecoline and morphology were determined. Results: Three morphological forms were detected; F1 spindle, F2 epitheloid and the F3 stellate. The F3 to F1 ratio was higher in OSF. Arecoline at 50ug/ml was stimulatory and at 150ug/ml cytotoxic to the cell lines. Conclusion: Arecoline seems to enhance proliferation of the fibroblast at lower concentrations but cytotoxic at higher levels. This is probably due to the generation of new cell lines and response of the arecoline receptors indicating phenotypic change.
abstract_unstemmed	Objective: The present study aimed to establish cell lines of fibroblast from human OSF tissues and their response to varying concentrations of arecoline. The various morphological forms of fibroblasts were identified to establish phenotypic change. Materials and Method: Fibroblast cell lines were obtained from control samples as well as from OSF cases. The cell lines were treated with 50/100/150/300/500 ug/ml of arecoline and morphology were determined. Results: Three morphological forms were detected; F1 spindle, F2 epitheloid and the F3 stellate. The F3 to F1 ratio was higher in OSF. Arecoline at 50ug/ml was stimulatory and at 150ug/ml cytotoxic to the cell lines. Conclusion: Arecoline seems to enhance proliferation of the fibroblast at lower concentrations but cytotoxic at higher levels. This is probably due to the generation of new cell lines and response of the arecoline receptors indicating phenotypic change.
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title_short	Phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: An assay through cell culture
url	https://doi.org/10.4103/jpbs.jpbs_408_21 https://doaj.org/article/d0c3667c553b4ceda39611deb26e9109 http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1234;epage=1239;aulast=Banerjee https://doaj.org/toc/0975-7406
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up_date	2024-07-04T01:36:39.325Z
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Phenotypic expression of oral fibroblasts derived from oral submucous fibrosis: An assay through cell culture

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