T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 res...
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Autor*in:	Ruth J. Napier [verfasserIn] Ellen J. Lee [verfasserIn] Michael P. Davey [verfasserIn] Emily E. Vance [verfasserIn] João M. Furtado [verfasserIn] Paige E. Snow [verfasserIn] Kimberly A. Samson [verfasserIn] Sydney J. Lashley [verfasserIn] Brieanna R. Brown [verfasserIn] Reiko Horai [verfasserIn] Mary J. Mattapallil [verfasserIn] Biying Xu [verfasserIn] Michelle C. Callegan [verfasserIn] Luke S. Uebelhoer [verfasserIn] Christina L. Lancioni [verfasserIn] Richard K. Vehe [verfasserIn] Bryce A. Binstadt [verfasserIn] Justine R. Smith [verfasserIn] Rachel R. Caspi [verfasserIn] Holly L. Rosenzweig [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 11(2020), 1, Seite 16
Übergeordnetes Werk:	volume:11 ; year:2020 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-020-18961-0

Katalog-ID:	DOAJ068538294

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author	Ruth J. Napier
spellingShingle	Ruth J. Napier misc Science misc Q T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
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topic_title	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
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title	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
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author_browse	Ruth J. Napier Ellen J. Lee Michael P. Davey Emily E. Vance João M. Furtado Paige E. Snow Kimberly A. Samson Sydney J. Lashley Brieanna R. Brown Reiko Horai Mary J. Mattapallil Biying Xu Michelle C. Callegan Luke S. Uebelhoer Christina L. Lancioni Richard K. Vehe Bryce A. Binstadt Justine R. Smith Rachel R. Caspi Holly L. Rosenzweig
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title_sort	cell-intrinsic role for nod2 in protection against th17-mediated uveitis
title_auth	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
abstract	How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 responses and uveitis.
abstractGer	How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 responses and uveitis.
abstract_unstemmed	How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 responses and uveitis.
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title_short	T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
url	https://doi.org/10.1038/s41467-020-18961-0 https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79 https://doaj.org/toc/2041-1723
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