Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect

Dendritic cells (DCs) are immune specialized cells playing a critical role in promoting immune response against antigens, and may represent important targets for therapeutic interventions in cancer. DCs can be stimulated ex vivo with pro-inflammatory molecules and loaded with tumor-specific antigen(...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sara Nava [verfasserIn] Daniela Lisini [verfasserIn] Simona Frigerio [verfasserIn] Anna Bersano [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	dendritic cells immunotherapy cancer adjuvant therapy

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 22(2021), 22, p 12339
Übergeordnetes Werk:	volume:22 ; year:2021 ; number:22, p 12339

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms222212339

Katalog-ID:	DOAJ068336284

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spelling	10.3390/ijms222212339 doi (DE-627)DOAJ068336284 (DE-599)DOAJ49f7a6990a9644eca8b165bba329a7dd DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sara Nava verfasserin aut Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dendritic cells (DCs) are immune specialized cells playing a critical role in promoting immune response against antigens, and may represent important targets for therapeutic interventions in cancer. DCs can be stimulated ex vivo with pro-inflammatory molecules and loaded with tumor-specific antigen(s). Protocols describing the specific details of DCs vaccination manufacturing vary widely, but regardless of the employed protocol, the DCs vaccination safety and its ability to induce antitumor responses is clearly established. Many years of studies have focused on the ability of DCs to provide overall survival benefits at least for a selection of cancer patients. Lessons learned from early trials lead to the hypothesis that, to improve the efficacy of DCs-based immunotherapy, this should be combined with other treatments. Thus, the vaccine’s ultimate role may lie in the combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy, more than in monotherapy. In this review, we address some key questions regarding the integration of DCs vaccination with multimodality therapy approaches for cancer treatment paradigms. dendritic cells immunotherapy cancer adjuvant therapy Biology (General) Chemistry Daniela Lisini verfasserin aut Simona Frigerio verfasserin aut Anna Bersano verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 22, p 12339 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:22, p 12339 https://doi.org/10.3390/ijms222212339 kostenfrei https://doaj.org/article/49f7a6990a9644eca8b165bba329a7dd kostenfrei https://www.mdpi.com/1422-0067/22/22/12339 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 22, p 12339
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allfieldsSound	10.3390/ijms222212339 doi (DE-627)DOAJ068336284 (DE-599)DOAJ49f7a6990a9644eca8b165bba329a7dd DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Sara Nava verfasserin aut Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dendritic cells (DCs) are immune specialized cells playing a critical role in promoting immune response against antigens, and may represent important targets for therapeutic interventions in cancer. DCs can be stimulated ex vivo with pro-inflammatory molecules and loaded with tumor-specific antigen(s). Protocols describing the specific details of DCs vaccination manufacturing vary widely, but regardless of the employed protocol, the DCs vaccination safety and its ability to induce antitumor responses is clearly established. Many years of studies have focused on the ability of DCs to provide overall survival benefits at least for a selection of cancer patients. Lessons learned from early trials lead to the hypothesis that, to improve the efficacy of DCs-based immunotherapy, this should be combined with other treatments. Thus, the vaccine’s ultimate role may lie in the combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy, more than in monotherapy. In this review, we address some key questions regarding the integration of DCs vaccination with multimodality therapy approaches for cancer treatment paradigms. dendritic cells immunotherapy cancer adjuvant therapy Biology (General) Chemistry Daniela Lisini verfasserin aut Simona Frigerio verfasserin aut Anna Bersano verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 22, p 12339 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:22, p 12339 https://doi.org/10.3390/ijms222212339 kostenfrei https://doaj.org/article/49f7a6990a9644eca8b165bba329a7dd kostenfrei https://www.mdpi.com/1422-0067/22/22/12339 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 22, p 12339
language	English
source	In International Journal of Molecular Sciences 22(2021), 22, p 12339 volume:22 year:2021 number:22, p 12339
sourceStr	In International Journal of Molecular Sciences 22(2021), 22, p 12339 volume:22 year:2021 number:22, p 12339
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topic_facet	dendritic cells immunotherapy cancer adjuvant therapy Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Sara Nava @@aut@@ Daniela Lisini @@aut@@ Simona Frigerio @@aut@@ Anna Bersano @@aut@@
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author	Sara Nava
spellingShingle	Sara Nava misc QH301-705.5 misc QD1-999 misc dendritic cells misc immunotherapy misc cancer misc adjuvant therapy misc Biology (General) misc Chemistry Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect
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topic	misc QH301-705.5 misc QD1-999 misc dendritic cells misc immunotherapy misc cancer misc adjuvant therapy misc Biology (General) misc Chemistry
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title	Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect
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title_auth	Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect
abstract	Dendritic cells (DCs) are immune specialized cells playing a critical role in promoting immune response against antigens, and may represent important targets for therapeutic interventions in cancer. DCs can be stimulated ex vivo with pro-inflammatory molecules and loaded with tumor-specific antigen(s). Protocols describing the specific details of DCs vaccination manufacturing vary widely, but regardless of the employed protocol, the DCs vaccination safety and its ability to induce antitumor responses is clearly established. Many years of studies have focused on the ability of DCs to provide overall survival benefits at least for a selection of cancer patients. Lessons learned from early trials lead to the hypothesis that, to improve the efficacy of DCs-based immunotherapy, this should be combined with other treatments. Thus, the vaccine’s ultimate role may lie in the combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy, more than in monotherapy. In this review, we address some key questions regarding the integration of DCs vaccination with multimodality therapy approaches for cancer treatment paradigms.
abstractGer	Dendritic cells (DCs) are immune specialized cells playing a critical role in promoting immune response against antigens, and may represent important targets for therapeutic interventions in cancer. DCs can be stimulated ex vivo with pro-inflammatory molecules and loaded with tumor-specific antigen(s). Protocols describing the specific details of DCs vaccination manufacturing vary widely, but regardless of the employed protocol, the DCs vaccination safety and its ability to induce antitumor responses is clearly established. Many years of studies have focused on the ability of DCs to provide overall survival benefits at least for a selection of cancer patients. Lessons learned from early trials lead to the hypothesis that, to improve the efficacy of DCs-based immunotherapy, this should be combined with other treatments. Thus, the vaccine’s ultimate role may lie in the combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy, more than in monotherapy. In this review, we address some key questions regarding the integration of DCs vaccination with multimodality therapy approaches for cancer treatment paradigms.
abstract_unstemmed	Dendritic cells (DCs) are immune specialized cells playing a critical role in promoting immune response against antigens, and may represent important targets for therapeutic interventions in cancer. DCs can be stimulated ex vivo with pro-inflammatory molecules and loaded with tumor-specific antigen(s). Protocols describing the specific details of DCs vaccination manufacturing vary widely, but regardless of the employed protocol, the DCs vaccination safety and its ability to induce antitumor responses is clearly established. Many years of studies have focused on the ability of DCs to provide overall survival benefits at least for a selection of cancer patients. Lessons learned from early trials lead to the hypothesis that, to improve the efficacy of DCs-based immunotherapy, this should be combined with other treatments. Thus, the vaccine’s ultimate role may lie in the combinatorial approaches of DCs-based immunotherapy with chemotherapy and radiotherapy, more than in monotherapy. In this review, we address some key questions regarding the integration of DCs vaccination with multimodality therapy approaches for cancer treatment paradigms.
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title_short	Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect
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