The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population

The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its associ...
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Autor*in:	Li Wang [verfasserIn] Jingyi Zhang [verfasserIn] Gen Li [verfasserIn] Chengqi Cao [verfasserIn] Ruojiao Fang [verfasserIn] Ping Liu [verfasserIn] Shu Luo [verfasserIn] Guangyi Zhao [verfasserIn] Yingqian Zhang [verfasserIn] Kunlin Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	ADCYAP1R1 posttraumatic stress disorder HPA axis SNP gene-gene interaction

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 12(2021)
Übergeordnetes Werk:	volume:12 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2021.665599

Katalog-ID:	DOAJ067716792

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allfields	10.3389/fpsyt.2021.665599 doi (DE-627)DOAJ067716792 (DE-599)DOAJ422421e5f6d6406c9e6890e4e2f6ad74 DE-627 ger DE-627 rakwb eng RC435-571 Li Wang verfasserin aut The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions. ADCYAP1R1 posttraumatic stress disorder HPA axis SNP gene-gene interaction Psychiatry Li Wang verfasserin aut Jingyi Zhang verfasserin aut Jingyi Zhang verfasserin aut Gen Li verfasserin aut Gen Li verfasserin aut Chengqi Cao verfasserin aut Chengqi Cao verfasserin aut Ruojiao Fang verfasserin aut Ruojiao Fang verfasserin aut Ping Liu verfasserin aut Shu Luo verfasserin aut Guangyi Zhao verfasserin aut Guangyi Zhao verfasserin aut Yingqian Zhang verfasserin aut Yingqian Zhang verfasserin aut Kunlin Zhang verfasserin aut Kunlin Zhang verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.665599 kostenfrei https://doaj.org/article/422421e5f6d6406c9e6890e4e2f6ad74 kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665599/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
spelling	10.3389/fpsyt.2021.665599 doi (DE-627)DOAJ067716792 (DE-599)DOAJ422421e5f6d6406c9e6890e4e2f6ad74 DE-627 ger DE-627 rakwb eng RC435-571 Li Wang verfasserin aut The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions. ADCYAP1R1 posttraumatic stress disorder HPA axis SNP gene-gene interaction Psychiatry Li Wang verfasserin aut Jingyi Zhang verfasserin aut Jingyi Zhang verfasserin aut Gen Li verfasserin aut Gen Li verfasserin aut Chengqi Cao verfasserin aut Chengqi Cao verfasserin aut Ruojiao Fang verfasserin aut Ruojiao Fang verfasserin aut Ping Liu verfasserin aut Shu Luo verfasserin aut Guangyi Zhao verfasserin aut Guangyi Zhao verfasserin aut Yingqian Zhang verfasserin aut Yingqian Zhang verfasserin aut Kunlin Zhang verfasserin aut Kunlin Zhang verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.665599 kostenfrei https://doaj.org/article/422421e5f6d6406c9e6890e4e2f6ad74 kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665599/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfields_unstemmed	10.3389/fpsyt.2021.665599 doi (DE-627)DOAJ067716792 (DE-599)DOAJ422421e5f6d6406c9e6890e4e2f6ad74 DE-627 ger DE-627 rakwb eng RC435-571 Li Wang verfasserin aut The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions. ADCYAP1R1 posttraumatic stress disorder HPA axis SNP gene-gene interaction Psychiatry Li Wang verfasserin aut Jingyi Zhang verfasserin aut Jingyi Zhang verfasserin aut Gen Li verfasserin aut Gen Li verfasserin aut Chengqi Cao verfasserin aut Chengqi Cao verfasserin aut Ruojiao Fang verfasserin aut Ruojiao Fang verfasserin aut Ping Liu verfasserin aut Shu Luo verfasserin aut Guangyi Zhao verfasserin aut Guangyi Zhao verfasserin aut Yingqian Zhang verfasserin aut Yingqian Zhang verfasserin aut Kunlin Zhang verfasserin aut Kunlin Zhang verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.665599 kostenfrei https://doaj.org/article/422421e5f6d6406c9e6890e4e2f6ad74 kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665599/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsGer	10.3389/fpsyt.2021.665599 doi (DE-627)DOAJ067716792 (DE-599)DOAJ422421e5f6d6406c9e6890e4e2f6ad74 DE-627 ger DE-627 rakwb eng RC435-571 Li Wang verfasserin aut The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions. ADCYAP1R1 posttraumatic stress disorder HPA axis SNP gene-gene interaction Psychiatry Li Wang verfasserin aut Jingyi Zhang verfasserin aut Jingyi Zhang verfasserin aut Gen Li verfasserin aut Gen Li verfasserin aut Chengqi Cao verfasserin aut Chengqi Cao verfasserin aut Ruojiao Fang verfasserin aut Ruojiao Fang verfasserin aut Ping Liu verfasserin aut Shu Luo verfasserin aut Guangyi Zhao verfasserin aut Guangyi Zhao verfasserin aut Yingqian Zhang verfasserin aut Yingqian Zhang verfasserin aut Kunlin Zhang verfasserin aut Kunlin Zhang verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.665599 kostenfrei https://doaj.org/article/422421e5f6d6406c9e6890e4e2f6ad74 kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665599/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
