Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia

Corticosteroids have been widely used for acute respiratory distress syndrome (ARDS), but their role in the early phase of SARS-CoV-2 infection is controversial. Our study aimed to determine the effectiveness of early corticosteroid therapy (ECT) in preventing the progression of disease, reducing th...
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Autor*in:	Chukwuma Okoye [verfasserIn] Sara Rogani [verfasserIn] Riccardo Franchi [verfasserIn] Igino Maria Pompilii [verfasserIn] Alessia Maria Calabrese [verfasserIn] Tessa Mazzarone [verfasserIn] Elena Bianchi [verfasserIn] Bianca Lemmi [verfasserIn] Valeria Calsolaro [verfasserIn] Fabio Monzani [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	corticosteroids older people COVID-19 pneumonia home therapy

Übergeordnetes Werk:	In: Geriatrics - MDPI AG, 2016, 7(2022), 1, p 21
Übergeordnetes Werk:	volume:7 ; year:2022 ; number:1, p 21

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/geriatrics7010021

Katalog-ID:	DOAJ069480885

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spelling	10.3390/geriatrics7010021 doi (DE-627)DOAJ069480885 (DE-599)DOAJ3201695104514767bca9cfdde9ac9747 DE-627 ger DE-627 rakwb eng RC952-954.6 Chukwuma Okoye verfasserin aut Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Corticosteroids have been widely used for acute respiratory distress syndrome (ARDS), but their role in the early phase of SARS-CoV-2 infection is controversial. Our study aimed to determine the effectiveness of early corticosteroid therapy (ECT) in preventing the progression of disease, reducing the escalation of care and improving clinical outcome in older patients hospitalized for COVID-19 pneumonia. A total of 90 subjects (47.7% women; mean age = 82.3 ± 6.7 years) were enrolled. ECT was administered to 33 out of 90 patients before the hospitalization. At admission, no difference was detected in median SOFA score (2, IQR:2 vs. 2, IQR: 2). We found a significant difference in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio during the first week of hospitalization between ECT patients and controls (F = 5.49, <i<p</i< = 0.002) and in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio over time (F = 6.94, <i<p</i< < 0.0001). We detected no-significant differences in terms of in-hospital mortality and transfer to ICU between ECT patients and controls (27.1% vs. 22.8%, respectively, <i<p</i< = 0.63). ECT was associated with worse clinical outcomes, showing no benefit in attenuating the progression of the disease or reducing the escalation of care. These findings are crucial given the current pandemic, and further studies are needed to provide additional data on the optimal timing of initiating corticosteroid treatment. corticosteroids older people COVID-19 pneumonia home therapy Geriatrics Sara Rogani verfasserin aut Riccardo Franchi verfasserin aut Igino Maria Pompilii verfasserin aut Alessia Maria Calabrese verfasserin aut Tessa Mazzarone verfasserin aut Elena Bianchi verfasserin aut Bianca Lemmi verfasserin aut Valeria Calsolaro verfasserin aut Fabio Monzani verfasserin aut In Geriatrics MDPI AG, 2016 7(2022), 1, p 21 (DE-627)1025498518 23083417 nnns volume:7 year:2022 number:1, p 21 https://doi.org/10.3390/geriatrics7010021 kostenfrei https://doaj.org/article/3201695104514767bca9cfdde9ac9747 kostenfrei https://www.mdpi.com/2308-3417/7/1/21 kostenfrei https://doaj.org/toc/2308-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2022 1, p 21
allfields_unstemmed	10.3390/geriatrics7010021 doi (DE-627)DOAJ069480885 (DE-599)DOAJ3201695104514767bca9cfdde9ac9747 DE-627 ger DE-627 rakwb eng RC952-954.6 Chukwuma Okoye verfasserin aut Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Corticosteroids have been widely used for acute respiratory distress syndrome (ARDS), but their role in the early phase of SARS-CoV-2 infection is controversial. Our study aimed to determine the effectiveness of early corticosteroid therapy (ECT) in preventing the progression of disease, reducing the escalation of care and improving clinical outcome in older patients hospitalized for COVID-19 pneumonia. A total of 90 subjects (47.7% women; mean age = 82.3 ± 6.7 years) were enrolled. ECT was administered to 33 out of 90 patients before the hospitalization. At admission, no difference was detected in median SOFA score (2, IQR:2 vs. 2, IQR: 2). We found a significant difference in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio during the first week of hospitalization between ECT patients and controls (F = 5.49, <i<p</i< = 0.002) and in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio over time (F = 6.94, <i<p</i< < 0.0001). We detected no-significant differences in terms of in-hospital mortality