An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial
Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy bet...
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Gespeichert in:
| Autor*in: |
Antonio Z. Gimeno-García [verfasserIn] Goretti Hernández [verfasserIn] José Luis Baute Dorta [verfasserIn] Cristina Reygosa [verfasserIn] Raquel de la Barreda [verfasserIn] Alberto Hernandez-Bustabad [verfasserIn] Carla Amaral [verfasserIn] Yaiza Cedrés [verfasserIn] Rocío del Castillo [verfasserIn] David Nicolás-Pérez [verfasserIn] Alejandro Jiménez [verfasserIn] Onofre Alarcon-Fernández [verfasserIn] Manuel Hernandez-Guerra [verfasserIn] Rafael Romero [verfasserIn] Inmaculada Alonso [verfasserIn] Yanira González [verfasserIn] Zaida Adrian [verfasserIn] Domingo Hernandez [verfasserIn] Laura Ramos [verfasserIn] Marta Carrillo [verfasserIn] Vanessa Felipe [verfasserIn] Anjara Hernández [verfasserIn] Consuelo Rodríguez-Jiménez [verfasserIn] Enrique Quintero [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Frontiers in Medicine - Frontiers Media S.A., 2014, 8(2021) |
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| Übergeordnetes Werk: |
volume:8 ; year:2021 |
| Links: |
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| DOI / URN: |
10.3389/fmed.2021.654847 |
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| Katalog-ID: |
DOAJ069133360 |
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| 245 | 1 | 3 | |a An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial |
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| 520 | |a Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. | ||
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10.3389/fmed.2021.654847 doi (DE-627)DOAJ069133360 (DE-599)DOAJb7004d09dc1f4d99969210c299458271 DE-627 ger DE-627 rakwb eng R5-920 Antonio Z. Gimeno-García verfasserin aut An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. bowel cleansing predictive score enhanced bowel preparation hard to prepare patients high volume bowel preparation low volume bowel preparation Medicine (General) Antonio Z. Gimeno-García verfasserin aut Goretti Hernández verfasserin aut Goretti Hernández verfasserin aut José Luis Baute Dorta verfasserin aut José Luis Baute Dorta verfasserin aut Cristina Reygosa verfasserin aut Cristina Reygosa verfasserin aut Raquel de la Barreda verfasserin aut Raquel de la Barreda verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Carla Amaral verfasserin aut Carla Amaral verfasserin aut Yaiza Cedrés verfasserin aut Yaiza Cedrés verfasserin aut Rocío del Castillo verfasserin aut Rocío del Castillo verfasserin aut David Nicolás-Pérez verfasserin aut David Nicolás-Pérez verfasserin aut Alejandro Jiménez verfasserin aut Onofre Alarcon-Fernández verfasserin aut Onofre Alarcon-Fernández verfasserin aut Manuel Hernandez-Guerra verfasserin aut Manuel Hernandez-Guerra verfasserin aut Rafael Romero verfasserin aut Rafael Romero verfasserin aut Inmaculada Alonso verfasserin aut Inmaculada Alonso verfasserin aut Yanira González verfasserin aut Yanira González verfasserin aut Zaida Adrian verfasserin aut Zaida Adrian verfasserin aut Domingo Hernandez verfasserin aut Domingo Hernandez verfasserin aut Laura Ramos verfasserin aut Laura Ramos verfasserin aut Marta Carrillo verfasserin aut Marta Carrillo verfasserin aut Vanessa Felipe verfasserin aut Vanessa Felipe verfasserin aut Anjara Hernández verfasserin aut Anjara Hernández verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Enrique Quintero verfasserin aut Enrique Quintero verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.654847 kostenfrei https://doaj.org/article/b7004d09dc1f4d99969210c299458271 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.654847/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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10.3389/fmed.2021.654847 doi (DE-627)DOAJ069133360 (DE-599)DOAJb7004d09dc1f4d99969210c299458271 DE-627 ger DE-627 rakwb eng R5-920 Antonio Z. Gimeno-García verfasserin aut An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. bowel cleansing predictive score enhanced bowel preparation hard to prepare patients high volume bowel preparation low volume bowel preparation Medicine (General) Antonio Z. Gimeno-García verfasserin aut Goretti Hernández verfasserin aut Goretti Hernández verfasserin aut José Luis Baute Dorta verfasserin aut José Luis Baute Dorta verfasserin aut Cristina Reygosa verfasserin aut Cristina Reygosa verfasserin aut Raquel de la Barreda verfasserin aut Raquel de la Barreda verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Carla Amaral verfasserin aut Carla Amaral verfasserin aut Yaiza Cedrés verfasserin aut Yaiza Cedrés verfasserin aut Rocío del Castillo