Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model
Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two anim...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Raheleh Assaei [verfasserIn] Naser Pajouhi * [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
|---|
| Schlagwörter: |
anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats |
|---|
| Übergeordnetes Werk: |
In: Herbal Medicines Journal - Lorestan University of Medical Sciences, 2017, 3(2019), 3, Seite 101-108 |
|---|---|
| Übergeordnetes Werk: |
volume:3 ; year:2019 ; number:3 ; pages:101-108 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.22087/herb med j.v3i3.743 |
|---|
| Katalog-ID: |
DOAJ068357567 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ068357567 | ||
| 003 | DE-627 | ||
| 005 | 20230501211046.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230228s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.22087/herb med j.v3i3.743 |2 doi | |
| 035 | |a (DE-627)DOAJ068357567 | ||
| 035 | |a (DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a RS1-441 | |
| 100 | 0 | |a Raheleh Assaei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. | ||
| 650 | 4 | |a anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats | |
| 653 | 0 | |a Pharmacy and materia medica | |
| 700 | 0 | |a Naser Pajouhi * |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Herbal Medicines Journal |d Lorestan University of Medical Sciences, 2017 |g 3(2019), 3, Seite 101-108 |w (DE-627)1760605298 |x 25382144 |7 nnns |
| 773 | 1 | 8 | |g volume:3 |g year:2019 |g number:3 |g pages:101-108 |
| 856 | 4 | 0 | |u https://doi.org/10.22087/herb med j.v3i3.743 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf |z kostenfrei |
| 856 | 4 | 0 | |u http://hmj.lums.ac.ir/index.php/hmj/article/view/743 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2538-2144 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2538-2144 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 3 |j 2019 |e 3 |h 101-108 | ||
| author_variant |
r a ra n p np |
|---|---|
| matchkey_str |
article:25382144:2019----::sostrjkuetncesniliseiteramnodaremdsfcinn |
| hierarchy_sort_str |
2019 |
| callnumber-subject-code |
RS |
| publishDate |
2019 |
| allfields |
10.22087/herb med j.v3i3.743 doi (DE-627)DOAJ068357567 (DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf DE-627 ger DE-627 rakwb eng RS1-441 Raheleh Assaei verfasserin aut Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats Pharmacy and materia medica Naser Pajouhi * verfasserin aut In Herbal Medicines Journal Lorestan University of Medical Sciences, 2017 3(2019), 3, Seite 101-108 (DE-627)1760605298 25382144 nnns volume:3 year:2019 number:3 pages:101-108 https://doi.org/10.22087/herb med j.v3i3.743 kostenfrei https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf kostenfrei http://hmj.lums.ac.ir/index.php/hmj/article/view/743 kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 3 101-108 |
| spelling |
10.22087/herb med j.v3i3.743 doi (DE-627)DOAJ068357567 (DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf DE-627 ger DE-627 rakwb eng RS1-441 Raheleh Assaei verfasserin aut Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats Pharmacy and materia medica Naser Pajouhi * verfasserin aut In Herbal Medicines Journal Lorestan University of Medical Sciences, 2017 3(2019), 3, Seite 101-108 (DE-627)1760605298 25382144 nnns volume:3 year:2019 number:3 pages:101-108 https://doi.org/10.22087/herb med j.v3i3.743 kostenfrei https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf kostenfrei http://hmj.lums.ac.ir/index.php/hmj/article/view/743 kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 3 101-108 |
| allfields_unstemmed |
10.22087/herb med j.v3i3.743 doi (DE-627)DOAJ068357567 (DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf DE-627 ger DE-627 rakwb eng RS1-441 Raheleh Assaei verfasserin aut Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats Pharmacy and materia medica Naser Pajouhi * verfasserin aut In Herbal Medicines Journal Lorestan University of Medical Sciences, 2017 3(2019), 3, Seite 101-108 (DE-627)1760605298 25382144 nnns volume:3 year:2019 number:3 pages:101-108 https://doi.org/10.22087/herb med j.v3i3.743 kostenfrei https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf kostenfrei http://hmj.lums.ac.ir/index.php/hmj/article/view/743 kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 3 101-108 |
| allfieldsGer |
