TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiqui...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Tsz-Yin Chan [verfasserIn] Christina M. Egbert [verfasserIn] Julia E. Maxson [verfasserIn] Adam Siddiqui [verfasserIn] Logan J. Larsen [verfasserIn] Kristina Kohler [verfasserIn] Eranga Roshan Balasooriya [verfasserIn] Katie L. Pennington [verfasserIn] Tsz-Ming Tsang [verfasserIn] Madison Frey [verfasserIn] Erik J. Soderblom [verfasserIn] Huimin Geng [verfasserIn] Markus Müschen [verfasserIn] Tetyana V. Forostyan [verfasserIn] Savannah Free [verfasserIn] Gaelle Mercenne [verfasserIn] Courtney J. Banks [verfasserIn] Jonard Valdoz [verfasserIn] Clifford J. Whatcott [verfasserIn] Jason M. Foulks [verfasserIn] David J. Bearss [verfasserIn] Thomas O’Hare [verfasserIn] David C. S. Huang [verfasserIn] Kenneth A. Christensen [verfasserIn] James Moody [verfasserIn] Steven L. Warner [verfasserIn] Jeffrey W. Tyner [verfasserIn] Joshua L. Andersen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 17
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; pages:17

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-021-25622-3

Katalog-ID:	DOAJ067963412

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ067963412
003	DE-627
005	20230309073121.0
007	cr uuu---uuuuu
008	230228s2021 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1038/s41467-021-25622-3 \|2 doi
035			\|a (DE-627)DOAJ067963412
035			\|a (DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	0		\|a Tsz-Yin Chan \|e verfasserin \|4 aut
245	1	0	\|a TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
264		1	\|c 2021
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo
653		0	\|a Science
653		0	\|a Q
700	0		\|a Christina M. Egbert \|e verfasserin \|4 aut
700	0		\|a Julia E. Maxson \|e verfasserin \|4 aut
700	0		\|a Adam Siddiqui \|e verfasserin \|4 aut
700	0		\|a Logan J. Larsen \|e verfasserin \|4 aut
700	0		\|a Kristina Kohler \|e verfasserin \|4 aut
700	0		\|a Eranga Roshan Balasooriya \|e verfasserin \|4 aut
700	0		\|a Katie L. Pennington \|e verfasserin \|4 aut
700	0		\|a Tsz-Ming Tsang \|e verfasserin \|4 aut
700	0		\|a Madison Frey \|e verfasserin \|4 aut
700	0		\|a Erik J. Soderblom \|e verfasserin \|4 aut
700	0		\|a Huimin Geng \|e verfasserin \|4 aut
700	0		\|a Markus Müschen \|e verfasserin \|4 aut
700	0		\|a Tetyana V. Forostyan \|e verfasserin \|4 aut
700	0		\|a Savannah Free \|e verfasserin \|4 aut
700	0		\|a Gaelle Mercenne \|e verfasserin \|4 aut
700	0		\|a Courtney J. Banks \|e verfasserin \|4 aut
700	0		\|a Jonard Valdoz \|e verfasserin \|4 aut
700	0		\|a Clifford J. Whatcott \|e verfasserin \|4 aut
700	0		\|a Jason M. Foulks \|e verfasserin \|4 aut
700	0		\|a David J. Bearss \|e verfasserin \|4 aut
700	0		\|a Thomas O’Hare \|e verfasserin \|4 aut
700	0		\|a David C. S. Huang \|e verfasserin \|4 aut
700	0		\|a Kenneth A. Christensen \|e verfasserin \|4 aut
700	0		\|a James Moody \|e verfasserin \|4 aut
700	0		\|a Steven L. Warner \|e verfasserin \|4 aut
700	0		\|a Jeffrey W. Tyner \|e verfasserin \|4 aut
700	0		\|a Joshua L. Andersen \|e verfasserin \|4 aut
773	0	8	\|i In \|t Nature Communications \|d Nature Portfolio, 2016 \|g 12(2021), 1, Seite 17 \|w (DE-627)626457688 \|w (DE-600)2553671-0 \|x 20411723 \|7 nnns
773	1	8	\|g volume:12 \|g year:2021 \|g number:1 \|g pages:17
856	4	0	\|u https://doi.org/10.1038/s41467-021-25622-3 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9 \|z kostenfrei
856	4	0	\|u https://doi.org/10.1038/s41467-021-25622-3 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2041-1723 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_211
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 12 \|j 2021 \|e 1 \|h 17

Indexfelder

author_variant	t y c tyc c m e cme j e m jem a s as l j l ljl k k kk e r b erb k l p klp t m t tmt m f mf e j s ejs h g hg m m mm t v f tvf s f sf g m gm c j b cjb j v jv c j w cjw j m f jmf d j b djb t o to d c s h dcsh k a c kac j m jm s l w slw j w t jwt j l a jla
matchkey_str	article:20411723:2021----::n1suiutnidnad43euaeknstacneagt
hierarchy_sort_str	2021
publishDate	2021
