Pre-diabetes and NAFLD; A study of an Algerian population sample

Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Said TAHARBOUCHT [verfasserIn] Rachida GUERMAZ [verfasserIn] Mansour BROURI [verfasserIn] Ahcene CHIBANE [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	nonalcoholic fatty liver disease steatosis pre-diabetes

Übergeordnetes Werk:	In: Endocrine and Metabolic Science - Elsevier, 2021, 1(2020), 3, Seite 100060-
Übergeordnetes Werk:	volume:1 ; year:2020 ; number:3 ; pages:100060-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.endmts.2020.100060

Katalog-ID:	DOAJ068700709

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520			\|a Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance.
650		4	\|a nonalcoholic fatty liver disease
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allfields	10.1016/j.endmts.2020.100060 doi (DE-627)DOAJ068700709 (DE-599)DOAJf5b716acc65b484d967950beb21d4551 DE-627 ger DE-627 rakwb eng RC648-665 Said TAHARBOUCHT verfasserin aut Pre-diabetes and NAFLD; A study of an Algerian population sample 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance. nonalcoholic fatty liver disease steatosis pre-diabetes Diseases of the endocrine glands. Clinical endocrinology Rachida GUERMAZ verfasserin aut Mansour BROURI verfasserin aut Ahcene CHIBANE verfasserin aut In Endocrine and Metabolic Science Elsevier, 2021 1(2020), 3, Seite 100060- (DE-627)1699273502 26663961 nnns volume:1 year:2020 number:3 pages:100060- https://doi.org/10.1016/j.endmts.2020.100060 kostenfrei https://doaj.org/article/f5b716acc65b484d967950beb21d4551 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666396120300145 kostenfrei https://doaj.org/toc/2666-3961 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 3 100060-
spelling	10.1016/j.endmts.2020.100060 doi (DE-627)DOAJ068700709 (DE-599)DOAJf5b716acc65b484d967950beb21d4551 DE-627 ger DE-627 rakwb eng RC648-665 Said TAHARBOUCHT verfasserin aut Pre-diabetes and NAFLD; A study of an Algerian population sample 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance. nonalcoholic fatty liver disease steatosis pre-diabetes Diseases of the endocrine glands. Clinical endocrinology Rachida GUERMAZ verfasserin aut Mansour BROURI verfasserin aut Ahcene CHIBANE verfasserin aut In Endocrine and Metabolic Science Elsevier, 2021 1(2020), 3, Seite 100060- (DE-627)1699273502 26663961 nnns volume:1 year:2020 number:3 pages:100060- https://doi.org/10.1016/j.endmts.2020.100060 kostenfrei https://doaj.org/article/f5b716acc65b484d967950beb21d4551 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666396120300145 kostenfrei https://doaj.org/toc/2666-3961 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 3 100060-
allfields_unstemmed	10.1016/j.endmts.2020.100060 doi (DE-627)DOAJ068700709 (DE-599)DOAJf5b716acc65b484d967950beb21d4551 DE-627 ger DE-627 rakwb eng RC648-665 Said TAHARBOUCHT verfasserin aut Pre-diabetes and NAFLD; A study of an Algerian population sample 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance. nonalcoholic fatty liver disease steatosis pre-diabetes Diseases of the endocrine glands. Clinical endocrinology Rachida GUERMAZ verfasserin aut Mansour BROURI verfasserin aut Ahcene CHIBANE verfasserin aut In Endocrine and Metabolic Science Elsevier, 2021 1(2020), 3, Seite 100060- (DE-627)1699273502 26663961 nnns volume:1 year:2020 number:3 pages:100060- https://doi.org/10.1016/j.endmts.2020.100060 kostenfrei https://doaj.org/article/f5b716acc65b484d967950beb21d4551 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666396120300145 kostenfrei https://doaj.org/toc/2666-3961 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 3 100060-
allfieldsGer	10.1016/j.endmts.2020.100060 doi (DE-627)DOAJ068700709 (DE-599)DOAJf5b716acc65b484d967950beb21d4551 DE-627 ger DE-627 rakwb eng RC648-665 Said TAHARBOUCHT verfasserin aut Pre-diabetes and NAFLD; A study of an Algerian population sample 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance. nonalcoholic fatty liver disease steatosis pre-diabetes Diseases of the endocrine glands. Clinical endocrinology Rachida GUERMAZ verfasserin aut Mansour BROURI verfasserin aut Ahcene CHIBANE verfasserin aut In Endocrine and Metabolic Science Elsevier, 2021 1(2020), 3, Seite 100060- (DE-627)1699273502 26663961 nnns volume:1 year:2020 number:3 pages:100060- https://doi.org/10.1016/j.endmts.2020.100060 kostenfrei https://doaj.org/article/f5b716acc65b484d967950beb21d4551 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666396120300145 kostenfrei https://doaj.org/toc/2666-3961 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 3 100060-
allfieldsSound	10.1016/j.endmts.2020.100060 doi (DE-627)DOAJ068700709 (DE-599)DOAJf5b716acc65b484d967950beb21d4551 DE-627 ger DE-627 rakwb eng RC648-665 Said TAHARBOUCHT verfasserin aut Pre-diabetes and NAFLD; A study of an Algerian population sample 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance. nonalcoholic fatty liver disease steatosis pre-diabetes Diseases of the endocrine glands. Clinical endocrinology Rachida GUERMAZ verfasserin aut Mansour BROURI verfasserin aut Ahcene CHIBANE verfasserin aut In Endocrine and Metabolic Science Elsevier, 2021 1(2020), 3, Seite 100060- (DE-627)1699273502 26663961 nnns volume:1 year:2020 number:3 pages:100060- https://doi.org/10.1016/j.endmts.2020.100060 kostenfrei https://doaj.org/article/f5b716acc65b484d967950beb21d4551 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666396120300145 kostenfrei https://doaj.org/toc/2666-3961 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2020 3 100060-
language	English
