Evidence for Oxidative Stress in Experimental Prion Disease

Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as mar...
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Autor*in:	Marin Guentchev [verfasserIn] Till Voigtländer [verfasserIn] Christine Haberler [verfasserIn] Martin H. Groschup [verfasserIn] Herbert Budka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2000

Übergeordnetes Werk:	In: Neurobiology of Disease - Elsevier, 2021, 7(2000), 4, Seite 270-273
Übergeordnetes Werk:	volume:7 ; year:2000 ; number:4 ; pages:270-273

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1006/nbdi.2000.0290

Katalog-ID:	DOAJ069073309

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allfields	10.1006/nbdi.2000.0290 doi (DE-627)DOAJ069073309 (DE-599)DOAJ3dd0cf4e16f4492aaa031fe119fca5c7 DE-627 ger DE-627 rakwb eng RC321-571 Marin Guentchev verfasserin aut Evidence for Oxidative Stress in Experimental Prion Disease 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders. Neurosciences. Biological psychiatry. Neuropsychiatry Till Voigtländer verfasserin aut Christine Haberler verfasserin aut Martin H. Groschup verfasserin aut Herbert Budka verfasserin aut In Neurobiology of Disease Elsevier, 2021 7(2000), 4, Seite 270-273 (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:7 year:2000 number:4 pages:270-273 https://doi.org/10.1006/nbdi.2000.0290 kostenfrei https://doaj.org/article/3dd0cf4e16f4492aaa031fe119fca5c7 kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996100902900 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4700 AR 7 2000 4 270-273
spelling	10.1006/nbdi.2000.0290 doi (DE-627)DOAJ069073309 (DE-599)DOAJ3dd0cf4e16f4492aaa031fe119fca5c7 DE-627 ger DE-627 rakwb eng RC321-571 Marin Guentchev verfasserin aut Evidence for Oxidative Stress in Experimental Prion Disease 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders. Neurosciences. Biological psychiatry. Neuropsychiatry Till Voigtländer verfasserin aut Christine Haberler verfasserin aut Martin H. Groschup verfasserin aut Herbert Budka verfasserin aut In Neurobiology of Disease Elsevier, 2021 7(2000), 4, Seite 270-273 (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:7 year:2000 number:4 pages:270-273 https://doi.org/10.1006/nbdi.2000.0290 kostenfrei https://doaj.org/article/3dd0cf4e16f4492aaa031fe119fca5c7 kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996100902900 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4700 AR 7 2000 4 270-273
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allfieldsGer	10.1006/nbdi.2000.0290 doi (DE-627)DOAJ069073309 (DE-599)DOAJ3dd0cf4e16f4492aaa031fe119fca5c7 DE-627 ger DE-627 rakwb eng RC321-571 Marin Guentchev verfasserin aut Evidence for Oxidative Stress in Experimental Prion Disease 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders. Neurosciences. Biological psychiatry. Neuropsychiatry Till Voigtländer verfasserin aut Christine Haberler verfasserin aut Martin H. Groschup verfasserin aut Herbert Budka verfasserin aut In Neurobiology of Disease Elsevier, 2021 7(2000), 4, Seite 270-273 (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:7 year:2000 number:4 pages:270-273 https://doi.org/10.1006/nbdi.2000.0290 kostenfrei https://doaj.org/article/3dd0cf4e16f4492aaa031fe119fca5c7 kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996100902900 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4700 AR 7 2000 4 270-273
allfieldsSound	10.1006/nbdi.2000.0290 doi (DE-627)DOAJ069073309 (DE-599)DOAJ3dd0cf4e16f4492aaa031fe119fca5c7 DE-627 ger DE-627 rakwb eng RC321-571 Marin Guentchev verfasserin aut Evidence for Oxidative Stress in Experimental Prion Disease 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders. Neurosciences. Biological psychiatry. Neuropsychiatry Till Voigtländer verfasserin aut Christine Haberler verfasserin aut Martin H. Groschup verfasserin aut Herbert Budka verfasserin aut In Neurobiology of Disease Elsevier, 2021 7(2000), 4, Seite 270-273 (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:7 year:2000 number:4 pages:270-273 https://doi.org/10.1006/nbdi.2000.0290 kostenfrei https://doaj.org/article/3dd0cf4e16f4492aaa031fe119fca5c7 kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996100902900 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4700 AR 7 2000 4 270-273
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author	Marin Guentchev
spellingShingle	Marin Guentchev misc RC321-571 misc Neurosciences. Biological psychiatry. Neuropsychiatry Evidence for Oxidative Stress in Experimental Prion Disease
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title	Evidence for Oxidative Stress in Experimental Prion Disease
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author_browse	Marin Guentchev Till Voigtländer Christine Haberler Martin H. Groschup Herbert Budka
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title_sort	evidence for oxidative stress in experimental prion disease
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title_auth	Evidence for Oxidative Stress in Experimental Prion Disease
abstract	Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.
abstractGer	Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.
abstract_unstemmed	Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.
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title_short	Evidence for Oxidative Stress in Experimental Prion Disease
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Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neurosciences. Biological psychiatry. 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Groschup</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Herbert Budka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Neurobiology of Disease</subfield><subfield code="d">Elsevier, 2021</subfield><subfield code="g">7(2000), 4, Seite 270-273</subfield><subfield code="w">(DE-627)268125414</subfield><subfield code="w">(DE-600)1471408-5</subfield><subfield code="x">1095953X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:7</subfield><subfield code="g">year:2000</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:270-273</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1006/nbdi.2000.0290</subfield><subfield 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Evidence for Oxidative Stress in Experimental Prion Disease

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