H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry
Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monox...
Ausführliche Beschreibung
Autor*in: |
Elisa Magli [verfasserIn] Elisa Perissutti [verfasserIn] Vincenzo Santagada [verfasserIn] Giuseppe Caliendo [verfasserIn] Angela Corvino [verfasserIn] Gianluca Esposito [verfasserIn] Giovanna Esposito [verfasserIn] Ferdinando Fiorino [verfasserIn] Marco Migliaccio [verfasserIn] Antonia Scognamiglio [verfasserIn] Beatrice Severino [verfasserIn] Rosa Sparaco [verfasserIn] Francesco Frecentese [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2021 |
---|
Schlagwörter: |
---|
Übergeordnetes Werk: |
In: Biomolecules - MDPI AG, 2013, 11(2021), 12, p 1899 |
---|---|
Übergeordnetes Werk: |
volume:11 ; year:2021 ; number:12, p 1899 |
Links: |
---|
DOI / URN: |
10.3390/biom11121899 |
---|
Katalog-ID: |
DOAJ069374961 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ069374961 | ||
003 | DE-627 | ||
005 | 20240412095418.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230228s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/biom11121899 |2 doi | |
035 | |a (DE-627)DOAJ069374961 | ||
035 | |a (DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
050 | 0 | |a QR1-502 | |
100 | 0 | |a Elisa Magli |e verfasserin |4 aut | |
245 | 1 | 0 | |a H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. | ||
650 | 4 | |a hydrogen sulfide | |
650 | 4 | |a natural H<sub<2</sub<S donors | |
650 | 4 | |a synthetic H<sub<2</sub<S donors | |
650 | 4 | |a H<sub<2</sub<S release | |
650 | 4 | |a medicinal chemistry | |
653 | 0 | |a Microbiology | |
700 | 0 | |a Elisa Perissutti |e verfasserin |4 aut | |
700 | 0 | |a Vincenzo Santagada |e verfasserin |4 aut | |
700 | 0 | |a Giuseppe Caliendo |e verfasserin |4 aut | |
700 | 0 | |a Angela Corvino |e verfasserin |4 aut | |
700 | 0 | |a Gianluca Esposito |e verfasserin |4 aut | |
700 | 0 | |a Giovanna Esposito |e verfasserin |4 aut | |
700 | 0 | |a Ferdinando Fiorino |e verfasserin |4 aut | |
700 | 0 | |a Marco Migliaccio |e verfasserin |4 aut | |
700 | 0 | |a Antonia Scognamiglio |e verfasserin |4 aut | |
700 | 0 | |a Beatrice Severino |e verfasserin |4 aut | |
700 | 0 | |a Rosa Sparaco |e verfasserin |4 aut | |
700 | 0 | |a Francesco Frecentese |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Biomolecules |d MDPI AG, 2013 |g 11(2021), 12, p 1899 |w (DE-627)735688915 |w (DE-600)2701262-1 |x 2218273X |7 nnns |
773 | 1 | 8 | |g volume:11 |g year:2021 |g number:12, p 1899 |
856 | 4 | 0 | |u https://doi.org/10.3390/biom11121899 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98 |z kostenfrei |
856 | 4 | 0 | |u https://www.mdpi.com/2218-273X/11/12/1899 |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/2218-273X |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_DOAJ | ||
912 | |a GBV_ILN_20 | ||
912 | |a GBV_ILN_22 | ||
912 | |a GBV_ILN_23 | ||
912 | |a GBV_ILN_24 | ||
912 | |a GBV_ILN_39 | ||
912 | |a GBV_ILN_40 | ||
912 | |a GBV_ILN_62 | ||
912 | |a GBV_ILN_63 | ||
912 | |a GBV_ILN_65 | ||
912 | |a GBV_ILN_69 | ||
912 | |a GBV_ILN_70 | ||
912 | |a GBV_ILN_73 | ||
912 | |a GBV_ILN_74 | ||
912 | |a GBV_ILN_95 | ||
912 | |a GBV_ILN_105 | ||
912 | |a GBV_ILN_110 | ||
912 | |a GBV_ILN_151 | ||
912 | |a GBV_ILN_161 | ||
912 | |a GBV_ILN_170 | ||
912 | |a GBV_ILN_206 | ||
912 | |a GBV_ILN_213 | ||
912 | |a GBV_ILN_230 | ||
912 | |a GBV_ILN_285 | ||
912 | |a GBV_ILN_293 | ||
912 | |a GBV_ILN_602 | ||
912 | |a GBV_ILN_2005 | ||
912 | |a GBV_ILN_2009 | ||
912 | |a GBV_ILN_2011 | ||
912 | |a GBV_ILN_2014 | ||
912 | |a GBV_ILN_2055 | ||
912 | |a GBV_ILN_2111 | ||
912 | |a GBV_ILN_4012 | ||
912 | |a GBV_ILN_4037 | ||
912 | |a GBV_ILN_4112 | ||
912 | |a GBV_ILN_4125 | ||
912 | |a GBV_ILN_4126 | ||
912 | |a GBV_ILN_4249 | ||
912 | |a GBV_ILN_4305 | ||
912 | |a GBV_ILN_4306 | ||
912 | |a GBV_ILN_4307 | ||
912 | |a GBV_ILN_4313 | ||
912 | |a GBV_ILN_4322 | ||
912 | |a GBV_ILN_4323 | ||
912 | |a GBV_ILN_4324 | ||
912 | |a GBV_ILN_4325 | ||
912 | |a GBV_ILN_4338 | ||
912 | |a GBV_ILN_4367 | ||
912 | |a GBV_ILN_4700 | ||
951 | |a AR | ||
952 | |d 11 |j 2021 |e 12, p 1899 |
