Expression patterns of MLC1 protein in the central and peripheral nervous systems

Mutations in MLC1 cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), a disorder characterized clinically by macrocephaly, deterioration of motor functions, epilepsy and mental decline. Recent studies have detected MLC1 mRNA and protein in astroglial processes. In addition, our g...
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Autor*in:	Oscar Teijido [verfasserIn] Ricardo Casaroli-Marano [verfasserIn] Tatjana Kharkovets [verfasserIn] Fernando Aguado [verfasserIn] Antonio Zorzano [verfasserIn] Manuel Palacín [verfasserIn] Eduardo Soriano [verfasserIn] Albert Martínez [verfasserIn] Raúl Estévez [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Myelin Leukodystrophy MLC Neuron Astrocyte Development

Übergeordnetes Werk:	In: Neurobiology of Disease - Elsevier, 2021, 26(2007), 3, Seite 532-545
Übergeordnetes Werk:	volume:26 ; year:2007 ; number:3 ; pages:532-545

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.nbd.2007.01.016

Katalog-ID:	DOAJ069114056

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allfields_unstemmed	10.1016/j.nbd.2007.01.016 doi (DE-627)DOAJ069114056 (DE-599)DOAJe47c313a52c24bb097b1c8797ac4292b DE-627 ger DE-627 rakwb eng RC321-571 Oscar Teijido verfasserin aut Expression patterns of MLC1 protein in the central and peripheral nervous systems 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mutations in MLC1 cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), a disorder characterized clinically by macrocephaly, deterioration of motor functions, epilepsy and mental decline. Recent studies have detected MLC1 mRNA and protein in astroglial processes. In addition, our group previously reported MLC1 expression in some neurons in the adult mouse brain. Here we performed an exhaustive study of the expression pattern of MLC1 in the developing mouse brain by means of optic and electron microscopy. In the central nervous system, MLC1 was detected mainly in axonal tracts early in development. In addition, MLC1 was also observed in the peripheral nervous system and in several sensory epithelia, as retina or saccula maculae. Post-embedding immunogold experiments indicated that MLC1 is localized in astrocyte–astrocyte junctions, but not in the perivascular membrane, indicating that MLC1 is not a component of the dystrophin–glycoprotein complex. In neurons, MLC1 is located at the plasma membrane and vesicular structures. Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction. Myelin Leukodystrophy MLC Neuron Astrocyte Development Neurosciences. Biological psychiatry. Neuropsychiatry Ricardo Casaroli-Marano verfasserin aut Tatjana Kharkovets verfasserin aut Fernando Aguado verfasserin aut Antonio Zorzano verfasserin aut Manuel Palacín verfasserin aut Eduardo Soriano verfasserin aut Albert Martínez verfasserin aut Raúl Estévez verfasserin aut In Neurobiology of Disease Elsevier, 2021 26(2007), 3, Seite 532-545 (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:26 year:2007 number:3 pages:532-545 https://doi.org/10.1016/j.nbd.2007.01.016 kostenfrei https://doaj.org/article/e47c313a52c24bb097b1c8797ac4292b kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996107000319 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4700 AR 26 2007 3 532-545
allfieldsGer	10.1016/j.nbd.2007.01.016 doi (DE-627)DOAJ069114056 (DE-599)DOAJe47c313a52c24bb097b1c8797ac4292b DE-627 ger DE-627 rakwb eng RC321-571 Oscar Teijido verfasserin aut Expression patterns of MLC1 protein in the central and peripheral nervous systems 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mutations in MLC1 cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), a disorder characterized clinically by macrocephaly, deterioration of motor functions, epilepsy and mental decline. Recent studies have detected MLC1 mRNA and protein in astroglial processes. In addition, our group previously reported MLC1 expression in some neurons in the adult mouse brain. Here we performed an exhaustive study of the expression pattern of MLC1 in the developing mouse brain by means of optic and electron microscopy. In the central nervous system, MLC1 was detected mainly in axonal tracts early in development. In addition, MLC1 was also observed in the peripheral nervous system and in several sensory epithelia, as retina or saccula maculae. Post-embedding immunogold experiments indicated that MLC1 is localized in astrocyte–astrocyte junctions, but not in the perivascular membrane, indicating that MLC1 is not a component of the dystrophin–glycoprotein complex. In neurons, MLC1 is located at the plasma membrane and vesicular structures. Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction. Myelin Leukodystrophy MLC Neuron Astrocyte Development Neurosciences. Biological psychiatry. Neuropsychiatry Ricardo Casaroli-Marano verfasserin aut Tatjana Kharkovets verfasserin aut Fernando Aguado verfasserin aut Antonio Zorzano verfasserin aut Manuel Palacín verfasserin aut Eduardo Soriano verfasserin aut Albert Martínez verfasserin aut Raúl Estévez verfasserin aut In Neurobiology of Disease Elsevier, 2021 26(2007), 3, Seite 532-545 (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:26 year:2007 number:3 pages:532-545 https://doi.org/10.1016/j.nbd.2007.01.016 kostenfrei https://doaj.org/article/e47c313a52c24bb097b1c8797ac4292b kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996107000319 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4700 AR 26 2007 3 532-545
