Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation
Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the di...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alicia Mayeuf-Louchart [verfasserIn] Steve Lancel [verfasserIn] Yasmine Sebti [verfasserIn] Benoit Pourcet [verfasserIn] Anne Loyens [verfasserIn] Stéphane Delhaye [verfasserIn] Christian Duhem [verfasserIn] Justine Beauchamp [verfasserIn] Lise Ferri [verfasserIn] Quentin Thorel [verfasserIn] Alexis Boulinguiez [verfasserIn] Mathilde Zecchin [verfasserIn] Julie Dubois-Chevalier [verfasserIn] Jérôme Eeckhoute [verfasserIn] Logan T. Vaughn [verfasserIn] Peter J. Roach [verfasserIn] Christian Dani [verfasserIn] Bartholomew A. Pederson [verfasserIn] Stéphane D. Vincent [verfasserIn] Bart Staels [verfasserIn] Hélène Duez [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Übergeordnetes Werk: |
In: Cell Reports - Elsevier, 2015, 29(2019), 6, Seite 1410-1418.e6 |
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| Übergeordnetes Werk: |
volume:29 ; year:2019 ; number:6 ; pages:1410-1418.e6 |
| Links: |
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| DOI / URN: |
10.1016/j.celrep.2019.09.073 |
|---|
| Katalog-ID: |
DOAJ068958862 |
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| 520 | |a Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT | ||
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10.1016/j.celrep.2019.09.073 doi (DE-627)DOAJ068958862 (DE-599)DOAJ00e94624b982459bb752e5e8a93046f6 DE-627 ger DE-627 rakwb eng QH301-705.5 Alicia Mayeuf-Louchart verfasserin aut Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT Biology (General) Steve Lancel verfasserin aut Yasmine Sebti verfasserin aut Benoit Pourcet verfasserin aut Anne Loyens verfasserin aut Stéphane Delhaye verfasserin aut Christian Duhem verfasserin aut Justine Beauchamp verfasserin aut Lise Ferri verfasserin aut Quentin Thorel verfasserin aut Alexis Boulinguiez verfasserin aut Mathilde Zecchin verfasserin aut Julie Dubois-Chevalier verfasserin aut Jérôme Eeckhoute verfasserin aut Logan T. Vaughn verfasserin aut Peter J. Roach verfasserin aut Christian Dani verfasserin aut Bartholomew A. Pederson verfasserin aut Stéphane D. Vincent verfasserin aut Bart Staels verfasserin aut Hélène Duez verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 6, Seite 1410-1418.e6 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:6 pages:1410-1418.e6 https://doi.org/10.1016/j.celrep.2019.09.073 kostenfrei https://doaj.org/article/00e94624b982459bb752e5e8a93046f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719312707 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 6 1410-1418.e6 |
| spelling |
10.1016/j.celrep.2019.09.073 doi (DE-627)DOAJ068958862 (DE-599)DOAJ00e94624b982459bb752e5e8a93046f6 DE-627 ger DE-627 rakwb eng QH301-705.5 Alicia Mayeuf-Louchart verfasserin aut Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT Biology (General) Steve Lancel verfasserin aut Yasmine Sebti verfasserin aut Benoit Pourcet verfasserin aut Anne Loyens verfasserin aut Stéphane Delhaye verfasserin aut Christian Duhem verfasserin aut Justine Beauchamp verfasserin aut Lise Ferri verfasserin aut Quentin Thorel verfasserin aut Alexis Boulinguiez verfasserin aut Mathilde Zecchin verfasserin aut Julie Dubois-Chevalier verfasserin aut Jérôme Eeckhoute verfasserin aut Logan T. Vaughn verfasserin aut Peter J. Roach verfasserin aut Christian Dani verfasserin aut Bartholomew A. Pederson verfasserin aut Stéphane D. Vincent verfasserin aut Bart Staels verfasserin aut Hélène Duez verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 6, Seite 1410-1418.e6 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:6 pages:1410-1418.e6 https://doi.org/10.1016/j.celrep.2019.09.073 kostenfrei https://doaj.org/article/00e94624b982459bb752e5e8a93046f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719312707 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 6 1410-1418.e6 |
| allfields_unstemmed |
10.1016/j.celrep.2019.09.073 doi (DE-627)DOAJ068958862 (DE-599)DOAJ00e94624b982459bb752e5e8a93046f6 DE-627 ger DE-627 rakwb eng QH301-705.5 Alicia Mayeuf-Louchart verfasserin aut Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT Biology (General) Steve Lancel verfasserin aut Yasmine Sebti verfasserin aut Benoit Pourcet verfasserin aut Anne Loyens verfasserin aut Stéphane Delhaye verfasserin aut Christian Duhem verfasserin aut Justine Beauchamp verfasserin aut Lise Ferri verfasserin aut Quentin Thorel verfasserin aut Alexis Boulinguiez verfasserin aut Mathilde Zecchin verfasserin aut Julie Dubois-Chevalier verfasserin aut Jérôme Eeckhoute verfasserin aut Logan T. Vaughn verfasserin aut Peter J. Roach verfasserin aut Christian Dani verfasserin aut Bartholomew A. Pederson verfasserin aut Stéphane D. Vincent verfasserin aut Bart Staels verfasserin aut Hélène Duez verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 6, Seite 1410-1418.e6 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:6 pages:1410-1418.e6 https://doi.org/10.1016/j.celrep.2019.09.073 kostenfrei https://doaj.org/article/00e94624b982459bb752e5e8a93046f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719312707 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 6 1410-1418.e6 |
