Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department

The thrombotic microangiopathy (TMA) score based on the development and morphological characteristics of schistocytes is a rapid, simple biomarker that is easily obtained from the complete blood cell count by an automated blood cell analyzer. We aimed to determine whether the TMA score is associated...
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Gespeichert in:

Autor*in:	Dong Ryul Ko [verfasserIn] Taeyoung Kong [verfasserIn] Hye Sun Lee [verfasserIn] Sinae Kim [verfasserIn] Jong Wook Lee [verfasserIn] Hyun Soo Chung [verfasserIn] Sung Phil Chung [verfasserIn] Je Sung You [verfasserIn] Jong Woo Park [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	sepsis thrombotic microangiopathy score mortality predictor

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 8(2019), 6, p 808
Übergeordnetes Werk:	volume:8 ; year:2019 ; number:6, p 808

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm8060808

Katalog-ID:	DOAJ06891038X

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allfields	10.3390/jcm8060808 doi (DE-627)DOAJ06891038X (DE-599)DOAJ85eca750710047a581eb5f7c61e51cb0 DE-627 ger DE-627 rakwb eng Dong Ryul Ko verfasserin aut Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The thrombotic microangiopathy (TMA) score based on the development and morphological characteristics of schistocytes is a rapid, simple biomarker that is easily obtained from the complete blood cell count by an automated blood cell analyzer. We aimed to determine whether the TMA score is associated with 30-day mortality of patients with early-stage septic shock. This observational cohort study was retrospectively conducted based on a prospective emergency department (ED) registry (June 2015−December 2016). We analyzed the TMA score at ED admission and 24 h later. The primary endpoint was all-cause mortality within 30 days of ED admission. A total of 221 patients were included. Increased TMA scores at time 0 (odds ratio (OR), 1.972; 95% confidence interval (CI), 1.253−3.106; <i<p</i< = 0.003) and at time 24 (OR, 1.863; 95% CI, 1.863−3.066; <i<p</i< = 0.014) were strong predictors of 30-day mortality. Increased predictability of 30-day mortality was closely associated with TMA scores ≥2 at time 0 (OR, 4.035; 95% CI, 1.651−9.863; <i<p</i< = 0.002) and ≥3 at time 24 (OR, 5.639; 95% CI, 2.190−14.519; <i<p</i< < 0.001). Increased TMA scores significantly predicted 30-day mortality for patients with severe sepsis and septic shock and can be helpful when determining the initial treatment strategies without additional costs or effort. sepsis thrombotic microangiopathy score mortality predictor Medicine R Taeyoung Kong verfasserin aut Hye Sun Lee verfasserin aut Sinae Kim verfasserin aut Jong Wook Lee verfasserin aut Hyun Soo Chung verfasserin aut Sung Phil Chung verfasserin aut Je Sung You verfasserin aut Jong Woo Park verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 6, p 808 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:6, p 808 https://doi.org/10.3390/jcm8060808 kostenfrei https://doaj.org/article/85eca750710047a581eb5f7c61e51cb0 kostenfrei https://www.mdpi.com/2077-0383/8/6/808 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 6, p 808
spelling	10.3390/jcm8060808 doi (DE-627)DOAJ06891038X (DE-599)DOAJ85eca750710047a581eb5f7c61e51cb0 DE-627 ger DE-627 rakwb eng Dong Ryul Ko verfasserin aut Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The thrombotic microangiopathy (TMA) score based on the development and morphological characteristics of schistocytes is a rapid, simple biomarker that is easily obtained from the complete blood cell count by an automated blood cell analyzer. We aimed to determine whether the TMA score is associated with 30-day mortality of patients with early-stage septic shock. This observational cohort study was retrospectively conducted based on a prospective emergency department (ED) registry (June 2015−December 2016). We analyzed the TMA score at ED admission and 24 h later. The primary endpoint was all-cause mortality within 30 days of ED admission. A total of 221 patients were included. Increased TMA scores at time 0 (odds ratio (OR), 1.972; 95% confidence interval (CI), 1.253−3.106; <i<p</i< = 0.003) and at time 24 (OR, 1.863; 95% CI, 1.863−3.066; <i<p</i< = 0.014) were strong predictors of 30-day mortality. Increased predictability of 30-day mortality was closely associated with TMA scores ≥2 at time 0 (OR, 4.035; 95% CI, 1.651−9.863; <i<p</i< = 0.002) and ≥3 at time 24 (OR, 5.639; 95% CI, 2.190−14.519; <i<p</i< < 0.001). Increased TMA scores significantly predicted 30-day mortality for patients with severe sepsis and septic shock and can be helpful when determining the initial treatment strategies without additional costs or effort. sepsis thrombotic microangiopathy score mortality predictor Medicine R Taeyoung Kong verfasserin aut Hye Sun Lee verfasserin aut Sinae Kim verfasserin aut Jong Wook Lee verfasserin aut Hyun Soo Chung verfasserin aut Sung Phil Chung verfasserin aut Je Sung You verfasserin aut Jong Woo Park verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 6, p 808 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:6, p 808 https://doi.org/10.3390/jcm8060808 kostenfrei https://doaj.org/article/85eca750710047a581eb5f7c61e51cb0 kostenfrei https://www.mdpi.com/2077-0383/8/6/808 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 6, p 808
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allfieldsGer	10.3390/jcm8060808 doi (DE-627)DOAJ06891038X (DE-599)DOAJ85eca750710047a581eb5f7c61e51cb0 DE-627 ger DE-627 rakwb eng Dong Ryul Ko verfasserin aut Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The thrombotic microangiopathy (TMA) score based on the development and morphological characteristics of schistocytes is a rapid, simple biomarker that is easily obtained from the complete blood cell count by an automated blood cell analyzer. We aimed to determine whether the TMA score is associated with 30-day mortality of patients with early-stage septic shock. This observational cohort study was retrospectively conducted based on a prospective emergency department (ED) registry (June 2015−December 2016). We analyzed the TMA score at ED admission and 24 h later. The primary endpoint was all-cause mortality within 30 days of ED admission. A total of 221 patients were included. Increased TMA scores at time 0 (odds ratio (OR), 1.972; 95% confidence interval (CI), 1.253−3.106; <i<p</i< = 0.003) and at time 24 (OR, 1.863; 95% CI, 1.863−3.066; <i<p</i< = 0.014) were strong predictors of 30-day mortality. Increased predictability of 30-day mortality was closely associated with TMA scores ≥2 at time 0 (OR, 4.035; 95% CI, 1.651−9.863; <i<p</i< = 0.002) and ≥3 at time 24 (OR, 5.639; 95% CI, 2.190−14.519; <i<p</i< < 0.001). Increased TMA scores significantly predicted 30-day mortality for patients with severe sepsis and septic shock and can be helpful when determining the initial treatment strategies without additional costs or effort. sepsis thrombotic microangiopathy score mortality predictor Medicine R Taeyoung Kong verfasserin aut Hye Sun Lee verfasserin aut Sinae Kim verfasserin aut Jong Wook Lee verfasserin aut Hyun Soo Chung verfasserin aut Sung Phil Chung verfasserin aut Je Sung You verfasserin aut Jong Woo Park verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 6, p 808 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:6, p 808 https://doi.org/10.3390/jcm8060808 kostenfrei https://doaj.org/article/85eca750710047a581eb5f7c61e51cb0 kostenfrei https://www.mdpi.com/2077-0383/8/6/808 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 6, p 808
allfieldsSound	10.3390/jcm8060808 doi (DE-627)DOAJ06891038X (DE-599)DOAJ85eca750710047a581eb5f7c61e51cb0 DE-627 ger DE-627 rakwb eng Dong Ryul Ko verfasserin aut Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The thrombotic microangiopathy (TMA) score based on the development and morphological characteristics of schistocytes is a rapid, simple biomarker that is easily obtained from the complete blood cell count by an automated blood cell analyzer. We aimed to determine whether the TMA score is associated with 30-day mortality of patients with early-stage septic shock. This observational cohort study was retrospectively conducted based on a prospective emergency department (ED) registry (June 2015−December 2016). We analyzed the TMA score at ED admission and 24 h later. The primary endpoint was all-cause mortality within 30 days of ED admission. A total of 221 patients were included. Increased TMA scores at time 0 (odds ratio (OR), 1.972; 95% confidence interval (CI), 1.253−3.106; <i<p</i< = 0.003) and at time 24 (OR, 1.863; 95% CI, 1.863−3.066; <i<p</i< = 0.014) were strong predictors of 30-day mortality. Increased predictability of 30-day mortality was closely associated with TMA scores ≥2 at time 0 (OR, 4.035; 95% CI, 1.651−9.863; <i<p</i< = 0.002) and ≥3 at time 24 (OR, 5.639; 95% CI, 2.190−14.519; <i<p</i< < 0.001). Increased TMA scores significantly predicted 30-day mortality for patients with severe sepsis and septic shock and can be helpful when determining the initial treatment strategies without additional costs or effort. sepsis thrombotic microangiopathy score mortality predictor Medicine R Taeyoung Kong verfasserin aut Hye Sun Lee verfasserin aut Sinae Kim verfasserin aut Jong Wook Lee verfasserin aut Hyun Soo Chung verfasserin aut Sung Phil Chung verfasserin aut Je Sung You verfasserin aut Jong Woo Park verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 6, p 808 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:6, p 808 https://doi.org/10.3390/jcm8060808 kostenfrei https://doaj.org/article/85eca750710047a581eb5f7c61e51cb0 kostenfrei https://www.mdpi.com/2077-0383/8/6/808 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 6, p 808
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author	Dong Ryul Ko
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topic_title	Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department sepsis thrombotic microangiopathy score mortality predictor
topic	misc sepsis misc thrombotic microangiopathy score misc mortality misc predictor misc Medicine misc R
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title	Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department
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title_full	Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department
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author_browse	Dong Ryul Ko Taeyoung Kong Hye Sun Lee Sinae Kim Jong Wook Lee Hyun Soo Chung Sung Phil Chung Je Sung You Jong Woo Park
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title_sort	usefulness of the thrombotic microangiopathy score as a promising prognostic marker of septic shock for patients in the emergency department
title_auth	Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department
abstract	The thrombotic microangiopathy (TMA) score based on the development and morphological characteristics of schistocytes is a rapid, simple biomarker that is easily obtained from the complete blood cell count by an automated blood cell analyzer. We aimed to determine whether the TMA score is associated with 30-day mortality of patients with early-stage septic shock. This observational cohort study was retrospectively conducted based on a prospective emergency department (ED) registry (June 2015−December 2016). We analyzed the TMA score at ED admission and 24 h later. The primary endpoint was all-cause mortality within 30 days of ED admission. A total of 221 patients were included. Increased TMA scores at time 0 (odds ratio (OR), 1.972; 95% confidence interval (CI), 1.253−3.106; <i<p</i< = 0.003) and at time 24 (OR, 1.863; 95% CI, 1.863−3.066; <i<p</i< = 0.014) were strong predictors of 30-day mortality. Increased predictability of 30-day mortality was closely associated with TMA scores ≥2 at time 0 (OR, 4.035; 95% CI, 1.651−9.863; <i<p</i< = 0.002) and ≥3 at time 24 (OR, 5.639; 95% CI, 2.190−14.519; <i<p</i< < 0.001). Increased TMA scores significantly predicted 30-day mortality for patients with severe sepsis and septic shock and can be helpful when determining the initial treatment strategies without additional costs or effort.
abstractGer	The thrombotic microangiopathy (TMA) score based on the development and morphological characteristics of schistocytes is a rapid, simple biomarker that is easily obtained from the complete blood cell count by an automated blood cell analyzer. We aimed to determine whether the TMA score is associated with 30-day mortality of patients with early-stage septic shock. This observational cohort study was retrospectively conducted based on a prospective emergency department (ED) registry (June 2015−December 2016). We analyzed the TMA score at ED admission and 24 h later. The primary endpoint was all-cause mortality within 30 days of ED admission. A total of 221 patients were included. Increased TMA scores at time 0 (odds ratio (OR), 1.972; 95% confidence interval (CI), 1.253−3.106; <i<p</i< = 0.003) and at time 24 (OR, 1.863; 95% CI, 1.863−3.066; <i<p</i< = 0.014) were strong predictors of 30-day mortality. Increased predictability of 30-day mortality was closely associated with TMA scores ≥2 at time 0 (OR, 4.035; 95% CI, 1.651−9.863; <i<p</i< = 0.002) and ≥3 at time 24 (OR, 5.639; 95% CI, 2.190−14.519; <i<p</i< < 0.001). Increased TMA scores significantly predicted 30-day mortality for patients with severe sepsis and septic shock and can be helpful when determining the initial treatment strategies without additional costs or effort.
abstract_unstemmed	The thrombotic microangiopathy (TMA) score based on the development and morphological characteristics of schistocytes is a rapid, simple biomarker that is easily obtained from the complete blood cell count by an automated blood cell analyzer. We aimed to determine whether the TMA score is associated with 30-day mortality of patients with early-stage septic shock. This observational cohort study was retrospectively conducted based on a prospective emergency department (ED) registry (June 2015−December 2016). We analyzed the TMA score at ED admission and 24 h later. The primary endpoint was all-cause mortality within 30 days of ED admission. A total of 221 patients were included. Increased TMA scores at time 0 (odds ratio (OR), 1.972; 95% confidence interval (CI), 1.253−3.106; <i<p</i< = 0.003) and at time 24 (OR, 1.863; 95% CI, 1.863−3.066; <i<p</i< = 0.014) were strong predictors of 30-day mortality. Increased predictability of 30-day mortality was closely associated with TMA scores ≥2 at time 0 (OR, 4.035; 95% CI, 1.651−9.863; <i<p</i< = 0.002) and ≥3 at time 24 (OR, 5.639; 95% CI, 2.190−14.519; <i<p</i< < 0.001). Increased TMA scores significantly predicted 30-day mortality for patients with severe sepsis and septic shock and can be helpful when determining the initial treatment strategies without additional costs or effort.
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title_short	Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department
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up_date	2024-07-03T20:26:36.123Z
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We aimed to determine whether the TMA score is associated with 30-day mortality of patients with early-stage septic shock. This observational cohort study was retrospectively conducted based on a prospective emergency department (ED) registry (June 2015−December 2016). We analyzed the TMA score at ED admission and 24 h later. The primary endpoint was all-cause mortality within 30 days of ED admission. A total of 221 patients were included. Increased TMA scores at time 0 (odds ratio (OR), 1.972; 95% confidence interval (CI), 1.253−3.106; <i<p</i< = 0.003) and at time 24 (OR, 1.863; 95% CI, 1.863−3.066; <i<p</i< = 0.014) were strong predictors of 30-day mortality. Increased predictability of 30-day mortality was closely associated with TMA scores ≥2 at time 0 (OR, 4.035; 95% CI, 1.651−9.863; <i<p</i< = 0.002) and ≥3 at time 24 (OR, 5.639; 95% CI, 2.190−14.519; <i<p</i< &lt; 0.001). 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Usefulness of the Thrombotic Microangiopathy Score as a Promising Prognostic Marker of Septic Shock for Patients in the Emergency Department

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