Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report

Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is theref...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Pierluigi Bonomo [verfasserIn] Sara Lucidi [verfasserIn] Isacco Desideri [verfasserIn] Vieri Scotti [verfasserIn] Marta Casati [verfasserIn] Annarita Palomba [verfasserIn] Cinzia Ciabatti [verfasserIn] Pietro Garlatti [verfasserIn] Daniela Massi [verfasserIn] Oreste Gallo [verfasserIn] Lorenzo Livi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Head and neck cancer Immunotherapy Re-irradiation Oligoprogression Intensity modulated radiotherapy Nivolumab

Übergeordnetes Werk:	In: Clinical and Translational Radiation Oncology - Elsevier, 2017, 23(2020), Seite 16-19
Übergeordnetes Werk:	volume:23 ; year:2020 ; pages:16-19

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ctro.2020.04.007

Katalog-ID:	DOAJ06924538X

Internformat


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520			\|a Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is therefore a critical factor for its efficacy at an individual level. In analogy to targeted agents, a limited pattern of progression, or “oligoprogression”, can occur. For locally recurrent HNSCC, the potential biologic interplay between the efficacy of ICIs and the design of radiation fields chosen for primary treatment is currently unknown. Here, we report on a patient who presented two subsequent oligoprogressions successfully treated with re-irradiation without interrupting Nivolumab. Both oligoprogressive lesions developed in previously unirradiated areas. We hypothesize the existence of a synergistic effect with optimal spatial cooperation between ICIs and re-irradiation for oligoprogressive disease under immunotherapy.
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650		4	\|a Immunotherapy
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650		4	\|a Oligoprogression
650		4	\|a Intensity modulated radiotherapy
650		4	\|a Nivolumab
653		0	\|a Medical physics. Medical radiology. Nuclear medicine
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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spelling	10.1016/j.ctro.2020.04.007 doi (DE-627)DOAJ06924538X (DE-599)DOAJ1a3596f7da0e4c7c94657f251dabae9b DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierluigi Bonomo verfasserin aut Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is therefore a critical factor for its efficacy at an individual level. In analogy to targeted agents, a limited pattern of progression, or “oligoprogression”, can occur. For locally recurrent HNSCC, the potential biologic interplay between the efficacy of ICIs and the design of radiation fields chosen for primary treatment is currently unknown. Here, we report on a patient who presented two subsequent oligoprogressions successfully treated with re-irradiation without interrupting Nivolumab. Both oligoprogressive lesions developed in previously unirradiated areas. We hypothesize the existence of a synergistic effect with optimal spatial cooperation between ICIs and re-irradiation for oligoprogressive disease under immunotherapy. Head and neck cancer Immunotherapy Re-irradiation Oligoprogression Intensity modulated radiotherapy Nivolumab Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sara Lucidi verfasserin aut Isacco Desideri verfasserin aut Vieri Scotti verfasserin aut Marta Casati verfasserin aut Annarita Palomba verfasserin aut Cinzia Ciabatti verfasserin aut Pietro Garlatti verfasserin aut Daniela Massi verfasserin aut Oreste Gallo verfasserin aut Lorenzo Livi verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 23(2020), Seite 16-19 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:23 year:2020 pages:16-19 https://doi.org/10.1016/j.ctro.2020.04.007 kostenfrei https://doaj.org/article/1a3596f7da0e4c7c94657f251dabae9b kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300318 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 16-19
allfields_unstemmed	10.1016/j.ctro.2020.04.007 doi (DE-627)DOAJ06924538X (DE-599)DOAJ1a3596f7da0e4c7c94657f251dabae9b DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierluigi Bonomo verfasserin aut Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is therefore a critical factor for its efficacy at an individual level. In analogy to targeted agents, a limited pattern of progression, or “oligoprogression”, can occur. For locally recurrent HNSCC, the potential biologic interplay between the efficacy of ICIs and the design of radiation fields chosen for primary treatment is currently unknown. Here, we report on a patient who presented two subsequent oligoprogressions successfully treated with re-irradiation without interrupting Nivolumab. Both oligoprogressive lesions developed in previously unirradiated areas. We hypothesize the existence of a synergistic effect with optimal spatial cooperation between ICIs and re-irradiation for oligoprogressive disease under immunotherapy. Head and neck cancer Immunotherapy Re-irradiation Oligoprogression Intensity modulated radiotherapy Nivolumab Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sara Lucidi verfasserin aut Isacco Desideri verfasserin aut Vieri Scotti verfasserin aut Marta Casati verfasserin aut Annarita Palomba verfasserin aut Cinzia Ciabatti verfasserin aut Pietro Garlatti verfasserin aut Daniela Massi verfasserin aut Oreste Gallo verfasserin aut Lorenzo Livi verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 23(2020), Seite 16-19 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:23 year:2020 pages:16-19 https://doi.org/10.1016/j.ctro.2020.04.007 kostenfrei https://doaj.org/article/1a3596f7da0e4c7c94657f251dabae9b kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300318 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 16-19
