Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism
The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key...
Ausführliche Beschreibung
Autor*in: |
Chih-Wei Chou [verfasserIn] Xi Tan [verfasserIn] Chia-Nung Hung [verfasserIn] Brandon Lieberman [verfasserIn] Meizhen Chen [verfasserIn] Meena Kusi [verfasserIn] Kohzoh Mitsuya [verfasserIn] Chun-Lin Lin [verfasserIn] Masahiro Morita [verfasserIn] Zhijie Liu [verfasserIn] Chun-Liang Chen [verfasserIn] Tim Hui-Ming Huang [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Cancers - MDPI AG, 2010, 12(2020), 9, p 2715 |
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Übergeordnetes Werk: |
volume:12 ; year:2020 ; number:9, p 2715 |
Links: |
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DOI / URN: |
10.3390/cancers12092715 |
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Katalog-ID: |
DOAJ068803370 |
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10.3390/cancers12092715 doi (DE-627)DOAJ068803370 (DE-599)DOAJff7fcb8e8b93430bae77bd6864b414ed DE-627 ger DE-627 rakwb eng RC254-282 Chih-Wei Chou verfasserin aut Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shRNA knockdowns of menin and MAPs result in reduced ATP production with proportional alterations of cellular energy generated through glycolysis and OXPHOS. When shRNA knockdown cells are exposed to metabolic stress, the dual functionality can clearly be distinguished among these metabolic regulators. A MAP can negatively counteract the regulatory mode of menin for OXPHOS while the same protein positively influences glycolysis. A close-proximity interaction between menin and MAPs allows transcriptional regulation for metabolic adjustment. This coordinate regulation by menin and MAPs is necessary for cells to rapidly adapt to fluctuating microenvironments and to maintain essential metabolic functions. menin menin-associated proteins oxidative phosphorylation glycolysis circulating tumor cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xi Tan verfasserin aut Chia-Nung Hung verfasserin aut Brandon Lieberman verfasserin aut Meizhen Chen verfasserin aut Meena Kusi verfasserin aut Kohzoh Mitsuya verfasserin aut Chun-Lin Lin verfasserin aut Masahiro Morita verfasserin aut Zhijie Liu verfasserin aut Chun-Liang Chen verfasserin aut Tim Hui-Ming Huang verfasserin aut In Cancers MDPI AG, 2010 12(2020), 9, p 2715 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:9, p 2715 https://doi.org/10.3390/cancers12092715 kostenfrei https://doaj.org/article/ff7fcb8e8b93430bae77bd6864b414ed kostenfrei https://www.mdpi.com/2072-6694/12/9/2715 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 9, p 2715 |
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10.3390/cancers12092715 doi (DE-627)DOAJ068803370 (DE-599)DOAJff7fcb8e8b93430bae77bd6864b414ed DE-627 ger DE-627 rakwb eng RC254-282 Chih-Wei Chou verfasserin aut Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shRNA knockdowns of menin and MAPs result in reduced ATP production with proportional alterations of cellular energy generated through glycolysis and OXPHOS. When shRNA knockdown cells are exposed to metabolic stress, the dual functionality can clearly be distinguished among these metabolic regulators. A MAP can negatively counteract the regulatory mode of menin for OXPHOS while the same protein positively influences glycolysis. A close-proximity interaction between menin and MAPs allows transcriptional regulation for metabolic adjustment. This coordinate regulation by menin and MAPs is necessary for cells to rapidly adapt to fluctuating microenvironments and to maintain essential metabolic functions. menin menin-associated proteins oxidative phosphorylation glycolysis circulating tumor cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xi Tan verfasserin aut Chia-Nung Hung verfasserin aut Brandon Lieberman verfasserin aut Meizhen Chen verfasserin aut Meena Kusi verfasserin aut Kohzoh Mitsuya verfasserin aut Chun-Lin Lin verfasserin aut Masahiro Morita verfasserin aut Zhijie Liu verfasserin aut Chun-Liang Chen verfasserin aut Tim Hui-Ming Huang verfasserin aut In Cancers MDPI AG, 2010 12(2020), 9, p 2715 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:9, p 2715 https://doi.org/10.3390/cancers12092715 kostenfrei https://doaj.org/article/ff7fcb8e8b93430bae77bd6864b414ed kostenfrei https://www.mdpi.com/2072-6694/12/9/2715 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 9, p 2715 |