allfields	10.1038/s41467-021-25622-3 doi (DE-627)DOAJ067963412 (DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9 DE-627 ger DE-627 rakwb eng Tsz-Yin Chan verfasserin aut TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo Science Q Christina M. Egbert verfasserin aut Julia E. Maxson verfasserin aut Adam Siddiqui verfasserin aut Logan J. Larsen verfasserin aut Kristina Kohler verfasserin aut Eranga Roshan Balasooriya verfasserin aut Katie L. Pennington verfasserin aut Tsz-Ming Tsang verfasserin aut Madison Frey verfasserin aut Erik J. Soderblom verfasserin aut Huimin Geng verfasserin aut Markus Müschen verfasserin aut Tetyana V. Forostyan verfasserin aut Savannah Free verfasserin aut Gaelle Mercenne verfasserin aut Courtney J. Banks verfasserin aut Jonard Valdoz verfasserin aut Clifford J. Whatcott verfasserin aut Jason M. Foulks verfasserin aut David J. Bearss verfasserin aut Thomas O’Hare verfasserin aut David C. S. Huang verfasserin aut Kenneth A. Christensen verfasserin aut James Moody verfasserin aut Steven L. Warner verfasserin aut Jeffrey W. Tyner verfasserin aut Joshua L. Andersen verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 17 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:17 https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9 kostenfrei https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 17
spelling	10.1038/s41467-021-25622-3 doi (DE-627)DOAJ067963412 (DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9 DE-627 ger DE-627 rakwb eng Tsz-Yin Chan verfasserin aut TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo Science Q Christina M. Egbert verfasserin aut Julia E. Maxson verfasserin aut Adam Siddiqui verfasserin aut Logan J. Larsen verfasserin aut Kristina Kohler verfasserin aut Eranga Roshan Balasooriya verfasserin aut Katie L. Pennington verfasserin aut Tsz-Ming Tsang verfasserin aut Madison Frey verfasserin aut Erik J. Soderblom verfasserin aut Huimin Geng verfasserin aut Markus Müschen verfasserin aut Tetyana V. Forostyan verfasserin aut Savannah Free verfasserin aut Gaelle Mercenne verfasserin aut Courtney J. Banks verfasserin aut Jonard Valdoz verfasserin aut Clifford J. Whatcott verfasserin aut Jason M. Foulks verfasserin aut David J. Bearss verfasserin aut Thomas O’Hare verfasserin aut David C. S. Huang verfasserin aut Kenneth A. Christensen verfasserin aut James Moody verfasserin aut Steven L. Warner verfasserin aut Jeffrey W. Tyner verfasserin aut Joshua L. Andersen verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 17 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:17 https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9 kostenfrei https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 17
allfields_unstemmed	10.1038/s41467-021-25622-3 doi (DE-627)DOAJ067963412 (DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9 DE-627 ger DE-627 rakwb eng Tsz-Yin Chan verfasserin aut TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo Science Q Christina M. Egbert verfasserin aut Julia E. Maxson verfasserin aut Adam Siddiqui verfasserin aut Logan J. Larsen verfasserin aut Kristina Kohler verfasserin aut Eranga Roshan Balasooriya verfasserin aut Katie L. Pennington verfasserin aut Tsz-Ming Tsang verfasserin aut Madison Frey verfasserin aut Erik J. Soderblom verfasserin aut Huimin Geng verfasserin aut Markus Müschen verfasserin aut Tetyana V. Forostyan verfasserin aut Savannah Free verfasserin aut Gaelle Mercenne verfasserin aut Courtney J. Banks verfasserin aut Jonard Valdoz verfasserin aut Clifford J. Whatcott verfasserin aut Jason M. Foulks verfasserin aut David J. Bearss verfasserin aut Thomas O’Hare verfasserin aut David C. S. Huang verfasserin aut Kenneth A. Christensen verfasserin aut James Moody verfasserin aut Steven L. Warner verfasserin aut Jeffrey W. Tyner verfasserin aut Joshua L. Andersen verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 17 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:17 https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9 kostenfrei https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 17
allfieldsGer	10.1038/s41467-021-25622-3 doi (DE-627)DOAJ067963412 (DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9 DE-627 ger DE-627 rakwb eng Tsz-Yin Chan verfasserin aut TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo Science Q Christina M. Egbert verfasserin aut Julia E. Maxson verfasserin aut Adam Siddiqui verfasserin aut Logan J. Larsen verfasserin aut Kristina Kohler verfasserin aut Eranga Roshan Balasooriya verfasserin aut Katie L. Pennington verfasserin aut Tsz-Ming Tsang verfasserin aut Madison Frey verfasserin aut Erik J. Soderblom verfasserin aut Huimin Geng verfasserin aut Markus Müschen verfasserin aut Tetyana V. Forostyan verfasserin aut Savannah Free verfasserin aut Gaelle Mercenne verfasserin aut Courtney J. Banks verfasserin aut Jonard Valdoz verfasserin aut Clifford J. Whatcott verfasserin aut Jason M. Foulks verfasserin aut David J. Bearss verfasserin aut Thomas O’Hare verfasserin aut David C. S. Huang verfasserin aut Kenneth A. Christensen verfasserin aut James Moody verfasserin aut Steven L. Warner verfasserin aut Jeffrey W. Tyner verfasserin aut Joshua L. Andersen verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 17 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:17 https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9 kostenfrei https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 17
