Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years

Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hideo Kimura [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	hydrogen sulfide polysulfides nitric oxide hydrogen peroxide

Übergeordnetes Werk:	In: Biomolecules - MDPI AG, 2013, 11(2021), 6, p 896
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:6, p 896

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/biom11060896

Katalog-ID:	DOAJ070245991

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ070245991
003	DE-627
005	20240412174116.0
007	cr uuu---uuuuu
008	230228s2021 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3390/biom11060896 \|2 doi
035			\|a (DE-627)DOAJ070245991
035			\|a (DE-599)DOAJe790b81818d744bb86b492292282dd7e
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a QR1-502
100	0		\|a Hideo Kimura \|e verfasserin \|4 aut
245	1	0	\|a Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years
264		1	\|c 2021
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years.
650		4	\|a hydrogen sulfide
650		4	\|a polysulfides
650		4	\|a <i<S</i<-sulfuration
650		4	\|a nitric oxide
650		4	\|a hydrogen peroxide
650		4	\|a <i<S</i<-nitrosylation
653		0	\|a Microbiology
773	0	8	\|i In \|t Biomolecules \|d MDPI AG, 2013 \|g 11(2021), 6, p 896 \|w (DE-627)735688915 \|w (DE-600)2701262-1 \|x 2218273X \|7 nnns
773	1	8	\|g volume:11 \|g year:2021 \|g number:6, p 896
856	4	0	\|u https://doi.org/10.3390/biom11060896 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/e790b81818d744bb86b492292282dd7e \|z kostenfrei
856	4	0	\|u https://www.mdpi.com/2218-273X/11/6/896 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2218-273X \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 11 \|j 2021 \|e 6, p 896

