Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration
The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<...
Ausführliche Beschreibung
Autor*in: |
Shadie Hatamie [verfasserIn] Po-Jen Shih [verfasserIn] Bo-Wei Chen [verfasserIn] I-Jong Wang [verfasserIn] Tai-Horng Young [verfasserIn] Da-Jeng Yao [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2020 |
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Übergeordnetes Werk: |
In: Nanomaterials - MDPI AG, 2012, 10(2020), 12, p 2555 |
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Übergeordnetes Werk: |
volume:10 ; year:2020 ; number:12, p 2555 |
Links: |
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DOI / URN: |
10.3390/nano10122555 |
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Katalog-ID: |
DOAJ067998461 |
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520 | |a The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. | ||
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10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555 |
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10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555 |
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10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555 |
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10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555 |
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10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555 |
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Shadie Hatamie @@aut@@ Po-Jen Shih @@aut@@ Bo-Wei Chen @@aut@@ I-Jong Wang @@aut@@ Tai-Horng Young @@aut@@ Da-Jeng Yao @@aut@@ |
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Shadie Hatamie |
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Shadie Hatamie misc QD1-999 misc WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites misc MRI misc BCECs misc photo thermal therapy misc Chemistry Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration |
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QD1-999 Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy |
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title |
Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration |
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Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration |
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Shadie Hatamie Po-Jen Shih Bo-Wei Chen I-Jong Wang Tai-Horng Young Da-Jeng Yao |
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10.3390/nano10122555 |
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effect of novel ws<sub<2</sub< carriers holding spherical cobalt ferrite cubic fe<sub<3</sub<o<sub<4</sub< (ws<sub<2</sub</s-cofe<sub<2</sub<o<sub<4</sub<@c-fe<sub<3</sub<o<sub<4</sub<) nanocomposites in magnetic resonance imaging and photothermal therapy for ocular treatments and investigation of corneal endothelial cell migration |
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Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration |
abstract |
The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. |
abstractGer |
The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. |
abstract_unstemmed |
The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. |
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title_short |
Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration |
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