Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies

Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalong...
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Autor*in:	Thet D [verfasserIn] Siritientong T [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	hiv antiretroviral therapy lipodystrophy metabolic lipid profile

Übergeordnetes Werk:	In: HIV/AIDS: Research and Palliative Care - Dove Medical Press, 2010, (2020), Seite 507-524
Übergeordnetes Werk:	year:2020 ; pages:507-524

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Katalog-ID:	DOAJ068379943

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520			\|a Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile
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allfields	(DE-627)DOAJ068379943 (DE-599)DOAJ0a2e16924bd342a88eef019f06ce9829 DE-627 ger DE-627 rakwb eng RC581-607 Thet D verfasserin aut Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile hiv antiretroviral therapy lipodystrophy metabolic lipid profile Immunologic diseases. Allergy Siritientong T verfasserin aut In HIV/AIDS: Research and Palliative Care Dove Medical Press, 2010 (2020), Seite 507-524 (DE-627)611726165 (DE-600)2520734-9 11791373 nnns year:2020 pages:507-524 https://doaj.org/article/0a2e16924bd342a88eef019f06ce9829 kostenfrei https://www.dovepress.com/antiretroviral-therapy-associated-metabolic-complications-review-of-th-peer-reviewed-article-HIV kostenfrei https://doaj.org/toc/1179-1373 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 507-524
spelling	(DE-627)DOAJ068379943 (DE-599)DOAJ0a2e16924bd342a88eef019f06ce9829 DE-627 ger DE-627 rakwb eng RC581-607 Thet D verfasserin aut Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile hiv antiretroviral therapy lipodystrophy metabolic lipid profile Immunologic diseases. Allergy Siritientong T verfasserin aut In HIV/AIDS: Research and Palliative Care Dove Medical Press, 2010 (2020), Seite 507-524 (DE-627)611726165 (DE-600)2520734-9 11791373 nnns year:2020 pages:507-524 https://doaj.org/article/0a2e16924bd342a88eef019f06ce9829 kostenfrei https://www.dovepress.com/antiretroviral-therapy-associated-metabolic-complications-review-of-th-peer-reviewed-article-HIV kostenfrei https://doaj.org/toc/1179-1373 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 507-524
allfields_unstemmed	(DE-627)DOAJ068379943 (DE-599)DOAJ0a2e16924bd342a88eef019f06ce9829 DE-627 ger DE-627 rakwb eng RC581-607 Thet D verfasserin aut Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile hiv antiretroviral therapy lipodystrophy metabolic lipid profile Immunologic diseases. Allergy Siritientong T verfasserin aut In HIV/AIDS: Research and Palliative Care Dove Medical Press, 2010 (2020), Seite 507-524 (DE-627)611726165 (DE-600)2520734-9 11791373 nnns year:2020 pages:507-524 https://doaj.org/article/0a2e16924bd342a88eef019f06ce9829 kostenfrei https://www.dovepress.com/antiretroviral-therapy-associated-metabolic-complications-review-of-th-peer-reviewed-article-HIV kostenfrei https://doaj.org/toc/1179-1373 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 507-524
allfieldsGer	(DE-627)DOAJ068379943 (DE-599)DOAJ0a2e16924bd342a88eef019f06ce9829 DE-627 ger DE-627 rakwb eng RC581-607 Thet D verfasserin aut Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile hiv antiretroviral therapy lipodystrophy metabolic lipid profile Immunologic diseases. Allergy Siritientong T verfasserin aut In HIV/AIDS: Research and Palliative Care Dove Medical Press, 2010 (2020), Seite 507-524 (DE-627)611726165 (DE-600)2520734-9 11791373 nnns year:2020 pages:507-524 https://doaj.org/article/0a2e16924bd342a88eef019f06ce9829 kostenfrei https://www.dovepress.com/antiretroviral-therapy-associated-metabolic-complications-review-of-th-peer-reviewed-article-HIV kostenfrei https://doaj.org/toc/1179-1373 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 507-524
allfieldsSound	(DE-627)DOAJ068379943 (DE-599)DOAJ0a2e16924bd342a88eef019f06ce9829 DE-627 ger DE-627 rakwb eng RC581-607 Thet D verfasserin aut Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile hiv antiretroviral therapy lipodystrophy metabolic lipid profile Immunologic diseases. Allergy Siritientong T verfasserin aut In HIV/AIDS: Research and Palliative Care Dove Medical Press, 2010 (2020), Seite 507-524 (DE-627)611726165 (DE-600)2520734-9 11791373 nnns year:2020 pages:507-524 https://doaj.org/article/0a2e16924bd342a88eef019f06ce9829 kostenfrei https://www.dovepress.com/antiretroviral-therapy-associated-metabolic-complications-review-of-th-peer-reviewed-article-HIV kostenfrei https://doaj.org/toc/1179-1373 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2020 507-524
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title	Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
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title_auth	Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
abstract	Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile
abstractGer	Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile
abstract_unstemmed	Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.spharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile
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title_short	Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
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Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies

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