Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study
ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the hist...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Joel Schmillevitch [verfasserIn] Maria Cristina Chammas [verfasserIn] Vincenzo Pugliese [verfasserIn] Edson Abdala [verfasserIn] Adriana Cortez Rizzon [verfasserIn] Venâncio Alves [verfasserIn] Luiz Augusto Carneiro [verfasserIn] Giovanni Cerri [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
In: São Paulo Medical Journal - Associação Paulista de Medicina, 2016 |
|---|
| Links: |
|---|
| DOI / URN: |
10.1590/1516-3180.2016.0158170816 |
|---|
| Katalog-ID: |
DOAJ067737749 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ067737749 | ||
| 003 | DE-627 | ||
| 005 | 20230309072046.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230228nuuuuuuuuxx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1590/1516-3180.2016.0158170816 |2 doi | |
| 035 | |a (DE-627)DOAJ067737749 | ||
| 035 | |a (DE-599)DOAJ8787046371d94a758ce30505b15cb0dd | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a Joel Schmillevitch |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. | ||
| 650 | 4 | |a Técnicas de imagem por elasticidade | |
| 650 | 4 | |a Transplante de fígado | |
| 650 | 4 | |a Fibrose | |
| 650 | 4 | |a Cirrose hepática | |
| 650 | 4 | |a Ultrassonografia | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 700 | 0 | |a Maria Cristina Chammas |e verfasserin |4 aut | |
| 700 | 0 | |a Vincenzo Pugliese |e verfasserin |4 aut | |
| 700 | 0 | |a Edson Abdala |e verfasserin |4 aut | |
| 700 | 0 | |a Adriana Cortez Rizzon |e verfasserin |4 aut | |
| 700 | 0 | |a Venâncio Alves |e verfasserin |4 aut | |
| 700 | 0 | |a Luiz Augusto Carneiro |e verfasserin |4 aut | |
| 700 | 0 | |a Giovanni Cerri |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t São Paulo Medical Journal |d Associação Paulista de Medicina, 2016 |w (DE-627)324825102 |w (DE-600)2031087-0 |x 18069460 |7 nnns |
| 856 | 4 | 0 | |u https://doi.org/10.1590/1516-3180.2016.0158170816 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/8787046371d94a758ce30505b15cb0dd |z kostenfrei |
| 856 | 4 | 0 | |u http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1806-9460 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| author_variant |
j s js m c c mcc v p vp e a ea a c r acr v a va l a c lac g c gc |
|---|---|
| matchkey_str |
article:18069460:uuuuuuuu::cutcaitofremusafeatgahcmaewtbosfrvlaigeaifboiatrietasl |
| allfields |
10.1590/1516-3180.2016.0158170816 doi (DE-627)DOAJ067737749 (DE-599)DOAJ8787046371d94a758ce30505b15cb0dd DE-627 ger DE-627 rakwb eng Joel Schmillevitch verfasserin aut Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. Técnicas de imagem por elasticidade Transplante de fígado Fibrose Cirrose hepática Ultrassonografia Medicine R Maria Cristina Chammas verfasserin aut Vincenzo Pugliese verfasserin aut Edson Abdala verfasserin aut Adriana Cortez Rizzon verfasserin aut Venâncio Alves verfasserin aut Luiz Augusto Carneiro verfasserin aut Giovanni Cerri verfasserin aut In São Paulo Medical Journal Associação Paulista de Medicina, 2016 (DE-627)324825102 (DE-600)2031087-0 18069460 nnns https://doi.org/10.1590/1516-3180.2016.0158170816 kostenfrei https://doaj.org/article/8787046371d94a758ce30505b15cb0dd kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-9460 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| spelling |
10.1590/1516-3180.2016.0158170816 doi (DE-627)DOAJ067737749 (DE-599)DOAJ8787046371d94a758ce30505b15cb0dd DE-627 ger DE-627 rakwb eng Joel Schmillevitch verfasserin aut Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. Técnicas de imagem por elasticidade Transplante de fígado Fibrose Cirrose hepática Ultrassonografia Medicine R Maria Cristina Chammas verfasserin aut Vincenzo Pugliese verfasserin aut Edson Abdala verfasserin aut Adriana Cortez Rizzon verfasserin aut Venâncio Alves verfasserin aut Luiz Augusto Carneiro verfasserin aut Giovanni Cerri verfasserin aut In São Paulo Medical Journal Associação Paulista de Medicina, 2016 (DE-627)324825102 (DE-600)2031087-0 18069460 nnns https://doi.org/10.1590/1516-3180.2016.0158170816 kostenfrei https://doaj.org/article/8787046371d94a758ce30505b15cb0dd kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-9460 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| allfields_unstemmed |
10.1590/1516-3180.2016.0158170816 doi (DE-627)DOAJ067737749 (DE-599)DOAJ8787046371d94a758ce30505b15cb0dd DE-627 ger DE-627 rakwb eng Joel Schmillevitch verfasserin aut Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. Técnicas de imagem por elasticidade Transplante de fígado Fibrose Cirrose hepática Ultrassonografia Medicine R Maria Cristina Chammas verfasserin aut Vincenzo Pugliese verfasserin aut Edson Abdala verfasserin aut Adriana Cortez Rizzon verfasserin aut Venâncio Alves verfasserin aut Luiz Augusto Carneiro verfasserin aut Giovanni Cerri verfasserin aut In São Paulo Medical Journal Associação Paulista de Medicina, 2016 (DE-627)324825102 (DE-600)2031087-0 18069460 nnns https://doi.org/10.1590/1516-3180.2016.0158170816 kostenfrei https://doaj.org/article/8787046371d94a758ce30505b15cb0dd kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-9460 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| allfieldsGer |