verfasserin aut Rocío del Castillo verfasserin aut David Nicolás-Pérez verfasserin aut David Nicolás-Pérez verfasserin aut Alejandro Jiménez verfasserin aut Onofre Alarcon-Fernández verfasserin aut Onofre Alarcon-Fernández verfasserin aut Manuel Hernandez-Guerra verfasserin aut Manuel Hernandez-Guerra verfasserin aut Rafael Romero verfasserin aut Rafael Romero verfasserin aut Inmaculada Alonso verfasserin aut Inmaculada Alonso verfasserin aut Yanira González verfasserin aut Yanira González verfasserin aut Zaida Adrian verfasserin aut Zaida Adrian verfasserin aut Domingo Hernandez verfasserin aut Domingo Hernandez verfasserin aut Laura Ramos verfasserin aut Laura Ramos verfasserin aut Marta Carrillo verfasserin aut Marta Carrillo verfasserin aut Vanessa Felipe verfasserin aut Vanessa Felipe verfasserin aut Anjara Hernández verfasserin aut Anjara Hernández verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Enrique Quintero verfasserin aut Enrique Quintero verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.654847 kostenfrei https://doaj.org/article/b7004d09dc1f4d99969210c299458271 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.654847/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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10.3389/fmed.2021.654847 doi (DE-627)DOAJ069133360 (DE-599)DOAJb7004d09dc1f4d99969210c299458271 DE-627 ger DE-627 rakwb eng R5-920 Antonio Z. Gimeno-García verfasserin aut An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. bowel cleansing predictive score enhanced bowel preparation hard to prepare patients high volume bowel preparation low volume bowel preparation Medicine (General) Antonio Z. Gimeno-García verfasserin aut Goretti Hernández verfasserin aut Goretti Hernández verfasserin aut José Luis Baute Dorta verfasserin aut José Luis Baute Dorta verfasserin aut Cristina Reygosa verfasserin aut Cristina Reygosa verfasserin aut Raquel de la Barreda verfasserin aut Raquel de la Barreda verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Carla Amaral verfasserin aut Carla Amaral verfasserin aut Yaiza Cedrés verfasserin aut Yaiza Cedrés verfasserin aut Rocío del Castillo verfasserin aut Rocío del Castillo verfasserin aut David Nicolás-Pérez verfasserin aut David Nicolás-Pérez verfasserin aut Alejandro Jiménez verfasserin aut Onofre Alarcon-Fernández verfasserin aut Onofre Alarcon-Fernández verfasserin aut Manuel Hernandez-Guerra verfasserin aut Manuel Hernandez-Guerra verfasserin aut Rafael Romero verfasserin aut Rafael Romero verfasserin aut Inmaculada Alonso verfasserin aut Inmaculada Alonso verfasserin aut Yanira González verfasserin aut Yanira González verfasserin aut Zaida Adrian verfasserin aut Zaida Adrian verfasserin aut Domingo Hernandez verfasserin aut Domingo Hernandez verfasserin aut Laura Ramos verfasserin aut Laura Ramos verfasserin aut Marta Carrillo verfasserin aut Marta Carrillo verfasserin aut Vanessa Felipe verfasserin aut Vanessa Felipe verfasserin aut Anjara Hernández verfasserin aut Anjara Hernández verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Enrique Quintero verfasserin aut Enrique Quintero verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.654847 kostenfrei https://doaj.org/article/b7004d09dc1f4d99969210c299458271 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.654847/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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10.3389/fmed.2021.654847 doi (DE-627)DOAJ069133360 (DE-599)DOAJb7004d09dc1f4d99969210c299458271 DE-627 ger DE-627 rakwb eng R5-920 Antonio Z. Gimeno-García verfasserin aut An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. bowel cleansing predictive score enhanced bowel preparation hard to prepare patients high volume bowel preparation low volume bowel preparation Medicine (General) Antonio Z. Gimeno-García verfasserin aut Goretti Hernández verfasserin aut Goretti Hernández verfasserin aut José Luis Baute Dorta verfasserin aut José Luis Baute Dorta verfasserin aut Cristina Reygosa verfasserin aut Cristina Reygosa verfasserin aut Raquel de la Barreda verfasserin aut Raquel de la Barreda verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Carla Amaral verfasserin aut Carla Amaral verfasserin aut Yaiza Cedrés verfasserin aut Yaiza Cedrés verfasserin aut Rocío del Castillo verfasserin aut Rocío del Castillo verfasserin aut David Nicolás-Pérez verfasserin aut David Nicolás-Pérez verfasserin aut Alejandro Jiménez verfasserin aut Onofre Alarcon-Fernández verfasserin aut Onofre Alarcon-Fernández verfasserin aut Manuel Hernandez-Guerra verfasserin aut Manuel Hernandez-Guerra verfasserin aut Rafael Romero verfasserin aut Rafael Romero verfasserin aut Inmaculada Alonso verfasserin