Small RNA Sequencing in Cells and Exosomes Identifies eQTLs and 14q32 as a Region of Active Export
Exosomes are small extracellular vesicles that carry heterogeneous cargo, including RNA, between cells. Increasing evidence suggests that exosomes are important mediators of intercellular communication and biomarkers of disease. Despite this, the variability of exosomal RNA between individuals has n...
Ausführliche Beschreibung
Autor*in: |
Emily K. Tsang [verfasserIn] Nathan S. Abell [verfasserIn] Xin Li [verfasserIn] Vanessa Anaya [verfasserIn] Konrad J. Karczewski [verfasserIn] David A. Knowles [verfasserIn] Raymond G. Sierra [verfasserIn] Kevin S. Smith [verfasserIn] Stephen B. Montgomery [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2017 |
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Übergeordnetes Werk: |
In: G3: Genes, Genomes, Genetics - Oxford University Press, 2012, 7(2017), 1, Seite 31-39 |
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Übergeordnetes Werk: |
volume:7 ; year:2017 ; number:1 ; pages:31-39 |
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DOI / URN: |
10.1534/g3.116.036137 |
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Katalog-ID: |
DOAJ070100055 |
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10.1534/g3.116.036137 doi (DE-627)DOAJ070100055 (DE-599)DOAJ9008996f7e0b48c48d88b1368237700a DE-627 ger DE-627 rakwb eng QH426-470 Emily K. Tsang verfasserin aut Small RNA Sequencing in Cells and Exosomes Identifies eQTLs and 14q32 as a Region of Active Export 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Exosomes are small extracellular vesicles that carry heterogeneous cargo, including RNA, between cells. Increasing evidence suggests that exosomes are important mediators of intercellular communication and biomarkers of disease. Despite this, the variability of exosomal RNA between individuals has not been well quantified. To assess this variability, we sequenced the small RNA of cells and exosomes from a 17-member family. Across individuals, we show that selective export of miRNAs occurs not only at the level of specific transcripts, but that a cluster of 74 mature miRNAs on chromosome 14q32 is massively exported in exosomes while mostly absent from cells. We also observe more interindividual variability between exosomal samples than between cellular ones and identify four miRNA expression quantitative trait loci shared between cells and exosomes. Our findings indicate that genomically colocated miRNAs can be exported together and highlight the variability in exosomal miRNA levels between individuals as relevant for exosome use as diagnostics. extracellular vesicles miRNA piRNA gene regulation Genetics Nathan S. Abell verfasserin aut Xin Li verfasserin aut Vanessa Anaya verfasserin aut Konrad J. Karczewski verfasserin aut David A. Knowles verfasserin aut Raymond G. Sierra verfasserin aut Kevin S. Smith verfasserin aut Stephen B. Montgomery verfasserin aut In G3: Genes, Genomes, Genetics Oxford University Press, 2012 7(2017), 1, Seite 31-39 (DE-627)668901071 (DE-600)2629978-1 21601836 nnns volume:7 year:2017 number:1 pages:31-39 https://doi.org/10.1534/g3.116.036137 kostenfrei https://doaj.org/article/9008996f7e0b48c48d88b1368237700a kostenfrei http://g3journal.org/lookup/doi/10.1534/g3.116.036137 kostenfrei https://doaj.org/toc/2160-1836 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 31-39 |
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Small RNA Sequencing in Cells and Exosomes Identifies eQTLs and 14q32 as a Region of Active Export |
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Exosomes are small extracellular vesicles that carry heterogeneous cargo, including RNA, between cells. Increasing evidence suggests that exosomes are important mediators of intercellular communication and biomarkers of disease. Despite this, the variability of exosomal RNA between individuals has not been well quantified. To assess this variability, we sequenced the small RNA of cells and exosomes from a 17-member family. Across individuals, we show that selective export of miRNAs occurs not only at the level of specific transcripts, but that a cluster of 74 mature miRNAs on chromosome 14q32 is massively exported in exosomes while mostly absent from cells. We also observe more interindividual variability between exosomal samples than between cellular ones and identify four miRNA expression quantitative trait loci shared between cells and exosomes. Our findings indicate that genomically colocated miRNAs can be exported together and highlight the variability in exosomal miRNA levels between individuals as relevant for exosome use as diagnostics. |
abstractGer |
Exosomes are small extracellular vesicles that carry heterogeneous cargo, including RNA, between cells. Increasing evidence suggests that exosomes are important mediators of intercellular communication and biomarkers of disease. Despite this, the variability of exosomal RNA between individuals has not been well quantified. To assess this variability, we sequenced the small RNA of cells and exosomes from a 17-member family. Across individuals, we show that selective export of miRNAs occurs not only at the level of specific transcripts, but that a cluster of 74 mature miRNAs on chromosome 14q32 is massively exported in exosomes while mostly absent from cells. We also observe more interindividual variability between exosomal samples than between cellular ones and identify four miRNA expression quantitative trait loci shared between cells and exosomes. Our findings indicate that genomically colocated miRNAs can be exported together and highlight the variability in exosomal miRNA levels between individuals as relevant for exosome use as diagnostics. |
abstract_unstemmed |
Exosomes are small extracellular vesicles that carry heterogeneous cargo, including RNA, between cells. Increasing evidence suggests that exosomes are important mediators of intercellular communication and biomarkers of disease. Despite this, the variability of exosomal RNA between individuals has not been well quantified. To assess this variability, we sequenced the small RNA of cells and exosomes from a 17-member family. Across individuals, we show that selective export of miRNAs occurs not only at the level of specific transcripts, but that a cluster of 74 mature miRNAs on chromosome 14q32 is massively exported in exosomes while mostly absent from cells. We also observe more interindividual variability between exosomal samples than between cellular ones and identify four miRNA expression quantitative trait loci shared between cells and exosomes. Our findings indicate that genomically colocated miRNAs can be exported together and highlight the variability in exosomal miRNA levels between individuals as relevant for exosome use as diagnostics. |
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