Prognosis of Preschool Eczema and Factors of Importance for Remission

Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission b...
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Autor*in:	Emma Kristin Johansson [verfasserIn] Anna Bergström [verfasserIn] Inger Kull [verfasserIn] Tomas Lind [verfasserIn] Cilla Söderhäll [verfasserIn] Erik Melén [verfasserIn] Samina Asad [verfasserIn] Maria Bradley [verfasserIn] Agne Liedén [verfasserIn] Natalia Ballardini [verfasserIn] Carl-Fredrik Wahlgren [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	atopicdermatitis birthcohort breastfeeding filaggrinmutations naturalcourse

Übergeordnetes Werk:	In: Acta Dermato-Venereologica - Medical Journals Sweden, 2011, 98(2018), 7, Seite 630-635
Übergeordnetes Werk:	volume:98 ; year:2018 ; number:7 ; pages:630-635

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2340/00015555-2919

Katalog-ID:	DOAJ069209669

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allfields	10.2340/00015555-2919 doi (DE-627)DOAJ069209669 (DE-599)DOAJa848f5cbc09b4db58b2a155a21900f9a DE-627 ger DE-627 rakwb eng RL1-803 Emma Kristin Johansson verfasserin aut Prognosis of Preschool Eczema and Factors of Importance for Remission 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18–0.41)), PSE with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0.59 (0.43–0.81)), parental allergy (0.73 (0.55–0.96)), parental smoking at child’s birth (0.70 (0.50–0.99)) and filaggrin mutation (R501X, R2447X, 2282del4) (0.47 (0.26–0.85)) were inversely associated with complete remission by school age. Male sex (1.37 (1.03–1.82)) and exclusive breastfeeding ≥4 months (1.44 (1.01–2.05)) were positively associated with complete remission by school age. In conclusion, half of the children with PSE were in complete remission by school age. The most important prognostic factors were persistent PSE and PSE with sleep disturbance due to itch. atopicdermatitis birthcohort breastfeeding filaggrinmutations naturalcourse Dermatology Anna Bergström verfasserin aut Inger Kull verfasserin aut Tomas Lind verfasserin aut Cilla Söderhäll verfasserin aut Erik Melén verfasserin aut Samina Asad verfasserin aut Maria Bradley verfasserin aut Agne Liedén verfasserin aut Natalia Ballardini verfasserin aut Carl-Fredrik Wahlgren verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 7, Seite 630-635 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:7 pages:630-635 https://doi.org/10.2340/00015555-2919 kostenfrei https://doaj.org/article/a848f5cbc09b4db58b2a155a21900f9a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2919 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 7 630-635
spelling	10.2340/00015555-2919 doi (DE-627)DOAJ069209669 (DE-599)DOAJa848f5cbc09b4db58b2a155a21900f9a DE-627 ger DE-627 rakwb eng RL1-803 Emma Kristin Johansson verfasserin aut Prognosis of Preschool Eczema and Factors of Importance for Remission 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18–0.41)), PSE with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0.59 (0.43–0.81)), parental allergy (0.73 (0.55–0.96)), parental smoking at child’s birth (0.70 (0.50–0.99)) and filaggrin mutation (R501X, R2447X, 2282del4) (0.47 (0.26–0.85)) were inversely associated with complete remission by school age. Male sex (1.37 (1.03–1.82)) and exclusive breastfeeding ≥4 months (1.44 (1.01–2.05)) were positively associated with complete remission by school age. In conclusion, half of the children with PSE were in complete remission by school age. The most important prognostic factors were persistent PSE and PSE with sleep disturbance due to itch. atopicdermatitis birthcohort breastfeeding filaggrinmutations naturalcourse Dermatology Anna Bergström verfasserin aut Inger Kull verfasserin aut Tomas Lind verfasserin aut Cilla Söderhäll verfasserin aut Erik Melén verfasserin aut Samina Asad verfasserin aut Maria Bradley verfasserin aut Agne Liedén verfasserin aut Natalia Ballardini verfasserin aut Carl-Fredrik Wahlgren verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 7, Seite 630-635 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:7 pages:630-635 https://doi.org/10.2340/00015555-2919 kostenfrei https://doaj.org/article/a848f5cbc09b4db58b2a155a21900f9a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2919 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 7 630-635
