Effect of orthokeratology on anisometropia control: A meta-analysis

Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane da...
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Autor*in:	Hou-Ren Tsai [verfasserIn] Jen-Hung Wang [verfasserIn] Cheng-Jen Chiu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia

Übergeordnetes Werk:	In: Journal of the Formosan Medical Association - Elsevier, 2017, 120(2021), 12, Seite 2120-2127
Übergeordnetes Werk:	volume:120 ; year:2021 ; number:12 ; pages:2120-2127

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jfma.2021.05.024

Katalog-ID:	DOAJ068517254

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520			\|a Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail.
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650		4	\|a Anisomyopia
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650		4	\|a Unilateral myopia
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allfields	10.1016/j.jfma.2021.05.024 doi (DE-627)DOAJ068517254 (DE-599)DOAJad1af8cfbd584aeb9c0bbe9eedc2d8df DE-627 ger DE-627 rakwb eng R5-920 Hou-Ren Tsai verfasserin aut Effect of orthokeratology on anisometropia control: A meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail. Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General) Jen-Hung Wang verfasserin aut Cheng-Jen Chiu verfasserin aut In Journal of the Formosan Medical Association Elsevier, 2017 120(2021), 12, Seite 2120-2127 (DE-627)517812649 (DE-600)2250901-X 09296646 nnns volume:120 year:2021 number:12 pages:2120-2127 https://doi.org/10.1016/j.jfma.2021.05.024 kostenfrei https://doaj.org/article/ad1af8cfbd584aeb9c0bbe9eedc2d8df kostenfrei http://www.sciencedirect.com/science/article/pii/S0929664621002394 kostenfrei https://doaj.org/toc/0929-6646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 120 2021 12 2120-2127
spelling	10.1016/j.jfma.2021.05.024 doi (DE-627)DOAJ068517254 (DE-599)DOAJad1af8cfbd584aeb9c0bbe9eedc2d8df DE-627 ger DE-627 rakwb eng R5-920 Hou-Ren Tsai verfasserin aut Effect of orthokeratology on anisometropia control: A meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail. Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General) Jen-Hung Wang verfasserin aut Cheng-Jen Chiu verfasserin aut In Journal of the Formosan Medical Association Elsevier, 2017 120(2021), 12, Seite 2120-2127 (DE-627)517812649 (DE-600)2250901-X 09296646 nnns volume:120 year:2021 number:12 pages:2120-2127 https://doi.org/10.1016/j.jfma.2021.05.024 kostenfrei https://doaj.org/article/ad1af8cfbd584aeb9c0bbe9eedc2d8df kostenfrei http://www.sciencedirect.com/science/article/pii/S0929664621002394 kostenfrei https://doaj.org/toc/0929-6646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 120 2021 12 2120-2127
allfields_unstemmed	10.1016/j.jfma.2021.05.024 doi (DE-627)DOAJ068517254 (DE-599)DOAJad1af8cfbd584aeb9c0bbe9eedc2d8df DE-627 ger DE-627 rakwb eng R5-920 Hou-Ren Tsai verfasserin aut Effect of orthokeratology on anisometropia control: A meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail. Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General) Jen-Hung Wang verfasserin aut Cheng-Jen Chiu verfasserin aut In Journal of the Formosan Medical Association Elsevier, 2017 120(2021), 12, Seite 2120-2127 (DE-627)517812649 (DE-600)2250901-X 09296646 nnns volume:120 year:2021 number:12 pages:2120-2127 https://doi.org/10.1016/j.jfma.2021.05.024 kostenfrei https://doaj.org/article/ad1af8cfbd584aeb9c0bbe9eedc2d8df kostenfrei http://www.sciencedirect.com/science/article/pii/S0929664621002394 kostenfrei https://doaj.org/toc/0929-6646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 120 2021 12 2120-2127
allfieldsGer	10.1016/j.jfma.2021.05.024 doi (DE-627)DOAJ068517254 (DE-599)DOAJad1af8cfbd584aeb9c0bbe9eedc2d8df DE-627 ger DE-627 rakwb eng R5-920 Hou-Ren Tsai verfasserin aut Effect of orthokeratology on anisometropia control: A meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail. Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General) Jen-Hung Wang verfasserin aut Cheng-Jen Chiu verfasserin aut In Journal of the Formosan Medical Association Elsevier, 2017 120(2021), 12, Seite 2120-2127 (DE-627)517812649 (DE-600)2250901-X 09296646 nnns volume:120 year:2021 number:12 pages:2120-2127 https://doi.org/10.1016/j.jfma.2021.05.024 kostenfrei https://doaj.org/article/ad1af8cfbd584aeb9c0bbe9eedc2d8df kostenfrei http://www.sciencedirect.com/science/article/pii/S0929664621002394 kostenfrei https://doaj.org/toc/0929-6646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 120 2021 12 2120-2127
