Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S]

The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations o...
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Gespeichert in:

Autor*in:	Sin Man Lam [verfasserIn] Louis Tong [verfasserIn] Xinrui Duan [verfasserIn] Andrea Petznick [verfasserIn] Markus R. Wenk [verfasserIn] Guanghou Shui [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	lipidomics mass spectrometry dry eye syndrome meibum tear lipidome cholesteryl sulfates

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 55(2014), 2, Seite 289-298
Übergeordnetes Werk:	volume:55 ; year:2014 ; number:2 ; pages:289-298

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1194/jlr.M044826

Katalog-ID:	DOAJ068834233

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spelling	10.1194/jlr.M044826 doi (DE-627)DOAJ068834233 (DE-599)DOAJ16e6907d3fd041aaaf6b6916898f0acf DE-627 ger DE-627 rakwb eng QD415-436 Sin Man Lam verfasserin aut Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S] 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphiphiles in tears that render their detection and accurate quantitation tedious. Using systematic and sensitive lipidomic approaches, we validated different tear collection techniques and report the most comprehensive human tear lipidome to date; comprising more than 600 lipid species from 17 major lipid classes. Our study confers novel insights to the compositional details of the existent tear film model, in particular the disputable amphiphilic lipid sublayer constituents, by demonstrating the presence of cholesteryl sulfate, O-acyl-ω-hydroxyfatty acids, and various sphingolipids and phospholipids in tears. The discovery and quantitation of the relative abundance of various tear lipid amphiphiles reported herein are expected to have a profound impact on the current understanding of the existent human tear film model. lipidomics mass spectrometry dry eye syndrome meibum tear lipidome cholesteryl sulfates Biochemistry Louis Tong verfasserin aut Xinrui Duan verfasserin aut Andrea Petznick verfasserin aut Markus R. Wenk verfasserin aut Guanghou Shui verfasserin aut In Journal of Lipid Research Elsevier, 2021 55(2014), 2, Seite 289-298 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:55 year:2014 number:2 pages:289-298 https://doi.org/10.1194/jlr.M044826 kostenfrei https://doaj.org/article/16e6907d3fd041aaaf6b6916898f0acf kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520350367 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2014 2 289-298
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allfieldsGer	10.1194/jlr.M044826 doi (DE-627)DOAJ068834233 (DE-599)DOAJ16e6907d3fd041aaaf6b6916898f0acf DE-627 ger DE-627 rakwb eng QD415-436 Sin Man Lam verfasserin aut Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S] 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphiphiles in tears that render their detection and accurate quantitation tedious. Using systematic and sensitive lipidomic approaches, we validated different tear collection techniques and report the most comprehensive human tear lipidome to date; comprising more than 600 lipid species from 17 major lipid classes. Our study confers novel insights to the compositional details of the existent tear film model, in particular the disputable amphiphilic lipid sublayer constituents, by demonstrating the presence of cholesteryl sulfate, O-acyl-ω-hydroxyfatty acids, and various sphingolipids and phospholipids in tears. The discovery and quantitation of the relative abundance of various tear lipid amphiphiles reported herein are expected to have a profound impact on the current understanding of the existent human tear film model. lipidomics mass spectrometry dry eye syndrome meibum tear lipidome cholesteryl sulfates Biochemistry Louis Tong verfasserin aut Xinrui Duan verfasserin aut Andrea Petznick verfasserin aut Markus R. Wenk verfasserin aut Guanghou Shui verfasserin aut In Journal of Lipid Research Elsevier, 2021 55(2014), 2, Seite 289-298 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:55 year:2014 number:2 pages:289-298 https://doi.org/10.1194/jlr.M044826 kostenfrei https://doaj.org/article/16e6907d3fd041aaaf6b6916898f0acf kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520350367 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2014 2 289-298
allfieldsSound	10.1194/jlr.M044826 doi (DE-627)DOAJ068834233 (DE-599)DOAJ16e6907d3fd041aaaf6b6916898f0acf DE-627 ger DE-627 rakwb eng QD415-436 Sin Man Lam verfasserin aut Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S] 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphiphiles in tears that render their detection and accurate quantitation tedious. Using systematic and sensitive lipidomic approaches, we validated different tear collection techniques and report the most comprehensive human tear lipidome to date; comprising more than 600 lipid species from 17 major lipid classes. Our study confers novel insights to the compositional details of the existent tear film model, in particular the disputable amphiphilic lipid sublayer constituents, by demonstrating the presence of cholesteryl sulfate, O-acyl-ω-hydroxyfatty acids, and various sphingolipids and phospholipids in tears. The discovery and quantitation of the relative abundance of various tear lipid amphiphiles reported herein are expected to have a profound impact on the current understanding of the existent human tear film model. lipidomics mass spectrometry dry eye syndrome meibum tear lipidome cholesteryl sulfates Biochemistry Louis Tong verfasserin aut Xinrui Duan verfasserin aut Andrea Petznick verfasserin aut Markus R. Wenk verfasserin aut Guanghou Shui verfasserin aut In Journal of Lipid Research Elsevier, 2021 55(2014), 2, Seite 289-298 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:55 year:2014 number:2 pages:289-298 https://doi.org/10.1194/jlr.M044826 kostenfrei https://doaj.org/article/16e6907d3fd041aaaf6b6916898f0acf kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520350367 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2014 2 289-298
