Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis

Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009 Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yuanling LI [verfasserIn] Xiaoyun XU [verfasserIn] Yue WANG [verfasserIn] Jing ZHANG [verfasserIn] Bo FENG [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Chinesisch

Erschienen:	2011

Schlagwörter:	Leukomalacia, periventricular Cognition disorders Magnetic resonance spectroscopy Hippocampus

Übergeordnetes Werk:	In: Chinese Journal of Contemporary Neurology and Neurosurgery - Tianjin Huanhu Hospital, 2013, 11(2011), 6, Seite 633-638
Übergeordnetes Werk:	volume:11 ; year:2011 ; number:6 ; pages:633-638

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ06953148X

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245	1	0	\|a Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis
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520			\|a Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009
650		4	\|a Leukomalacia, periventricular
650		4	\|a Cognition disorders
650		4	\|a Magnetic resonance spectroscopy
650		4	\|a Hippocampus
653		0	\|a Neurology. Diseases of the nervous system
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700	0		\|a Jing ZHANG \|e verfasserin \|4 aut
700	0		\|a Bo FENG \|e verfasserin \|4 aut
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allfields	(DE-627)DOAJ06953148X (DE-599)DOAJ8619878b3bbf4adc99c82b0c0bb50395 DE-627 ger DE-627 rakwb eng chi RC346-429 Yuanling LI verfasserin aut Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009 Leukomalacia, periventricular Cognition disorders Magnetic resonance spectroscopy Hippocampus Neurology. Diseases of the nervous system Xiaoyun XU verfasserin aut Yue WANG verfasserin aut Jing ZHANG verfasserin aut Bo FENG verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 11(2011), 6, Seite 633-638 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:11 year:2011 number:6 pages:633-638 https://doaj.org/article/8619878b3bbf4adc99c82b0c0bb50395 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/96 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 6 633-638
spelling	(DE-627)DOAJ06953148X (DE-599)DOAJ8619878b3bbf4adc99c82b0c0bb50395 DE-627 ger DE-627 rakwb eng chi RC346-429 Yuanling LI verfasserin aut Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009 Leukomalacia, periventricular Cognition disorders Magnetic resonance spectroscopy Hippocampus Neurology. Diseases of the nervous system Xiaoyun XU verfasserin aut Yue WANG verfasserin aut Jing ZHANG verfasserin aut Bo FENG verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 11(2011), 6, Seite 633-638 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:11 year:2011 number:6 pages:633-638 https://doaj.org/article/8619878b3bbf4adc99c82b0c0bb50395 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/96 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 6 633-638
allfields_unstemmed	(DE-627)DOAJ06953148X (DE-599)DOAJ8619878b3bbf4adc99c82b0c0bb50395 DE-627 ger DE-627 rakwb eng chi RC346-429 Yuanling LI verfasserin aut Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009 Leukomalacia, periventricular Cognition disorders Magnetic resonance spectroscopy Hippocampus Neurology. Diseases of the nervous system Xiaoyun XU verfasserin aut Yue WANG verfasserin aut Jing ZHANG verfasserin aut Bo FENG verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 11(2011), 6, Seite 633-638 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:11 year:2011 number:6 pages:633-638 https://doaj.org/article/8619878b3bbf4adc99c82b0c0bb50395 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/96 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 6 633-638
allfieldsGer	(DE-627)DOAJ06953148X (DE-599)DOAJ8619878b3bbf4adc99c82b0c0bb50395 DE-627 ger DE-627 rakwb eng chi RC346-429 Yuanling LI verfasserin aut Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009 Leukomalacia, periventricular Cognition disorders Magnetic resonance spectroscopy Hippocampus Neurology. Diseases of the nervous system Xiaoyun XU verfasserin aut Yue WANG verfasserin aut Jing ZHANG verfasserin aut Bo FENG verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 11(2011), 6, Seite 633-638 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:11 year:2011 number:6 pages:633-638 https://doaj.org/article/8619878b3bbf4adc99c82b0c0bb50395 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/96 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 6 633-638
allfieldsSound	(DE-627)DOAJ06953148X (DE-599)DOAJ8619878b3bbf4adc99c82b0c0bb50395 DE-627 ger DE-627 rakwb eng chi RC346-429 Yuanling LI verfasserin aut Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009 Leukomalacia, periventricular Cognition disorders Magnetic resonance spectroscopy Hippocampus Neurology. Diseases of the nervous system Xiaoyun XU verfasserin aut Yue WANG verfasserin aut Jing ZHANG verfasserin aut Bo FENG verfasserin aut In Chinese Journal of Contemporary Neurology and Neurosurgery Tianjin Huanhu Hospital, 2013 11(2011), 6, Seite 633-638 (DE-627)741171848 (DE-600)2710763-2 16726731 nnns volume:11 year:2011 number:6 pages:633-638 https://doaj.org/article/8619878b3bbf4adc99c82b0c0bb50395 kostenfrei http://www.cjcnn.org/index.php/cjcnn/article/view/96 kostenfrei https://doaj.org/toc/1672-6731 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 6 633-638
language	English Chinese