10.1590/1516-3180.2016.0158170816 doi (DE-627)DOAJ067737749 (DE-599)DOAJ8787046371d94a758ce30505b15cb0dd DE-627 ger DE-627 rakwb eng Joel Schmillevitch verfasserin aut Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. Técnicas de imagem por elasticidade Transplante de fígado Fibrose Cirrose hepática Ultrassonografia Medicine R Maria Cristina Chammas verfasserin aut Vincenzo Pugliese verfasserin aut Edson Abdala verfasserin aut Adriana Cortez Rizzon verfasserin aut Venâncio Alves verfasserin aut Luiz Augusto Carneiro verfasserin aut Giovanni Cerri verfasserin aut In São Paulo Medical Journal Associação Paulista de Medicina, 2016 (DE-627)324825102 (DE-600)2031087-0 18069460 nnns https://doi.org/10.1590/1516-3180.2016.0158170816 kostenfrei https://doaj.org/article/8787046371d94a758ce30505b15cb0dd kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-9460 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| allfieldsSound |
10.1590/1516-3180.2016.0158170816 doi (DE-627)DOAJ067737749 (DE-599)DOAJ8787046371d94a758ce30505b15cb0dd DE-627 ger DE-627 rakwb eng Joel Schmillevitch verfasserin aut Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. Técnicas de imagem por elasticidade Transplante de fígado Fibrose Cirrose hepática Ultrassonografia Medicine R Maria Cristina Chammas verfasserin aut Vincenzo Pugliese verfasserin aut Edson Abdala verfasserin aut Adriana Cortez Rizzon verfasserin aut Venâncio Alves verfasserin aut Luiz Augusto Carneiro verfasserin aut Giovanni Cerri verfasserin aut In São Paulo Medical Journal Associação Paulista de Medicina, 2016 (DE-627)324825102 (DE-600)2031087-0 18069460 nnns https://doi.org/10.1590/1516-3180.2016.0158170816 kostenfrei https://doaj.org/article/8787046371d94a758ce30505b15cb0dd kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en kostenfrei https://doaj.org/toc/1806-9460 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
| language |
English |
| source |
In São Paulo Medical Journal |
| sourceStr |
In São Paulo Medical Journal |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Técnicas de imagem por elasticidade Transplante de fígado Fibrose Cirrose hepática Ultrassonografia Medicine R |
| isfreeaccess_bool |
true |
| container_title |
São Paulo Medical Journal |
| authorswithroles_txt_mv |
Joel Schmillevitch @@aut@@ Maria Cristina Chammas @@aut@@ Vincenzo Pugliese @@aut@@ Edson Abdala @@aut@@ Adriana Cortez Rizzon @@aut@@ Venâncio Alves @@aut@@ Luiz Augusto Carneiro @@aut@@ Giovanni Cerri @@aut@@ |
| publishDateDaySort_date |
2024-01-01T00:00:00Z |
| hierarchy_top_id |
324825102 |
| id |
DOAJ067737749 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ067737749</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309072046.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228nuuuuuuuuxx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1590/1516-3180.2016.0158170816</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ067737749</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ8787046371d94a758ce30505b15cb0dd</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Joel Schmillevitch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Técnicas de imagem por elasticidade</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Transplante de fígado</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fibrose</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cirrose hepática</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ultrassonografia</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Cristina Chammas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vincenzo Pugliese</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Edson Abdala</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adriana Cortez Rizzon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Venâncio Alves</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luiz Augusto Carneiro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giovanni Cerri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">São Paulo Medical Journal</subfield><subfield code="d">Associação Paulista de Medicina, 2016</subfield><subfield code="w">(DE-627)324825102</subfield><subfield code="w">(DE-600)2031087-0</subfield><subfield code="x">18069460</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1590/1516-3180.2016.0158170816</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/8787046371d94a758ce30505b15cb0dd</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1806-9460</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield></record></collection>
|
| author |
Joel Schmillevitch |
| spellingShingle |
Joel Schmillevitch misc Técnicas de imagem por elasticidade misc Transplante de fígado misc Fibrose misc Cirrose hepática misc Ultrassonografia misc Medicine misc R Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study |
| authorStr |