source	In Endocrine and Metabolic Science 1(2020), 3, Seite 100060- volume:1 year:2020 number:3 pages:100060-
sourceStr	In Endocrine and Metabolic Science 1(2020), 3, Seite 100060- volume:1 year:2020 number:3 pages:100060-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	nonalcoholic fatty liver disease steatosis pre-diabetes Diseases of the endocrine glands. Clinical endocrinology
isfreeaccess_bool	true
container_title	Endocrine and Metabolic Science
authorswithroles_txt_mv	Said TAHARBOUCHT @@aut@@ Rachida GUERMAZ @@aut@@ Mansour BROURI @@aut@@ Ahcene CHIBANE @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	1699273502
id	DOAJ068700709
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ068700709</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309080513.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.endmts.2020.100060</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ068700709</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJf5b716acc65b484d967950beb21d4551</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC648-665</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Said TAHARBOUCHT</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Pre-diabetes and NAFLD; A study of an Algerian population sample</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. 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callnumber-first	R - Medicine
author	Said TAHARBOUCHT
spellingShingle	Said TAHARBOUCHT misc RC648-665 misc nonalcoholic fatty liver disease misc steatosis misc pre-diabetes misc Diseases of the endocrine glands. Clinical endocrinology Pre-diabetes and NAFLD; A study of an Algerian population sample
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topic_title	RC648-665 Pre-diabetes and NAFLD; A study of an Algerian population sample nonalcoholic fatty liver disease steatosis pre-diabetes
topic	misc RC648-665 misc nonalcoholic fatty liver disease misc steatosis misc pre-diabetes misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc nonalcoholic fatty liver disease misc steatosis misc pre-diabetes misc Diseases of the endocrine glands. Clinical endocrinology
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title	Pre-diabetes and NAFLD; A study of an Algerian population sample
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title_full	Pre-diabetes and NAFLD; A study of an Algerian population sample
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journal	Endocrine and Metabolic Science
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author_browse	Said TAHARBOUCHT Rachida GUERMAZ Mansour BROURI Ahcene CHIBANE
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title_sort	pre-diabetes and nafld; a study of an algerian population sample
callnumber	RC648-665
title_auth	Pre-diabetes and NAFLD; A study of an Algerian population sample
abstract	Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance.
abstractGer	Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance.
abstract_unstemmed	Introduction: Insulin resistance is one of the most important mechanisms involved in the genesis of NAFLD (Non-Alcoholic Fatty Liver Disease), which explains the potential risk of diabetes in this population. The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. Its higher prevalence in this population is probably underpinned by insulin resistance.
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title_short	Pre-diabetes and NAFLD; A study of an Algerian population sample
url	https://doi.org/10.1016/j.endmts.2020.100060 https://doaj.org/article/f5b716acc65b484d967950beb21d4551 http://www.sciencedirect.com/science/article/pii/S2666396120300145 https://doaj.org/toc/2666-3961
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up_date	2024-07-03T19:17:04.762Z
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The objective of our study was to compare the prevalence of pre-diabetes in people with metabolic steatopathy or NAFLD with that of a general population free from hepatic steatosis. Patients and methods: It is a prospective case-control study which focused on non-diabetic patients aged between 30 and 70 years. A clinical and biological assessment was carried out for all patients. Hepatic steatosis was diagnosed by ultrasound. Insulinemia was measured by Fluorescence Enzyme Immunoassay (Tosoh AIA 360) expressed in µU /Ml. The insulin resistance calculation was done using the HOMA formula. Pre diabetes is defined by the American Diabetes Association (ADA) as a fasting blood sugar (8 hours) between 1 and 1.25 g / l. Statistical analyzes were performed using SPSS 21.0 software (IBM). Results: 426 patients aged 48.52 ± 10.13 years (226 women (53.6%)), including 213 with fatty liver disease, were enrolled. The mean fasting blood glucose in NAFLD patients was significantly higher (0.97 ± 0.13 213 Vs 0.92 ± 0.11, p <0.001). The prevalence of pre-diabetes was higher in the NAFLDs than in the control population (14.6% vs 8.9%, p <0.001), women were more affected than men (20.4% vs 8%, P <0.01). We noted a positive correlation between pre-diabetes and insulin resistance (n = 426, r = 0.124 P = 0.013). In multivariate analysis, the factors independently associated with pre-diabetes were metabolic syndrome, plasma cholesterol≥ 2g/l, and insulin resistance. Conclusion: In view of these results, we recommend systematic research for pre-diabetes in NAFLDs for effective prevention of diabetes and its complications. 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Pre-diabetes and NAFLD; A study of an Algerian population sample

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