Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by unpaired blood glycaemia maintenance. T2DM can be treated by inhibiting carbohydrate hydrolyzing enzymes (α-amylases and α-glucosidases) to decrease postprandial hyperglycemia. Acarbose and voglibose are inhibitors used in clin...
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Gespeichert in:

Autor*in:	Francesca Capetti [verfasserIn] Cecilia Cagliero [verfasserIn] Arianna Marengo [verfasserIn] Carlo Bicchi [verfasserIn] Patrizia Rubiolo [verfasserIn] Barbara Sgorbini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	essential oil α-amylase inhibition bio-guided fractionation

Übergeordnetes Werk:	In: Plants - MDPI AG, 2013, 9(2020), 9, p 1242
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:9, p 1242

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/plants9091242

Katalog-ID:	DOAJ06919968X

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callnumber-first	Q - Science
author	Francesca Capetti
spellingShingle	Francesca Capetti misc QK1-989 misc essential oil misc α-amylase inhibition misc bio-guided fractionation misc <i<Myristica fragrans</i< misc <i<Eucalyptus radiata</i< misc Botany Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity
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topic_title	QK1-989 Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity essential oil α-amylase inhibition bio-guided fractionation <i<Myristica fragrans</i< <i<Eucalyptus radiata</i<
topic	misc QK1-989 misc essential oil misc α-amylase inhibition misc bio-guided fractionation misc <i<Myristica fragrans</i< misc <i<Eucalyptus radiata</i< misc Botany
topic_unstemmed	misc QK1-989 misc essential oil misc α-amylase inhibition misc bio-guided fractionation misc <i<Myristica fragrans</i< misc <i<Eucalyptus radiata</i< misc Botany
topic_browse	misc QK1-989 misc essential oil misc α-amylase inhibition misc bio-guided fractionation misc <i<Myristica fragrans</i< misc <i<Eucalyptus radiata</i< misc Botany
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title	Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity
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title_full	Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity
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title_sort	bio-guided fractionation driven by in vitro α-amylase inhibition assays of essential oils bearing specialized metabolites with potential hypoglycemic activity
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title_auth	Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity
abstract	Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by unpaired blood glycaemia maintenance. T2DM can be treated by inhibiting carbohydrate hydrolyzing enzymes (α-amylases and α-glucosidases) to decrease postprandial hyperglycemia. Acarbose and voglibose are inhibitors used in clinical practice. However, these drugs are associated with unpleasant gastrointestinal side effects. This study explores new α-amylase inhibitors deriving from plant volatile specialized metabolites. Sixty-two essential oils (EOs) from different plant species and botanical families were subjected to α-amylase in vitro enzymatic assay and chemically characterized using gas chromatography coupled to mass spectrometry. Several EOs were found to be potential α-amylase inhibitors, and <i<Eucalyptus radiata</i<, <i<Laurus nobilis</i<, and <i<Myristica</i<<i<fragrans</i< EOs displayed inhibitory capacities comparable to that of the positive control (i.e., acarbose). A bio-guided fractionation approach was adopted to isolate and identify the active fractions/compounds of <i<Eucalyptus radiata</i< and <i<Myristica fragrans</i< EOs. The bio-guided fractionation revealed that EOs α-amylase inhibitory activity is often the result of antagonist, additive, or synergistic interactions among their bioactive constituents and led to the identification of 1,8-cineole, 4-terpineol, α-terpineol, α-pinene, and β-pinene as bioactive compounds, also confirmed when they were tested singularly. These results demonstrate that EO oils are a promising source of potential α-amylase inhibitors.
abstractGer	Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by unpaired blood glycaemia maintenance. T2DM can be treated by inhibiting carbohydrate hydrolyzing enzymes (α-amylases and α-glucosidases) to decrease postprandial hyperglycemia. Acarbose and voglibose are inhibitors used in clinical practice. However, these drugs are associated with unpleasant gastrointestinal side effects. This study explores new α-amylase inhibitors deriving from plant volatile specialized metabolites. Sixty-two essential oils (EOs) from different plant species and botanical families were subjected to α-amylase in vitro enzymatic assay and chemically characterized using gas chromatography coupled to mass spectrometry. Several EOs were found to be potential α-amylase inhibitors, and <i<Eucalyptus radiata</i<, <i<Laurus nobilis</i<, and <i<Myristica</i<<i<fragrans</i< EOs displayed inhibitory capacities comparable to that of the positive control (i.e., acarbose). A bio-guided fractionation approach was adopted to isolate and identify the active fractions/compounds of <i<Eucalyptus radiata</i< and <i<Myristica fragrans</i< EOs. The bio-guided fractionation revealed that EOs α-amylase inhibitory activity is often the result of antagonist, additive, or synergistic interactions among their bioactive constituents and led to the identification of 1,8-cineole, 4-terpineol, α-terpineol, α-pinene, and β-pinene as bioactive compounds, also confirmed when they were tested singularly. These results demonstrate that EO oils are a promising source of potential α-amylase inhibitors.
abstract_unstemmed	Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by unpaired blood glycaemia maintenance. T2DM can be treated by inhibiting carbohydrate hydrolyzing enzymes (α-amylases and α-glucosidases) to decrease postprandial hyperglycemia. Acarbose and voglibose are inhibitors used in clinical practice. However, these drugs are associated with unpleasant gastrointestinal side effects. This study explores new α-amylase inhibitors deriving from plant volatile specialized metabolites. Sixty-two essential oils (EOs) from different plant species and botanical families were subjected to α-amylase in vitro enzymatic assay and chemically characterized using gas chromatography coupled to mass spectrometry. Several EOs were found to be potential α-amylase inhibitors, and <i<Eucalyptus radiata</i<, <i<Laurus nobilis</i<, and <i<Myristica</i<<i<fragrans</i< EOs displayed inhibitory capacities comparable to that of the positive control (i.e., acarbose). A bio-guided fractionation approach was adopted to isolate and identify the active fractions/compounds of <i<Eucalyptus radiata</i< and <i<Myristica fragrans</i< EOs. The bio-guided fractionation revealed that EOs α-amylase inhibitory activity is often the result of antagonist, additive, or synergistic interactions among their bioactive constituents and led to the identification of 1,8-cineole, 4-terpineol, α-terpineol, α-pinene, and β-pinene as bioactive compounds, also confirmed when they were tested singularly. These results demonstrate that EO oils are a promising source of potential α-amylase inhibitors.
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container_issue	9, p 1242
title_short	Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity
url	https://doi.org/10.3390/plants9091242 https://doaj.org/article/1f59a093a71447ddb499122b17b6aba1 https://www.mdpi.com/2223-7747/9/9/1242 https://doaj.org/toc/2223-7747
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Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity

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