source	In Chinese Journal of Contemporary Neurology and Neurosurgery 11(2011), 6, Seite 633-638 volume:11 year:2011 number:6 pages:633-638
sourceStr	In Chinese Journal of Contemporary Neurology and Neurosurgery 11(2011), 6, Seite 633-638 volume:11 year:2011 number:6 pages:633-638
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Leukomalacia, periventricular Cognition disorders Magnetic resonance spectroscopy Hippocampus Neurology. Diseases of the nervous system
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container_title	Chinese Journal of Contemporary Neurology and Neurosurgery
authorswithroles_txt_mv	Yuanling LI @@aut@@ Xiaoyun XU @@aut@@ Yue WANG @@aut@@ Jing ZHANG @@aut@@ Bo FENG @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
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language_de	englisch chinesisch
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Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. 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callnumber-first	R - Medicine
author	Yuanling LI
spellingShingle	Yuanling LI misc RC346-429 misc Leukomalacia, periventricular misc Cognition disorders misc Magnetic resonance spectroscopy misc Hippocampus misc Neurology. Diseases of the nervous system Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis
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topic_title	RC346-429 Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis Leukomalacia, periventricular Cognition disorders Magnetic resonance spectroscopy Hippocampus
topic	misc RC346-429 misc Leukomalacia, periventricular misc Cognition disorders misc Magnetic resonance spectroscopy misc Hippocampus misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc Leukomalacia, periventricular misc Cognition disorders misc Magnetic resonance spectroscopy misc Hippocampus misc Neurology. Diseases of the nervous system
topic_browse	misc RC346-429 misc Leukomalacia, periventricular misc Cognition disorders misc Magnetic resonance spectroscopy misc Hippocampus misc Neurology. Diseases of the nervous system
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title	Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis
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title_full	Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis
author_sort	Yuanling LI
journal	Chinese Journal of Contemporary Neurology and Neurosurgery
journalStr	Chinese Journal of Contemporary Neurology and Neurosurgery
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lang_code	eng chi
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publishDateSort	2011
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container_start_page	633
author_browse	Yuanling LI Xiaoyun XU Yue WANG Jing ZHANG Bo FENG
container_volume	11
class	RC346-429
format_se	Elektronische Aufsätze
author-letter	Yuanling LI
author2-role	verfasserin
title_sort	study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis
callnumber	RC346-429
title_auth	Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis
abstract	Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009
abstractGer	Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009
abstract_unstemmed	Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by 1H ⁃ magnetic resonance spectroscopy (1H ⁃ MRS) in patients with leukoaraiosis. Methods One hundred and eight patients with hypomnesis were recruited. There was 54 cases in leukoaraiosis (LA) group and also 54 in non⁃leukoaraiosis (non⁃LA) group. Mini⁃ Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Wechsler Memory Scale⁃Chinese Revised (WMS⁃CR) were used for assessment. A 3.0T MR was used for STEAM 1H⁃MRS analysis. The value of N⁃acetylaspartate (NAA), creatine and phosphocreatine (Cr), myoinositol (mI), choline⁃containing compounds (Cho) and glutamate complex⁃ α (Glx⁃ α) were measured in the left hippocampus. The ratio including NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr were calculated. The differences between two groups were compared. Results Both MMSE and MoCA scores (24.00 and 16.50) in LA group were significantly lower than those in non⁃LA group (27.00 and 21.00) (P = 0.000). In MoCA, the scores of LA group and non⁃LA group were as follow: 1.00 and 3.00 in visuospatial execution, 4.00 and 5.00 in attention, 1.00 and 2.00 in language, 0.00 and 2.00 in delayed recall (P < 0.05). In WMS⁃CR, immediate memory scores (5.06 ± 2.86) and short⁃term memory scores (32.76 ± 13.31) of LA group were lower than those in the non⁃LA group which were (7.68 ± 4.41) and (46.95 ± 14.81) (P < 0.05). No significant difference was shown in NAA/Cr, mI/Cr, Cho/Cr and Glx⁃α/Cr ratio among two groups. Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution, attention, language and memory (especially immediate memory and short⁃term memory). No metabolic change in hippocampus via 1H⁃MRS scan was found between LA group and non⁃LA group. No relation between these changes and left hippocampus metabolic changes was seen. DOI：10.3969/j.issn.1672-6731.2011.06.009
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title_short	Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis
url	https://doaj.org/article/8619878b3bbf4adc99c82b0c0bb50395 http://www.cjcnn.org/index.php/cjcnn/article/view/96 https://doaj.org/toc/1672-6731
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up_date	2024-07-03T23:40:43.978Z
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