aut Inmaculada Alonso verfasserin aut Yanira González verfasserin aut Yanira González verfasserin aut Zaida Adrian verfasserin aut Zaida Adrian verfasserin aut Domingo Hernandez verfasserin aut Domingo Hernandez verfasserin aut Laura Ramos verfasserin aut Laura Ramos verfasserin aut Marta Carrillo verfasserin aut Marta Carrillo verfasserin aut Vanessa Felipe verfasserin aut Vanessa Felipe verfasserin aut Anjara Hernández verfasserin aut Anjara Hernández verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Enrique Quintero verfasserin aut Enrique Quintero verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.654847 kostenfrei https://doaj.org/article/b7004d09dc1f4d99969210c299458271 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.654847/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
| allfieldsSound |
10.3389/fmed.2021.654847 doi (DE-627)DOAJ069133360 (DE-599)DOAJb7004d09dc1f4d99969210c299458271 DE-627 ger DE-627 rakwb eng R5-920 Antonio Z. Gimeno-García verfasserin aut An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. bowel cleansing predictive score enhanced bowel preparation hard to prepare patients high volume bowel preparation low volume bowel preparation Medicine (General) Antonio Z. Gimeno-García verfasserin aut Goretti Hernández verfasserin aut Goretti Hernández verfasserin aut José Luis Baute Dorta verfasserin aut José Luis Baute Dorta verfasserin aut Cristina Reygosa verfasserin aut Cristina Reygosa verfasserin aut Raquel de la Barreda verfasserin aut Raquel de la Barreda verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Alberto Hernandez-Bustabad verfasserin aut Carla Amaral verfasserin aut Carla Amaral verfasserin aut Yaiza Cedrés verfasserin aut Yaiza Cedrés verfasserin aut Rocío del Castillo verfasserin aut Rocío del Castillo verfasserin aut David Nicolás-Pérez verfasserin aut David Nicolás-Pérez verfasserin aut Alejandro Jiménez verfasserin aut Onofre Alarcon-Fernández verfasserin aut Onofre Alarcon-Fernández verfasserin aut Manuel Hernandez-Guerra verfasserin aut Manuel Hernandez-Guerra verfasserin aut Rafael Romero verfasserin aut Rafael Romero verfasserin aut Inmaculada Alonso verfasserin aut Inmaculada Alonso verfasserin aut Yanira González verfasserin aut Yanira González verfasserin aut Zaida Adrian verfasserin aut Zaida Adrian verfasserin aut Domingo Hernandez verfasserin aut Domingo Hernandez verfasserin aut Laura Ramos verfasserin aut Laura Ramos verfasserin aut Marta Carrillo verfasserin aut Marta Carrillo verfasserin aut Vanessa Felipe verfasserin aut Vanessa Felipe verfasserin aut Anjara Hernández verfasserin aut Anjara Hernández verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Consuelo Rodríguez-Jiménez verfasserin aut Enrique Quintero verfasserin aut Enrique Quintero verfasserin aut In Frontiers in Medicine Frontiers Media S.A., 2014 8(2021) (DE-627)789482991 (DE-600)2775999-4 2296858X nnns volume:8 year:2021 https://doi.org/10.3389/fmed.2021.654847 kostenfrei https://doaj.org/article/b7004d09dc1f4d99969210c299458271 kostenfrei https://www.frontiersin.org/articles/10.3389/fmed.2021.654847/full kostenfrei https://doaj.org/toc/2296-858X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 |
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Antonio Z. Gimeno-García @@aut@@ Goretti Hernández @@aut@@ José Luis Baute Dorta @@aut@@ Cristina Reygosa @@aut@@ Raquel de la Barreda @@aut@@ Alberto Hernandez-Bustabad @@aut@@ Carla Amaral @@aut@@ Yaiza Cedrés @@aut@@ Rocío del Castillo @@aut@@ David Nicolás-Pérez @@aut@@ Alejandro Jiménez @@aut@@ Onofre Alarcon-Fernández @@aut@@ Manuel Hernandez-Guerra @@aut@@ Rafael Romero @@aut@@ Inmaculada Alonso @@aut@@ Yanira González @@aut@@ Zaida Adrian @@aut@@ Domingo Hernandez @@aut@@ Laura Ramos @@aut@@ Marta Carrillo @@aut@@ Vanessa Felipe @@aut@@ Anjara Hernández @@aut@@ Consuelo Rodríguez-Jiménez @@aut@@ Enrique Quintero @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ069133360</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503114325.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3389/fmed.2021.654847</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ069133360</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJb7004d09dc1f4d99969210c299458271</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Antonio Z. Gimeno-García</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="3"><subfield code="a">An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored &gt;1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. 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R5-920 An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial bowel cleansing predictive score enhanced bowel preparation hard to prepare patients high volume bowel preparation low volume bowel preparation |
