Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration

The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Shadie Hatamie [verfasserIn] Po-Jen Shih [verfasserIn] Bo-Wei Chen [verfasserIn] I-Jong Wang [verfasserIn] Tai-Horng Young [verfasserIn] Da-Jeng Yao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	WS MRI BCECs photo thermal therapy

Übergeordnetes Werk:	In: Nanomaterials - MDPI AG, 2012, 10(2020), 12, p 2555
Übergeordnetes Werk:	volume:10 ; year:2020 ; number:12, p 2555

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nano10122555

Katalog-ID:	DOAJ067998461

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ067998461
003	DE-627
005	20240412192929.0
007	cr uuu---uuuuu
008	230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3390/nano10122555 \|2 doi
035			\|a (DE-627)DOAJ067998461
035			\|a (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a QD1-999
100	0		\|a Shadie Hatamie \|e verfasserin \|4 aut
245	1	9	\|a Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration
264		1	\|c 2020
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.
650		4	\|a WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites
650		4	\|a MRI
650		4	\|a BCECs
650		4	\|a photo thermal therapy
653		0	\|a Chemistry
700	0		\|a Po-Jen Shih \|e verfasserin \|4 aut
700	0		\|a Bo-Wei Chen \|e verfasserin \|4 aut
700	0		\|a I-Jong Wang \|e verfasserin \|4 aut
700	0		\|a Tai-Horng Young \|e verfasserin \|4 aut
700	0		\|a Da-Jeng Yao \|e verfasserin \|4 aut
773	0	8	\|i In \|t Nanomaterials \|d MDPI AG, 2012 \|g 10(2020), 12, p 2555 \|w (DE-627)718627199 \|w (DE-600)2662255-5 \|x 20794991 \|7 nnns
773	1	8	\|g volume:10 \|g year:2020 \|g number:12, p 2555
856	4	0	\|u https://doi.org/10.3390/nano10122555 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 \|z kostenfrei
856	4	0	\|u https://www.mdpi.com/2079-4991/10/12/2555 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2079-4991 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 10 \|j 2020 \|e 12, p 2555