author_variant |
e m em e p ep v s vs g c gc a c ac g e ge g e ge f f ff m m mm a s as b s bs r s rs f f ff |
---|---|
matchkey_str |
article:2218273X:2021----::sbsbdnradhiuenei |
hierarchy_sort_str |
2021 |
callnumber-subject-code |
QR |
publishDate |
2021 |
allfields |
10.3390/biom11121899 doi (DE-627)DOAJ069374961 (DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98 DE-627 ger DE-627 rakwb eng QR1-502 Elisa Magli verfasserin aut H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. hydrogen sulfide natural H<sub<2</sub<S donors synthetic H<sub<2</sub<S donors H<sub<2</sub<S release medicinal chemistry Microbiology Elisa Perissutti verfasserin aut Vincenzo Santagada verfasserin aut Giuseppe Caliendo verfasserin aut Angela Corvino verfasserin aut Gianluca Esposito verfasserin aut Giovanna Esposito verfasserin aut Ferdinando Fiorino verfasserin aut Marco Migliaccio verfasserin aut Antonia Scognamiglio verfasserin aut Beatrice Severino verfasserin aut Rosa Sparaco verfasserin aut Francesco Frecentese verfasserin aut In Biomolecules MDPI AG, 2013 11(2021), 12, p 1899 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:12, p 1899 https://doi.org/10.3390/biom11121899 kostenfrei https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98 kostenfrei https://www.mdpi.com/2218-273X/11/12/1899 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1899 |
spelling |
10.3390/biom11121899 doi (DE-627)DOAJ069374961 (DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98 DE-627 ger DE-627 rakwb eng QR1-502 Elisa Magli verfasserin aut H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. hydrogen sulfide natural H<sub<2</sub<S donors synthetic H<sub<2</sub<S donors H<sub<2</sub<S release medicinal chemistry Microbiology Elisa Perissutti verfasserin aut Vincenzo Santagada verfasserin aut Giuseppe Caliendo verfasserin aut Angela Corvino verfasserin aut Gianluca Esposito verfasserin aut Giovanna Esposito verfasserin aut Ferdinando Fiorino verfasserin aut Marco Migliaccio verfasserin aut Antonia Scognamiglio verfasserin aut Beatrice Severino verfasserin aut Rosa Sparaco verfasserin aut Francesco Frecentese verfasserin aut In Biomolecules MDPI AG, 2013 11(2021), 12, p 1899 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:12, p 1899 https://doi.org/10.3390/biom11121899 kostenfrei https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98 kostenfrei https://www.mdpi.com/2218-273X/11/12/1899 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1899 |
allfields_unstemmed |
10.3390/biom11121899 doi (DE-627)DOAJ069374961 (DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98 DE-627 ger DE-627 rakwb eng QR1-502 Elisa Magli verfasserin aut H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. hydrogen sulfide natural H<sub<2</sub<S donors synthetic H<sub<2</sub<S donors H<sub<2</sub<S release medicinal chemistry Microbiology Elisa Perissutti verfasserin aut Vincenzo Santagada verfasserin aut Giuseppe Caliendo verfasserin aut Angela Corvino verfasserin aut Gianluca Esposito verfasserin aut Giovanna Esposito verfasserin aut Ferdinando Fiorino verfasserin aut Marco Migliaccio verfasserin aut Antonia Scognamiglio verfasserin aut Beatrice Severino verfasserin aut Rosa Sparaco verfasserin aut Francesco Frecentese verfasserin aut In Biomolecules MDPI AG, 2013 11(2021), 12, p 1899 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:12, p 1899 https://doi.org/10.3390/biom11121899 kostenfrei https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98 kostenfrei https://www.mdpi.com/2218-273X/11/12/1899 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1899 |
allfieldsGer |
