Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice

Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yao Lu [verfasserIn] Yutao Zhou [verfasserIn] Yingying Lin [verfasserIn] Wusun Li [verfasserIn] Shousheng Tian [verfasserIn] Xianghui Hao [verfasserIn] Huiyuan Guo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 84(2021), Seite 104603-
Übergeordnetes Werk:	volume:84 ; year:2021 ; pages:104603-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2021.104603

Katalog-ID:	DOAJ070106983

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allfields	10.1016/j.jff.2021.104603 doi (DE-627)DOAJ070106983 (DE-599)DOAJe5b601fecfb24499b001827ab8e455b5 DE-627 ger DE-627 rakwb eng TX341-641 Yao Lu verfasserin aut Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma. Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation Nutrition. Foods and food supply Yutao Zhou verfasserin aut Yingying Lin verfasserin aut Wusun Li verfasserin aut Shousheng Tian verfasserin aut Xianghui Hao verfasserin aut Huiyuan Guo verfasserin aut In Journal of Functional Foods Elsevier, 2021 84(2021), Seite 104603- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:84 year:2021 pages:104603- https://doi.org/10.1016/j.jff.2021.104603 kostenfrei https://doaj.org/article/e5b601fecfb24499b001827ab8e455b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464621002528 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 84 2021 104603-
spelling	10.1016/j.jff.2021.104603 doi (DE-627)DOAJ070106983 (DE-599)DOAJe5b601fecfb24499b001827ab8e455b5 DE-627 ger DE-627 rakwb eng TX341-641 Yao Lu verfasserin aut Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma. Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation Nutrition. Foods and food supply Yutao Zhou verfasserin aut Yingying Lin verfasserin aut Wusun Li verfasserin aut Shousheng Tian verfasserin aut Xianghui Hao verfasserin aut Huiyuan Guo verfasserin aut In Journal of Functional Foods Elsevier, 2021 84(2021), Seite 104603- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:84 year:2021 pages:104603- https://doi.org/10.1016/j.jff.2021.104603 kostenfrei https://doaj.org/article/e5b601fecfb24499b001827ab8e455b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464621002528 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 84 2021 104603-
allfields_unstemmed	10.1016/j.jff.2021.104603 doi (DE-627)DOAJ070106983 (DE-599)DOAJe5b601fecfb24499b001827ab8e455b5 DE-627 ger DE-627 rakwb eng TX341-641 Yao Lu verfasserin aut Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma. Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation Nutrition. Foods and food supply Yutao Zhou verfasserin aut Yingying Lin verfasserin aut Wusun Li verfasserin aut Shousheng Tian verfasserin aut Xianghui Hao verfasserin aut Huiyuan Guo verfasserin aut In Journal of Functional Foods Elsevier, 2021 84(2021), Seite 104603- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:84 year:2021 pages:104603- https://doi.org/10.1016/j.jff.2021.104603 kostenfrei https://doaj.org/article/e5b601fecfb24499b001827ab8e455b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464621002528 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 84 2021 104603-
allfieldsGer	10.1016/j.jff.2021.104603 doi (DE-627)DOAJ070106983 (DE-599)DOAJe5b601fecfb24499b001827ab8e455b5 DE-627 ger DE-627 rakwb eng TX341-641 Yao Lu verfasserin aut Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma. Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation Nutrition. Foods and food supply Yutao Zhou verfasserin aut Yingying Lin verfasserin aut Wusun Li verfasserin aut Shousheng Tian verfasserin aut Xianghui Hao verfasserin aut Huiyuan Guo verfasserin aut In Journal of Functional Foods Elsevier, 2021 84(2021), Seite 104603- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:84 year:2021 pages:104603- https://doi.org/10.1016/j.jff.2021.104603 kostenfrei https://doaj.org/article/e5b601fecfb24499b001827ab8e455b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464621002528 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 84 2021 104603-
allfieldsSound	10.1016/j.jff.2021.104603 doi (DE-627)DOAJ070106983 (DE-599)DOAJe5b601fecfb24499b001827ab8e455b5 DE-627 ger DE-627 rakwb eng TX341-641 Yao Lu verfasserin aut Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma. Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation Nutrition. Foods and food supply Yutao Zhou verfasserin aut Yingying Lin verfasserin aut Wusun Li verfasserin aut Shousheng Tian verfasserin aut Xianghui Hao verfasserin aut Huiyuan Guo verfasserin aut In Journal of Functional Foods Elsevier, 2021 84(2021), Seite 104603- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:84 year:2021 pages:104603- https://doi.org/10.1016/j.jff.2021.104603 kostenfrei https://doaj.org/article/e5b601fecfb24499b001827ab8e455b5 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464621002528 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 84 2021 104603-
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callnumber-first	T - Technology
author	Yao Lu
spellingShingle	Yao Lu misc TX341-641 misc Donkey milk powder misc Allergic asthma misc Airway hyperresponsiveness misc Airway remodeling misc Mucus hypersecretion misc Airway inflammation misc Nutrition. Foods and food supply Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice
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topic_title	TX341-641 Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation
topic	misc TX341-641 misc Donkey milk powder misc Allergic asthma misc Airway hyperresponsiveness misc Airway remodeling misc Mucus hypersecretion misc Airway inflammation misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Donkey milk powder misc Allergic asthma misc Airway hyperresponsiveness misc Airway remodeling misc Mucus hypersecretion misc Airway inflammation misc Nutrition. Foods and food supply
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title	Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice
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title_full	Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice
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title_sort	preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice
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title_auth	Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice
abstract	Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma.
abstractGer	Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma.
abstract_unstemmed	Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma.
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title_short	Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice
url	https://doi.org/10.1016/j.jff.2021.104603 https://doaj.org/article/e5b601fecfb24499b001827ab8e455b5 http://www.sciencedirect.com/science/article/pii/S1756464621002528 https://doaj.org/toc/1756-4646
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Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice

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