Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults

Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical ma...
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Autor*in:	Hama Diallo [verfasserIn] Abdoulaye Katile [verfasserIn] Jennifer L. Kwan [verfasserIn] Mahamadou S. Sissoko [verfasserIn] Sara A. Healy [verfasserIn] Ogobara K. Doumbo [verfasserIn] Patrick E. Duffy [verfasserIn] Irfan Zaidi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Clinical malaria Plasmodium falciparum γδ T cells Longitudinal analysis

Übergeordnetes Werk:	In: Malaria Journal - BMC, 2003, 18(2019), 1, Seite 10
Übergeordnetes Werk:	volume:18 ; year:2019 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12936-019-2702-5

Katalog-ID:	DOAJ068280149

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245	1	0	\|a Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults
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520			\|a Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases.
650		4	\|a Clinical malaria
650		4	\|a Plasmodium falciparum
650		4	\|a γδ T cells
650		4	\|a Longitudinal analysis
653		0	\|a Arctic medicine. Tropical medicine
653		0	\|a Infectious and parasitic diseases
700	0		\|a Abdoulaye Katile \|e verfasserin \|4 aut
700	0		\|a Jennifer L. Kwan \|e verfasserin \|4 aut
700	0		\|a Mahamadou S. Sissoko \|e verfasserin \|4 aut
700	0		\|a Sara A. Healy \|e verfasserin \|4 aut
700	0		\|a Ogobara K. Doumbo \|e verfasserin \|4 aut
700	0		\|a Patrick E. Duffy \|e verfasserin \|4 aut
700	0		\|a Irfan Zaidi \|e verfasserin \|4 aut
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author_variant	h d hd a k ak j l k jlk m s s mss s a h sah o k d okd p e d ped i z iz
matchkey_str	article:14752875:2019----::ogtdnlnlssfamdlaclsbesuigaaiif
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callnumber-subject-code	RC
publishDate	2019
allfields	10.1186/s12936-019-2702-5 doi (DE-627)DOAJ068280149 (DE-599)DOAJ28103ce5b4f6436899791be9d9303956 DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Hama Diallo verfasserin aut Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases. Clinical malaria Plasmodium falciparum γδ T cells Longitudinal analysis Arctic medicine. Tropical medicine Infectious and parasitic diseases Abdoulaye Katile verfasserin aut Jennifer L. Kwan verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara A. Healy verfasserin aut Ogobara K. Doumbo verfasserin aut Patrick E. Duffy verfasserin aut Irfan Zaidi verfasserin aut In Malaria Journal BMC, 2003 18(2019), 1, Seite 10 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:18 year:2019 number:1 pages:10 https://doi.org/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/article/28103ce5b4f6436899791be9d9303956 kostenfrei http://link.springer.com/article/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 10
spelling	10.1186/s12936-019-2702-5 doi (DE-627)DOAJ068280149 (DE-599)DOAJ28103ce5b4f6436899791be9d9303956 DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Hama Diallo verfasserin aut Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases. Clinical malaria Plasmodium falciparum γδ T cells Longitudinal analysis Arctic medicine. Tropical medicine Infectious and parasitic diseases Abdoulaye Katile verfasserin aut Jennifer L. Kwan verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara A. Healy verfasserin aut Ogobara K. Doumbo verfasserin aut Patrick E. Duffy verfasserin aut Irfan Zaidi verfasserin aut In Malaria Journal BMC, 2003 18(2019), 1, Seite 10 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:18 year:2019 number:1 pages:10 https://doi.org/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/article/28103ce5b4f6436899791be9d9303956 kostenfrei http://link.springer.com/article/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 10
allfields_unstemmed	10.1186/s12936-019-2702-5 doi (DE-627)DOAJ068280149 (DE-599)DOAJ28103ce5b4f6436899791be9d9303956 DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Hama Diallo verfasserin aut Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases. Clinical malaria Plasmodium falciparum γδ T cells Longitudinal analysis Arctic medicine. Tropical medicine Infectious and parasitic diseases Abdoulaye Katile verfasserin aut Jennifer L. Kwan verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara A. Healy verfasserin aut Ogobara K. Doumbo verfasserin aut Patrick E. Duffy verfasserin aut Irfan Zaidi verfasserin aut In Malaria Journal BMC, 2003 18(2019), 1, Seite 10 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:18 year:2019 number:1 pages:10 https://doi.org/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/article/28103ce5b4f6436899791be9d9303956 kostenfrei http://link.springer.com/article/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 10
allfieldsGer	10.1186/s12936-019-2702-5 doi (DE-627)DOAJ068280149 (DE-599)DOAJ28103ce5b4f6436899791be9d9303956 DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Hama Diallo verfasserin aut Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases. Clinical malaria Plasmodium falciparum γδ T cells Longitudinal analysis Arctic medicine. Tropical medicine Infectious and parasitic diseases Abdoulaye Katile verfasserin aut Jennifer L. Kwan verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara A. Healy verfasserin aut Ogobara K. Doumbo verfasserin aut Patrick E. Duffy verfasserin aut Irfan Zaidi verfasserin aut In Malaria Journal BMC, 2003 18(2019), 1, Seite 10 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:18 year:2019 number:1 pages:10 https://doi.org/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/article/28103ce5b4f6436899791be9d9303956 kostenfrei http://link.springer.com/article/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 10
