Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health

ABSTRACT Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to s...
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Autor*in:	Cheryl P. Andam [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	bacterial pathogens microbial evolution microbial population genomics

Übergeordnetes Werk:	In: mSystems - American Society for Microbiology, 2017, 4(2019), 3
Übergeordnetes Werk:	volume:4 ; year:2019 ; number:3

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1128/mSystems.00097-19

Katalog-ID:	DOAJ068057644

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spelling	10.1128/mSystems.00097-19 doi (DE-627)DOAJ068057644 (DE-599)DOAJ2286f8c2d6fc4a7cb19bdeb6214ed599 DE-627 ger DE-627 rakwb eng QR1-502 Cheryl P. Andam verfasserin aut Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to study in microbes owing to pervasive horizontal gene flow, widespread geographical distribution, and cryptic ecological niches that structure microbial populations. Understanding the origins of genomic variation in microbial species and populations is fundamental to questions critical to society and public health, such as “Are emerging diseases new species or variants of existing ones?,” “What makes a resistant strain successful?,” and “How will a pathogen respond to selective pressures?” To explore these questions, I use whole-genome sequencing of closely related strains to understand the evolutionary, ecological, and epidemiological dynamics of bacterial pathogens to inform effective, more precisely targeted public health interventions. bacterial pathogens microbial evolution microbial population genomics Microbiology In mSystems American Society for Microbiology, 2017 4(2019), 3 (DE-627)84597212X (DE-600)2844333-0 23795077 nnns volume:4 year:2019 number:3 https://doi.org/10.1128/mSystems.00097-19 kostenfrei https://doaj.org/article/2286f8c2d6fc4a7cb19bdeb6214ed599 kostenfrei https://journals.asm.org/doi/10.1128/mSystems.00097-19 kostenfrei https://doaj.org/toc/2379-5077 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2019 3
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callnumber-first	Q - Science
author	Cheryl P. Andam
spellingShingle	Cheryl P. Andam misc QR1-502 misc bacterial pathogens misc microbial evolution misc microbial population genomics misc Microbiology Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
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topic_title	QR1-502 Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health bacterial pathogens microbial evolution microbial population genomics
topic	misc QR1-502 misc bacterial pathogens misc microbial evolution misc microbial population genomics misc Microbiology
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title	Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
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title_sort	clonal yet different: understanding the causes of genomic heterogeneity in microbial species and impacts on public health
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title_auth	Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
abstract	ABSTRACT Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to study in microbes owing to pervasive horizontal gene flow, widespread geographical distribution, and cryptic ecological niches that structure microbial populations. Understanding the origins of genomic variation in microbial species and populations is fundamental to questions critical to society and public health, such as “Are emerging diseases new species or variants of existing ones?,” “What makes a resistant strain successful?,” and “How will a pathogen respond to selective pressures?” To explore these questions, I use whole-genome sequencing of closely related strains to understand the evolutionary, ecological, and epidemiological dynamics of bacterial pathogens to inform effective, more precisely targeted public health interventions.
abstractGer	ABSTRACT Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to study in microbes owing to pervasive horizontal gene flow, widespread geographical distribution, and cryptic ecological niches that structure microbial populations. Understanding the origins of genomic variation in microbial species and populations is fundamental to questions critical to society and public health, such as “Are emerging diseases new species or variants of existing ones?,” “What makes a resistant strain successful?,” and “How will a pathogen respond to selective pressures?” To explore these questions, I use whole-genome sequencing of closely related strains to understand the evolutionary, ecological, and epidemiological dynamics of bacterial pathogens to inform effective, more precisely targeted public health interventions.
abstract_unstemmed	ABSTRACT Why are members of a microbial species not the same? They may be clonal, but microbial populations are often composed of multiple cocirculating lineages distinguished by large phenotypic and genetic differences. Species and the mechanisms of speciation have been notoriously challenging to study in microbes owing to pervasive horizontal gene flow, widespread geographical distribution, and cryptic ecological niches that structure microbial populations. Understanding the origins of genomic variation in microbial species and populations is fundamental to questions critical to society and public health, such as “Are emerging diseases new species or variants of existing ones?,” “What makes a resistant strain successful?,” and “How will a pathogen respond to selective pressures?” To explore these questions, I use whole-genome sequencing of closely related strains to understand the evolutionary, ecological, and epidemiological dynamics of bacterial pathogens to inform effective, more precisely targeted public health interventions.
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title_short	Clonal yet Different: Understanding the Causes of Genomic Heterogeneity in Microbial Species and Impacts on Public Health
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