Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy

Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Li Y [verfasserIn] Xu M [verfasserIn] Dhawan U [verfasserIn] Liu WC [verfasserIn] Wu KT [verfasserIn] Liu X [verfasserIn] Lin CP [verfasserIn] Zhao G [verfasserIn] Wu YC [verfasserIn] Chung RJ [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release

Übergeordnetes Werk:	In: International Journal of Nanomedicine - Dove Medical Press, 2018, (2018), Seite 5499-5509
Übergeordnetes Werk:	year:2018 ; pages:5499-5509

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ067784976

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ067784976
003	DE-627
005	20230309072252.0
007	cr uuu---uuuuu
008	230228s2018 xx \|\|\|\|\|o 00\| \|\|eng c
035			\|a (DE-627)DOAJ067784976
035			\|a (DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a R5-920
100	0		\|a Li Y \|e verfasserin \|4 aut
245	1	0	\|a Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy
264		1	\|c 2018
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release
650		4	\|a iron-gold nanoparticles
650		4	\|a methotrexate
650		4	\|a hyperthermia
650		4	\|a superparamagnetic
650		4	\|a controlled drug release
653		0	\|a Medicine (General)
700	0		\|a Xu M \|e verfasserin \|4 aut
700	0		\|a Dhawan U \|e verfasserin \|4 aut
700	0		\|a Liu WC \|e verfasserin \|4 aut
700	0		\|a Wu KT \|e verfasserin \|4 aut
700	0		\|a Liu X \|e verfasserin \|4 aut
700	0		\|a Lin CP \|e verfasserin \|4 aut
700	0		\|a Zhao G \|e verfasserin \|4 aut
700	0		\|a Wu YC \|e verfasserin \|4 aut
700	0		\|a Chung RJ \|e verfasserin \|4 aut
773	0	8	\|i In \|t International Journal of Nanomedicine \|d Dove Medical Press, 2018 \|g (2018), Seite 5499-5509 \|w (DE-627)537879560 \|w (DE-600)2377464-2 \|x 11782013 \|7 nnns
773	1	8	\|g year:2018 \|g pages:5499-5509
856	4	0	\|u https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7 \|z kostenfrei
856	4	0	\|u https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/1178-2013 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|j 2018 \|h 5499-5509

