Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia
Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Part...
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| Autor*in: |
Jianzhen Zhang [verfasserIn] Helen G. Healy [verfasserIn] Keshwar Baboolal [verfasserIn] Zaimin Wang [verfasserIn] Sree K. Venuthurupalli [verfasserIn] Ken-Soon Tan [verfasserIn] Anne Cameron [verfasserIn] Wendy E. Hoy [verfasserIn] Prof Robert Fassett [verfasserIn] Dr Thin Han [verfasserIn] Dr George Kan [verfasserIn] A/Prof Thomas Titus [verfasserIn] Dr Krishan Madhan [verfasserIn] Dr Murty Mantha [verfasserIn] Ms Chris Banny [verfasserIn] Dr Sridivi Govindarajulu [verfasserIn] Dr Nicholas Gray [verfasserIn] Ms Andrea Rolfe [verfasserIn] Dr Dwarakanathan Ranganathan [verfasserIn] Dr Clyson Mutatiri [verfasserIn] Dr Shahadat Hossain [verfasserIn] Dr Danielle Wu [verfasserIn] Dr Roy Cherian [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Übergeordnetes Werk: |
In: Kidney Medicine - Elsevier, 2019, 1(2019), 4, Seite 180-190 |
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| Übergeordnetes Werk: |
volume:1 ; year:2019 ; number:4 ; pages:180-190 |
| Links: |
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| DOI / URN: |
10.1016/j.xkme.2019.06.005 |
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| Katalog-ID: |
DOAJ069556466 |
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| 245 | 1 | 0 | |a Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia |
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| 520 | |a Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis | ||
| 653 | 0 | |a Diseases of the genitourinary system. Urology | |
| 700 | 0 | |a Helen G. Healy |e verfasserin |4 aut | |
| 700 | 0 | |a Keshwar Baboolal |e verfasserin |4 aut | |
| 700 | 0 | |a Zaimin Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Sree K. Venuthurupalli |e verfasserin |4 aut | |
| 700 | 0 | |a Ken-Soon Tan |e verfasserin |4 aut | |
| 700 | 0 | |a Anne Cameron |e verfasserin |4 aut | |
| 700 | 0 | |a Wendy E. Hoy |e verfasserin |4 aut | |
| 700 | 0 | |a Prof Robert Fassett |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Thin Han |e verfasserin |4 aut | |
| 700 | 0 | |a Dr George Kan |e verfasserin |4 aut | |
| 700 | 0 | |a A/Prof Thomas Titus |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Krishan Madhan |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Murty Mantha |e verfasserin |4 aut | |
| 700 | 0 | |a Ms Chris Banny |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Sridivi Govindarajulu |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Nicholas Gray |e verfasserin |4 aut | |
| 700 | 0 | |a Ms Andrea Rolfe |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Dwarakanathan Ranganathan |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Clyson Mutatiri |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Shahadat Hossain |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Danielle Wu |e verfasserin |4 aut | |
| 700 | 0 | |a Dr Roy Cherian |e verfasserin |4 aut | |
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10.1016/j.xkme.2019.06.005 doi (DE-627)DOAJ069556466 (DE-599)DOAJ92982422052549f687b9f6c447c99a71 DE-627 ger DE-627 rakwb eng RC870-923 Jianzhen Zhang verfasserin aut Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis Diseases of the genitourinary system. Urology Helen G. Healy verfasserin aut Keshwar Baboolal verfasserin aut Zaimin Wang verfasserin aut Sree K. Venuthurupalli verfasserin aut Ken-Soon Tan verfasserin aut Anne Cameron verfasserin aut Wendy E. Hoy verfasserin aut Prof Robert Fassett verfasserin aut Dr Thin Han verfasserin aut Dr George Kan verfasserin aut A/Prof Thomas Titus verfasserin aut Dr Krishan Madhan verfasserin aut Dr Murty Mantha verfasserin aut Ms Chris Banny verfasserin aut Dr Sridivi Govindarajulu verfasserin aut Dr Nicholas Gray verfasserin aut Ms Andrea Rolfe verfasserin aut Dr Dwarakanathan Ranganathan verfasserin aut Dr Clyson Mutatiri verfasserin aut Dr Shahadat Hossain verfasserin aut Dr Danielle Wu verfasserin aut Dr Roy Cherian verfasserin aut In Kidney Medicine Elsevier, 2019 1(2019), 4, Seite 180-190 (DE-627)1691027731 25900595 nnns volume:1 year:2019 number:4 pages:180-190 https://doi.org/10.1016/j.xkme.2019.06.005 kostenfrei https://doaj.org/article/92982422052549f687b9f6c447c99a71 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590059519300597 kostenfrei https://doaj.org/toc/2590-0595 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2019 4 180-190 |