allfieldsSound	10.1038/s41467-021-25622-3 doi (DE-627)DOAJ067963412 (DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9 DE-627 ger DE-627 rakwb eng Tsz-Yin Chan verfasserin aut TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo Science Q Christina M. Egbert verfasserin aut Julia E. Maxson verfasserin aut Adam Siddiqui verfasserin aut Logan J. Larsen verfasserin aut Kristina Kohler verfasserin aut Eranga Roshan Balasooriya verfasserin aut Katie L. Pennington verfasserin aut Tsz-Ming Tsang verfasserin aut Madison Frey verfasserin aut Erik J. Soderblom verfasserin aut Huimin Geng verfasserin aut Markus Müschen verfasserin aut Tetyana V. Forostyan verfasserin aut Savannah Free verfasserin aut Gaelle Mercenne verfasserin aut Courtney J. Banks verfasserin aut Jonard Valdoz verfasserin aut Clifford J. Whatcott verfasserin aut Jason M. Foulks verfasserin aut David J. Bearss verfasserin aut Thomas O’Hare verfasserin aut David C. S. Huang verfasserin aut Kenneth A. Christensen verfasserin aut James Moody verfasserin aut Steven L. Warner verfasserin aut Jeffrey W. Tyner verfasserin aut Joshua L. Andersen verfasserin aut In Nature Communications Nature Portfolio, 2016 12(2021), 1, Seite 17 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:12 year:2021 number:1 pages:17 https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9 kostenfrei https://doi.org/10.1038/s41467-021-25622-3 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 17
language	English
source	In Nature Communications 12(2021), 1, Seite 17 volume:12 year:2021 number:1 pages:17
sourceStr	In Nature Communications 12(2021), 1, Seite 17 volume:12 year:2021 number:1 pages:17
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Science Q
isfreeaccess_bool	true
container_title	Nature Communications
authorswithroles_txt_mv	Tsz-Yin Chan @@aut@@ Christina M. Egbert @@aut@@ Julia E. Maxson @@aut@@ Adam Siddiqui @@aut@@ Logan J. Larsen @@aut@@ Kristina Kohler @@aut@@ Eranga Roshan Balasooriya @@aut@@ Katie L. Pennington @@aut@@ Tsz-Ming Tsang @@aut@@ Madison Frey @@aut@@ Erik J. Soderblom @@aut@@ Huimin Geng @@aut@@ Markus Müschen @@aut@@ Tetyana V. Forostyan @@aut@@ Savannah Free @@aut@@ Gaelle Mercenne @@aut@@ Courtney J. Banks @@aut@@ Jonard Valdoz @@aut@@ Clifford J. Whatcott @@aut@@ Jason M. Foulks @@aut@@ David J. Bearss @@aut@@ Thomas O’Hare @@aut@@ David C. S. Huang @@aut@@ Kenneth A. Christensen @@aut@@ James Moody @@aut@@ Steven L. Warner @@aut@@ Jeffrey W. Tyner @@aut@@ Joshua L. Andersen @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	626457688
id	DOAJ067963412
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ067963412</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309073121.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1038/s41467-021-25622-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ067963412</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Tsz-Yin Chan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Science</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Q</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christina M. Egbert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julia E. Maxson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adam Siddiqui</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Logan J. Larsen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kristina Kohler</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eranga Roshan Balasooriya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katie L. Pennington</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tsz-Ming Tsang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Madison Frey</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Erik J. Soderblom</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Huimin Geng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Markus Müschen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tetyana