allfields_unstemmed	10.2340/00015555-2919 doi (DE-627)DOAJ069209669 (DE-599)DOAJa848f5cbc09b4db58b2a155a21900f9a DE-627 ger DE-627 rakwb eng RL1-803 Emma Kristin Johansson verfasserin aut Prognosis of Preschool Eczema and Factors of Importance for Remission 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18–0.41)), PSE with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0.59 (0.43–0.81)), parental allergy (0.73 (0.55–0.96)), parental smoking at child’s birth (0.70 (0.50–0.99)) and filaggrin mutation (R501X, R2447X, 2282del4) (0.47 (0.26–0.85)) were inversely associated with complete remission by school age. Male sex (1.37 (1.03–1.82)) and exclusive breastfeeding ≥4 months (1.44 (1.01–2.05)) were positively associated with complete remission by school age. In conclusion, half of the children with PSE were in complete remission by school age. The most important prognostic factors were persistent PSE and PSE with sleep disturbance due to itch. atopicdermatitis birthcohort breastfeeding filaggrinmutations naturalcourse Dermatology Anna Bergström verfasserin aut Inger Kull verfasserin aut Tomas Lind verfasserin aut Cilla Söderhäll verfasserin aut Erik Melén verfasserin aut Samina Asad verfasserin aut Maria Bradley verfasserin aut Agne Liedén verfasserin aut Natalia Ballardini verfasserin aut Carl-Fredrik Wahlgren verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 7, Seite 630-635 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:7 pages:630-635 https://doi.org/10.2340/00015555-2919 kostenfrei https://doaj.org/article/a848f5cbc09b4db58b2a155a21900f9a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2919 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 7 630-635
allfieldsGer	10.2340/00015555-2919 doi (DE-627)DOAJ069209669 (DE-599)DOAJa848f5cbc09b4db58b2a155a21900f9a DE-627 ger DE-627 rakwb eng RL1-803 Emma Kristin Johansson verfasserin aut Prognosis of Preschool Eczema and Factors of Importance for Remission 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18–0.41)), PSE with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0.59 (0.43–0.81)), parental allergy (0.73 (0.55–0.96)), parental smoking at child’s birth (0.70 (0.50–0.99)) and filaggrin mutation (R501X, R2447X, 2282del4) (0.47 (0.26–0.85)) were inversely associated with complete remission by school age. Male sex (1.37 (1.03–1.82)) and exclusive breastfeeding ≥4 months (1.44 (1.01–2.05)) were positively associated with complete remission by school age. In conclusion, half of the children with PSE were in complete remission by school age. The most important prognostic factors were persistent PSE and PSE with sleep disturbance due to itch. atopicdermatitis birthcohort breastfeeding filaggrinmutations naturalcourse Dermatology Anna Bergström verfasserin aut Inger Kull verfasserin aut Tomas Lind verfasserin aut Cilla Söderhäll verfasserin aut Erik Melén verfasserin aut Samina Asad verfasserin aut Maria Bradley verfasserin aut Agne Liedén verfasserin aut Natalia Ballardini verfasserin aut Carl-Fredrik Wahlgren verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 7, Seite 630-635 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:7 pages:630-635 https://doi.org/10.2340/00015555-2919 kostenfrei https://doaj.org/article/a848f5cbc09b4db58b2a155a21900f9a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2919 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 7 630-635
allfieldsSound	10.2340/00015555-2919 doi (DE-627)DOAJ069209669 (DE-599)DOAJa848f5cbc09b4db58b2a155a21900f9a DE-627 ger DE-627 rakwb eng RL1-803 Emma Kristin Johansson verfasserin aut Prognosis of Preschool Eczema and Factors of Importance for Remission 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18–0.41)), PSE with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0.59 (0.43–0.81)), parental allergy (0.73 (0.55–0.96)), parental smoking at child’s birth (0.70 (0.50–0.99)) and filaggrin mutation (R501X, R2447X, 2282del4) (0.47 (0.26–0.85)) were inversely associated with complete remission by school age. Male sex (1.37 (1.03–1.82)) and exclusive breastfeeding ≥4 months (1.44 (1.01–2.05)) were positively associated with complete remission by school age. In conclusion, half of the children with PSE were in complete remission by school age. The most important prognostic factors were persistent PSE and PSE with sleep disturbance due to itch. atopicdermatitis birthcohort breastfeeding filaggrinmutations naturalcourse Dermatology Anna Bergström verfasserin aut Inger Kull verfasserin aut Tomas Lind verfasserin aut Cilla Söderhäll verfasserin aut Erik Melén verfasserin aut Samina Asad verfasserin aut Maria Bradley verfasserin aut Agne Liedén verfasserin aut Natalia Ballardini verfasserin aut Carl-Fredrik Wahlgren verfasserin aut In Acta Dermato-Venereologica Medical Journals Sweden, 2011 98(2018), 7, Seite 630-635 (DE-627)302725431 (DE-600)1492617-9 16512057 nnns volume:98 year:2018 number:7 pages:630-635 https://doi.org/10.2340/00015555-2919 kostenfrei https://doaj.org/article/a848f5cbc09b4db58b2a155a21900f9a kostenfrei https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2919 kostenfrei https://doaj.org/toc/0001-5555 Journal toc kostenfrei https://doaj.org/toc/1651-2057 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 98 2018 7 630-635