allfieldsSound	10.1016/j.nbd.2007.01.016 doi (DE-627)DOAJ069114056 (DE-599)DOAJe47c313a52c24bb097b1c8797ac4292b DE-627 ger DE-627 rakwb eng RC321-571 Oscar Teijido verfasserin aut Expression patterns of MLC1 protein in the central and peripheral nervous systems 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mutations in MLC1 cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), a disorder characterized clinically by macrocephaly, deterioration of motor functions, epilepsy and mental decline. Recent studies have detected MLC1 mRNA and protein in astroglial processes. In addition, our group previously reported MLC1 expression in some neurons in the adult mouse brain. Here we performed an exhaustive study of the expression pattern of MLC1 in the developing mouse brain by means of optic and electron microscopy. In the central nervous system, MLC1 was detected mainly in axonal tracts early in development. In addition, MLC1 was also observed in the peripheral nervous system and in several sensory epithelia, as retina or saccula maculae. Post-embedding immunogold experiments indicated that MLC1 is localized in astrocyte–astrocyte junctions, but not in the perivascular membrane, indicating that MLC1 is not a component of the dystrophin–glycoprotein complex. In neurons, MLC1 is located at the plasma membrane and vesicular structures. Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction. Myelin Leukodystrophy MLC Neuron Astrocyte Development Neurosciences. Biological psychiatry. Neuropsychiatry Ricardo Casaroli-Marano verfasserin aut Tatjana Kharkovets verfasserin aut Fernando Aguado verfasserin aut Antonio Zorzano verfasserin aut Manuel Palacín verfasserin aut Eduardo Soriano verfasserin aut Albert Martínez verfasserin aut Raúl Estévez verfasserin aut In Neurobiology of Disease Elsevier, 2021 26(2007), 3, Seite 532-545 (DE-627)268125414 (DE-600)1471408-5 1095953X nnns volume:26 year:2007 number:3 pages:532-545 https://doi.org/10.1016/j.nbd.2007.01.016 kostenfrei https://doaj.org/article/e47c313a52c24bb097b1c8797ac4292b kostenfrei http://www.sciencedirect.com/science/article/pii/S0969996107000319 kostenfrei https://doaj.org/toc/1095-953X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_165 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4700 AR 26 2007 3 532-545
language	English
source	In Neurobiology of Disease 26(2007), 3, Seite 532-545 volume:26 year:2007 number:3 pages:532-545
sourceStr	In Neurobiology of Disease 26(2007), 3, Seite 532-545 volume:26 year:2007 number:3 pages:532-545
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Myelin Leukodystrophy MLC Neuron Astrocyte Development Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Neurobiology of Disease
authorswithroles_txt_mv	Oscar Teijido @@aut@@ Ricardo Casaroli-Marano @@aut@@ Tatjana Kharkovets @@aut@@ Fernando Aguado @@aut@@ Antonio Zorzano @@aut@@ Manuel Palacín @@aut@@ Eduardo Soriano @@aut@@ Albert Martínez @@aut@@ Raúl Estévez @@aut@@
publishDateDaySort_date	2007-01-01T00:00:00Z
hierarchy_top_id	268125414
id	DOAJ069114056
language_de	englisch
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callnumber-first	R - Medicine
author	Oscar Teijido
spellingShingle	Oscar Teijido misc RC321-571 misc Myelin misc Leukodystrophy misc MLC misc Neuron misc Astrocyte misc Development misc Neurosciences. Biological psychiatry. Neuropsychiatry Expression patterns of MLC1 protein in the central and peripheral nervous systems
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topic_title	RC321-571 Expression patterns of MLC1 protein in the central and peripheral nervous systems Myelin Leukodystrophy MLC Neuron Astrocyte Development
topic	misc RC321-571 misc Myelin misc Leukodystrophy misc MLC misc Neuron misc Astrocyte misc Development misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Myelin misc Leukodystrophy misc MLC misc Neuron misc Astrocyte misc Development misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc Myelin misc Leukodystrophy misc MLC misc Neuron misc Astrocyte misc Development misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Expression patterns of MLC1 protein in the central and peripheral nervous systems
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title_full	Expression patterns of MLC1 protein in the central and peripheral nervous systems
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title_sort	expression patterns of mlc1 protein in the central and peripheral nervous systems