V. Forostyan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Savannah Free</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gaelle Mercenne</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Courtney J. Banks</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jonard Valdoz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Clifford J. Whatcott</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jason M. Foulks</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David J. Bearss</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thomas O’Hare</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David C. S. Huang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenneth A. Christensen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">James Moody</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven L. Warner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jeffrey W. Tyner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joshua L. Andersen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Nature Communications</subfield><subfield code="d">Nature Portfolio, 2016</subfield><subfield code="g">12(2021), 1, Seite 17</subfield><subfield code="w">(DE-627)626457688</subfield><subfield code="w">(DE-600)2553671-0</subfield><subfield code="x">20411723</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:17</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1038/s41467-021-25622-3</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1038/s41467-021-25622-3</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2041-1723</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_211</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2021</subfield><subfield code="e">1</subfield><subfield code="h">17</subfield></datafield></record></collection>
author	Tsz-Yin Chan
spellingShingle	Tsz-Yin Chan misc Science misc Q TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
authorStr	Tsz-Yin Chan
ppnlink_with_tag_str_mv	@@773@@(DE-627)626457688
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
illustrated	Not Illustrated
issn	20411723
topic_title	TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
topic	misc Science misc Q
topic_unstemmed	misc Science misc Q
topic_browse	misc Science misc Q
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Nature Communications
hierarchy_parent_id	626457688
hierarchy_top_title	Nature Communications
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)626457688 (DE-600)2553671-0
title	TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
ctrlnum	(DE-627)DOAJ067963412 (DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9
title_full	TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
author_sort	Tsz-Yin Chan
journal	Nature Communications
journalStr	Nature Communications
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2021
contenttype_str_mv	txt
container_start_page	17
author_browse	Tsz-Yin Chan Christina M. Egbert Julia E. Maxson Adam Siddiqui Logan J. Larsen Kristina Kohler Eranga Roshan Balasooriya Katie L. Pennington Tsz-Ming Tsang Madison Frey Erik J. Soderblom Huimin Geng Markus Müschen Tetyana V. Forostyan Savannah Free Gaelle Mercenne Courtney J. Banks Jonard Valdoz Clifford J. Whatcott Jason M. Foulks David J. Bearss Thomas O’Hare David C. S. Huang Kenneth A. Christensen James Moody Steven L. Warner Jeffrey W. Tyner Joshua L. Andersen
container_volume	12
format_se	Elektronische Aufsätze
author-letter	Tsz-Yin Chan
doi_str_mv	10.1038/s41467-021-25622-3
author2-role	verfasserin
title_sort	tnk1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
title_auth	TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
abstract	The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo
abstractGer	The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo
abstract_unstemmed	The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	1
title_short	TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
url	https://doi.org/10.1038/s41467-021-25622-3 https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9 https://doaj.org/toc/2041-1723
remote_bool	true
author2	Christina M. Egbert Julia E. Maxson Adam Siddiqui Logan J. Larsen Kristina Kohler Eranga Roshan Balasooriya Katie L. Pennington Tsz-Ming Tsang Madison Frey Erik J. Soderblom Huimin Geng Markus Müschen Tetyana V. Forostyan Savannah Free Gaelle Mercenne Courtney J. Banks Jonard Valdoz Clifford J. Whatcott Jason M. Foulks David J. Bearss Thomas O’Hare David C. S. Huang Kenneth A. Christensen James Moody Steven L. Warner Jeffrey W. Tyner Joshua L. Andersen