Indexfelder

author_variant	s h sh p j s pjs b w c bwc i j w ijw t h y thy d j y djy
matchkey_str	article:20794991:2020----::yegcfetfoewsbsbaresodnshrcloatertcbceu3uou4uwsbsbcfsbsbsbsbfsbsbsbsbaoopstsnantceoaciaignpoohrateay
hierarchy_sort_str	2020
callnumber-subject-code	QD
publishDate	2020
allfields	10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555
spelling	10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555
allfields_unstemmed	10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555
allfieldsGer	10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555
allfieldsSound	10.3390/nano10122555 doi (DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4 DE-627 ger DE-627 rakwb eng QD1-999 Shadie Hatamie verfasserin aut Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI. WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry Po-Jen Shih verfasserin aut Bo-Wei Chen verfasserin aut I-Jong Wang verfasserin aut Tai-Horng Young verfasserin aut Da-Jeng Yao verfasserin aut In Nanomaterials MDPI AG, 2012 10(2020), 12, p 2555 (DE-627)718627199 (DE-600)2662255-5 20794991 nnns volume:10 year:2020 number:12, p 2555 https://doi.org/10.3390/nano10122555 kostenfrei https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 kostenfrei https://www.mdpi.com/2079-4991/10/12/2555 kostenfrei https://doaj.org/toc/2079-4991 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 12, p 2555
language	English
source	In Nanomaterials 10(2020), 12, p 2555 volume:10 year:2020 number:12, p 2555
sourceStr	In Nanomaterials 10(2020), 12, p 2555 volume:10 year:2020 number:12, p 2555
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy Chemistry
isfreeaccess_bool	true
container_title	Nanomaterials
authorswithroles_txt_mv	Shadie Hatamie @@aut@@ Po-Jen Shih @@aut@@ Bo-Wei Chen @@aut@@ I-Jong Wang @@aut@@ Tai-Horng Young @@aut@@ Da-Jeng Yao @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	718627199
id	DOAJ067998461
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ067998461</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412192929.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/nano10122555</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ067998461</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QD1-999</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Shadie Hatamie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="9"><subfield code="a">Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MRI</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">BCECs</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">photo thermal therapy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Chemistry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Po-Jen Shih</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bo-Wei Chen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">I-Jong Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tai-Horng Young</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Da-Jeng Yao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Nanomaterials</subfield><subfield code="d">MDPI AG, 2012</subfield><subfield code="g">10(2020), 12, p 2555</subfield><subfield code="w">(DE-627)718627199</subfield><subfield code="w">(DE-600)2662255-5</subfield><subfield code="x">20794991</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:10</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:12, p 2555</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/nano10122555</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2079-4991/10/12/2555</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2079-4991</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2119</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">10</subfield><subfield code="j">2020</subfield><subfield code="e">12, p 2555</subfield></datafield></record></collection>
callnumber-first	Q - Science
author	Shadie Hatamie
spellingShingle	Shadie Hatamie misc QD1-999 misc WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites misc MRI misc BCECs misc photo thermal therapy misc Chemistry Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration
authorStr	Shadie Hatamie
ppnlink_with_tag_str_mv	@@773@@(DE-627)718627199
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	QD1-999
illustrated	Not Illustrated
issn	20794991
topic_title	QD1-999 Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites MRI BCECs photo thermal therapy
topic	misc QD1-999 misc WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites misc MRI misc BCECs misc photo thermal therapy misc Chemistry
topic_unstemmed	misc QD1-999 misc WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites misc MRI misc BCECs misc photo thermal therapy misc Chemistry
topic_browse	misc QD1-999 misc WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites misc MRI misc BCECs misc photo thermal therapy misc Chemistry
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Nanomaterials
hierarchy_parent_id	718627199
hierarchy_top_title	Nanomaterials
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)718627199 (DE-600)2662255-5
title	Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration
ctrlnum	(DE-627)DOAJ067998461 (DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4
title_full	Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration
author_sort	Shadie Hatamie
journal	Nanomaterials
journalStr	Nanomaterials
callnumber-first-code	Q
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2020
contenttype_str_mv	txt
author_browse	Shadie Hatamie Po-Jen Shih Bo-Wei Chen I-Jong Wang Tai-Horng Young Da-Jeng Yao
container_volume	10
class	QD1-999
format_se	Elektronische Aufsätze
author-letter	Shadie Hatamie
doi_str_mv	10.3390/nano10122555
author2-role	verfasserin
title_sort	effect of novel ws<sub<2</sub< carriers holding spherical cobalt ferrite cubic fe<sub<3</sub<o<sub<4</sub< (ws<sub<2</sub</s-cofe<sub<2</sub<o<sub<4</sub<@c-fe<sub<3</sub<o<sub<4</sub<) nanocomposites in magnetic resonance imaging and photothermal therapy for ocular treatments and investigation of corneal endothelial cell migration
callnumber	QD1-999
title_auth	Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration
abstract	The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.
abstractGer	The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.
abstract_unstemmed	The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	12, p 2555
title_short	Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration
url	https://doi.org/10.3390/nano10122555 https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4 https://www.mdpi.com/2079-4991/10/12/2555 https://doaj.org/toc/2079-4991
remote_bool	true
author2	Po-Jen Shih Bo-Wei Chen I-Jong Wang Tai-Horng Young Da-Jeng Yao
author2Str	Po-Jen Shih Bo-Wei Chen I-Jong Wang Tai-Horng Young Da-Jeng Yao
ppnlink	718627199
callnumber-subject	QD - Chemistry
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3390/nano10122555
callnumber-a	QD1-999
up_date	2024-07-03T15:17:17.361Z
_version_	1803571520985890816
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ067998461</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412192929.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/nano10122555</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ067998461</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ1efdad5334424b8da45ec4cb774c1ed4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QD1-999</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Shadie Hatamie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="9"><subfield code="a">Synergic Effect of Novel WS<sub<2</sub< Carriers Holding Spherical Cobalt Ferrite cubic Fe<sub<3</sub<O<sub<4</sub< (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub<) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<c-Fe<sub<3</sub<O<sub<4</sub<). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< NPs were attached on the WS<sub<2</sub< sheet surfaces. The cytotoxicity of the WS<sub<2</sub< sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS<sub<2</sub< sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T<sub<2</sub<-weighted imaging with an r<sub<2</sub< contrast of 108 mM<sup<−1</sup< S<sup<−1</sup<. The in vitro photothermal therapy based on WS<sub<2</sub< sheets and WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub< @c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">WS<sub<2</sub</s-CoFe<sub<2</sub<O<sub<4</sub<@c-Fe<sub<3</sub<O<sub<4</sub< nanocomposites</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MRI</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">BCECs</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">photo thermal therapy</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Chemistry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Po-Jen Shih</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bo-Wei Chen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">I-Jong Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tai-Horng Young</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Da-Jeng Yao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Nanomaterials</subfield><subfield code="d">MDPI AG, 2012</subfield><subfield code="g">10(2020), 12, p 2555</subfield><subfield code="w">(DE-627)718627199</subfield><subfield code="w">(DE-600)2662255-5</subfield><subfield code="x">20794991</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:10</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:12, p 2555</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/nano10122555</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/1efdad5334424b8da45ec4cb774c1ed4</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2079-4991/10/12/2555</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2079-4991</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2119</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">10</subfield><subfield code="j">2020</subfield><subfield code="e">12, p 2555</subfield></datafield></record></collection>
score	7.3975964

Nicht das Richtige dabei?

Schreiben Sie uns!

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?