Indexfelder

author_variant	l y ly x m xm d u du l w lw w k wk l x lx l c lc z g zg w y wy c r cr
matchkey_str	article:11782013:2018----::rndsglalyaoatcesrescresoenyetemaeitdotol
hierarchy_sort_str	2018
callnumber-subject-code	R
publishDate	2018
allfields	(DE-627)DOAJ067784976 (DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7 DE-627 ger DE-627 rakwb eng R5-920 Li Y verfasserin aut Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release Medicine (General) Xu M verfasserin aut Dhawan U verfasserin aut Liu WC verfasserin aut Wu KT verfasserin aut Liu X verfasserin aut Lin CP verfasserin aut Zhao G verfasserin aut Wu YC verfasserin aut Chung RJ verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2018), Seite 5499-5509 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2018 pages:5499-5509 https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7 kostenfrei https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 5499-5509
spelling	(DE-627)DOAJ067784976 (DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7 DE-627 ger DE-627 rakwb eng R5-920 Li Y verfasserin aut Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release Medicine (General) Xu M verfasserin aut Dhawan U verfasserin aut Liu WC verfasserin aut Wu KT verfasserin aut Liu X verfasserin aut Lin CP verfasserin aut Zhao G verfasserin aut Wu YC verfasserin aut Chung RJ verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2018), Seite 5499-5509 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2018 pages:5499-5509 https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7 kostenfrei https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 5499-5509
allfields_unstemmed	(DE-627)DOAJ067784976 (DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7 DE-627 ger DE-627 rakwb eng R5-920 Li Y verfasserin aut Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release Medicine (General) Xu M verfasserin aut Dhawan U verfasserin aut Liu WC verfasserin aut Wu KT verfasserin aut Liu X verfasserin aut Lin CP verfasserin aut Zhao G verfasserin aut Wu YC verfasserin aut Chung RJ verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2018), Seite 5499-5509 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2018 pages:5499-5509 https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7 kostenfrei https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 5499-5509
allfieldsGer	(DE-627)DOAJ067784976 (DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7 DE-627 ger DE-627 rakwb eng R5-920 Li Y verfasserin aut Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release Medicine (General) Xu M verfasserin aut Dhawan U verfasserin aut Liu WC verfasserin aut Wu KT verfasserin aut Liu X verfasserin aut Lin CP verfasserin aut Zhao G verfasserin aut Wu YC verfasserin aut Chung RJ verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2018), Seite 5499-5509 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2018 pages:5499-5509 https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7 kostenfrei https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 5499-5509
allfieldsSound	(DE-627)DOAJ067784976 (DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7 DE-627 ger DE-627 rakwb eng R5-920 Li Y verfasserin aut Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release Medicine (General) Xu M verfasserin aut Dhawan U verfasserin aut Liu WC verfasserin aut Wu KT verfasserin aut Liu X verfasserin aut Lin CP verfasserin aut Zhao G verfasserin aut Wu YC verfasserin aut Chung RJ verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2018), Seite 5499-5509 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2018 pages:5499-5509 https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7 kostenfrei https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 5499-5509
language	English
source	In International Journal of Nanomedicine (2018), Seite 5499-5509 year:2018 pages:5499-5509
sourceStr	In International Journal of Nanomedicine (2018), Seite 5499-5509 year:2018 pages:5499-5509
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release Medicine (General)
isfreeaccess_bool	true
container_title	International Journal of Nanomedicine
authorswithroles_txt_mv	Li Y @@aut@@ Xu M @@aut@@ Dhawan U @@aut@@ Liu WC @@aut@@ Wu KT @@aut@@ Liu X @@aut@@ Lin CP @@aut@@ Zhao G @@aut@@ Wu YC @@aut@@ Chung RJ @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	537879560
id	DOAJ067784976
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ067784976</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309072252.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ067784976</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Li Y</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Iron&ndash;gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People&rsquo;s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People&rsquo;s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron&ndash;gold alloy magnetic nanoparticles (Fe&ndash;Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug&ndash;nanoparticle conjugate (NFA&ndash;MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2&theta; peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA&ndash;MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA&ndash;MTX conjugate, triggering a 95% decrease in cellular viability at 100 &micro;g/mL.Conclusion: The ability of NFA&ndash;MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron&ndash;gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">iron-gold nanoparticles</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">methotrexate</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hyperthermia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">superparamagnetic</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">controlled drug release</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xu M</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dhawan U</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liu WC</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wu KT</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liu X</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lin CP</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zhao G</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wu YC</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chung RJ</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Nanomedicine</subfield><subfield code="d">Dove Medical Press, 2018</subfield><subfield code="g">(2018), Seite 5499-5509</subfield><subfield code="w">(DE-627)537879560</subfield><subfield code="w">(DE-600)2377464-2</subfield><subfield code="x">11782013</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">year:2018</subfield><subfield code="g">pages:5499-5509</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1178-2013</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="j">2018</subfield><subfield code="h">5499-5509</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Li Y
spellingShingle	Li Y misc R5-920 misc iron-gold nanoparticles misc methotrexate misc hyperthermia misc superparamagnetic misc controlled drug release misc Medicine (General) Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy
authorStr	Li Y
ppnlink_with_tag_str_mv	@@773@@(DE-627)537879560
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	R5-920
illustrated	Not Illustrated
issn	11782013
topic_title	R5-920 Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy iron-gold nanoparticles methotrexate hyperthermia superparamagnetic controlled drug release
topic	misc R5-920 misc iron-gold nanoparticles misc methotrexate misc hyperthermia misc superparamagnetic misc controlled drug release misc Medicine (General)
topic_unstemmed	misc R5-920 misc iron-gold nanoparticles misc methotrexate misc hyperthermia misc superparamagnetic misc controlled drug release misc Medicine (General)
