Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therape...
Ausführliche Beschreibung
Autor*in: |
Benjamin M. Janus [verfasserIn] Nydia van Dyk [verfasserIn] Xuelian Zhao [verfasserIn] Katie A. Howell [verfasserIn] Cinque Soto [verfasserIn] M. Javad Aman [verfasserIn] Yuxing Li [verfasserIn] Thomas R. Fuerst [verfasserIn] Gilad Ofek [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 12 |
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Übergeordnetes Werk: |
volume:9 ; year:2018 ; number:1 ; pages:12 |
Links: |
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DOI / URN: |
10.1038/s41467-018-06113-4 |
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Katalog-ID: |
DOAJ068537166 |
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10.1038/s41467-018-06113-4 doi (DE-627)DOAJ068537166 (DE-599)DOAJ20e66fb349b04412a89f063ca2921f9c DE-627 ger DE-627 rakwb eng Benjamin M. Janus verfasserin aut Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therapeutics. Science Q Nydia van Dyk verfasserin aut Xuelian Zhao verfasserin aut Katie A. Howell verfasserin aut Cinque Soto verfasserin aut M. Javad Aman verfasserin aut Yuxing Li verfasserin aut Thomas R. Fuerst verfasserin aut Gilad Ofek verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:12 https://doi.org/10.1038/s41467-018-06113-4 kostenfrei https://doaj.org/article/20e66fb349b04412a89f063ca2921f9c kostenfrei https://doi.org/10.1038/s41467-018-06113-4 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 12 |
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The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therapeutics. |
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The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therapeutics. |
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The Ebola virus glycoprotein is a target for cross-protective antibodies. Here, Janus et al. report the crystal structure of the antigen-binding fragment of a pan-reactive antibody bound to a conserved epitope of the glycoprotein, facilitating rational design of cross-protective vaccines and therapeutics. |
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score |
7.401534 |