Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies

Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Esther Melamed [verfasserIn] Michael William Lee [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	multiple sclerosis disease modifying therapy cancer treatment of autoimmune disease multiple sclerosis drug mechanism cancer treatment

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 10(2020)
Übergeordnetes Werk:	volume:10 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2019.02954

Katalog-ID:	DOAJ06762961X

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spelling	10.3389/fimmu.2019.02954 doi (DE-627)DOAJ06762961X (DE-599)DOAJ05e0361bfeab46be99f23b01bc7ab619 DE-627 ger DE-627 rakwb eng RC581-607 Esther Melamed verfasserin aut Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is also critical for identifying and eliminating malignant cells, immunosuppression from DMTs may predictably increase the risk of cancer development in MS patients. Compared with healthy controls, patients with autoimmune conditions, such as MS, may already have a higher risk of developing certain malignancies and this risk may further be magnified by DMT treatments. For those patients who develop both MS and cancer, these comorbid presentations create a challenge for clinicians on how to therapeutically address management of cancer in the context of MS autoimmunity. As there are currently no accepted guidelines for managing MS patients with prior history of or newly developed malignancy, we undertook this review to evaluate the molecular mechanisms of current DMTs and their potential for instigating and treating cancer in patients living with MS. multiple sclerosis disease modifying therapy cancer treatment of autoimmune disease multiple sclerosis drug mechanism cancer treatment Immunologic diseases. Allergy Michael William Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2020) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2020 https://doi.org/10.3389/fimmu.2019.02954 kostenfrei https://doaj.org/article/05e0361bfeab46be99f23b01bc7ab619 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.02954/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
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allfieldsGer	10.3389/fimmu.2019.02954 doi (DE-627)DOAJ06762961X (DE-599)DOAJ05e0361bfeab46be99f23b01bc7ab619 DE-627 ger DE-627 rakwb eng RC581-607 Esther Melamed verfasserin aut Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is also critical for identifying and eliminating malignant cells, immunosuppression from DMTs may predictably increase the risk of cancer development in MS patients. Compared with healthy controls, patients with autoimmune conditions, such as MS, may already have a higher risk of developing certain malignancies and this risk may further be magnified by DMT treatments. For those patients who develop both MS and cancer, these comorbid presentations create a challenge for clinicians on how to therapeutically address management of cancer in the context of MS autoimmunity. As there are currently no accepted guidelines for managing MS patients with prior history of or newly developed malignancy, we undertook this review to evaluate the molecular mechanisms of current DMTs and their potential for instigating and treating cancer in patients living with MS. multiple sclerosis disease modifying therapy cancer treatment of autoimmune disease multiple sclerosis drug mechanism cancer treatment Immunologic diseases. Allergy Michael William Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2020) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2020 https://doi.org/10.3389/fimmu.2019.02954 kostenfrei https://doaj.org/article/05e0361bfeab46be99f23b01bc7ab619 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.02954/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
allfieldsSound	10.3389/fimmu.2019.02954 doi (DE-627)DOAJ06762961X (DE-599)DOAJ05e0361bfeab46be99f23b01bc7ab619 DE-627 ger DE-627 rakwb eng RC581-607 Esther Melamed verfasserin aut Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is also critical for identifying and eliminating malignant cells, immunosuppression from DMTs may predictably increase the risk of cancer development in MS patients. Compared with healthy controls, patients with autoimmune conditions, such as MS, may already have a higher risk of developing certain malignancies and this risk may further be magnified by DMT treatments. For those patients who develop both MS and cancer, these comorbid presentations create a challenge for clinicians on how to therapeutically address management of cancer in the context of MS autoimmunity. As there are currently no accepted guidelines for managing MS patients with prior history of or newly developed malignancy, we undertook this review to evaluate the molecular mechanisms of current DMTs and their potential for instigating and treating cancer in patients living with MS. multiple sclerosis disease modifying therapy cancer treatment of autoimmune disease multiple sclerosis drug mechanism cancer treatment Immunologic diseases. Allergy Michael William Lee verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2020) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2020 https://doi.org/10.3389/fimmu.2019.02954 kostenfrei https://doaj.org/article/05e0361bfeab46be99f23b01bc7ab619 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.02954/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
