A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.

Gespeichert in:

Autor*in:	Joshua D. Ooi [verfasserIn] Jhih-Hang Jiang [verfasserIn] Peter J. Eggenhuizen [verfasserIn] Ling L. Chua [verfasserIn] Mirjan van Timmeren [verfasserIn] Khai L. Loh [verfasserIn] Kim M. O’Sullivan [verfasserIn] Poh Y. Gan [verfasserIn] Yong Zhong [verfasserIn] Kirill Tsyganov [verfasserIn] Lani R. Shochet [verfasserIn] Jessica Ryan [verfasserIn] Coen A. Stegeman [verfasserIn] Lars Fugger [verfasserIn] Hugh H. Reid [verfasserIn] Jamie Rossjohn [verfasserIn] Peter Heeringa [verfasserIn] Stephen R. Holdsworth [verfasserIn] Anton Y. Peleg [verfasserIn] A. Richard Kitching [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 10(2019), 1, Seite 14
Übergeordnetes Werk:	volume:10 ; year:2019 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-019-11255-0

Katalog-ID:	DOAJ067905277

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author	Joshua D. Ooi
spellingShingle	Joshua D. Ooi misc Science misc Q A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
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topic_title	A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
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title	A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
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title_full	A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
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author_browse	Joshua D. Ooi Jhih-Hang Jiang Peter J. Eggenhuizen Ling L. Chua Mirjan van Timmeren Khai L. Loh Kim M. O’Sullivan Poh Y. Gan Yong Zhong Kirill Tsyganov Lani R. Shochet Jessica Ryan Coen A. Stegeman Lars Fugger Hugh H. Reid Jamie Rossjohn Peter Heeringa Stephen R. Holdsworth Anton Y. Peleg A. Richard Kitching
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title_sort	plasmid-encoded peptide from staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
title_auth	A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
abstract	Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.
abstractGer	Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.
abstract_unstemmed	Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.
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title_short	A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
url	https://doi.org/10.1038/s41467-019-11255-0 https://doaj.org/article/ec5422e66a47466790d6d136a48ebe74 https://doaj.org/toc/2041-1723
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