Joel Schmillevitch |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)324825102 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut |
| collection |
DOAJ |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
18069460 |
| topic_title |
Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study Técnicas de imagem por elasticidade Transplante de fígado Fibrose Cirrose hepática Ultrassonografia |
| topic |
misc Técnicas de imagem por elasticidade misc Transplante de fígado misc Fibrose misc Cirrose hepática misc Ultrassonografia misc Medicine misc R |
| topic_unstemmed |
misc Técnicas de imagem por elasticidade misc Transplante de fígado misc Fibrose misc Cirrose hepática misc Ultrassonografia misc Medicine misc R |
| topic_browse |
misc Técnicas de imagem por elasticidade misc Transplante de fígado misc Fibrose misc Cirrose hepática misc Ultrassonografia misc Medicine misc R |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
São Paulo Medical Journal |
| hierarchy_parent_id |
324825102 |
| hierarchy_top_title |
São Paulo Medical Journal |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)324825102 (DE-600)2031087-0 |
| title |
Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study |
| ctrlnum |
(DE-627)DOAJ067737749 (DE-599)DOAJ8787046371d94a758ce30505b15cb0dd |
| title_full |
Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study |
| author_sort |
Joel Schmillevitch |
| journal |
São Paulo Medical Journal |
| journalStr |
São Paulo Medical Journal |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| contenttype_str_mv |
txt |
| author_browse |
Joel Schmillevitch Maria Cristina Chammas Vincenzo Pugliese Edson Abdala Adriana Cortez Rizzon Venâncio Alves Luiz Augusto Carneiro Giovanni Cerri |
| format_se |
Elektronische Aufsätze |
| author-letter |
Joel Schmillevitch |
| doi_str_mv |
10.1590/1516-3180.2016.0158170816 |
| author2-role |
verfasserin |
| title_sort |
acoustic radiation force impulse (arfi) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study |
| title_auth |
Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study |
| abstract |
ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. |
| abstractGer |
ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. |
| abstract_unstemmed |
ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ |
| title_short |
Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study |
| url |
https://doi.org/10.1590/1516-3180.2016.0158170816 https://doaj.org/article/8787046371d94a758ce30505b15cb0dd http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en https://doaj.org/toc/1806-9460 |
| remote_bool |
true |
| author2 |
Maria Cristina Chammas Vincenzo Pugliese Edson Abdala Adriana Cortez Rizzon Venâncio Alves Luiz Augusto Carneiro Giovanni Cerri |
| author2Str |
Maria Cristina Chammas Vincenzo Pugliese Edson Abdala Adriana Cortez Rizzon Venâncio Alves Luiz Augusto Carneiro Giovanni Cerri |
| ppnlink |
324825102 |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.1590/1516-3180.2016.0158170816 |
| up_date |
2024-07-03T13:47:49.801Z |
| _version_ |
1803565892687101952 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ067737749</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309072046.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228nuuuuuuuuxx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1590/1516-3180.2016.0158170816</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ067737749</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ8787046371d94a758ce30505b15cb0dd</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Joel Schmillevitch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Técnicas de imagem por elasticidade</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Transplante de fígado</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fibrose</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cirrose hepática</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ultrassonografia</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Cristina Chammas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vincenzo Pugliese</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Edson Abdala</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adriana Cortez Rizzon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Venâncio Alves</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luiz Augusto Carneiro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giovanni Cerri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">São Paulo Medical Journal</subfield><subfield code="d">Associação Paulista de Medicina, 2016</subfield><subfield code="w">(DE-627)324825102</subfield><subfield code="w">(DE-600)2031087-0</subfield><subfield code="x">18069460</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1590/1516-3180.2016.0158170816</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/8787046371d94a758ce30505b15cb0dd</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000600513&lng=en&tlng=en</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1806-9460</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield></record></collection>
|
| score |
7.400197 |