allfieldsSound	10.1186/s12936-019-2702-5 doi (DE-627)DOAJ068280149 (DE-599)DOAJ28103ce5b4f6436899791be9d9303956 DE-627 ger DE-627 rakwb eng RC955-962 RC109-216 Hama Diallo verfasserin aut Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases. Clinical malaria Plasmodium falciparum γδ T cells Longitudinal analysis Arctic medicine. Tropical medicine Infectious and parasitic diseases Abdoulaye Katile verfasserin aut Jennifer L. Kwan verfasserin aut Mahamadou S. Sissoko verfasserin aut Sara A. Healy verfasserin aut Ogobara K. Doumbo verfasserin aut Patrick E. Duffy verfasserin aut Irfan Zaidi verfasserin aut In Malaria Journal BMC, 2003 18(2019), 1, Seite 10 (DE-627)355986582 (DE-600)2091229-8 14752875 nnns volume:18 year:2019 number:1 pages:10 https://doi.org/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/article/28103ce5b4f6436899791be9d9303956 kostenfrei http://link.springer.com/article/10.1186/s12936-019-2702-5 kostenfrei https://doaj.org/toc/1475-2875 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 10
language	English
source	In Malaria Journal 18(2019), 1, Seite 10 volume:18 year:2019 number:1 pages:10
sourceStr	In Malaria Journal 18(2019), 1, Seite 10 volume:18 year:2019 number:1 pages:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Clinical malaria Plasmodium falciparum γδ T cells Longitudinal analysis Arctic medicine. Tropical medicine Infectious and parasitic diseases
isfreeaccess_bool	true
container_title	Malaria Journal
authorswithroles_txt_mv	Hama Diallo @@aut@@ Abdoulaye Katile @@aut@@ Jennifer L. Kwan @@aut@@ Mahamadou S. Sissoko @@aut@@ Sara A. Healy @@aut@@ Ogobara K. Doumbo @@aut@@ Patrick E. Duffy @@aut@@ Irfan Zaidi @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	355986582
id	DOAJ068280149
language_de	englisch
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Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. 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callnumber-first	R - Medicine
author	Hama Diallo
spellingShingle	Hama Diallo misc RC955-962 misc RC109-216 misc Clinical malaria misc Plasmodium falciparum misc γδ T cells misc Longitudinal analysis misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults
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topic_title	RC955-962 RC109-216 Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults Clinical malaria Plasmodium falciparum γδ T cells Longitudinal analysis
topic	misc RC955-962 misc RC109-216 misc Clinical malaria misc Plasmodium falciparum misc γδ T cells misc Longitudinal analysis misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases
topic_unstemmed	misc RC955-962 misc RC109-216 misc Clinical malaria misc Plasmodium falciparum misc γδ T cells misc Longitudinal analysis misc Arctic medicine. Tropical medicine misc Infectious and parasitic diseases
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title	Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults
ctrlnum	(DE-627)DOAJ068280149 (DE-599)DOAJ28103ce5b4f6436899791be9d9303956
title_full	Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults
author_sort	Hama Diallo
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author_browse	Hama Diallo Abdoulaye Katile Jennifer L. Kwan Mahamadou S. Sissoko Sara A. Healy Ogobara K. Doumbo Patrick E. Duffy Irfan Zaidi
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title_sort	longitudinal analysis of gamma delta t cell subsets during malaria infections in malian adults
callnumber	RC955-962
title_auth	Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults
abstract	Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases.
abstractGer	Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases.
abstract_unstemmed	Abstract Background Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularly the Vδ2+ subset, have been associated with development of clinical malaria in children. In this study, the dynamics of total γδ T cells, Vδ2+ and Vδ2− T cells were measured during a malaria transmission season in Malian adults. Methods This study explored γδ T cell dynamics and Plasmodium falciparum infection outcomes over the course of the malaria transmission season in Malian adults enrolled in the placebo arm of a double-blind randomized vaccine trial. All volunteers were treated with anti-malarial drugs prior to the start of the transmission season and blood smears were assessed for P. falciparum infection every 2 weeks from July 2014 to January 2015. The study participants were stratified as either asymptomatic infections or clinical malaria cases. Vδ2+ and Vδ2− γδ T cell frequencies and activation (as measured by CD38 expression) were measured in all study participants at baseline and then every 2 months using a whole blood flow cytometry assay. Results Forty of the forty-three subjects became infected with P. falciparum and, of those, 21 individuals were diagnosed with clinical malaria at least once during the season. The γδ T cell percentage and activation increased over the duration of the transmission season. Both the Vδ2+ and Vδ2− γδ T cells were activated by P. falciparum infection. Conclusion γδ T cells increased during a malaria transmission season and this expansion was noted in both the Vδ2+ and Vδ2− γδ T cells. However, neither expansion or activation of either γδ T cell subsets discriminated study participants that had asymptomatic infections from those that had clinical malaria cases.
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title_short	Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults
url	https://doi.org/10.1186/s12936-019-2702-5 https://doaj.org/article/28103ce5b4f6436899791be9d9303956 http://link.springer.com/article/10.1186/s12936-019-2702-5 https://doaj.org/toc/1475-2875
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author2	Abdoulaye Katile Jennifer L. Kwan Mahamadou S. Sissoko Sara A. Healy Ogobara K. Doumbo Patrick E. Duffy Irfan Zaidi
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Longitudinal analysis of gamma delta T cell subsets during malaria infections in Malian adults

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