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10.1016/j.xkme.2019.06.005 doi (DE-627)DOAJ069556466 (DE-599)DOAJ92982422052549f687b9f6c447c99a71 DE-627 ger DE-627 rakwb eng RC870-923 Jianzhen Zhang verfasserin aut Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis Diseases of the genitourinary system. Urology Helen G. Healy verfasserin aut Keshwar Baboolal verfasserin aut Zaimin Wang verfasserin aut Sree K. Venuthurupalli verfasserin aut Ken-Soon Tan verfasserin aut Anne Cameron verfasserin aut Wendy E. Hoy verfasserin aut Prof Robert Fassett verfasserin aut Dr Thin Han verfasserin aut Dr George Kan verfasserin aut A/Prof Thomas Titus verfasserin aut Dr Krishan Madhan verfasserin aut Dr Murty Mantha verfasserin aut Ms Chris Banny verfasserin aut Dr Sridivi Govindarajulu verfasserin aut Dr Nicholas Gray verfasserin aut Ms Andrea Rolfe verfasserin aut Dr Dwarakanathan Ranganathan verfasserin aut Dr Clyson Mutatiri verfasserin aut Dr Shahadat Hossain verfasserin aut Dr Danielle Wu verfasserin aut Dr Roy Cherian verfasserin aut In Kidney Medicine Elsevier, 2019 1(2019), 4, Seite 180-190 (DE-627)1691027731 25900595 nnns volume:1 year:2019 number:4 pages:180-190 https://doi.org/10.1016/j.xkme.2019.06.005 kostenfrei https://doaj.org/article/92982422052549f687b9f6c447c99a71 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590059519300597 kostenfrei https://doaj.org/toc/2590-0595 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2019 4 180-190 |
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10.1016/j.xkme.2019.06.005 doi (DE-627)DOAJ069556466 (DE-599)DOAJ92982422052549f687b9f6c447c99a71 DE-627 ger DE-627 rakwb eng RC870-923 Jianzhen Zhang verfasserin aut Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis Diseases of the genitourinary system. Urology Helen G. Healy verfasserin aut Keshwar Baboolal verfasserin aut Zaimin Wang verfasserin aut Sree K. Venuthurupalli verfasserin aut Ken-Soon Tan verfasserin aut Anne Cameron verfasserin aut Wendy E. Hoy verfasserin aut Prof Robert Fassett verfasserin aut Dr Thin Han verfasserin aut Dr George Kan verfasserin aut A/Prof Thomas Titus verfasserin aut Dr Krishan Madhan verfasserin aut Dr Murty Mantha verfasserin aut Ms Chris Banny verfasserin aut Dr Sridivi Govindarajulu verfasserin aut Dr Nicholas Gray verfasserin aut Ms Andrea Rolfe verfasserin aut Dr Dwarakanathan Ranganathan verfasserin aut Dr Clyson Mutatiri verfasserin aut Dr Shahadat Hossain verfasserin aut Dr Danielle Wu verfasserin aut Dr Roy Cherian verfasserin aut In Kidney Medicine Elsevier, 2019 1(2019), 4, Seite 180-190 (DE-627)1691027731 25900595 nnns volume:1 year:2019 number:4 pages:180-190 https://doi.org/10.1016/j.xkme.2019.06.005 kostenfrei https://doaj.org/article/92982422052549f687b9f6c447c99a71 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590059519300597 kostenfrei https://doaj.org/toc/2590-0595 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2019 4 180-190 |
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10.1016/j.xkme.2019.06.005 doi (DE-627)DOAJ069556466 (DE-599)DOAJ92982422052549f687b9f6c447c99a71 DE-627 ger DE-627 rakwb eng RC870-923 Jianzhen Zhang verfasserin aut Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis Diseases of the genitourinary system. Urology Helen G. Healy verfasserin aut Keshwar Baboolal verfasserin aut Zaimin Wang verfasserin aut Sree K. Venuthurupalli verfasserin aut Ken-Soon Tan verfasserin aut Anne Cameron verfasserin aut Wendy E. Hoy verfasserin aut Prof Robert Fassett verfasserin aut Dr Thin Han verfasserin aut Dr George Kan verfasserin aut A/Prof Thomas Titus verfasserin aut Dr Krishan Madhan verfasserin aut Dr Murty Mantha verfasserin aut Ms Chris Banny verfasserin aut Dr Sridivi Govindarajulu verfasserin aut Dr Nicholas Gray verfasserin aut Ms Andrea Rolfe verfasserin aut Dr Dwarakanathan Ranganathan verfasserin aut Dr Clyson Mutatiri verfasserin aut Dr Shahadat Hossain verfasserin aut Dr Danielle Wu verfasserin aut Dr Roy Cherian verfasserin aut In Kidney Medicine Elsevier, 2019 1(2019), 4, Seite 180-190 (DE-627)1691027731 25900595 nnns volume:1 year:2019 number:4 pages:180-190 https://doi.org/10.1016/j.xkme.2019.06.005 kostenfrei https://doaj.org/article/92982422052549f687b9f6c447c99a71 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590059519300597 kostenfrei https://doaj.org/toc/2590-0595 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2019 4 180-190 |