allfieldsSound	10.1016/j.jfma.2021.05.024 doi (DE-627)DOAJ068517254 (DE-599)DOAJad1af8cfbd584aeb9c0bbe9eedc2d8df DE-627 ger DE-627 rakwb eng R5-920 Hou-Ren Tsai verfasserin aut Effect of orthokeratology on anisometropia control: A meta-analysis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail. Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General) Jen-Hung Wang verfasserin aut Cheng-Jen Chiu verfasserin aut In Journal of the Formosan Medical Association Elsevier, 2017 120(2021), 12, Seite 2120-2127 (DE-627)517812649 (DE-600)2250901-X 09296646 nnns volume:120 year:2021 number:12 pages:2120-2127 https://doi.org/10.1016/j.jfma.2021.05.024 kostenfrei https://doaj.org/article/ad1af8cfbd584aeb9c0bbe9eedc2d8df kostenfrei http://www.sciencedirect.com/science/article/pii/S0929664621002394 kostenfrei https://doaj.org/toc/0929-6646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 120 2021 12 2120-2127
language	English
source	In Journal of the Formosan Medical Association 120(2021), 12, Seite 2120-2127 volume:120 year:2021 number:12 pages:2120-2127
sourceStr	In Journal of the Formosan Medical Association 120(2021), 12, Seite 2120-2127 volume:120 year:2021 number:12 pages:2120-2127
format_phy_str_mv	Article
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topic_facet	Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia Medicine (General)
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author	Hou-Ren Tsai
spellingShingle	Hou-Ren Tsai misc R5-920 misc Anisometropia misc Anisomyopia misc Axial length misc Orthokeratology misc Ortho-K lens misc Unilateral myopia misc Medicine (General) Effect of orthokeratology on anisometropia control: A meta-analysis
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topic_title	R5-920 Effect of orthokeratology on anisometropia control: A meta-analysis Anisometropia Anisomyopia Axial length Orthokeratology Ortho-K lens Unilateral myopia
topic	misc R5-920 misc Anisometropia misc Anisomyopia misc Axial length misc Orthokeratology misc Ortho-K lens misc Unilateral myopia misc Medicine (General)
topic_unstemmed	misc R5-920 misc Anisometropia misc Anisomyopia misc Axial length misc Orthokeratology misc Ortho-K lens misc Unilateral myopia misc Medicine (General)
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title	Effect of orthokeratology on anisometropia control: A meta-analysis
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title_sort	effect of orthokeratology on anisometropia control: a meta-analysis
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title_auth	Effect of orthokeratology on anisometropia control: A meta-analysis
abstract	Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail.
abstractGer	Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail.
abstract_unstemmed	Background: The effectiveness of orthokeratology in retarding anisometropic progression has been investigated in several small-sample studies. This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. However, additional wellstructured randomized controlled trials or prospective studies with longer follow-up periods are warranted to address this topic in more detail.
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title_short	Effect of orthokeratology on anisometropia control: A meta-analysis
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This quantitative analysis aimed to elucidate the efficacy of orthokeratology for anisometropia control. Methods: We searched PubMed, Embase, and Cochrane databases for relevant studies through September 2020. Axial length (AL) data at baseline and final follow-up were extracted, and AL elongation and difference were calculated. Methodological quality was evaluated using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Meta-analyses were performed using a fixed-effect model based on the heterogeneity. Results: A total of 10 cohort studies (nine retrospective studies; one prospective study) were included. The pooled results for the unilateral myopia group showed that the mean AL elongation difference between myopic and emmetropic eyes was −0.27 mm (95% CI, −0.31 to −0.22; p < 0.01) at the one-year follow-up (four studies) and −0.17 mm (95% CI, −0.33 to −0.02; p = 0.03) at the two-year follow-up (two studies). In the bilateral anisomyopic group, mean AL elongation difference between high and low myopic eyes was −0.06 mm (95% CI, −0.09 to −0.04; p < 0.01) at the one-year follow-up (seven studies) and −0.13 mm (95% CI, −0.21 to −0.06; p < 0.01) at the two-year followup (three studies). Conclusion: This study demonstrated that orthokeratology can effectively retard myopic progression and reduce anisomyopic values. 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Effect of orthokeratology on anisometropia control: A meta-analysis

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