10.22087/herb med j.v3i3.743 doi (DE-627)DOAJ068357567 (DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf DE-627 ger DE-627 rakwb eng RS1-441 Raheleh Assaei verfasserin aut Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats Pharmacy and materia medica Naser Pajouhi * verfasserin aut In Herbal Medicines Journal Lorestan University of Medical Sciences, 2017 3(2019), 3, Seite 101-108 (DE-627)1760605298 25382144 nnns volume:3 year:2019 number:3 pages:101-108 https://doi.org/10.22087/herb med j.v3i3.743 kostenfrei https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf kostenfrei http://hmj.lums.ac.ir/index.php/hmj/article/view/743 kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 3 101-108 |
| allfieldsSound |
10.22087/herb med j.v3i3.743 doi (DE-627)DOAJ068357567 (DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf DE-627 ger DE-627 rakwb eng RS1-441 Raheleh Assaei verfasserin aut Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats Pharmacy and materia medica Naser Pajouhi * verfasserin aut In Herbal Medicines Journal Lorestan University of Medical Sciences, 2017 3(2019), 3, Seite 101-108 (DE-627)1760605298 25382144 nnns volume:3 year:2019 number:3 pages:101-108 https://doi.org/10.22087/herb med j.v3i3.743 kostenfrei https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf kostenfrei http://hmj.lums.ac.ir/index.php/hmj/article/view/743 kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei https://doaj.org/toc/2538-2144 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 3 2019 3 101-108 |
| language |
English |
| source |
In Herbal Medicines Journal 3(2019), 3, Seite 101-108 volume:3 year:2019 number:3 pages:101-108 |
| sourceStr |
In Herbal Medicines Journal 3(2019), 3, Seite 101-108 volume:3 year:2019 number:3 pages:101-108 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats Pharmacy and materia medica |
| isfreeaccess_bool |
true |
| container_title |
Herbal Medicines Journal |
| authorswithroles_txt_mv |
Raheleh Assaei @@aut@@ Naser Pajouhi * @@aut@@ |
| publishDateDaySort_date |
2019-01-01T00:00:00Z |
| hierarchy_top_id |
1760605298 |
| id |
DOAJ068357567 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ068357567</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230501211046.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.22087/herb med j.v3i3.743</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ068357567</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RS1-441</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Raheleh Assaei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pharmacy and materia medica</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Naser Pajouhi *</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Herbal Medicines Journal</subfield><subfield code="d">Lorestan University of Medical Sciences, 2017</subfield><subfield code="g">3(2019), 3, Seite 101-108</subfield><subfield code="w">(DE-627)1760605298</subfield><subfield code="x">25382144</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:101-108</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.22087/herb med j.v3i3.743</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://hmj.lums.ac.ir/index.php/hmj/article/view/743</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2538-2144</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2538-2144</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">2019</subfield><subfield code="e">3</subfield><subfield code="h">101-108</subfield></datafield></record></collection>
|
| callnumber-first |
R - Medicine |
| author |
Raheleh Assaei |
| spellingShingle |
Raheleh Assaei misc RS1-441 misc anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats misc Pharmacy and materia medica Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model |
| authorStr |
Raheleh Assaei |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)1760605298 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut |
| collection |
DOAJ |
| remote_str |
true |
| callnumber-label |
RS1-441 |
| illustrated |
Not Illustrated |
| issn |
25382144 |
| topic_title |
RS1-441 Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats |
| topic |
misc RS1-441 misc anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats misc Pharmacy and materia medica |
| topic_unstemmed |
misc RS1-441 misc anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats misc Pharmacy and materia medica |
| topic_browse |
misc RS1-441 misc anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats misc Pharmacy and materia medica |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Herbal Medicines Journal |
| hierarchy_parent_id |
1760605298 |
| hierarchy_top_title |
Herbal Medicines Journal |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)1760605298 |
| title |
Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model |
| ctrlnum |
(DE-627)DOAJ068357567 (DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf |
| title_full |
Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model |
| author_sort |
Raheleh Assaei |
| journal |
Herbal Medicines Journal |
| journalStr |