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title_auth	Expression patterns of MLC1 protein in the central and peripheral nervous systems
abstract	Mutations in MLC1 cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), a disorder characterized clinically by macrocephaly, deterioration of motor functions, epilepsy and mental decline. Recent studies have detected MLC1 mRNA and protein in astroglial processes. In addition, our group previously reported MLC1 expression in some neurons in the adult mouse brain. Here we performed an exhaustive study of the expression pattern of MLC1 in the developing mouse brain by means of optic and electron microscopy. In the central nervous system, MLC1 was detected mainly in axonal tracts early in development. In addition, MLC1 was also observed in the peripheral nervous system and in several sensory epithelia, as retina or saccula maculae. Post-embedding immunogold experiments indicated that MLC1 is localized in astrocyte–astrocyte junctions, but not in the perivascular membrane, indicating that MLC1 is not a component of the dystrophin–glycoprotein complex. In neurons, MLC1 is located at the plasma membrane and vesicular structures. Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction.
abstractGer	Mutations in MLC1 cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), a disorder characterized clinically by macrocephaly, deterioration of motor functions, epilepsy and mental decline. Recent studies have detected MLC1 mRNA and protein in astroglial processes. In addition, our group previously reported MLC1 expression in some neurons in the adult mouse brain. Here we performed an exhaustive study of the expression pattern of MLC1 in the developing mouse brain by means of optic and electron microscopy. In the central nervous system, MLC1 was detected mainly in axonal tracts early in development. In addition, MLC1 was also observed in the peripheral nervous system and in several sensory epithelia, as retina or saccula maculae. Post-embedding immunogold experiments indicated that MLC1 is localized in astrocyte–astrocyte junctions, but not in the perivascular membrane, indicating that MLC1 is not a component of the dystrophin–glycoprotein complex. In neurons, MLC1 is located at the plasma membrane and vesicular structures. Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction.
abstract_unstemmed	Mutations in MLC1 cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), a disorder characterized clinically by macrocephaly, deterioration of motor functions, epilepsy and mental decline. Recent studies have detected MLC1 mRNA and protein in astroglial processes. In addition, our group previously reported MLC1 expression in some neurons in the adult mouse brain. Here we performed an exhaustive study of the expression pattern of MLC1 in the developing mouse brain by means of optic and electron microscopy. In the central nervous system, MLC1 was detected mainly in axonal tracts early in development. In addition, MLC1 was also observed in the peripheral nervous system and in several sensory epithelia, as retina or saccula maculae. Post-embedding immunogold experiments indicated that MLC1 is localized in astrocyte–astrocyte junctions, but not in the perivascular membrane, indicating that MLC1 is not a component of the dystrophin–glycoprotein complex. In neurons, MLC1 is located at the plasma membrane and vesicular structures. Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction.
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title_short	Expression patterns of MLC1 protein in the central and peripheral nervous systems
url	https://doi.org/10.1016/j.nbd.2007.01.016 https://doaj.org/article/e47c313a52c24bb097b1c8797ac4292b http://www.sciencedirect.com/science/article/pii/S0969996107000319 https://doaj.org/toc/1095-953X
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Recent studies have detected MLC1 mRNA and protein in astroglial processes. In addition, our group previously reported MLC1 expression in some neurons in the adult mouse brain. Here we performed an exhaustive study of the expression pattern of MLC1 in the developing mouse brain by means of optic and electron microscopy. In the central nervous system, MLC1 was detected mainly in axonal tracts early in development. In addition, MLC1 was also observed in the peripheral nervous system and in several sensory epithelia, as retina or saccula maculae. Post-embedding immunogold experiments indicated that MLC1 is localized in astrocyte–astrocyte junctions, but not in the perivascular membrane, indicating that MLC1 is not a component of the dystrophin–glycoprotein complex. In neurons, MLC1 is located at the plasma membrane and vesicular structures. 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Expression patterns of MLC1 protein in the central and peripheral nervous systems

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