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10.3390/cancers12092715 doi (DE-627)DOAJ068803370 (DE-599)DOAJff7fcb8e8b93430bae77bd6864b414ed DE-627 ger DE-627 rakwb eng RC254-282 Chih-Wei Chou verfasserin aut Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shRNA knockdowns of menin and MAPs result in reduced ATP production with proportional alterations of cellular energy generated through glycolysis and OXPHOS. When shRNA knockdown cells are exposed to metabolic stress, the dual functionality can clearly be distinguished among these metabolic regulators. A MAP can negatively counteract the regulatory mode of menin for OXPHOS while the same protein positively influences glycolysis. A close-proximity interaction between menin and MAPs allows transcriptional regulation for metabolic adjustment. This coordinate regulation by menin and MAPs is necessary for cells to rapidly adapt to fluctuating microenvironments and to maintain essential metabolic functions. menin menin-associated proteins oxidative phosphorylation glycolysis circulating tumor cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xi Tan verfasserin aut Chia-Nung Hung verfasserin aut Brandon Lieberman verfasserin aut Meizhen Chen verfasserin aut Meena Kusi verfasserin aut Kohzoh Mitsuya verfasserin aut Chun-Lin Lin verfasserin aut Masahiro Morita verfasserin aut Zhijie Liu verfasserin aut Chun-Liang Chen verfasserin aut Tim Hui-Ming Huang verfasserin aut In Cancers MDPI AG, 2010 12(2020), 9, p 2715 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:9, p 2715 https://doi.org/10.3390/cancers12092715 kostenfrei https://doaj.org/article/ff7fcb8e8b93430bae77bd6864b414ed kostenfrei https://www.mdpi.com/2072-6694/12/9/2715 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 9, p 2715 |
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10.3390/cancers12092715 doi (DE-627)DOAJ068803370 (DE-599)DOAJff7fcb8e8b93430bae77bd6864b414ed DE-627 ger DE-627 rakwb eng RC254-282 Chih-Wei Chou verfasserin aut Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shRNA knockdowns of menin and MAPs result in reduced ATP production with proportional alterations of cellular energy generated through glycolysis and OXPHOS. When shRNA knockdown cells are exposed to metabolic stress, the dual functionality can clearly be distinguished among these metabolic regulators. A MAP can negatively counteract the regulatory mode of menin for OXPHOS while the same protein positively influences glycolysis. A close-proximity interaction between menin and MAPs allows transcriptional regulation for metabolic adjustment. This coordinate regulation by menin and MAPs is necessary for cells to rapidly adapt to fluctuating microenvironments and to maintain essential metabolic functions. menin menin-associated proteins oxidative phosphorylation glycolysis circulating tumor cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xi Tan verfasserin aut Chia-Nung Hung verfasserin aut Brandon Lieberman verfasserin aut Meizhen Chen verfasserin aut Meena Kusi verfasserin aut Kohzoh Mitsuya verfasserin aut Chun-Lin Lin verfasserin aut Masahiro Morita verfasserin aut Zhijie Liu verfasserin aut Chun-Liang Chen verfasserin aut Tim Hui-Ming Huang verfasserin aut In Cancers MDPI AG, 2010 12(2020), 9, p 2715 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:9, p 2715 https://doi.org/10.3390/cancers12092715 kostenfrei https://doaj.org/article/ff7fcb8e8b93430bae77bd6864b414ed kostenfrei https://www.mdpi.com/2072-6694/12/9/2715 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 9, p 2715 |