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source	In Frontiers in Immunology 10(2020) volume:10 year:2020
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topic_facet	multiple sclerosis disease modifying therapy cancer treatment of autoimmune disease multiple sclerosis drug mechanism cancer treatment Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	Esther Melamed @@aut@@ Michael William Lee @@aut@@
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author	Esther Melamed
spellingShingle	Esther Melamed misc RC581-607 misc multiple sclerosis misc disease modifying therapy misc cancer misc treatment of autoimmune disease misc multiple sclerosis drug mechanism misc cancer treatment misc Immunologic diseases. Allergy Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies
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topic_title	RC581-607 Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies multiple sclerosis disease modifying therapy cancer treatment of autoimmune disease multiple sclerosis drug mechanism cancer treatment
topic	misc RC581-607 misc multiple sclerosis misc disease modifying therapy misc cancer misc treatment of autoimmune disease misc multiple sclerosis drug mechanism misc cancer treatment misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc multiple sclerosis misc disease modifying therapy misc cancer misc treatment of autoimmune disease misc multiple sclerosis drug mechanism misc cancer treatment misc Immunologic diseases. Allergy
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title	Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies
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title_sort	multiple sclerosis and cancer: the ying-yang effect of disease modifying therapies
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title_auth	Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies
abstract	Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is also critical for identifying and eliminating malignant cells, immunosuppression from DMTs may predictably increase the risk of cancer development in MS patients. Compared with healthy controls, patients with autoimmune conditions, such as MS, may already have a higher risk of developing certain malignancies and this risk may further be magnified by DMT treatments. For those patients who develop both MS and cancer, these comorbid presentations create a challenge for clinicians on how to therapeutically address management of cancer in the context of MS autoimmunity. As there are currently no accepted guidelines for managing MS patients with prior history of or newly developed malignancy, we undertook this review to evaluate the molecular mechanisms of current DMTs and their potential for instigating and treating cancer in patients living with MS.
abstractGer	Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is also critical for identifying and eliminating malignant cells, immunosuppression from DMTs may predictably increase the risk of cancer development in MS patients. Compared with healthy controls, patients with autoimmune conditions, such as MS, may already have a higher risk of developing certain malignancies and this risk may further be magnified by DMT treatments. For those patients who develop both MS and cancer, these comorbid presentations create a challenge for clinicians on how to therapeutically address management of cancer in the context of MS autoimmunity. As there are currently no accepted guidelines for managing MS patients with prior history of or newly developed malignancy, we undertook this review to evaluate the molecular mechanisms of current DMTs and their potential for instigating and treating cancer in patients living with MS.
abstract_unstemmed	Over the past two decades, the field of multiple sclerosis (MS) has been transformed by the rapidly expanding arsenal of new disease modifying therapies (DMTs). Current DMTs for MS aim to modulate innate and adaptive immune responses toward a less inflammatory phenotype. Since the immune system is also critical for identifying and eliminating malignant cells, immunosuppression from DMTs may predictably increase the risk of cancer development in MS patients. Compared with healthy controls, patients with autoimmune conditions, such as MS, may already have a higher risk of developing certain malignancies and this risk may further be magnified by DMT treatments. For those patients who develop both MS and cancer, these comorbid presentations create a challenge for clinicians on how to therapeutically address management of cancer in the context of MS autoimmunity. As there are currently no accepted guidelines for managing MS patients with prior history of or newly developed malignancy, we undertook this review to evaluate the molecular mechanisms of current DMTs and their potential for instigating and treating cancer in patients living with MS.
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title_short	Multiple Sclerosis and Cancer: The Ying-Yang Effect of Disease Modifying Therapies
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