Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides

Most preterm infant formulas contain medium-chain triacylglycerols (M80), but the effects of MCT on polyunsaturated fatty acid status and metabolism are controversial. Thus, we studied the effects of MCT on linoleic acid metabolism using stable isotopes. Enterally fed preterm infants were randomized...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Maria Rodriguez [verfasserIn] Simone Funke [verfasserIn] Maria Fink [verfasserIn] Hans Demmelmair [verfasserIn] Marco Turini [verfasserIn] Gayle Crozier [verfasserIn] Berthold Koletzko [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Schlagwörter:	long chain polyunsaturated fatty acid tracer long-chain triacylglycerols LCT fatty acid oxidation

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 44(2003), 1, Seite 41-48
Übergeordnetes Werk:	volume:44 ; year:2003 ; number:1 ; pages:41-48

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M200218-JLR200

Katalog-ID:	DOAJ068815123

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callnumber-first	Q - Science
author	Maria Rodriguez
spellingShingle	Maria Rodriguez misc QD415-436 misc long chain polyunsaturated fatty acid misc tracer misc long-chain triacylglycerols misc LCT misc fatty acid oxidation misc Biochemistry Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides
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topic_title	QD415-436 Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides long chain polyunsaturated fatty acid tracer long-chain triacylglycerols LCT fatty acid oxidation
topic	misc QD415-436 misc long chain polyunsaturated fatty acid misc tracer misc long-chain triacylglycerols misc LCT misc fatty acid oxidation misc Biochemistry
topic_unstemmed	misc QD415-436 misc long chain polyunsaturated fatty acid misc tracer misc long-chain triacylglycerols misc LCT misc fatty acid oxidation misc Biochemistry
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title	Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides
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title_full	Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides
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author_browse	Maria Rodriguez Simone Funke Maria Fink Hans Demmelmair Marco Turini Gayle Crozier Berthold Koletzko
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title_sort	plasma fatty acids and [13c]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides
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title_auth	Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides
abstract	Most preterm infant formulas contain medium-chain triacylglycerols (M80), but the effects of MCT on polyunsaturated fatty acid status and metabolism are controversial. Thus, we studied the effects of MCT on linoleic acid metabolism using stable isotopes. Enterally fed preterm infants were randomized to receive for 7 days 40% of fat as MCT (n = 10) or a formula without MCT (n = 9). At study day 5, infants received orally 2 mg/kg body weight of 13C-labeled linoleic acid. Fatty acids in plasma lipid classes and 13C enrichment of phospholipid fatty acids were measured and tracer oxidation was monitored. Compared with the control group, the MCT group showed lower breath 13CO2 and higher plasma triacylglycerol contents of octanoic acid, of decanoic acid, and of total long-chain polyunsaturated fatty acids (57.1 ± 4.4 μmol/l vs. 37.9 ± 4.8 μmol/l, P < 0.01). Concentrations of several polyunsaturated fatty acids in plasma phospholipids and non esterified fatty acids were higher in the MCT group. 13C concentrations in phospholipid n-6 fatty acids indicated no difference in the relative conversion of linoleic to arachidonic acid.We conclude that oral MCT effectively reduce polyunsaturated fatty acid and long chain polyunsaturated fatty acid oxidation in preterm infants without compromising endogenous n-6 long chain polyunsaturated fatty acid synthesis.
abstractGer	Most preterm infant formulas contain medium-chain triacylglycerols (M80), but the effects of MCT on polyunsaturated fatty acid status and metabolism are controversial. Thus, we studied the effects of MCT on linoleic acid metabolism using stable isotopes. Enterally fed preterm infants were randomized to receive for 7 days 40% of fat as MCT (n = 10) or a formula without MCT (n = 9). At study day 5, infants received orally 2 mg/kg body weight of 13C-labeled linoleic acid. Fatty acids in plasma lipid classes and 13C enrichment of phospholipid fatty acids were measured and tracer oxidation was monitored. Compared with the control group, the MCT group showed lower breath 13CO2 and higher plasma triacylglycerol contents of octanoic acid, of decanoic acid, and of total long-chain polyunsaturated fatty acids (57.1 ± 4.4 μmol/l vs. 37.9 ± 4.8 μmol/l, P < 0.01). Concentrations of several polyunsaturated fatty acids in plasma phospholipids and non esterified fatty acids were higher in the MCT group. 13C concentrations in phospholipid n-6 fatty acids indicated no difference in the relative conversion of linoleic to arachidonic acid.We conclude that oral MCT effectively reduce polyunsaturated fatty acid and long chain polyunsaturated fatty acid oxidation in preterm infants without compromising endogenous n-6 long chain polyunsaturated fatty acid synthesis.
abstract_unstemmed	Most preterm infant formulas contain medium-chain triacylglycerols (M80), but the effects of MCT on polyunsaturated fatty acid status and metabolism are controversial. Thus, we studied the effects of MCT on linoleic acid metabolism using stable isotopes. Enterally fed preterm infants were randomized to receive for 7 days 40% of fat as MCT (n = 10) or a formula without MCT (n = 9). At study day 5, infants received orally 2 mg/kg body weight of 13C-labeled linoleic acid. Fatty acids in plasma lipid classes and 13C enrichment of phospholipid fatty acids were measured and tracer oxidation was monitored. Compared with the control group, the MCT group showed lower breath 13CO2 and higher plasma triacylglycerol contents of octanoic acid, of decanoic acid, and of total long-chain polyunsaturated fatty acids (57.1 ± 4.4 μmol/l vs. 37.9 ± 4.8 μmol/l, P < 0.01). Concentrations of several polyunsaturated fatty acids in plasma phospholipids and non esterified fatty acids were higher in the MCT group. 13C concentrations in phospholipid n-6 fatty acids indicated no difference in the relative conversion of linoleic to arachidonic acid.We conclude that oral MCT effectively reduce polyunsaturated fatty acid and long chain polyunsaturated fatty acid oxidation in preterm infants without compromising endogenous n-6 long chain polyunsaturated fatty acid synthesis.
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title_short	Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides
url	https://doi.org/10.1194/jlr.M200218-JLR200 https://doaj.org/article/f52a45908779452789a01959e93391e4 http://www.sciencedirect.com/science/article/pii/S0022227520327127 https://doaj.org/toc/0022-2275
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author2	Simone Funke Maria Fink Hans Demmelmair Marco Turini Gayle Crozier Berthold Koletzko
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up_date	2024-07-03T19:54:32.550Z
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Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides

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