and transfer to ICU between ECT patients and controls (27.1% vs. 22.8%, respectively, <i<p</i< = 0.63). ECT was associated with worse clinical outcomes, showing no benefit in attenuating the progression of the disease or reducing the escalation of care. These findings are crucial given the current pandemic, and further studies are needed to provide additional data on the optimal timing of initiating corticosteroid treatment. corticosteroids older people COVID-19 pneumonia home therapy Geriatrics Sara Rogani verfasserin aut Riccardo Franchi verfasserin aut Igino Maria Pompilii verfasserin aut Alessia Maria Calabrese verfasserin aut Tessa Mazzarone verfasserin aut Elena Bianchi verfasserin aut Bianca Lemmi verfasserin aut Valeria Calsolaro verfasserin aut Fabio Monzani verfasserin aut In Geriatrics MDPI AG, 2016 7(2022), 1, p 21 (DE-627)1025498518 23083417 nnns volume:7 year:2022 number:1, p 21 https://doi.org/10.3390/geriatrics7010021 kostenfrei https://doaj.org/article/3201695104514767bca9cfdde9ac9747 kostenfrei https://www.mdpi.com/2308-3417/7/1/21 kostenfrei https://doaj.org/toc/2308-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2022 1, p 21
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allfieldsSound	10.3390/geriatrics7010021 doi (DE-627)DOAJ069480885 (DE-599)DOAJ3201695104514767bca9cfdde9ac9747 DE-627 ger DE-627 rakwb eng RC952-954.6 Chukwuma Okoye verfasserin aut Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Corticosteroids have been widely used for acute respiratory distress syndrome (ARDS), but their role in the early phase of SARS-CoV-2 infection is controversial. Our study aimed to determine the effectiveness of early corticosteroid therapy (ECT) in preventing the progression of disease, reducing the escalation of care and improving clinical outcome in older patients hospitalized for COVID-19 pneumonia. A total of 90 subjects (47.7% women; mean age = 82.3 ± 6.7 years) were enrolled. ECT was administered to 33 out of 90 patients before the hospitalization. At admission, no difference was detected in median SOFA score (2, IQR:2 vs. 2, IQR: 2). We found a significant difference in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio during the first week of hospitalization between ECT patients and controls (F = 5.49, <i<p</i< = 0.002) and in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio over time (F = 6.94, <i<p</i< < 0.0001). We detected no-significant differences in terms of in-hospital mortality and transfer to ICU between ECT patients and controls (27.1% vs. 22.8%, respectively, <i<p</i< = 0.63). ECT was associated with worse clinical outcomes, showing no benefit in attenuating the progression of the disease or reducing the escalation of care. These findings are crucial given the current pandemic, and further studies are needed to provide additional data on the optimal timing of initiating corticosteroid treatment. corticosteroids older people COVID-19 pneumonia home therapy Geriatrics Sara Rogani verfasserin aut Riccardo Franchi verfasserin aut Igino Maria Pompilii verfasserin aut Alessia Maria Calabrese verfasserin aut Tessa Mazzarone verfasserin aut Elena Bianchi verfasserin aut Bianca Lemmi verfasserin aut Valeria Calsolaro verfasserin aut Fabio Monzani verfasserin aut In Geriatrics MDPI AG, 2016 7(2022), 1, p 21 (DE-627)1025498518 23083417 nnns volume:7 year:2022 number:1, p 21 https://doi.org/10.3390/geriatrics7010021 kostenfrei https://doaj.org/article/3201695104514767bca9cfdde9ac9747 kostenfrei https://www.mdpi.com/2308-3417/7/1/21 kostenfrei https://doaj.org/toc/2308-3417 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2022 1, p 21
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callnumber-first	R - Medicine
author	Chukwuma Okoye
spellingShingle	Chukwuma Okoye misc RC952-954.6 misc corticosteroids misc older people misc COVID-19 misc pneumonia misc home therapy misc Geriatrics Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia
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topic_title	RC952-954.6 Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia corticosteroids older people COVID-19 pneumonia home therapy
topic	misc RC952-954.6 misc corticosteroids misc older people misc COVID-19 misc pneumonia misc home therapy misc Geriatrics
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title	Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia
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title_sort	pitfalls of early systemic corticosteroids home therapy in older patients with covid-19 pneumonia
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title_auth	Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia
abstract	Corticosteroids have been widely used for acute respiratory distress syndrome (ARDS), but their role in the early phase of SARS-CoV-2 infection is controversial. Our study aimed to determine the effectiveness of early corticosteroid therapy (ECT) in preventing the progression of disease, reducing the escalation of care and improving clinical outcome in older patients hospitalized for COVID-19 pneumonia. A total of 90 subjects (47.7% women; mean age = 82.3 ± 6.7 years) were enrolled. ECT was administered to 33 out of 90 patients before the hospitalization. At admission, no difference was detected in median SOFA score (2, IQR:2 vs. 2, IQR: 2). We found a significant difference in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio during the first week of hospitalization between ECT patients and controls (F = 5.49, <i<p</i< = 0.002) and in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio over time (F = 6.94, <i<p</i< < 0.0001). We detected no-significant differences in terms of in-hospital mortality and transfer to ICU between ECT patients and controls (27.1% vs. 22.8%, respectively, <i<p</i< = 0.63). ECT was associated with worse clinical outcomes, showing no benefit in attenuating the progression of the disease or reducing the escalation of care. These findings are crucial given the current pandemic, and further studies are needed to provide additional data on the optimal timing of initiating corticosteroid treatment.
abstractGer	Corticosteroids have been widely used for acute respiratory distress syndrome (ARDS), but their role in the early phase of SARS-CoV-2 infection is controversial. Our study aimed to determine the effectiveness of early corticosteroid therapy (ECT) in preventing the progression of disease, reducing the escalation of care and improving clinical outcome in older patients hospitalized for COVID-19 pneumonia. A total of 90 subjects (47.7% women; mean age = 82.3 ± 6.7 years) were enrolled. ECT was administered to 33 out of 90 patients before the hospitalization. At admission, no difference was detected in median SOFA score (2, IQR:2 vs. 2, IQR: 2). We found a significant difference in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio during the first week of hospitalization between ECT patients and controls (F = 5.49, <i<p</i< = 0.002) and in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio over time (F = 6.94, <i<p</i< < 0.0001). We detected no-significant differences in terms of in-hospital mortality and transfer to ICU between ECT patients and controls (27.1% vs. 22.8%, respectively, <i<p</i< = 0.63). ECT was associated with worse clinical outcomes, showing no benefit in attenuating the progression of the disease or reducing the escalation of care. These findings are crucial given the current pandemic, and further studies are needed to provide additional data on the optimal timing of initiating corticosteroid treatment.
abstract_unstemmed	Corticosteroids have been widely used for acute respiratory distress syndrome (ARDS), but their role in the early phase of SARS-CoV-2 infection is controversial. Our study aimed to determine the effectiveness of early corticosteroid therapy (ECT) in preventing the progression of disease, reducing the escalation of care and improving clinical outcome in older patients hospitalized for COVID-19 pneumonia. A total of 90 subjects (47.7% women; mean age = 82.3 ± 6.7 years) were enrolled. ECT was administered to 33 out of 90 patients before the hospitalization. At admission, no difference was detected in median SOFA score (2, IQR:2 vs. 2, IQR: 2). We found a significant difference in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio during the first week of hospitalization between ECT patients and controls (F = 5.49, <i<p</i< = 0.002) and in mean PaO<sub<2</sub</FiO<sub<2</sub< ratio over time (F = 6.94, <i<p</i< < 0.0001). We detected no-significant differences in terms of in-hospital mortality and transfer to ICU between ECT patients and controls (27.1% vs. 22.8%, respectively, <i<p</i< = 0.63). ECT was associated with worse clinical outcomes, showing no benefit in attenuating the progression of the disease or reducing the escalation of care. These findings are crucial given the current pandemic, and further studies are needed to provide additional data on the optimal timing of initiating corticosteroid treatment.
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title_short	Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia
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ECT was associated with worse clinical outcomes, showing no benefit in attenuating the progression of the disease or reducing the escalation of care. 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Pitfalls of Early Systemic Corticosteroids Home Therapy in Older Patients with COVID-19 Pneumonia

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