Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis

Whether the 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial. To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jia-Dong Xia [verfasserIn] Jie Chen [verfasserIn] You-Feng Han [verfasserIn] Hai Chen [verfasserIn] Wen Yu [verfasserIn] Yun Chen [verfasserIn] Yu-Tian Dai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	haplotype; male infertility; meta-analysis; ubiquitin-specific protease 26

Übergeordnetes Werk:	In: Asian Journal of Andrology - Wolters Kluwer Medknow Publications, 2014, 16(2014), 5, Seite 720-724
Übergeordnetes Werk:	volume:16 ; year:2014 ; number:5 ; pages:720-724

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/1008-682X.129134

Katalog-ID:	DOAJ067789285

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allfieldsGer	10.4103/1008-682X.129134 doi (DE-627)DOAJ067789285 (DE-599)DOAJcee1b6aa42754b219332cc2051a2733e DE-627 ger DE-627 rakwb eng RC870-923 Jia-Dong Xia verfasserin aut Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Whether the 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial. To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and Embase. Pooled odd ratio (OR) with 95% confidence interval (CI) was calculated with fixed effect models. Ten studies with 1603 patients and 2505 controls were included. Overall, the results indicated that there was an association between the haplotype and male infertile risk (OR = 1.74, 95% CI: 1.09-2.77). The OR calculated based on the five studies in Asia and three in Europe was 1.96 (95% CI: 1.05-3.67) and 1.54 (95% CI: 0.75-3.16) respectively, however, the OR was 0.86 (95% CI: 0.05-15.29) based on the two investigations in America. In addition, the data from the patients with azoospermia (AZO) showed an increased pooled OR of 2.35 (95% CI: 1.22-4.50). In contrast, the studies with oligoasthenoteratozoospermia (OAT) exhibited that the pooled OR was 0.97 (95% CI: 0.43-2.16). Our analyses indicate that there is an association of alteration in USP26 with male infertility, especially in AZO and Asian population. haplotype; male infertility; meta-analysis; ubiquitin-specific protease 26 Diseases of the genitourinary system. Urology Jie Chen verfasserin aut You-Feng Han verfasserin aut Hai Chen verfasserin aut Wen Yu verfasserin aut Yun Chen verfasserin aut Yu-Tian Dai verfasserin aut In Asian Journal of Andrology Wolters Kluwer Medknow Publications, 2014 16(2014), 5, Seite 720-724 (DE-627)352261013 (DE-600)2085228-9 17457262 nnns volume:16 year:2014 number:5 pages:720-724 https://doi.org/10.4103/1008-682X.129134 kostenfrei https://doaj.org/article/cee1b6aa42754b219332cc2051a2733e kostenfrei http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=5;spage=720;epage=724;aulast=Xia kostenfrei https://doaj.org/toc/1008-682X Journal toc kostenfrei https://doaj.org/toc/1745-7262 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2014 5 720-724
allfieldsSound	10.4103/1008-682X.129134 doi (DE-627)DOAJ067789285 (DE-599)DOAJcee1b6aa42754b219332cc2051a2733e DE-627 ger DE-627 rakwb eng RC870-923 Jia-Dong Xia verfasserin aut Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Whether the 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial. To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and Embase. Pooled odd ratio (OR) with 95% confidence interval (CI) was calculated with fixed effect models. Ten studies with 1603 patients and 2505 controls were included. Overall, the results indicated that there was an association between the haplotype and male infertile risk (OR = 1.74, 95% CI: 1.09-2.77). The OR calculated based on the five studies in Asia and three in Europe was 1.96 (95% CI: 1.05-3.67) and 1.54 (95% CI: 0.75-3.16) respectively, however, the OR was 0.86 (95% CI: 0.05-15.29) based on the two investigations in America. In addition, the data from the patients with azoospermia (AZO) showed an increased pooled OR of 2.35 (95% CI: 1.22-4.50). In contrast, the studies with oligoasthenoteratozoospermia (OAT) exhibited that the pooled OR was 0.97 (95% CI: 0.43-2.16). Our analyses indicate that there is an association of alteration in USP26 with male infertility, especially in AZO and Asian population. haplotype; male infertility; meta-analysis; ubiquitin-specific protease 26 Diseases of the genitourinary system. Urology Jie Chen verfasserin aut You-Feng Han verfasserin aut Hai Chen verfasserin aut Wen Yu verfasserin aut Yun Chen verfasserin aut Yu-Tian Dai verfasserin aut In Asian Journal of Andrology Wolters Kluwer Medknow Publications, 2014 16(2014), 5, Seite 720-724 (DE-627)352261013 (DE-600)2085228-9 17457262 nnns volume:16 year:2014 number:5 pages:720-724 https://doi.org/10.4103/1008-682X.129134 kostenfrei https://doaj.org/article/cee1b6aa42754b219332cc2051a2733e kostenfrei http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=5;spage=720;epage=724;aulast=Xia kostenfrei https://doaj.org/toc/1008-682X Journal toc kostenfrei https://doaj.org/toc/1745-7262 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2014 5 720-724
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topic_title	RC870-923 Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis haplotype; male infertility; meta-analysis; ubiquitin-specific protease 26
topic	misc RC870-923 misc haplotype; male infertility; meta-analysis; ubiquitin-specific protease 26 misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc haplotype; male infertility; meta-analysis; ubiquitin-specific protease 26 misc Diseases of the genitourinary system. Urology
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title	Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis
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title_full	Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis
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title_sort	association of 370-371insaca, 494t<c, and 1423c<t haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis
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title_auth	Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis
abstract	Whether the 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial. To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and Embase. Pooled odd ratio (OR) with 95% confidence interval (CI) was calculated with fixed effect models. Ten studies with 1603 patients and 2505 controls were included. Overall, the results indicated that there was an association between the haplotype and male infertile risk (OR = 1.74, 95% CI: 1.09-2.77). The OR calculated based on the five studies in Asia and three in Europe was 1.96 (95% CI: 1.05-3.67) and 1.54 (95% CI: 0.75-3.16) respectively, however, the OR was 0.86 (95% CI: 0.05-15.29) based on the two investigations in America. In addition, the data from the patients with azoospermia (AZO) showed an increased pooled OR of 2.35 (95% CI: 1.22-4.50). In contrast, the studies with oligoasthenoteratozoospermia (OAT) exhibited that the pooled OR was 0.97 (95% CI: 0.43-2.16). Our analyses indicate that there is an association of alteration in USP26 with male infertility, especially in AZO and Asian population.
abstractGer	Whether the 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial. To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and Embase. Pooled odd ratio (OR) with 95% confidence interval (CI) was calculated with fixed effect models. Ten studies with 1603 patients and 2505 controls were included. Overall, the results indicated that there was an association between the haplotype and male infertile risk (OR = 1.74, 95% CI: 1.09-2.77). The OR calculated based on the five studies in Asia and three in Europe was 1.96 (95% CI: 1.05-3.67) and 1.54 (95% CI: 0.75-3.16) respectively, however, the OR was 0.86 (95% CI: 0.05-15.29) based on the two investigations in America. In addition, the data from the patients with azoospermia (AZO) showed an increased pooled OR of 2.35 (95% CI: 1.22-4.50). In contrast, the studies with oligoasthenoteratozoospermia (OAT) exhibited that the pooled OR was 0.97 (95% CI: 0.43-2.16). Our analyses indicate that there is an association of alteration in USP26 with male infertility, especially in AZO and Asian population.
abstract_unstemmed	Whether the 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial. To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and Embase. Pooled odd ratio (OR) with 95% confidence interval (CI) was calculated with fixed effect models. Ten studies with 1603 patients and 2505 controls were included. Overall, the results indicated that there was an association between the haplotype and male infertile risk (OR = 1.74, 95% CI: 1.09-2.77). The OR calculated based on the five studies in Asia and three in Europe was 1.96 (95% CI: 1.05-3.67) and 1.54 (95% CI: 0.75-3.16) respectively, however, the OR was 0.86 (95% CI: 0.05-15.29) based on the two investigations in America. In addition, the data from the patients with azoospermia (AZO) showed an increased pooled OR of 2.35 (95% CI: 1.22-4.50). In contrast, the studies with oligoasthenoteratozoospermia (OAT) exhibited that the pooled OR was 0.97 (95% CI: 0.43-2.16). Our analyses indicate that there is an association of alteration in USP26 with male infertility, especially in AZO and Asian population.
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title_short	Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis
url	https://doi.org/10.4103/1008-682X.129134 https://doaj.org/article/cee1b6aa42754b219332cc2051a2733e http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=5;spage=720;epage=724;aulast=Xia https://doaj.org/toc/1008-682X https://doaj.org/toc/1745-7262
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To clarify this issue, we conducted a meta-analysis based on the most recent studies. Eligible studies were screened by using PubMed and Embase. Pooled odd ratio (OR) with 95% confidence interval (CI) was calculated with fixed effect models. Ten studies with 1603 patients and 2505 controls were included. Overall, the results indicated that there was an association between the haplotype and male infertile risk (OR = 1.74, 95% CI: 1.09-2.77). The OR calculated based on the five studies in Asia and three in Europe was 1.96 (95% CI: 1.05-3.67) and 1.54 (95% CI: 0.75-3.16) respectively, however, the OR was 0.86 (95% CI: 0.05-15.29) based on the two investigations in America. In addition, the data from the patients with azoospermia (AZO) showed an increased pooled OR of 2.35 (95% CI: 1.22-4.50). In contrast, the studies with oligoasthenoteratozoospermia (OAT) exhibited that the pooled OR was 0.97 (95% CI: 0.43-2.16). 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code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Asian Journal of Andrology</subfield><subfield code="d">Wolters Kluwer Medknow Publications, 2014</subfield><subfield code="g">16(2014), 5, Seite 720-724</subfield><subfield code="w">(DE-627)352261013</subfield><subfield code="w">(DE-600)2085228-9</subfield><subfield code="x">17457262</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:16</subfield><subfield code="g">year:2014</subfield><subfield code="g">number:5</subfield><subfield code="g">pages:720-724</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.4103/1008-682X.129134</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/cee1b6aa42754b219332cc2051a2733e</subfield><subfield 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Association of 370-371insACA, 494T<C, and 1423C<T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis

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