Indexfelder

author_variant	h k hk
matchkey_str	article:2218273X:2021----::yrgnufdhu2usnplsliesbsbsbsbi
hierarchy_sort_str	2021
callnumber-subject-code	QR
publishDate	2021
allfields	10.3390/biom11060896 doi (DE-627)DOAJ070245991 (DE-599)DOAJe790b81818d744bb86b492292282dd7e DE-627 ger DE-627 rakwb eng QR1-502 Hideo Kimura verfasserin aut Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years. hydrogen sulfide polysulfides <i<S</i<-sulfuration nitric oxide hydrogen peroxide <i<S</i<-nitrosylation Microbiology In Biomolecules MDPI AG, 2013 11(2021), 6, p 896 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:6, p 896 https://doi.org/10.3390/biom11060896 kostenfrei https://doaj.org/article/e790b81818d744bb86b492292282dd7e kostenfrei https://www.mdpi.com/2218-273X/11/6/896 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 6, p 896
spelling	10.3390/biom11060896 doi (DE-627)DOAJ070245991 (DE-599)DOAJe790b81818d744bb86b492292282dd7e DE-627 ger DE-627 rakwb eng QR1-502 Hideo Kimura verfasserin aut Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years. hydrogen sulfide polysulfides <i<S</i<-sulfuration nitric oxide hydrogen peroxide <i<S</i<-nitrosylation Microbiology In Biomolecules MDPI AG, 2013 11(2021), 6, p 896 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:6, p 896 https://doi.org/10.3390/biom11060896 kostenfrei https://doaj.org/article/e790b81818d744bb86b492292282dd7e kostenfrei https://www.mdpi.com/2218-273X/11/6/896 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 6, p 896
allfields_unstemmed	10.3390/biom11060896 doi (DE-627)DOAJ070245991 (DE-599)DOAJe790b81818d744bb86b492292282dd7e DE-627 ger DE-627 rakwb eng QR1-502 Hideo Kimura verfasserin aut Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years. hydrogen sulfide polysulfides <i<S</i<-sulfuration nitric oxide hydrogen peroxide <i<S</i<-nitrosylation Microbiology In Biomolecules MDPI AG, 2013 11(2021), 6, p 896 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:6, p 896 https://doi.org/10.3390/biom11060896 kostenfrei https://doaj.org/article/e790b81818d744bb86b492292282dd7e kostenfrei https://www.mdpi.com/2218-273X/11/6/896 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 6, p 896
allfieldsGer	10.3390/biom11060896 doi (DE-627)DOAJ070245991 (DE-599)DOAJe790b81818d744bb86b492292282dd7e DE-627 ger DE-627 rakwb eng QR1-502 Hideo Kimura verfasserin aut Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years. hydrogen sulfide polysulfides <i<S</i<-sulfuration nitric oxide hydrogen peroxide <i<S</i<-nitrosylation Microbiology In Biomolecules MDPI AG, 2013 11(2021), 6, p 896 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:6, p 896 https://doi.org/10.3390/biom11060896 kostenfrei https://doaj.org/article/e790b81818d744bb86b492292282dd7e kostenfrei https://www.mdpi.com/2218-273X/11/6/896 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 6, p 896
allfieldsSound	10.3390/biom11060896 doi (DE-627)DOAJ070245991 (DE-599)DOAJe790b81818d744bb86b492292282dd7e DE-627 ger DE-627 rakwb eng QR1-502 Hideo Kimura verfasserin aut Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years. hydrogen sulfide polysulfides <i<S</i<-sulfuration nitric oxide hydrogen peroxide <i<S</i<-nitrosylation Microbiology In Biomolecules MDPI AG, 2013 11(2021), 6, p 896 (DE-627)735688915 (DE-600)2701262-1 2218273X nnns volume:11 year:2021 number:6, p 896 https://doi.org/10.3390/biom11060896 kostenfrei https://doaj.org/article/e790b81818d744bb86b492292282dd7e kostenfrei https://www.mdpi.com/2218-273X/11/6/896 kostenfrei https://doaj.org/toc/2218-273X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 6, p 896
language	English
source	In Biomolecules 11(2021), 6, p 896 volume:11 year:2021 number:6, p 896
sourceStr	In Biomolecules 11(2021), 6, p 896 volume:11 year:2021 number:6, p 896
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hydrogen sulfide polysulfides <i<S</i<-sulfuration nitric oxide hydrogen peroxide <i<S</i<-nitrosylation Microbiology
isfreeaccess_bool	true
container_title	Biomolecules
authorswithroles_txt_mv	Hideo Kimura @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	735688915
id	DOAJ070245991
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ070245991</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412174116.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/biom11060896</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ070245991</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe790b81818d744bb86b492292282dd7e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR1-502</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Hideo Kimura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hydrogen sulfide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">polysulfides</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<S</i<-sulfuration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nitric oxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hydrogen peroxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<S</i<-nitrosylation</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Microbiology</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Biomolecules</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">11(2021), 6, p 896</subfield><subfield code="w">(DE-627)735688915</subfield><subfield code="w">(DE-600)2701262-1</subfield><subfield code="x">2218273X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:11</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:6, p 896</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/biom11060896</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/e790b81818d744bb86b492292282dd7e</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2218-273X/11/6/896</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2218-273X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">11</subfield><subfield code="j">2021</subfield><subfield code="e">6, p 896</subfield></datafield></record></collection>
callnumber-first	Q - Science
author	Hideo Kimura
spellingShingle	Hideo Kimura misc QR1-502 misc hydrogen sulfide misc polysulfides misc <i<S</i<-sulfuration misc nitric oxide misc hydrogen peroxide misc <i<S</i<-nitrosylation misc Microbiology Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years
