A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit

(1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on...
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Autor*in:	Ian Postuma [verfasserIn] Sara González [verfasserIn] Maria S Herrera [verfasserIn] Lucas Provenzano [verfasserIn] Michele Ferrarini [verfasserIn] Chiara Magni [verfasserIn] Nicoletta Protti [verfasserIn] Setareh Fatemi [verfasserIn] Valerio Vercesi [verfasserIn] Giuseppe Battistoni [verfasserIn] Umberto Anselmi Tamburini [verfasserIn] Yuan Hao Liu [verfasserIn] Leena Kankaanranta [verfasserIn] Hanna Koivunoro [verfasserIn] Saverio Altieri [verfasserIn] Silva Bortolussi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	BNCT BSA UTCP epithermal neutron beam radiobiological figure of merit out-of-beam dosimetry

Übergeordnetes Werk:	In: Biology - MDPI AG, 2012, 10(2021), 3, p 174
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:3, p 174

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biology10030174

Katalog-ID:	DOAJ068487126

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allfields	10.3390/biology10030174 doi (DE-627)DOAJ068487126 (DE-599)DOAJaf6515f0f605421c8356bf702ac92611 DE-627 ger DE-627 rakwb eng QH301-705.5 Ian Postuma verfasserin aut A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment. BNCT BSA UTCP epithermal neutron beam radiobiological figure of merit out-of-beam dosimetry Biology (General) Sara González verfasserin aut Maria S Herrera verfasserin aut Lucas Provenzano verfasserin aut Michele Ferrarini verfasserin aut Chiara Magni verfasserin aut Nicoletta Protti verfasserin aut Setareh Fatemi verfasserin aut Valerio Vercesi verfasserin aut Giuseppe Battistoni verfasserin aut Umberto Anselmi Tamburini verfasserin aut Yuan Hao Liu verfasserin aut Leena Kankaanranta verfasserin aut Hanna Koivunoro verfasserin aut Saverio Altieri verfasserin aut Silva Bortolussi verfasserin aut In Biology MDPI AG, 2012 10(2021), 3, p 174 (DE-627)718622073 (DE-600)2661517-4 20797737 nnns volume:10 year:2021 number:3, p 174 https://doi.org/10.3390/biology10030174 kostenfrei https://doaj.org/article/af6515f0f605421c8356bf702ac92611 kostenfrei https://www.mdpi.com/2079-7737/10/3/174 kostenfrei https://doaj.org/toc/2079-7737 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 174
spelling	10.3390/biology10030174 doi (DE-627)DOAJ068487126 (DE-599)DOAJaf6515f0f605421c8356bf702ac92611 DE-627 ger DE-627 rakwb eng QH301-705.5 Ian Postuma verfasserin aut A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment. BNCT BSA UTCP epithermal neutron beam radiobiological figure of merit out-of-beam dosimetry Biology (General) Sara González verfasserin aut Maria S Herrera verfasserin aut Lucas Provenzano verfasserin aut Michele Ferrarini verfasserin aut Chiara Magni verfasserin aut Nicoletta Protti verfasserin aut Setareh Fatemi verfasserin aut Valerio Vercesi verfasserin aut Giuseppe Battistoni verfasserin aut Umberto Anselmi Tamburini verfasserin aut Yuan Hao Liu verfasserin aut Leena Kankaanranta verfasserin aut Hanna Koivunoro verfasserin aut Saverio Altieri verfasserin aut Silva Bortolussi verfasserin aut In Biology MDPI AG, 2012 10(2021), 3, p 174 (DE-627)718622073 (DE-600)2661517-4 20797737 nnns volume:10 year:2021 number:3, p 174 https://doi.org/10.3390/biology10030174 kostenfrei https://doaj.org/article/af6515f0f605421c8356bf702ac92611 kostenfrei https://www.mdpi.com/2079-7737/10/3/174 kostenfrei https://doaj.org/toc/2079-7737 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 174
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allfieldsSound	10.3390/biology10030174 doi (DE-627)DOAJ068487126 (DE-599)DOAJaf6515f0f605421c8356bf702ac92611 DE-627 ger DE-627 rakwb eng QH301-705.5 Ian Postuma verfasserin aut A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment. BNCT BSA UTCP epithermal neutron beam radiobiological figure of merit out-of-beam dosimetry Biology (General) Sara González verfasserin aut Maria S Herrera verfasserin aut Lucas Provenzano verfasserin aut Michele Ferrarini verfasserin aut Chiara Magni verfasserin aut Nicoletta Protti verfasserin aut Setareh Fatemi verfasserin aut Valerio Vercesi verfasserin aut Giuseppe Battistoni verfasserin aut Umberto Anselmi Tamburini verfasserin aut Yuan Hao Liu verfasserin aut Leena Kankaanranta verfasserin aut Hanna Koivunoro verfasserin aut Saverio Altieri verfasserin aut Silva Bortolussi verfasserin aut In Biology MDPI AG, 2012 10(2021), 3, p 174 (DE-627)718622073 (DE-600)2661517-4 20797737 nnns volume:10 year:2021 number:3, p 174 https://doi.org/10.3390/biology10030174 kostenfrei https://doaj.org/article/af6515f0f605421c8356bf702ac92611 kostenfrei https://www.mdpi.com/2079-7737/10/3/174 kostenfrei https://doaj.org/toc/2079-7737 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 3, p 174
language	English
source	In Biology 10(2021), 3, p 174 volume:10 year:2021 number:3, p 174
sourceStr	In Biology 10(2021), 3, p 174 volume:10 year:2021 number:3, p 174
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authorswithroles_txt_mv	Ian Postuma @@aut@@ Sara González @@aut@@ Maria S Herrera @@aut@@ Lucas Provenzano @@aut@@ Michele Ferrarini @@aut@@ Chiara Magni @@aut@@ Nicoletta Protti @@aut@@ Setareh Fatemi @@aut@@ Valerio Vercesi @@aut@@ Giuseppe Battistoni @@aut@@ Umberto Anselmi Tamburini @@aut@@ Yuan Hao Liu @@aut@@ Leena Kankaanranta @@aut@@ Hanna Koivunoro @@aut@@ Saverio Altieri @@aut@@ Silva Bortolussi @@aut@@
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callnumber-first	Q - Science
author	Ian Postuma
spellingShingle	Ian Postuma misc QH301-705.5 misc BNCT misc BSA misc UTCP misc epithermal neutron beam misc radiobiological figure of merit misc out-of-beam dosimetry misc Biology (General) A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
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topic_title	QH301-705.5 A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit BNCT BSA UTCP epithermal neutron beam radiobiological figure of merit out-of-beam dosimetry
topic	misc QH301-705.5 misc BNCT misc BSA misc UTCP misc epithermal neutron beam misc radiobiological figure of merit misc out-of-beam dosimetry misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc BNCT misc BSA misc UTCP misc epithermal neutron beam misc radiobiological figure of merit misc out-of-beam dosimetry misc Biology (General)
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title	A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
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title_full	A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
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author_browse	Ian Postuma Sara González Maria S Herrera Lucas Provenzano Michele Ferrarini Chiara Magni Nicoletta Protti Setareh Fatemi Valerio Vercesi Giuseppe Battistoni Umberto Anselmi Tamburini Yuan Hao Liu Leena Kankaanranta Hanna Koivunoro Saverio Altieri Silva Bortolussi
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title_sort	novel approach to design and evaluate bnct neutron beams combining physical, radiobiological, and dosimetric figures of merit
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title_auth	A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
abstract	(1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment.
abstractGer	(1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment.
abstract_unstemmed	(1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment.
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title_short	A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
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Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. 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A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit

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