allfieldsGer	10.1016/j.ctro.2020.04.007 doi (DE-627)DOAJ06924538X (DE-599)DOAJ1a3596f7da0e4c7c94657f251dabae9b DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierluigi Bonomo verfasserin aut Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is therefore a critical factor for its efficacy at an individual level. In analogy to targeted agents, a limited pattern of progression, or “oligoprogression”, can occur. For locally recurrent HNSCC, the potential biologic interplay between the efficacy of ICIs and the design of radiation fields chosen for primary treatment is currently unknown. Here, we report on a patient who presented two subsequent oligoprogressions successfully treated with re-irradiation without interrupting Nivolumab. Both oligoprogressive lesions developed in previously unirradiated areas. We hypothesize the existence of a synergistic effect with optimal spatial cooperation between ICIs and re-irradiation for oligoprogressive disease under immunotherapy. Head and neck cancer Immunotherapy Re-irradiation Oligoprogression Intensity modulated radiotherapy Nivolumab Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sara Lucidi verfasserin aut Isacco Desideri verfasserin aut Vieri Scotti verfasserin aut Marta Casati verfasserin aut Annarita Palomba verfasserin aut Cinzia Ciabatti verfasserin aut Pietro Garlatti verfasserin aut Daniela Massi verfasserin aut Oreste Gallo verfasserin aut Lorenzo Livi verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 23(2020), Seite 16-19 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:23 year:2020 pages:16-19 https://doi.org/10.1016/j.ctro.2020.04.007 kostenfrei https://doaj.org/article/1a3596f7da0e4c7c94657f251dabae9b kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300318 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 16-19
allfieldsSound	10.1016/j.ctro.2020.04.007 doi (DE-627)DOAJ06924538X (DE-599)DOAJ1a3596f7da0e4c7c94657f251dabae9b DE-627 ger DE-627 rakwb eng R895-920 RC254-282 Pierluigi Bonomo verfasserin aut Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is therefore a critical factor for its efficacy at an individual level. In analogy to targeted agents, a limited pattern of progression, or “oligoprogression”, can occur. For locally recurrent HNSCC, the potential biologic interplay between the efficacy of ICIs and the design of radiation fields chosen for primary treatment is currently unknown. Here, we report on a patient who presented two subsequent oligoprogressions successfully treated with re-irradiation without interrupting Nivolumab. Both oligoprogressive lesions developed in previously unirradiated areas. We hypothesize the existence of a synergistic effect with optimal spatial cooperation between ICIs and re-irradiation for oligoprogressive disease under immunotherapy. Head and neck cancer Immunotherapy Re-irradiation Oligoprogression Intensity modulated radiotherapy Nivolumab Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sara Lucidi verfasserin aut Isacco Desideri verfasserin aut Vieri Scotti verfasserin aut Marta Casati verfasserin aut Annarita Palomba verfasserin aut Cinzia Ciabatti verfasserin aut Pietro Garlatti verfasserin aut Daniela Massi verfasserin aut Oreste Gallo verfasserin aut Lorenzo Livi verfasserin aut In Clinical and Translational Radiation Oncology Elsevier, 2017 23(2020), Seite 16-19 (DE-627)880788097 (DE-600)2885426-3 24056308 nnns volume:23 year:2020 pages:16-19 https://doi.org/10.1016/j.ctro.2020.04.007 kostenfrei https://doaj.org/article/1a3596f7da0e4c7c94657f251dabae9b kostenfrei http://www.sciencedirect.com/science/article/pii/S2405630820300318 kostenfrei https://doaj.org/toc/2405-6308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 23 2020 16-19
language	English
source	In Clinical and Translational Radiation Oncology 23(2020), Seite 16-19 volume:23 year:2020 pages:16-19
sourceStr	In Clinical and Translational Radiation Oncology 23(2020), Seite 16-19 volume:23 year:2020 pages:16-19
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Head and neck cancer Immunotherapy Re-irradiation Oligoprogression Intensity modulated radiotherapy Nivolumab Medical physics. Medical radiology. Nuclear medicine Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Clinical and Translational Radiation Oncology
authorswithroles_txt_mv	Pierluigi Bonomo @@aut@@ Sara Lucidi @@aut@@ Isacco Desideri @@aut@@ Vieri Scotti @@aut@@ Marta Casati @@aut@@ Annarita Palomba @@aut@@ Cinzia Ciabatti @@aut@@ Pietro Garlatti @@aut@@ Daniela Massi @@aut@@ Oreste Gallo @@aut@@ Lorenzo Livi @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	880788097
id	DOAJ06924538X
language_de	englisch