author2Str	Christina M. Egbert Julia E. Maxson Adam Siddiqui Logan J. Larsen Kristina Kohler Eranga Roshan Balasooriya Katie L. Pennington Tsz-Ming Tsang Madison Frey Erik J. Soderblom Huimin Geng Markus Müschen Tetyana V. Forostyan Savannah Free Gaelle Mercenne Courtney J. Banks Jonard Valdoz Clifford J. Whatcott Jason M. Foulks David J. Bearss Thomas O’Hare David C. S. Huang Kenneth A. Christensen James Moody Steven L. Warner Jeffrey W. Tyner Joshua L. Andersen
ppnlink	626457688
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1038/s41467-021-25622-3
up_date	2024-07-03T15:05:39.365Z
_version_	1803570789084037120
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ067963412</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309073121.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1038/s41467-021-25622-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ067963412</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ3bf3573d63094261ac7abe05b09d7ee9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Tsz-Yin Chan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The mechanisms underlying the activity of non-receptor tyrosine kinase, TNK1, in cancers are unclear. Here the authors show that MARK mediates 14-3-3 and TNK1 interaction which restrains TNK1 activity, while the release of TNK1 from 14-3-3 leads to TNK1 activation through its interaction with ubiquitin and thus results in TNK1-mediated tumor growth in vivo</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Science</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Q</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christina M. Egbert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Julia E. Maxson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adam Siddiqui</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Logan J. Larsen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kristina Kohler</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eranga Roshan Balasooriya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katie L. Pennington</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tsz-Ming Tsang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Madison Frey</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Erik J. Soderblom</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Huimin Geng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Markus Müschen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tetyana V. Forostyan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Savannah Free</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gaelle Mercenne</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Courtney J. Banks</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jonard Valdoz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Clifford J. Whatcott</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jason M. Foulks</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David J. Bearss</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thomas O’Hare</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David C. S. Huang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenneth A. Christensen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">James Moody</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven L. Warner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jeffrey W. Tyner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joshua L. Andersen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Nature Communications</subfield><subfield code="d">Nature Portfolio, 2016</subfield><subfield code="g">12(2021), 1, Seite 17</subfield><subfield code="w">(DE-627)626457688</subfield><subfield code="w">(DE-600)2553671-0</subfield><subfield code="x">20411723</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:17</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1038/s41467-021-25622-3</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/3bf3573d63094261ac7abe05b09d7ee9</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1038/s41467-021-25622-3</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2041-1723</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_211</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2021</subfield><subfield code="e">1</subfield><subfield code="h">17</subfield></datafield></record></collection>
score	7.3994865

Nicht das Richtige dabei?

Schreiben Sie uns!

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?