topic_browse	misc R5-920 misc iron-gold nanoparticles misc methotrexate misc hyperthermia misc superparamagnetic misc controlled drug release misc Medicine (General)
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	International Journal of Nanomedicine
hierarchy_parent_id	537879560
hierarchy_top_title	International Journal of Nanomedicine
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)537879560 (DE-600)2377464-2
title	Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy
ctrlnum	(DE-627)DOAJ067784976 (DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7
title_full	Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy
author_sort	Li Y
journal	International Journal of Nanomedicine
journalStr	International Journal of Nanomedicine
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2018
contenttype_str_mv	txt
container_start_page	5499
author_browse	Li Y Xu M Dhawan U Liu WC Wu KT Liu X Lin CP Zhao G Wu YC Chung RJ
class	R5-920
format_se	Elektronische Aufsätze
author-letter	Li Y
author2-role	verfasserin
title_sort	iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy
callnumber	R5-920
title_auth	Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy
abstract	Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release
abstractGer	Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release
abstract_unstemmed	Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People’s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People’s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron–gold alloy magnetic nanoparticles (Fe–Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug–nanoparticle conjugate (NFA–MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2θ peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA–MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA–MTX conjugate, triggering a 95% decrease in cellular viability at 100 µg/mL.Conclusion: The ability of NFA–MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron–gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy
url	https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7 https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN https://doaj.org/toc/1178-2013
remote_bool	true
author2	Xu M Dhawan U Liu WC Wu KT Liu X Lin CP Zhao G Wu YC Chung RJ
author2Str	Xu M Dhawan U Liu WC Wu KT Liu X Lin CP Zhao G Wu YC Chung RJ
ppnlink	537879560
callnumber-subject	R - General Medicine
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
callnumber-a	R5-920
up_date	2024-07-03T14:03:42.832Z
_version_	1803566892015681537
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ067784976</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309072252.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ067784976</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJbe9e3374f26c41818a0e75f3d95106e7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Li Y</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Iron&ndash;gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Yun-Qian Li,1,* Meng Xu,2,* Udesh Dhawan,3,4 Wai-Ching Liu,5 Kou-Ting Wu,5 Xin-Rui Liu,1 Chingpo Lin,1 Gang Zhao,1 Yu-Chuan Wu,3,6,7 Ren-Jei Chung5 1Department of Neurosurgical Oncology, First Hospital, Jilin University, Changchun, People&rsquo;s Republic of China; 2School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, People&rsquo;s Republic of China; 3Department of Materials and Mineral Resources Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 4Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China; 5Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 6Institute of Materials Science and Engineering, National Taipei University of Technology (Taipei Tech), Taipei, Taiwan, Republic of China; 7Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan, Republic of China *These authors contributed equally to this work Introduction: The efficacy of a chemotherapy drug in cancer therapy is highly determined by the ability to control the rate and extent of its release in vivo. However, the lack of techniques to accurately control drug release drastically limits the potency of a chemotherapy drug.Materials and methods: Here, we present a novel strategy to precisely monitor drug release under magnetic stimulation. Methotrexate (MTX), an anticancer drug, was covalently functionalized onto iron&ndash;gold alloy magnetic nanoparticles (Fe&ndash;Au alloy nanoparticles or NFAs) through 2-aminoethanethiol grafting and the ability of this drug&ndash;nanoparticle conjugate (NFA&ndash;MTX) in limiting HepG2 (liver carcinoma) cell growth was studied. Well-dispersed NFAs were prepared through pyrolysis.Results and discussion: Transmission electron microscopy revealed the average nanoparticle size to be 7.22+-2.6 nm, while X-ray diffraction showed distinct 2&theta; peaks for iron and gold, confirming the presence of iron and gold nanoparticles. Inductively coupled plasma mass spectrometry revealed that the amount of NFA&ndash;MTX conjugate ingested by HepG2 cancer cells was 1.5 times higher than that ingested by L929 fibroblasts, thereby proving a higher selective ingestion by cancer cells compared to normal cells. Fourier-transform infrared spectroscopy revealed the breakage of Au-S bonds by the heat generated under magnetic field stimulation to release MTX from the NFA&ndash;MTX conjugate, triggering a 95% decrease in cellular viability at 100 &micro;g/mL.Conclusion: The ability of NFA&ndash;MTX to dissociate under the influence of an applied magnetic field provides a new strategy to induce cancer cell death via hyperthermia. Applications in drug delivery, drug development, and cancer research are expected. Keywords: iron&ndash;gold nanoparticles, methotrexate, hyperthermia, superparamagnetic, controlled drug release</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">iron-gold nanoparticles</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">methotrexate</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hyperthermia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">superparamagnetic</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">controlled drug release</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xu M</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dhawan U</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liu WC</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wu KT</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Liu X</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lin CP</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zhao G</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Wu YC</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chung RJ</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">International Journal of Nanomedicine</subfield><subfield code="d">Dove Medical Press, 2018</subfield><subfield code="g">(2018), Seite 5499-5509</subfield><subfield code="w">(DE-627)537879560</subfield><subfield code="w">(DE-600)2377464-2</subfield><subfield code="x">11782013</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">year:2018</subfield><subfield code="g">pages:5499-5509</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/be9e3374f26c41818a0e75f3d95106e7</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.dovepress.com/iron-gold-alloy-nanoparticles-serve-as-a-cornerstone-in-hyperthermia-m-peer-reviewed-article-IJN</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1178-2013</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="j">2018</subfield><subfield code="h">5499-5509</subfield></datafield></record></collection>
score	7.4012003

Nicht das Richtige dabei?

Schreiben Sie uns!

Iron&ndash;gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?

Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy