Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study
Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were...
Ausführliche Beschreibung
Autor*in: |
Sang Ha Woo [verfasserIn] Jung Hee Lee [verfasserIn] Cho-in Lee [verfasserIn] Yun Kyu Lee [verfasserIn] Hyun-Jong Lee [verfasserIn] Jae Soo Kim [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch ; Koreanisch |
Erschienen: |
2021 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Journal of Acupuncture Research - E-Tree Publishing, 2019, 38(2021), 1, Seite 47-59 |
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Übergeordnetes Werk: |
volume:38 ; year:2021 ; number:1 ; pages:47-59 |
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Link aufrufen |
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DOI / URN: |
10.13045/jar.2020.00332 |
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Katalog-ID: |
DOAJ06892755X |
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520 | |a Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. | ||
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700 | 0 | |a Jae Soo Kim |e verfasserin |4 aut | |
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10.13045/jar.2020.00332 doi (DE-627)DOAJ06892755X (DE-599)DOAJ2234c4b5fd63475592dbcd72174e2117 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Sang Ha Woo verfasserin aut Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. pharmacopuncture toxicity morbidity body weight changes hematologic test Miscellaneous systems and treatments Therapeutics. Pharmacology Jung Hee Lee verfasserin aut Cho-in Lee verfasserin aut Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 1, Seite 47-59 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:1 pages:47-59 https://doi.org/10.13045/jar.2020.00332 kostenfrei https://doaj.org/article/2234c4b5fd63475592dbcd72174e2117 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00332.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 1 47-59 |
spelling |
10.13045/jar.2020.00332 doi (DE-627)DOAJ06892755X (DE-599)DOAJ2234c4b5fd63475592dbcd72174e2117 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Sang Ha Woo verfasserin aut Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. pharmacopuncture toxicity morbidity body weight changes hematologic test Miscellaneous systems and treatments Therapeutics. Pharmacology Jung Hee Lee verfasserin aut Cho-in Lee verfasserin aut Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 1, Seite 47-59 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:1 pages:47-59 https://doi.org/10.13045/jar.2020.00332 kostenfrei https://doaj.org/article/2234c4b5fd63475592dbcd72174e2117 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00332.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 1 47-59 |
allfields_unstemmed |
10.13045/jar.2020.00332 doi (DE-627)DOAJ06892755X (DE-599)DOAJ2234c4b5fd63475592dbcd72174e2117 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Sang Ha Woo verfasserin aut Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. pharmacopuncture toxicity morbidity body weight changes hematologic test Miscellaneous systems and treatments Therapeutics. Pharmacology Jung Hee Lee verfasserin aut Cho-in Lee verfasserin aut Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 1, Seite 47-59 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:1 pages:47-59 https://doi.org/10.13045/jar.2020.00332 kostenfrei https://doaj.org/article/2234c4b5fd63475592dbcd72174e2117 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00332.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 1 47-59 |
allfieldsGer |
10.13045/jar.2020.00332 doi (DE-627)DOAJ06892755X (DE-599)DOAJ2234c4b5fd63475592dbcd72174e2117 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Sang Ha Woo verfasserin aut Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. pharmacopuncture toxicity morbidity body weight changes hematologic test Miscellaneous systems and treatments Therapeutics. Pharmacology Jung Hee Lee verfasserin aut Cho-in Lee verfasserin aut Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 1, Seite 47-59 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:1 pages:47-59 https://doi.org/10.13045/jar.2020.00332 kostenfrei https://doaj.org/article/2234c4b5fd63475592dbcd72174e2117 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00332.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 1 47-59 |
allfieldsSound |
10.13045/jar.2020.00332 doi (DE-627)DOAJ06892755X (DE-599)DOAJ2234c4b5fd63475592dbcd72174e2117 DE-627 ger DE-627 rakwb eng kor RZ409.7-999 RM1-950 Sang Ha Woo verfasserin aut Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. pharmacopuncture toxicity morbidity body weight changes hematologic test Miscellaneous systems and treatments Therapeutics. Pharmacology Jung Hee Lee verfasserin aut Cho-in Lee verfasserin aut Yun Kyu Lee verfasserin aut Hyun-Jong Lee verfasserin aut Jae Soo Kim verfasserin aut In Journal of Acupuncture Research E-Tree Publishing, 2019 38(2021), 1, Seite 47-59 (DE-627)1760649716 (DE-600)3073165-3 25862898 nnns volume:38 year:2021 number:1 pages:47-59 https://doi.org/10.13045/jar.2020.00332 kostenfrei https://doaj.org/article/2234c4b5fd63475592dbcd72174e2117 kostenfrei http://www.e-jar.org/upload/pdf/jar-2020-00332.pdf kostenfrei https://doaj.org/toc/2586-288X Journal toc kostenfrei https://doaj.org/toc/2586-2898 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 38 2021 1 47-59 |
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Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">pharmacopuncture</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">toxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">morbidity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">body weight changes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hematologic test</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Miscellaneous systems and treatments</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. 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Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study |
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Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. |
abstractGer |
Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. |
abstract_unstemmed |
Background This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture. Methods To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regimen, the mice were assigned into 4 groups (5 males, 5 females per group). Then, 15.625, 31.25, and 62.5 mg/kg of ASN pharmacopuncture at ST36 were administered to the mice in the experimental groups, while 0.2 mL of normal saline was administered to the control group at ST36. Mortality, morbidity, general body and organ weight changes (after 4 weeks repeated dose), serum hematological and biochemical values, and histopathological changes in the liver and kidney were observed. Results In both single and 4-week repeated dose toxicity experiments, no deaths or symptoms occurred in any of the groups. There were no significant differences between groups in terms of body and organ weights, serum hematological and biochemical values, and specific organ histopathological changes. Conclusion ASN pharmacopuncture injection did not demonstrate significant toxicity in BALB/c mice compared with the control group, with a no-observed-adverse-effect level for a single dose of <125 mg/kg, and for 4 weeks repeated dose it was more than 62.5 mg/kg/day. |
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Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study |
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