Herbal Medicines Journal |
| callnumber-first-code |
R |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2019 |
| contenttype_str_mv |
txt |
| container_start_page |
101 |
| author_browse |
Raheleh Assaei Naser Pajouhi * |
| container_volume |
3 |
| class |
RS1-441 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Raheleh Assaei |
| doi_str_mv |
10.22087/herb med j.v3i3.743 |
| author2-role |
verfasserin |
| title_sort |
use of satureja khuzestanica essential oil (skeo) in the treatment of diarrhea: modes of action on intestinal function in animal model |
| callnumber |
RS1-441 |
| title_auth |
Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model |
| abstract |
Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. |
| abstractGer |
Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. |
| abstract_unstemmed |
Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA |
| container_issue |
3 |
| title_short |
Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model |
| url |
https://doi.org/10.22087/herb med j.v3i3.743 https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf http://hmj.lums.ac.ir/index.php/hmj/article/view/743 https://doaj.org/toc/2538-2144 |
| remote_bool |
true |
| author2 |
Naser Pajouhi * |
| author2Str |
Naser Pajouhi * |
| ppnlink |
1760605298 |
| callnumber-subject |
RS - Pharmacy |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.22087/herb med j.v3i3.743 |
| callnumber-a |
RS1-441 |
| up_date |
2024-07-03T17:19:27.065Z |
| _version_ |
1803579206735495168 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ068357567</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230501211046.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.22087/herb med j.v3i3.743</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ068357567</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ66bc93b670fd455e9b217da9caaca8bf</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RS1-441</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Raheleh Assaei</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Use of Satureja khuzestanica Essential Oil (SKEO) in the Treatment of Diarrhea: Modes of Action on Intestinal Function in Animal Model</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background and Aim: Satureja khuzestanica is an annual herb that is used in Iranian traditional medicine to treat intestinal disorders such as abdominal pain and diarrhea. Satureja khuzestanica essential oil (SKEO) was tested to elucidate the mechanism(s) of its gastrointestinal activity in two animal models. Materials and Methods: The in vitro test of the effect of SKEO on the contractions induced by different spasmogens in isolated rat ileum preparations was carried out. The impacts of SKEO on intestinal transit, diarrhea, and intestinal secretion in mice were investigated with the charcoal meal, castor oil-induced diarrhea, and entropooling assays. Results: Pretreatment with SKEO at doses of (5-20 µg/mL) had a significant and concentration-dependent relaxant effect on contractions induced by acetylcholine, nicotine, histamine and serotonin in isolated rat ileum preparations. Moreover, it had an inhibitory effect on both K+- and Ca2+-induced contractions in the same tissue. At doses of 100 and 200 mg/kg, SKEO decreased intestinal transit, fecal weight and intestinal secretion. Conclusion: SKEO showed anti-diarrheal, anti-motility and anti-secretory activities that might prove beneficial in the treatment of gastrointestinal disorders.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">anti-spasmodic, diarrhea, satureja khuzestanica, intestinal transit, intestinal secretion, rats</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Pharmacy and materia medica</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Naser Pajouhi *</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Herbal Medicines Journal</subfield><subfield code="d">Lorestan University of Medical Sciences, 2017</subfield><subfield code="g">3(2019), 3, Seite 101-108</subfield><subfield code="w">(DE-627)1760605298</subfield><subfield code="x">25382144</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:101-108</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.22087/herb med j.v3i3.743</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/66bc93b670fd455e9b217da9caaca8bf</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://hmj.lums.ac.ir/index.php/hmj/article/view/743</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2538-2144</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2538-2144</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">2019</subfield><subfield code="e">3</subfield><subfield code="h">101-108</subfield></datafield></record></collection>
|
| score |
7.4005556 |