allfieldsSound	10.3389/fpsyt.2021.665599 doi (DE-627)DOAJ067716792 (DE-599)DOAJ422421e5f6d6406c9e6890e4e2f6ad74 DE-627 ger DE-627 rakwb eng RC435-571 Li Wang verfasserin aut The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions. ADCYAP1R1 posttraumatic stress disorder HPA axis SNP gene-gene interaction Psychiatry Li Wang verfasserin aut Jingyi Zhang verfasserin aut Jingyi Zhang verfasserin aut Gen Li verfasserin aut Gen Li verfasserin aut Chengqi Cao verfasserin aut Chengqi Cao verfasserin aut Ruojiao Fang verfasserin aut Ruojiao Fang verfasserin aut Ping Liu verfasserin aut Shu Luo verfasserin aut Guangyi Zhao verfasserin aut Guangyi Zhao verfasserin aut Yingqian Zhang verfasserin aut Yingqian Zhang verfasserin aut Kunlin Zhang verfasserin aut Kunlin Zhang verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 12(2021) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:12 year:2021 https://doi.org/10.3389/fpsyt.2021.665599 kostenfrei https://doaj.org/article/422421e5f6d6406c9e6890e4e2f6ad74 kostenfrei https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665599/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021
language	English
source	In Frontiers in Psychiatry 12(2021) volume:12 year:2021
sourceStr	In Frontiers in Psychiatry 12(2021) volume:12 year:2021
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ADCYAP1R1 posttraumatic stress disorder HPA axis SNP gene-gene interaction Psychiatry
isfreeaccess_bool	true
container_title	Frontiers in Psychiatry
authorswithroles_txt_mv	Li Wang @@aut@@ Jingyi Zhang @@aut@@ Gen Li @@aut@@ Chengqi Cao @@aut@@ Ruojiao Fang @@aut@@ Ping Liu @@aut@@ Shu Luo @@aut@@ Guangyi Zhao @@aut@@ Yingqian Zhang @@aut@@ Kunlin Zhang @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	631498796
id	DOAJ067716792
language_de	englisch
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callnumber-first	R - Medicine
author	Li Wang
spellingShingle	Li Wang misc RC435-571 misc ADCYAP1R1 misc posttraumatic stress disorder misc HPA axis misc SNP misc gene-gene interaction misc Psychiatry The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population
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topic_title	RC435-571 The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population ADCYAP1R1 posttraumatic stress disorder HPA axis SNP gene-gene interaction
topic	misc RC435-571 misc ADCYAP1R1 misc posttraumatic stress disorder misc HPA axis misc SNP misc gene-gene interaction misc Psychiatry
topic_unstemmed	misc RC435-571 misc ADCYAP1R1 misc posttraumatic stress disorder misc HPA axis misc SNP misc gene-gene interaction misc Psychiatry
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title	The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population
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title_full	The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population
author_sort	Li Wang
journal	Frontiers in Psychiatry
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author_browse	Li Wang Jingyi Zhang Gen Li Chengqi Cao Ruojiao Fang Ping Liu Shu Luo Guangyi Zhao Yingqian Zhang Kunlin Zhang
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title_sort	adcyap1r1 gene is correlated with posttraumatic stress disorder symptoms through diverse epistases in a traumatized chinese population
callnumber	RC435-571
title_auth	The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population
abstract	The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions.
abstractGer	The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions.
abstract_unstemmed	The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions.
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title_short	The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population
url	https://doi.org/10.3389/fpsyt.2021.665599 https://doaj.org/article/422421e5f6d6406c9e6890e4e2f6ad74 https://www.frontiersin.org/articles/10.3389/fpsyt.2021.665599/full https://doaj.org/toc/1664-0640
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author2	Li Wang Jingyi Zhang Gen Li Chengqi Cao Ruojiao Fang Ping Liu Shu Luo Guangyi Zhao Yingqian Zhang Kunlin Zhang
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The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population

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Zugang & Verfügbarkeit

Vorhandene Bände

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