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callnumber-first	R - Medicine
author	Pierluigi Bonomo
spellingShingle	Pierluigi Bonomo misc R895-920 misc RC254-282 misc Head and neck cancer misc Immunotherapy misc Re-irradiation misc Oligoprogression misc Intensity modulated radiotherapy misc Nivolumab misc Medical physics. Medical radiology. Nuclear medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report
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topic_title	R895-920 RC254-282 Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report Head and neck cancer Immunotherapy Re-irradiation Oligoprogression Intensity modulated radiotherapy Nivolumab
topic	misc R895-920 misc RC254-282 misc Head and neck cancer misc Immunotherapy misc Re-irradiation misc Oligoprogression misc Intensity modulated radiotherapy misc Nivolumab misc Medical physics. Medical radiology. Nuclear medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc R895-920 misc RC254-282 misc Head and neck cancer misc Immunotherapy misc Re-irradiation misc Oligoprogression misc Intensity modulated radiotherapy misc Nivolumab misc Medical physics. Medical radiology. Nuclear medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc R895-920 misc RC254-282 misc Head and neck cancer misc Immunotherapy misc Re-irradiation misc Oligoprogression misc Intensity modulated radiotherapy misc Nivolumab misc Medical physics. Medical radiology. Nuclear medicine misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report
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title_full	Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report
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title_sort	re-irradiation for oligoprogression under nivolumab in recurrent head and neck squamous cell carcinoma: a case report
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title_auth	Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report
abstract	Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is therefore a critical factor for its efficacy at an individual level. In analogy to targeted agents, a limited pattern of progression, or “oligoprogression”, can occur. For locally recurrent HNSCC, the potential biologic interplay between the efficacy of ICIs and the design of radiation fields chosen for primary treatment is currently unknown. Here, we report on a patient who presented two subsequent oligoprogressions successfully treated with re-irradiation without interrupting Nivolumab. Both oligoprogressive lesions developed in previously unirradiated areas. We hypothesize the existence of a synergistic effect with optimal spatial cooperation between ICIs and re-irradiation for oligoprogressive disease under immunotherapy.
abstractGer	Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is therefore a critical factor for its efficacy at an individual level. In analogy to targeted agents, a limited pattern of progression, or “oligoprogression”, can occur. For locally recurrent HNSCC, the potential biologic interplay between the efficacy of ICIs and the design of radiation fields chosen for primary treatment is currently unknown. Here, we report on a patient who presented two subsequent oligoprogressions successfully treated with re-irradiation without interrupting Nivolumab. Both oligoprogressive lesions developed in previously unirradiated areas. We hypothesize the existence of a synergistic effect with optimal spatial cooperation between ICIs and re-irradiation for oligoprogressive disease under immunotherapy.
abstract_unstemmed	Immune checkpoint inhibitors (ICIs) represent a recently introduced class of agents active in head and neck squamous cell carcinoma (HNSCC). For a subgroup of patients with recurrent or metastatic disease, long-term benefit can be achieved: maintaining a sustained response to immunotherapy is therefore a critical factor for its efficacy at an individual level. In analogy to targeted agents, a limited pattern of progression, or “oligoprogression”, can occur. For locally recurrent HNSCC, the potential biologic interplay between the efficacy of ICIs and the design of radiation fields chosen for primary treatment is currently unknown. Here, we report on a patient who presented two subsequent oligoprogressions successfully treated with re-irradiation without interrupting Nivolumab. Both oligoprogressive lesions developed in previously unirradiated areas. We hypothesize the existence of a synergistic effect with optimal spatial cooperation between ICIs and re-irradiation for oligoprogressive disease under immunotherapy.
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title_short	Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report
url	https://doi.org/10.1016/j.ctro.2020.04.007 https://doaj.org/article/1a3596f7da0e4c7c94657f251dabae9b http://www.sciencedirect.com/science/article/pii/S2405630820300318 https://doaj.org/toc/2405-6308
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up_date	2024-07-03T22:16:35.315Z
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Re-irradiation for oligoprogression under Nivolumab in recurrent head and neck squamous cell carcinoma: A case report

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