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10.1016/j.xkme.2019.06.005 doi (DE-627)DOAJ069556466 (DE-599)DOAJ92982422052549f687b9f6c447c99a71 DE-627 ger DE-627 rakwb eng RC870-923 Jianzhen Zhang verfasserin aut Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis Diseases of the genitourinary system. Urology Helen G. Healy verfasserin aut Keshwar Baboolal verfasserin aut Zaimin Wang verfasserin aut Sree K. Venuthurupalli verfasserin aut Ken-Soon Tan verfasserin aut Anne Cameron verfasserin aut Wendy E. Hoy verfasserin aut Prof Robert Fassett verfasserin aut Dr Thin Han verfasserin aut Dr George Kan verfasserin aut A/Prof Thomas Titus verfasserin aut Dr Krishan Madhan verfasserin aut Dr Murty Mantha verfasserin aut Ms Chris Banny verfasserin aut Dr Sridivi Govindarajulu verfasserin aut Dr Nicholas Gray verfasserin aut Ms Andrea Rolfe verfasserin aut Dr Dwarakanathan Ranganathan verfasserin aut Dr Clyson Mutatiri verfasserin aut Dr Shahadat Hossain verfasserin aut Dr Danielle Wu verfasserin aut Dr Roy Cherian verfasserin aut In Kidney Medicine Elsevier, 2019 1(2019), 4, Seite 180-190 (DE-627)1691027731 25900595 nnns volume:1 year:2019 number:4 pages:180-190 https://doi.org/10.1016/j.xkme.2019.06.005 kostenfrei https://doaj.org/article/92982422052549f687b9f6c447c99a71 kostenfrei http://www.sciencedirect.com/science/article/pii/S2590059519300597 kostenfrei https://doaj.org/toc/2590-0595 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 1 2019 4 180-190 |
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Jianzhen Zhang @@aut@@ Helen G. Healy @@aut@@ Keshwar Baboolal @@aut@@ Zaimin Wang @@aut@@ Sree K. Venuthurupalli @@aut@@ Ken-Soon Tan @@aut@@ Anne Cameron @@aut@@ Wendy E. Hoy @@aut@@ Prof Robert Fassett @@aut@@ Dr Thin Han @@aut@@ Dr George Kan @@aut@@ A/Prof Thomas Titus @@aut@@ Dr Krishan Madhan @@aut@@ Dr Murty Mantha @@aut@@ Ms Chris Banny @@aut@@ Dr Sridivi Govindarajulu @@aut@@ Dr Nicholas Gray @@aut@@ Ms Andrea Rolfe @@aut@@ Dr Dwarakanathan Ranganathan @@aut@@ Dr Clyson Mutatiri @@aut@@ Dr Shahadat Hossain @@aut@@ Dr Danielle Wu @@aut@@ Dr Roy Cherian @@aut@@ |
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We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the genitourinary system. Urology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Helen G. 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Jianzhen Zhang |
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Jianzhen Zhang misc RC870-923 misc Diseases of the genitourinary system. Urology Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia |
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RC870-923 Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia |
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misc RC870-923 misc Diseases of the genitourinary system. Urology |
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Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia |
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Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia |
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Jianzhen Zhang Helen G. Healy Keshwar Baboolal Zaimin Wang Sree K. Venuthurupalli Ken-Soon Tan Anne Cameron Wendy E. Hoy Prof Robert Fassett Dr Thin Han Dr George Kan A/Prof Thomas Titus Dr Krishan Madhan Dr Murty Mantha Ms Chris Banny Dr Sridivi Govindarajulu Dr Nicholas Gray Ms Andrea Rolfe Dr Dwarakanathan Ranganathan Dr Clyson Mutatiri Dr Shahadat Hossain Dr Danielle Wu Dr Roy Cherian |
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frequency and consequences of acute kidney injury in patients with ckd: a registry study in queensland australia |