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10.1016/j.celrep.2019.09.073 doi (DE-627)DOAJ068958862 (DE-599)DOAJ00e94624b982459bb752e5e8a93046f6 DE-627 ger DE-627 rakwb eng QH301-705.5 Alicia Mayeuf-Louchart verfasserin aut Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT Biology (General) Steve Lancel verfasserin aut Yasmine Sebti verfasserin aut Benoit Pourcet verfasserin aut Anne Loyens verfasserin aut Stéphane Delhaye verfasserin aut Christian Duhem verfasserin aut Justine Beauchamp verfasserin aut Lise Ferri verfasserin aut Quentin Thorel verfasserin aut Alexis Boulinguiez verfasserin aut Mathilde Zecchin verfasserin aut Julie Dubois-Chevalier verfasserin aut Jérôme Eeckhoute verfasserin aut Logan T. Vaughn verfasserin aut Peter J. Roach verfasserin aut Christian Dani verfasserin aut Bartholomew A. Pederson verfasserin aut Stéphane D. Vincent verfasserin aut Bart Staels verfasserin aut Hélène Duez verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 6, Seite 1410-1418.e6 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:6 pages:1410-1418.e6 https://doi.org/10.1016/j.celrep.2019.09.073 kostenfrei https://doaj.org/article/00e94624b982459bb752e5e8a93046f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719312707 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 6 1410-1418.e6 |
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10.1016/j.celrep.2019.09.073 doi (DE-627)DOAJ068958862 (DE-599)DOAJ00e94624b982459bb752e5e8a93046f6 DE-627 ger DE-627 rakwb eng QH301-705.5 Alicia Mayeuf-Louchart verfasserin aut Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT Biology (General) Steve Lancel verfasserin aut Yasmine Sebti verfasserin aut Benoit Pourcet verfasserin aut Anne Loyens verfasserin aut Stéphane Delhaye verfasserin aut Christian Duhem verfasserin aut Justine Beauchamp verfasserin aut Lise Ferri verfasserin aut Quentin Thorel verfasserin aut Alexis Boulinguiez verfasserin aut Mathilde Zecchin verfasserin aut Julie Dubois-Chevalier verfasserin aut Jérôme Eeckhoute verfasserin aut Logan T. Vaughn verfasserin aut Peter J. Roach verfasserin aut Christian Dani verfasserin aut Bartholomew A. Pederson verfasserin aut Stéphane D. Vincent verfasserin aut Bart Staels verfasserin aut Hélène Duez verfasserin aut In Cell Reports Elsevier, 2015 29(2019), 6, Seite 1410-1418.e6 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:29 year:2019 number:6 pages:1410-1418.e6 https://doi.org/10.1016/j.celrep.2019.09.073 kostenfrei https://doaj.org/article/00e94624b982459bb752e5e8a93046f6 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124719312707 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 29 2019 6 1410-1418.e6 |
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Alicia Mayeuf-Louchart @@aut@@ Steve Lancel @@aut@@ Yasmine Sebti @@aut@@ Benoit Pourcet @@aut@@ Anne Loyens @@aut@@ Stéphane Delhaye @@aut@@ Christian Duhem @@aut@@ Justine Beauchamp @@aut@@ Lise Ferri @@aut@@ Quentin Thorel @@aut@@ Alexis Boulinguiez @@aut@@ Mathilde Zecchin @@aut@@ Julie Dubois-Chevalier @@aut@@ Jérôme Eeckhoute @@aut@@ Logan T. Vaughn @@aut@@ Peter J. Roach @@aut@@ Christian Dani @@aut@@ Bartholomew A. Pederson @@aut@@ Stéphane D. Vincent @@aut@@ Bart Staels @@aut@@ Hélène Duez @@aut@@ |
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glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation |
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Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation |
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Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT |
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Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT |
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Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases. However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. Keywords: brown adipose tissue, adipocyte differentiation, lipid droplet biogenesis, lipid, glycogen, autophagy, glycophagy, embryonic development, adipocyte metabolism, BAT |
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However, our poor understanding of the mechanisms that govern the differentiation and activation of brown adipocytes limits the development of such therapy. Various genetic factors controlling the differentiation of brown adipocytes have been identified, although most studies have been performed using in vitro cultured pre-adipocytes. We investigate here the differentiation of brown adipocytes from adipose progenitors in the mouse embryo. We demonstrate that the formation of multiple lipid droplets (LDs) is initiated within clusters of glycogen, which is degraded through glycophagy to provide the metabolic substrates essential for de novo lipogenesis and LD formation. Therefore, this study uncovers the role of glycogen in the generation of LDs. : Lipid droplet formation is a major feature of brown adipocyte differentiation. Mayeuf-Louchart et al. characterize the different steps of brown adipocyte differentiation in the mouse embryo and report the essential role of glycogen production and degradation by glycophagy for lipid droplet biogenesis. 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