10.3390/biom11121899 doi (DE-627)DOAJ069374961 (DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98 DE-627 ger DE-627 rakwb eng QR1-502 Elisa Magli verfasserin aut H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. hydrogen sulfide natural H<sub<2</sub<S donors synthetic H<sub<2</sub<S donors H<sub<2</sub<S release medicinal chemistry Microbiology Elisa Perissutti verfasserin aut Vincenzo Santagada verfasserin aut Giuseppe Caliendo verfasserin aut Angela Corvino verfasserin aut Gianluca Esposito verfasserin aut Giovanna Esposito verfasserin aut Ferdinando Fiorino verfasserin aut Marco Migliaccio verfasserin aut Antonia Scognamiglio verfasserin aut Beatrice Severino verfasserin aut Rosa Sparaco verfasserin aut Francesco Frecentese verfasserin aut In Biomolecules MDPI AG, 2013 11(2021), 12, p 1899 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:12, p 1899 https://doi.org/10.3390/biom11121899 kostenfrei https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98 kostenfrei https://www.mdpi.com/2218-273X/11/12/1899 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1899 |
allfieldsSound |
10.3390/biom11121899 doi (DE-627)DOAJ069374961 (DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98 DE-627 ger DE-627 rakwb eng QR1-502 Elisa Magli verfasserin aut H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. hydrogen sulfide natural H<sub<2</sub<S donors synthetic H<sub<2</sub<S donors H<sub<2</sub<S release medicinal chemistry Microbiology Elisa Perissutti verfasserin aut Vincenzo Santagada verfasserin aut Giuseppe Caliendo verfasserin aut Angela Corvino verfasserin aut Gianluca Esposito verfasserin aut Giovanna Esposito verfasserin aut Ferdinando Fiorino verfasserin aut Marco Migliaccio verfasserin aut Antonia Scognamiglio verfasserin aut Beatrice Severino verfasserin aut Rosa Sparaco verfasserin aut Francesco Frecentese verfasserin aut In Biomolecules MDPI AG, 2013 11(2021), 12, p 1899 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:12, p 1899 https://doi.org/10.3390/biom11121899 kostenfrei https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98 kostenfrei https://www.mdpi.com/2218-273X/11/12/1899 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 12, p 1899 |
language |
English |
source |
In Biomolecules 11(2021), 12, p 1899 volume:11 year:2021 number:12, p 1899 |
sourceStr |
In Biomolecules 11(2021), 12, p 1899 volume:11 year:2021 number:12, p 1899 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
hydrogen sulfide natural H<sub<2</sub<S donors synthetic H<sub<2</sub<S donors H<sub<2</sub<S release medicinal chemistry Microbiology |
isfreeaccess_bool |
true |
container_title |
Biomolecules |
authorswithroles_txt_mv |
Elisa Magli @@aut@@ Elisa Perissutti @@aut@@ Vincenzo Santagada @@aut@@ Giuseppe Caliendo @@aut@@ Angela Corvino @@aut@@ Gianluca Esposito @@aut@@ Giovanna Esposito @@aut@@ Ferdinando Fiorino @@aut@@ Marco Migliaccio @@aut@@ Antonia Scognamiglio @@aut@@ Beatrice Severino @@aut@@ Rosa Sparaco @@aut@@ Francesco Frecentese @@aut@@ |
publishDateDaySort_date |
2021-01-01T00:00:00Z |
hierarchy_top_id |
735688915 |
id |
DOAJ069374961 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ069374961</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412095418.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/biom11121899</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ069374961</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR1-502</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Elisa Magli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hydrogen sulfide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">natural H<sub<2</sub<S donors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">synthetic H<sub<2</sub<S donors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">H<sub<2</sub<S release</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">medicinal chemistry</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Microbiology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elisa Perissutti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vincenzo Santagada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Caliendo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angela Corvino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gianluca Esposito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giovanna Esposito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ferdinando Fiorino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marco Migliaccio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonia Scognamiglio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Beatrice Severino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rosa Sparaco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Frecentese</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Biomolecules</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">11(2021), 12, p 1899</subfield><subfield code="w">(DE-627)735688915</subfield><subfield code="w">(DE-600)2701262-1</subfield><subfield code="x">2218273X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:11</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:12, p 1899</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/biom11121899</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2218-273X/11/12/1899</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2218-273X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">11</subfield><subfield code="j">2021</subfield><subfield code="e">12, p 1899</subfield></datafield></record></collection>
|
callnumber-first |
Q - Science |
author |
Elisa Magli |
spellingShingle |
Elisa Magli misc QR1-502 misc hydrogen sulfide misc natural H<sub<2</sub<S donors misc synthetic H<sub<2</sub<S donors misc H<sub<2</sub<S release misc medicinal chemistry misc Microbiology H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry |
authorStr |
Elisa Magli |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)735688915 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut aut aut aut aut aut aut aut aut aut aut aut |
collection |
DOAJ |
remote_str |
true |
callnumber-label |
QR1-502 |
illustrated |
Not Illustrated |
issn |
2218273X |
topic_title |
QR1-502 H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry hydrogen sulfide natural H<sub<2</sub<S donors synthetic H<sub<2</sub<S donors H<sub<2</sub<S release medicinal chemistry |
topic |
misc QR1-502 misc hydrogen sulfide misc natural H<sub<2</sub<S donors misc synthetic H<sub<2</sub<S donors misc H<sub<2</sub<S release misc medicinal chemistry misc Microbiology |
topic_unstemmed |
misc QR1-502 misc hydrogen sulfide misc natural H<sub<2</sub<S donors misc synthetic H<sub<2</sub<S donors misc H<sub<2</sub<S release misc medicinal chemistry misc Microbiology |
topic_browse |
misc QR1-502 misc hydrogen sulfide misc natural H<sub<2</sub<S donors misc synthetic H<sub<2</sub<S donors misc H<sub<2</sub<S release misc medicinal chemistry misc Microbiology |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
Biomolecules |
hierarchy_parent_id |
735688915 |
hierarchy_top_title |
Biomolecules |
isfreeaccess_txt |
true |
familylinks_str_mv |
(DE-627)735688915 (DE-600)2701262-1 |
title |
H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry |
ctrlnum |
(DE-627)DOAJ069374961 (DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98 |
title_full |
H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry |
author_sort |
Elisa Magli |
journal |
Biomolecules |
journalStr |
Biomolecules |
callnumber-first-code |
Q |
lang_code |
eng |
isOA_bool |
true |
recordtype |
marc |
publishDateSort |
2021 |
contenttype_str_mv |
txt |
author_browse |
Elisa Magli Elisa Perissutti Vincenzo Santagada Giuseppe Caliendo Angela Corvino Gianluca Esposito Giovanna Esposito Ferdinando Fiorino Marco Migliaccio Antonia Scognamiglio Beatrice Severino Rosa Sparaco Francesco Frecentese |
container_volume |
11 |
class |
QR1-502 |
format_se |
Elektronische Aufsätze |
author-letter |
Elisa Magli |
doi_str_mv |
10.3390/biom11121899 |
author2-role |
verfasserin |
title_sort |
h<sub<2</sub<s donors and their use in medicinal chemistry |
callnumber |
QR1-502 |
title_auth |
H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry |
abstract |
Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. |
abstractGer |
Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. |
abstract_unstemmed |
Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications. |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 |
container_issue |
12, p 1899 |
title_short |
H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry |
url |