authorStr	Hideo Kimura
ppnlink_with_tag_str_mv	@@773@@(DE-627)735688915
format	electronic Article
delete_txt_mv	keep
author_role	aut
collection	DOAJ
remote_str	true
callnumber-label	QR1-502
illustrated	Not Illustrated
issn	2218273X
topic_title	QR1-502 Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years hydrogen sulfide polysulfides <i<S</i<-sulfuration nitric oxide hydrogen peroxide <i<S</i<-nitrosylation
topic	misc QR1-502 misc hydrogen sulfide misc polysulfides misc <i<S</i<-sulfuration misc nitric oxide misc hydrogen peroxide misc <i<S</i<-nitrosylation misc Microbiology
topic_unstemmed	misc QR1-502 misc hydrogen sulfide misc polysulfides misc <i<S</i<-sulfuration misc nitric oxide misc hydrogen peroxide misc <i<S</i<-nitrosylation misc Microbiology
topic_browse	misc QR1-502 misc hydrogen sulfide misc polysulfides misc <i<S</i<-sulfuration misc nitric oxide misc hydrogen peroxide misc <i<S</i<-nitrosylation misc Microbiology
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Biomolecules
hierarchy_parent_id	735688915
hierarchy_top_title	Biomolecules
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)735688915 (DE-600)2701262-1
title	Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years
ctrlnum	(DE-627)DOAJ070245991 (DE-599)DOAJe790b81818d744bb86b492292282dd7e
title_full	Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years
author_sort	Hideo Kimura
journal	Biomolecules
journalStr	Biomolecules
callnumber-first-code	Q
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2021
contenttype_str_mv	txt
author_browse	Hideo Kimura
container_volume	11
class	QR1-502
format_se	Elektronische Aufsätze
author-letter	Hideo Kimura
doi_str_mv	10.3390/biom11060896
title_sort	hydrogen sulfide (h<sub<2</sub<s) and polysulfide (h<sub<2</sub<s<sub<n</sub<) signaling: the first 25 years
callnumber	QR1-502
title_auth	Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years
abstract	Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years.
abstractGer	Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years.
abstract_unstemmed	Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	6, p 896
title_short	Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years
url	https://doi.org/10.3390/biom11060896 https://doaj.org/article/e790b81818d744bb86b492292282dd7e https://www.mdpi.com/2218-273X/11/6/896 https://doaj.org/toc/2218-273X
remote_bool	true
ppnlink	735688915
callnumber-subject	QR - Microbiology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3390/biom11060896
callnumber-a	QR1-502
up_date	2024-07-03T13:47:04.247Z
_version_	1803565844926562304
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ070245991</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412174116.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230228s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/biom11060896</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ070245991</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe790b81818d744bb86b492292282dd7e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR1-502</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Hideo Kimura</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Since the first description of hydrogen sulfide (H<sub<2</sub<S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H<sub<2</sub<S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H<sub<2</sub<S in the brain, suggesting that H<sub<2</sub<S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H<sub<2</sub<S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H<sub<2</sub<S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H<sub<2</sub<S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H<sub<2</sub<S have been subsequently demonstrated. Two additional pathways for the production of H<sub<2</sub<S with 3-mercaptopyruvate sulfurtransferase (3MST) from <span style="font-variant: small-caps;"<l</span<- and <span style="font-variant: small-caps;"<d</span<-cysteine have been identified. We also discovered that hydrogen polysulfides (H<sub<2</sub<S<sub<n</sub<, n ≥ 2) are potential signaling molecules produced by 3MST. H<sub<2</sub<S<sub<n</sub< regulate the activity of ion channels and enzymes, as well as even the growth of tumors. <i<S</i<-Sulfuration (<i<S</i<-sulfhydration) proposed by Snyder is the main mechanism for H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H<sub<2</sub<S/H<sub<2</sub<S<sub<n</sub< signaling during the first 25 years.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hydrogen sulfide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">polysulfides</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<S</i<-sulfuration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">nitric oxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hydrogen peroxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<S</i<-nitrosylation</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Microbiology</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Biomolecules</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">11(2021), 6, p 896</subfield><subfield code="w">(DE-627)735688915</subfield><subfield code="w">(DE-600)2701262-1</subfield><subfield code="x">2218273X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:11</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:6, p 896</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/biom11060896</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/e790b81818d744bb86b492292282dd7e</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2218-273X/11/6/896</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2218-273X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">11</subfield><subfield code="j">2021</subfield><subfield code="e">6, p 896</subfield></datafield></record></collection>
score	7.401477

Nicht das Richtige dabei?

Schreiben Sie uns!

Hydrogen Sulfide (H<sub<2</sub<S) and Polysulfide (H<sub<2</sub<S<sub<n</sub<) Signaling: The First 25 Years

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?