language	English
source	In Journal of Lipid Research 55(2014), 2, Seite 289-298 volume:55 year:2014 number:2 pages:289-298
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authorswithroles_txt_mv	Sin Man Lam @@aut@@ Louis Tong @@aut@@ Xinrui Duan @@aut@@ Andrea Petznick @@aut@@ Markus R. Wenk @@aut@@ Guanghou Shui @@aut@@
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callnumber-first	Q - Science
author	Sin Man Lam
spellingShingle	Sin Man Lam misc QD415-436 misc lipidomics misc mass spectrometry misc dry eye syndrome misc meibum misc tear lipidome misc cholesteryl sulfates misc Biochemistry Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S]
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topic_title	QD415-436 Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S] lipidomics mass spectrometry dry eye syndrome meibum tear lipidome cholesteryl sulfates
topic	misc QD415-436 misc lipidomics misc mass spectrometry misc dry eye syndrome misc meibum misc tear lipidome misc cholesteryl sulfates misc Biochemistry
topic_unstemmed	misc QD415-436 misc lipidomics misc mass spectrometry misc dry eye syndrome misc meibum misc tear lipidome misc cholesteryl sulfates misc Biochemistry
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title	Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S]
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title_full	Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S]
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title_sort	extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[s]
callnumber	QD415-436
title_auth	Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S]
abstract	The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphiphiles in tears that render their detection and accurate quantitation tedious. Using systematic and sensitive lipidomic approaches, we validated different tear collection techniques and report the most comprehensive human tear lipidome to date; comprising more than 600 lipid species from 17 major lipid classes. Our study confers novel insights to the compositional details of the existent tear film model, in particular the disputable amphiphilic lipid sublayer constituents, by demonstrating the presence of cholesteryl sulfate, O-acyl-ω-hydroxyfatty acids, and various sphingolipids and phospholipids in tears. The discovery and quantitation of the relative abundance of various tear lipid amphiphiles reported herein are expected to have a profound impact on the current understanding of the existent human tear film model.
abstractGer	The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphiphiles in tears that render their detection and accurate quantitation tedious. Using systematic and sensitive lipidomic approaches, we validated different tear collection techniques and report the most comprehensive human tear lipidome to date; comprising more than 600 lipid species from 17 major lipid classes. Our study confers novel insights to the compositional details of the existent tear film model, in particular the disputable amphiphilic lipid sublayer constituents, by demonstrating the presence of cholesteryl sulfate, O-acyl-ω-hydroxyfatty acids, and various sphingolipids and phospholipids in tears. The discovery and quantitation of the relative abundance of various tear lipid amphiphiles reported herein are expected to have a profound impact on the current understanding of the existent human tear film model.
abstract_unstemmed	The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphiphiles in tears that render their detection and accurate quantitation tedious. Using systematic and sensitive lipidomic approaches, we validated different tear collection techniques and report the most comprehensive human tear lipidome to date; comprising more than 600 lipid species from 17 major lipid classes. Our study confers novel insights to the compositional details of the existent tear film model, in particular the disputable amphiphilic lipid sublayer constituents, by demonstrating the presence of cholesteryl sulfate, O-acyl-ω-hydroxyfatty acids, and various sphingolipids and phospholipids in tears. The discovery and quantitation of the relative abundance of various tear lipid amphiphiles reported herein are expected to have a profound impact on the current understanding of the existent human tear film model.
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title_short	Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S]
url	https://doi.org/10.1194/jlr.M044826 https://doaj.org/article/16e6907d3fd041aaaf6b6916898f0acf http://www.sciencedirect.com/science/article/pii/S0022227520350367 https://doaj.org/toc/0022-2275
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Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles1[S]

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