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Antonio Z. Gimeno-García Goretti Hernández José Luis Baute Dorta Cristina Reygosa Raquel de la Barreda Alberto Hernandez-Bustabad Carla Amaral Yaiza Cedrés Rocío del Castillo David Nicolás-Pérez Alejandro Jiménez Onofre Alarcon-Fernández Manuel Hernandez-Guerra Rafael Romero Inmaculada Alonso Yanira González Zaida Adrian Domingo Hernandez Laura Ramos Marta Carrillo Vanessa Felipe Anjara Hernández Consuelo Rodríguez-Jiménez Enrique Quintero |
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enhanced high-volume preparation for colonoscopy is not better than a conventional low-volume one in patients at risk of poor bowel cleansing: a randomized controlled trial |
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An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial |
| abstract |
Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. |
| abstractGer |
Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. |
| abstract_unstemmed |
Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored >1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). No statistically significant differences were found in the BBPS scale between the two groups in the ITT analysis (CBS 76.8% vs. EBS 79.7%, P = 0.58) or PP analysis (CBS 78% vs. EBS 84.3%, P = 0.21), risk difference 2.9% (95% CI−7.26 to 39.16) in the ITT analysis, or risk difference 6.3% (95% CI−3.48 to 16.08) in PP analysis. No differences in preparation tolerance, compliance, adverse effects, or colonoscopy findings were found.Conclusion: EBS is not superior to CBS in hard-to-prepare patients. (EUDRACT: 2017-000787-15, NCT03830489).Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT03830489. |
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An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial |
| url |
https://doi.org/10.3389/fmed.2021.654847 https://doaj.org/article/b7004d09dc1f4d99969210c299458271 https://www.frontiersin.org/articles/10.3389/fmed.2021.654847/full https://doaj.org/toc/2296-858X |
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Antonio Z. Gimeno-García Goretti Hernández José Luis Baute Dorta Cristina Reygosa Raquel de la Barreda Alberto Hernandez-Bustabad Carla Amaral Yaiza Cedrés Rocío del Castillo David Nicolás-Pérez Alejandro Jiménez Onofre Alarcon-Fernández Manuel Hernandez-Guerra Rafael Romero Inmaculada Alonso Yanira González Zaida Adrian Domingo Hernandez Laura Ramos Marta Carrillo Vanessa Felipe Anjara Hernández Consuelo Rodríguez-Jiménez Enrique Quintero |
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Antonio Z. Gimeno-García Goretti Hernández José Luis Baute Dorta Cristina Reygosa Raquel de la Barreda Alberto Hernandez-Bustabad Carla Amaral Yaiza Cedrés Rocío del Castillo David Nicolás-Pérez Alejandro Jiménez Onofre Alarcon-Fernández Manuel Hernandez-Guerra Rafael Romero Inmaculada Alonso Yanira González Zaida Adrian Domingo Hernandez Laura Ramos Marta Carrillo Vanessa Felipe Anjara Hernández Consuelo Rodríguez-Jiménez Enrique Quintero |
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10.3389/fmed.2021.654847 |
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2024-07-03T21:40:51.350Z |
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Gimeno-García</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="3"><subfield code="a">An Enhanced High-Volume Preparation for Colonoscopy Is Not Better Than a Conventional Low-Volume One in Patients at Risk of Poor Bowel Cleansing: A Randomized Controlled Trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective: We tested the hypothesis that an enhanced bowel preparation strategy (EBS) improves colonic cleansing in patients at high risk for inadequate bowel cleansing (HRI).Methods: This prospective randomized clinical trial included consecutive HRI patients referred for outpatient colonoscopy between February and October 2019. HRI was considered if patients scored &gt;1.225 according to a previously validated bowel-cleansing predictive score. HRI patients were randomized (1:1) to a low-volume conventional bowel cleansing strategy (CBS) (1-day low residue diet (LRD) plus 2 L of polyethylene glycol (PEG) plus ascorbic acid) or to an EBS (3-day LRD plus 10 mg oral bisacodyl plus 4 L PEG). The Boston Bowel Preparation Scale (BBPS) was used to assess the quality of cleanliness. Intention-to-treat (ITT) and per protocol (PP) analyses were performed. A sample size of 130 patients per group was estimated to reach a 15% difference in favor of EBP.Results: A total of 253 HRI patients were included (mean age 69.8 ± 9.5 years, 51.8% women). 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|
| score |
7.39927 |