Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma

T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epi...
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Gespeichert in:

Autor*in:	Kevin W Ng [verfasserIn] Erin A Marshall [verfasserIn] Katey SS Enfield [verfasserIn] Spencer D Martin [verfasserIn] Katy Milne [verfasserIn] Michelle E Pewarchuk [verfasserIn] Ninan Abraham [verfasserIn] Wan L Lam [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	t follicular helper cell tertiary lymphoid organ lung adenocarcinoma neoantigen ct antigen

Übergeordnetes Werk:	In: OncoImmunology - Taylor & Francis Group, 2020, 7(2018), 12
Übergeordnetes Werk:	volume:7 ; year:2018 ; number:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1080/2162402X.2018.1504728

Katalog-ID:	DOAJ068886330

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520			\|a T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens.
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allfields	10.1080/2162402X.2018.1504728 doi (DE-627)DOAJ068886330 (DE-599)DOAJ1693684fd5994a61a6437b2678b2d8ea DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Kevin W Ng verfasserin aut Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens. t follicular helper cell tertiary lymphoid organ lung adenocarcinoma neoantigen ct antigen Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erin A Marshall verfasserin aut Katey SS Enfield verfasserin aut Spencer D Martin verfasserin aut Katy Milne verfasserin aut Michelle E Pewarchuk verfasserin aut Ninan Abraham verfasserin aut Wan L Lam verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 7(2018), 12 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:7 year:2018 number:12 https://doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/article/1693684fd5994a61a6437b2678b2d8ea kostenfrei http://dx.doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 12
spelling	10.1080/2162402X.2018.1504728 doi (DE-627)DOAJ068886330 (DE-599)DOAJ1693684fd5994a61a6437b2678b2d8ea DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Kevin W Ng verfasserin aut Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens. t follicular helper cell tertiary lymphoid organ lung adenocarcinoma neoantigen ct antigen Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erin A Marshall verfasserin aut Katey SS Enfield verfasserin aut Spencer D Martin verfasserin aut Katy Milne verfasserin aut Michelle E Pewarchuk verfasserin aut Ninan Abraham verfasserin aut Wan L Lam verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 7(2018), 12 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:7 year:2018 number:12 https://doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/article/1693684fd5994a61a6437b2678b2d8ea kostenfrei http://dx.doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 12
allfields_unstemmed	10.1080/2162402X.2018.1504728 doi (DE-627)DOAJ068886330 (DE-599)DOAJ1693684fd5994a61a6437b2678b2d8ea DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Kevin W Ng verfasserin aut Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens. t follicular helper cell tertiary lymphoid organ lung adenocarcinoma neoantigen ct antigen Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erin A Marshall verfasserin aut Katey SS Enfield verfasserin aut Spencer D Martin verfasserin aut Katy Milne verfasserin aut Michelle E Pewarchuk verfasserin aut Ninan Abraham verfasserin aut Wan L Lam verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 7(2018), 12 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:7 year:2018 number:12 https://doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/article/1693684fd5994a61a6437b2678b2d8ea kostenfrei http://dx.doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 12
allfieldsGer	10.1080/2162402X.2018.1504728 doi (DE-627)DOAJ068886330 (DE-599)DOAJ1693684fd5994a61a6437b2678b2d8ea DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Kevin W Ng verfasserin aut Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens. t follicular helper cell tertiary lymphoid organ lung adenocarcinoma neoantigen ct antigen Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erin A Marshall verfasserin aut Katey SS Enfield verfasserin aut Spencer D Martin verfasserin aut Katy Milne verfasserin aut Michelle E Pewarchuk verfasserin aut Ninan Abraham verfasserin aut Wan L Lam verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 7(2018), 12 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:7 year:2018 number:12 https://doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/article/1693684fd5994a61a6437b2678b2d8ea kostenfrei http://dx.doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 12
allfieldsSound	10.1080/2162402X.2018.1504728 doi (DE-627)DOAJ068886330 (DE-599)DOAJ1693684fd5994a61a6437b2678b2d8ea DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Kevin W Ng verfasserin aut Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens. t follicular helper cell tertiary lymphoid organ lung adenocarcinoma neoantigen ct antigen Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Erin A Marshall verfasserin aut Katey SS Enfield verfasserin aut Spencer D Martin verfasserin aut Katy Milne verfasserin aut Michelle E Pewarchuk verfasserin aut Ninan Abraham verfasserin aut Wan L Lam verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 7(2018), 12 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:7 year:2018 number:12 https://doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/article/1693684fd5994a61a6437b2678b2d8ea kostenfrei http://dx.doi.org/10.1080/2162402X.2018.1504728 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2018 12
language	English
source	In OncoImmunology 7(2018), 12 volume:7 year:2018 number:12
sourceStr	In OncoImmunology 7(2018), 12 volume:7 year:2018 number:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	t follicular helper cell tertiary lymphoid organ lung adenocarcinoma neoantigen ct antigen Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	OncoImmunology
authorswithroles_txt_mv	Kevin W Ng @@aut@@ Erin A Marshall @@aut@@ Katey SS Enfield @@aut@@ Spencer D Martin @@aut@@ Katy Milne @@aut@@ Michelle E Pewarchuk @@aut@@ Ninan Abraham @@aut@@ Wan L Lam @@aut@@
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callnumber-first	R - Medicine
author	Kevin W Ng
spellingShingle	Kevin W Ng misc RC581-607 misc RC254-282 misc t follicular helper cell misc tertiary lymphoid organ misc lung adenocarcinoma misc neoantigen misc ct antigen misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma
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topic_title	RC581-607 RC254-282 Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma t follicular helper cell tertiary lymphoid organ lung adenocarcinoma neoantigen ct antigen
topic	misc RC581-607 misc RC254-282 misc t follicular helper cell misc tertiary lymphoid organ misc lung adenocarcinoma misc neoantigen misc ct antigen misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC581-607 misc RC254-282 misc t follicular helper cell misc tertiary lymphoid organ misc lung adenocarcinoma misc neoantigen misc ct antigen misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC581-607 misc RC254-282 misc t follicular helper cell misc tertiary lymphoid organ misc lung adenocarcinoma misc neoantigen misc ct antigen misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma
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title_full	Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma
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title_sort	somatic mutation-associated t follicular helper cell elevation in lung adenocarcinoma
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title_auth	Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma
abstract	T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens.
abstractGer	T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens.
abstract_unstemmed	T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens.
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title_short	Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma
url	https://doi.org/10.1080/2162402X.2018.1504728 https://doaj.org/article/1693684fd5994a61a6437b2678b2d8ea http://dx.doi.org/10.1080/2162402X.2018.1504728 https://doaj.org/toc/2162-402X
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