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10.3390/cancers12092715 doi (DE-627)DOAJ068803370 (DE-599)DOAJff7fcb8e8b93430bae77bd6864b414ed DE-627 ger DE-627 rakwb eng RC254-282 Chih-Wei Chou verfasserin aut Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shRNA knockdowns of menin and MAPs result in reduced ATP production with proportional alterations of cellular energy generated through glycolysis and OXPHOS. When shRNA knockdown cells are exposed to metabolic stress, the dual functionality can clearly be distinguished among these metabolic regulators. A MAP can negatively counteract the regulatory mode of menin for OXPHOS while the same protein positively influences glycolysis. A close-proximity interaction between menin and MAPs allows transcriptional regulation for metabolic adjustment. This coordinate regulation by menin and MAPs is necessary for cells to rapidly adapt to fluctuating microenvironments and to maintain essential metabolic functions. menin menin-associated proteins oxidative phosphorylation glycolysis circulating tumor cells Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xi Tan verfasserin aut Chia-Nung Hung verfasserin aut Brandon Lieberman verfasserin aut Meizhen Chen verfasserin aut Meena Kusi verfasserin aut Kohzoh Mitsuya verfasserin aut Chun-Lin Lin verfasserin aut Masahiro Morita verfasserin aut Zhijie Liu verfasserin aut Chun-Liang Chen verfasserin aut Tim Hui-Ming Huang verfasserin aut In Cancers MDPI AG, 2010 12(2020), 9, p 2715 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:9, p 2715 https://doi.org/10.3390/cancers12092715 kostenfrei https://doaj.org/article/ff7fcb8e8b93430bae77bd6864b414ed kostenfrei https://www.mdpi.com/2072-6694/12/9/2715 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 9, p 2715 |
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Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism |
abstract |
The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shRNA knockdowns of menin and MAPs result in reduced ATP production with proportional alterations of cellular energy generated through glycolysis and OXPHOS. When shRNA knockdown cells are exposed to metabolic stress, the dual functionality can clearly be distinguished among these metabolic regulators. A MAP can negatively counteract the regulatory mode of menin for OXPHOS while the same protein positively influences glycolysis. A close-proximity interaction between menin and MAPs allows transcriptional regulation for metabolic adjustment. This coordinate regulation by menin and MAPs is necessary for cells to rapidly adapt to fluctuating microenvironments and to maintain essential metabolic functions. |
abstractGer |
The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shRNA knockdowns of menin and MAPs result in reduced ATP production with proportional alterations of cellular energy generated through glycolysis and OXPHOS. When shRNA knockdown cells are exposed to metabolic stress, the dual functionality can clearly be distinguished among these metabolic regulators. A MAP can negatively counteract the regulatory mode of menin for OXPHOS while the same protein positively influences glycolysis. A close-proximity interaction between menin and MAPs allows transcriptional regulation for metabolic adjustment. This coordinate regulation by menin and MAPs is necessary for cells to rapidly adapt to fluctuating microenvironments and to maintain essential metabolic functions. |
abstract_unstemmed |
The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor prognosis. A group of menin-associated proteins (MAPs), including KMT2A, MED12, WAPL, and GATA3, is found to restrain menin’s full function in this transcription regulation. shRNA knockdowns of menin and MAPs result in reduced ATP production with proportional alterations of cellular energy generated through glycolysis and OXPHOS. When shRNA knockdown cells are exposed to metabolic stress, the dual functionality can clearly be distinguished among these metabolic regulators. A MAP can negatively counteract the regulatory mode of menin for OXPHOS while the same protein positively influences glycolysis. A close-proximity interaction between menin and MAPs allows transcriptional regulation for metabolic adjustment. This coordinate regulation by menin and MAPs is necessary for cells to rapidly adapt to fluctuating microenvironments and to maintain essential metabolic functions. |
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7.39966 |