A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.

Gespeichert in:

Autor*in:	Alison Roth [verfasserIn] Steven P. Maher [verfasserIn] Amy J. Conway [verfasserIn] Ratawan Ubalee [verfasserIn] Victor Chaumeau [verfasserIn] Chiara Andolina [verfasserIn] Stephen A. Kaba [verfasserIn] Amélie Vantaux [verfasserIn] Malina A. Bakowski [verfasserIn] Richard Thomson-Luque [verfasserIn] Swamy Rakesh Adapa [verfasserIn] Naresh Singh [verfasserIn] Samantha J. Barnes [verfasserIn] Caitlin A. Cooper [verfasserIn] Mélanie Rouillier [verfasserIn] Case W. McNamara [verfasserIn] Sebastian A. Mikolajczak [verfasserIn] Noah Sather [verfasserIn] Benoît Witkowski [verfasserIn] Brice Campo [verfasserIn] Stefan H. I. Kappe [verfasserIn] David E. Lanar [verfasserIn] François Nosten [verfasserIn] Silas Davidson [verfasserIn] Rays H. Y. Jiang [verfasserIn] Dennis E. Kyle [verfasserIn] John H. Adams [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 16
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-018-04221-9

Katalog-ID:	DOAJ067962556

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allfields	10.1038/s41467-018-04221-9 doi (DE-627)DOAJ067962556 (DE-599)DOAJ0b14f6d533014ef091394f171d42ba23 DE-627 ger DE-627 rakwb eng Alison Roth verfasserin aut A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens. Science Q Steven P. Maher verfasserin aut Amy J. Conway verfasserin aut Ratawan Ubalee verfasserin aut Victor Chaumeau verfasserin aut Chiara Andolina verfasserin aut Stephen A. Kaba verfasserin aut Amélie Vantaux verfasserin aut Malina A. Bakowski verfasserin aut Richard Thomson-Luque verfasserin aut Swamy Rakesh Adapa verfasserin aut Naresh Singh verfasserin aut Samantha J. Barnes verfasserin aut Caitlin A. Cooper verfasserin aut Mélanie Rouillier verfasserin aut Case W. McNamara verfasserin aut Sebastian A. Mikolajczak verfasserin aut Noah Sather verfasserin aut Benoît Witkowski verfasserin aut Brice Campo verfasserin aut Stefan H. I. Kappe verfasserin aut David E. Lanar verfasserin aut François Nosten verfasserin aut Silas Davidson verfasserin aut Rays H. Y. Jiang verfasserin aut Dennis E. Kyle verfasserin aut John H. Adams verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:16 https://doi.org/10.1038/s41467-018-04221-9 kostenfrei https://doaj.org/article/0b14f6d533014ef091394f171d42ba23 kostenfrei https://doi.org/10.1038/s41467-018-04221-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 16
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allfieldsSound	10.1038/s41467-018-04221-9 doi (DE-627)DOAJ067962556 (DE-599)DOAJ0b14f6d533014ef091394f171d42ba23 DE-627 ger DE-627 rakwb eng Alison Roth verfasserin aut A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens. Science Q Steven P. Maher verfasserin aut Amy J. Conway verfasserin aut Ratawan Ubalee verfasserin aut Victor Chaumeau verfasserin aut Chiara Andolina verfasserin aut Stephen A. Kaba verfasserin aut Amélie Vantaux verfasserin aut Malina A. Bakowski verfasserin aut Richard Thomson-Luque verfasserin aut Swamy Rakesh Adapa verfasserin aut Naresh Singh verfasserin aut Samantha J. Barnes verfasserin aut Caitlin A. Cooper verfasserin aut Mélanie Rouillier verfasserin aut Case W. McNamara verfasserin aut Sebastian A. Mikolajczak verfasserin aut Noah Sather verfasserin aut Benoît Witkowski verfasserin aut Brice Campo verfasserin aut Stefan H. I. Kappe verfasserin aut David E. Lanar verfasserin aut François Nosten verfasserin aut Silas Davidson verfasserin aut Rays H. Y. Jiang verfasserin aut Dennis E. Kyle verfasserin aut John H. Adams verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:16 https://doi.org/10.1038/s41467-018-04221-9 kostenfrei https://doaj.org/article/0b14f6d533014ef091394f171d42ba23 kostenfrei https://doi.org/10.1038/s41467-018-04221-9 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 16
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author	Alison Roth
spellingShingle	Alison Roth misc Science misc Q A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
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topic_title	A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
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title	A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
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title_full	A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
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author_browse	Alison Roth Steven P. Maher Amy J. Conway Ratawan Ubalee Victor Chaumeau Chiara Andolina Stephen A. Kaba Amélie Vantaux Malina A. Bakowski Richard Thomson-Luque Swamy Rakesh Adapa Naresh Singh Samantha J. Barnes Caitlin A. Cooper Mélanie Rouillier Case W. McNamara Sebastian A. Mikolajczak Noah Sather Benoît Witkowski Brice Campo Stefan H. I. Kappe David E. Lanar François Nosten Silas Davidson Rays H. Y. Jiang Dennis E. Kyle John H. Adams
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title_sort	comprehensive model for assessment of liver stage therapies targeting plasmodium vivax and plasmodium falciparum
title_auth	A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
abstract	Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.
abstractGer	Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.
abstract_unstemmed	Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.
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title_short	A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
url	https://doi.org/10.1038/s41467-018-04221-9 https://doaj.org/article/0b14f6d533014ef091394f171d42ba23 https://doaj.org/toc/2041-1723
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author2	Steven P. Maher Amy J. Conway Ratawan Ubalee Victor Chaumeau Chiara Andolina Stephen A. Kaba Amélie Vantaux Malina A. Bakowski Richard Thomson-Luque Swamy Rakesh Adapa Naresh Singh Samantha J. Barnes Caitlin A. Cooper Mélanie Rouillier Case W. McNamara Sebastian A. Mikolajczak Noah Sather Benoît Witkowski Brice Campo Stefan H. I. Kappe David E. Lanar François Nosten Silas Davidson Rays H. Y. Jiang Dennis E. Kyle John H. Adams
author2Str	Steven P. Maher Amy J. Conway Ratawan Ubalee Victor Chaumeau Chiara Andolina Stephen A. Kaba Amélie Vantaux Malina A. Bakowski Richard Thomson-Luque Swamy Rakesh Adapa Naresh Singh Samantha J. Barnes Caitlin A. Cooper Mélanie Rouillier Case W. McNamara Sebastian A. Mikolajczak Noah Sather Benoît Witkowski Brice Campo Stefan H. I. Kappe David E. Lanar François Nosten Silas Davidson Rays H. Y. Jiang Dennis E. Kyle John H. Adams
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up_date	2024-07-03T15:05:10.161Z
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