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Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia |
| abstract |
Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis |
| abstractGer |
Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis |
| abstract_unstemmed |
Background: Acute kidney injury (AKI) contributes to and complicates chronic kidney disease (CKD). We describe AKI documented in hospital encounters in patients with CKD from the CKD Queensland registry. Study Design: A retrospective cohort study during 2011 to 2016. Setting & Participants: Participants had been admitted to a hospital in Queensland. Predictors: AKI was identified from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification codes. Outcomes: All-cause mortality with or without kidney replacement therapy (KRT), start-up KRT and maintenance KRT, costs of care. Analytical Approach: Time to outcomes for those with versus without AKI was evaluated using Cox regression models. Mann-Whitney test was used to compare number of admissions, hospitalized days and costs by AKI status. Results: Among 6,365 patients followed up for up to 5.4 years, 2,199 (35%) had 4,711 hospital encounters with an AKI diagnosis. Those with AKI were older (68 vs 64 years old), were more often men (36.7% vs 32.2%; P < 0.001), had more advanced CKD stages (stage 3b, 34%; stage 4, 35%; and stage 5, 10%), had more admissions (12 vs 5; P < 0.001), and stayed in the hospital longer (56 vs 14 days; P < 0.001) than those without AKI. Almost 90% of AKI admissions were through the emergency department. Of those with AKI, 554 (25%) subsequently died without any form of KRT and 285 (13%) started KRT, compared with 282 (6.8%) who died and 315 (7.6%) who started KRT among those without AKI; P < 0.001 for each. Adjusted for other significant factors, hazard ratios for all deaths or death without KRT were 2.95 (95% CI, 2.56-3.39; P < 0.001) and 3.02 (95% CI, 2.60-3.51; P < 0.001), respectively, in patients with AKI relative to those without AKI. The hazard ratio for all KRT was 1.40 (95% CI, 1.18-1.66; P < 0.001), and for maintenance KRT was 1.21 (95% CI, 0.98-1.48; P = 0.07). Mean total hospital cost in patients with AKI was more than triple that of patients with no AKI (A $93,042 vs A $30,778; P < 0.001). Limitations: These findings may not be generalizable to CKD populations from the general community or in other health care environments. Conclusions: AKI is associated with strikingly increased deaths, increased rates of KRT, and higher hospital costs. Index Words: Acute kidney injury, chronic kidney disease, all-cause mortality, kidney replacement therapy, dialysis |
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Frequency and Consequences of Acute Kidney Injury in Patients With CKD: A Registry Study in Queensland Australia |
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https://doi.org/10.1016/j.xkme.2019.06.005 https://doaj.org/article/92982422052549f687b9f6c447c99a71 http://www.sciencedirect.com/science/article/pii/S2590059519300597 https://doaj.org/toc/2590-0595 |
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Helen G. Healy Keshwar Baboolal Zaimin Wang Sree K. Venuthurupalli Ken-Soon Tan Anne Cameron Wendy E. Hoy Prof Robert Fassett Dr Thin Han Dr George Kan A/Prof Thomas Titus Dr Krishan Madhan Dr Murty Mantha Ms Chris Banny Dr Sridivi Govindarajulu Dr Nicholas Gray Ms Andrea Rolfe Dr Dwarakanathan Ranganathan Dr Clyson Mutatiri Dr Shahadat Hossain Dr Danielle Wu Dr Roy Cherian |
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Helen G. Healy Keshwar Baboolal Zaimin Wang Sree K. Venuthurupalli Ken-Soon Tan Anne Cameron Wendy E. Hoy Prof Robert Fassett Dr Thin Han Dr George Kan A/Prof Thomas Titus Dr Krishan Madhan Dr Murty Mantha Ms Chris Banny Dr Sridivi Govindarajulu Dr Nicholas Gray Ms Andrea Rolfe Dr Dwarakanathan Ranganathan Dr Clyson Mutatiri Dr Shahadat Hossain Dr Danielle Wu Dr Roy Cherian |
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10.1016/j.xkme.2019.06.005 |
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2024-07-03T23:46:36.195Z |
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| score |
7.400832 |