The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity
Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes i...
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Azam Foroughi pour [verfasserIn] Rokhsareh Meamar [verfasserIn] |
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E-Artikel |
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| Sprache: |
Persisch |
| Erschienen: |
2015 |
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In: Yafteh - Lorestan University of Medical Science, 2017, 16(2015), 4, Seite 110-117 |
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volume:16 ; year:2015 ; number:4 ; pages:110-117 |
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DOAJ067719260 |
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| 520 | |a Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. | ||
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(DE-627)DOAJ067719260 (DE-599)DOAJ3dede88a26984e9ea68270a30b7336ad DE-627 ger DE-627 rakwb per R5-920 Azam Foroughi pour verfasserin aut The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. Multiple Sclerosis Testestrone Follicular phase Luteal phase. Medicine R Medicine (General) Rokhsareh Meamar verfasserin aut In Yafteh Lorestan University of Medical Science, 2017 16(2015), 4, Seite 110-117 (DE-627)1760642266 15630773 nnns volume:16 year:2015 number:4 pages:110-117 https://doaj.org/article/3dede88a26984e9ea68270a30b7336ad kostenfrei http://yafte.lums.ac.ir/browse.php?a_code=A-10-1280-37&slc_lang=en&sid=1 kostenfrei https://doaj.org/toc/1563-0773 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 16 2015 4 110-117 |
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(DE-627)DOAJ067719260 (DE-599)DOAJ3dede88a26984e9ea68270a30b7336ad DE-627 ger DE-627 rakwb per R5-920 Azam Foroughi pour verfasserin aut The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. Multiple Sclerosis Testestrone Follicular phase Luteal phase. Medicine R Medicine (General) Rokhsareh Meamar verfasserin aut In Yafteh Lorestan University of Medical Science, 2017 16(2015), 4, Seite 110-117 (DE-627)1760642266 15630773 nnns volume:16 year:2015 number:4 pages:110-117 https://doaj.org/article/3dede88a26984e9ea68270a30b7336ad kostenfrei http://yafte.lums.ac.ir/browse.php?a_code=A-10-1280-37&slc_lang=en&sid=1 kostenfrei https://doaj.org/toc/1563-0773 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 16 2015 4 110-117 |
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(DE-627)DOAJ067719260 (DE-599)DOAJ3dede88a26984e9ea68270a30b7336ad DE-627 ger DE-627 rakwb per R5-920 Azam Foroughi pour verfasserin aut The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. Multiple Sclerosis Testestrone Follicular phase Luteal phase. Medicine R Medicine (General) Rokhsareh Meamar verfasserin aut In Yafteh Lorestan University of Medical Science, 2017 16(2015), 4, Seite 110-117 (DE-627)1760642266 15630773 nnns volume:16 year:2015 number:4 pages:110-117 https://doaj.org/article/3dede88a26984e9ea68270a30b7336ad kostenfrei http://yafte.lums.ac.ir/browse.php?a_code=A-10-1280-37&slc_lang=en&sid=1 kostenfrei https://doaj.org/toc/1563-0773 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 16 2015 4 110-117 |
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(DE-627)DOAJ067719260 (DE-599)DOAJ3dede88a26984e9ea68270a30b7336ad DE-627 ger DE-627 rakwb per R5-920 Azam Foroughi pour verfasserin aut The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. Multiple Sclerosis Testestrone Follicular phase Luteal phase. Medicine R Medicine (General) Rokhsareh Meamar verfasserin aut In Yafteh Lorestan University of Medical Science, 2017 16(2015), 4, Seite 110-117 (DE-627)1760642266 15630773 nnns volume:16 year:2015 number:4 pages:110-117 https://doaj.org/article/3dede88a26984e9ea68270a30b7336ad kostenfrei http://yafte.lums.ac.ir/browse.php?a_code=A-10-1280-37&slc_lang=en&sid=1 kostenfrei https://doaj.org/toc/1563-0773 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 16 2015 4 110-117 |
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(DE-627)DOAJ067719260 (DE-599)DOAJ3dede88a26984e9ea68270a30b7336ad DE-627 ger DE-627 rakwb per R5-920 Azam Foroughi pour verfasserin aut The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. Multiple Sclerosis Testestrone Follicular phase Luteal phase. Medicine R Medicine (General) Rokhsareh Meamar verfasserin aut In Yafteh Lorestan University of Medical Science, 2017 16(2015), 4, Seite 110-117 (DE-627)1760642266 15630773 nnns volume:16 year:2015 number:4 pages:110-117 https://doaj.org/article/3dede88a26984e9ea68270a30b7336ad kostenfrei http://yafte.lums.ac.ir/browse.php?a_code=A-10-1280-37&slc_lang=en&sid=1 kostenfrei https://doaj.org/toc/1563-0773 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 16 2015 4 110-117 |
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The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity |
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Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. |
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Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. |
| abstract_unstemmed |
Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested. |
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The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity |
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https://doaj.org/article/3dede88a26984e9ea68270a30b7336ad http://yafte.lums.ac.ir/browse.php?a_code=A-10-1280-37&slc_lang=en&sid=1 https://doaj.org/toc/1563-0773 |
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