https://doi.org/10.3390/biom11121899 https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98 https://www.mdpi.com/2218-273X/11/12/1899 https://doaj.org/toc/2218-273X |
remote_bool |
true |
author2 |
Elisa Perissutti Vincenzo Santagada Giuseppe Caliendo Angela Corvino Gianluca Esposito Giovanna Esposito Ferdinando Fiorino Marco Migliaccio Antonia Scognamiglio Beatrice Severino Rosa Sparaco Francesco Frecentese |
author2Str |
Elisa Perissutti Vincenzo Santagada Giuseppe Caliendo Angela Corvino Gianluca Esposito Giovanna Esposito Ferdinando Fiorino Marco Migliaccio Antonia Scognamiglio Beatrice Severino Rosa Sparaco Francesco Frecentese |
ppnlink |
735688915 |
callnumber-subject |
QR - Microbiology |
mediatype_str_mv |
c |
isOA_txt |
true |
hochschulschrift_bool |
false |
doi_str |
10.3390/biom11121899 |
callnumber-a |
QR1-502 |
up_date |
2024-07-03T22:57:01.204Z |
_version_ |
1803600444744794112 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ069374961</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412095418.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/biom11121899</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ069374961</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ3f0d2b2493524ef4939b8bf200265b98</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR1-502</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Elisa Magli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">H<sub<2</sub<S Donors and Their Use in Medicinal Chemistry</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Hydrogen sulfide (H<sub<2</sub<S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H<sub<2</sub<S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H<sub<2</sub<S levels has a potential therapeutic value. Consequently, synthetic H<sub<2</sub<S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H<sub<2</sub<S donors; furthermore, herein we discuss their preparation, the H<sub<2</sub<S-releasing mechanisms, and their -biological applications.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hydrogen sulfide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">natural H<sub<2</sub<S donors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">synthetic H<sub<2</sub<S donors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">H<sub<2</sub<S release</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">medicinal chemistry</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Microbiology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elisa Perissutti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vincenzo Santagada</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giuseppe Caliendo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angela Corvino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gianluca Esposito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giovanna Esposito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ferdinando Fiorino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marco Migliaccio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Antonia Scognamiglio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Beatrice Severino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rosa Sparaco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francesco Frecentese</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Biomolecules</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">11(2021), 12, p 1899</subfield><subfield code="w">(DE-627)735688915</subfield><subfield code="w">(DE-600)2701262-1</subfield><subfield code="x">2218273X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:11</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:12, p 1899</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/biom11121899</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/3f0d2b2493524ef4939b8bf200265b98</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2218-273X/11/12/1899</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2218-273X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">11</subfield><subfield code="j">2021</subfield><subfield code="e">12, p 1899</subfield></datafield></record></collection>
|
score |
7.401513 |