language	English
source	In Acta Dermato-Venereologica 98(2018), 7, Seite 630-635 volume:98 year:2018 number:7 pages:630-635
sourceStr	In Acta Dermato-Venereologica 98(2018), 7, Seite 630-635 volume:98 year:2018 number:7 pages:630-635
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	atopicdermatitis birthcohort breastfeeding filaggrinmutations naturalcourse Dermatology
isfreeaccess_bool	true
container_title	Acta Dermato-Venereologica
authorswithroles_txt_mv	Emma Kristin Johansson @@aut@@ Anna Bergström @@aut@@ Inger Kull @@aut@@ Tomas Lind @@aut@@ Cilla Söderhäll @@aut@@ Erik Melén @@aut@@ Samina Asad @@aut@@ Maria Bradley @@aut@@ Agne Liedén @@aut@@ Natalia Ballardini @@aut@@ Carl-Fredrik Wahlgren @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	302725431
id	DOAJ069209669
language_de	englisch
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callnumber-first	R - Medicine
author	Emma Kristin Johansson
spellingShingle	Emma Kristin Johansson misc RL1-803 misc atopicdermatitis misc birthcohort misc breastfeeding misc filaggrinmutations misc naturalcourse misc Dermatology Prognosis of Preschool Eczema and Factors of Importance for Remission
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title	Prognosis of Preschool Eczema and Factors of Importance for Remission
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title_full	Prognosis of Preschool Eczema and Factors of Importance for Remission
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title_sort	prognosis of preschool eczema and factors of importance for remission
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title_auth	Prognosis of Preschool Eczema and Factors of Importance for Remission
abstract	Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18–0.41)), PSE with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0.59 (0.43–0.81)), parental allergy (0.73 (0.55–0.96)), parental smoking at child’s birth (0.70 (0.50–0.99)) and filaggrin mutation (R501X, R2447X, 2282del4) (0.47 (0.26–0.85)) were inversely associated with complete remission by school age. Male sex (1.37 (1.03–1.82)) and exclusive breastfeeding ≥4 months (1.44 (1.01–2.05)) were positively associated with complete remission by school age. In conclusion, half of the children with PSE were in complete remission by school age. The most important prognostic factors were persistent PSE and PSE with sleep disturbance due to itch.
abstractGer	Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18–0.41)), PSE with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0.59 (0.43–0.81)), parental allergy (0.73 (0.55–0.96)), parental smoking at child’s birth (0.70 (0.50–0.99)) and filaggrin mutation (R501X, R2447X, 2282del4) (0.47 (0.26–0.85)) were inversely associated with complete remission by school age. Male sex (1.37 (1.03–1.82)) and exclusive breastfeeding ≥4 months (1.44 (1.01–2.05)) were positively associated with complete remission by school age. In conclusion, half of the children with PSE were in complete remission by school age. The most important prognostic factors were persistent PSE and PSE with sleep disturbance due to itch.
abstract_unstemmed	Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18–0.41)), PSE with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0.59 (0.43–0.81)), parental allergy (0.73 (0.55–0.96)), parental smoking at child’s birth (0.70 (0.50–0.99)) and filaggrin mutation (R501X, R2447X, 2282del4) (0.47 (0.26–0.85)) were inversely associated with complete remission by school age. Male sex (1.37 (1.03–1.82)) and exclusive breastfeeding ≥4 months (1.44 (1.01–2.05)) were positively associated with complete remission by school age. In conclusion, half of the children with PSE were in complete remission by school age. The most important prognostic factors were persistent PSE and PSE with sleep disturbance due to itch.
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title_short	Prognosis of Preschool Eczema and Factors of Importance for Remission
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