Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this...
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Autor*in:	Marco Ferrari [verfasserIn] Stefano Taboni [verfasserIn] Andrea Luigi Camillo Carobbio [verfasserIn] Enzo Emanuelli [verfasserIn] Roberto Maroldi [verfasserIn] Paolo Bossi [verfasserIn] Piero Nicolai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	sinonasal cancer nasal cavity paranasal sinuses squamous cell carcinoma diagnosis staging

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 11, p 2835
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:11, p 2835

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13112835

Katalog-ID:	DOAJ070288240

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allfieldsSound	10.3390/cancers13112835 doi (DE-627)DOAJ070288240 (DE-599)DOAJc20b0cba18b54fbdb3fc46a5bc155695 DE-627 ger DE-627 rakwb eng RC254-282 Marco Ferrari verfasserin aut Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this sinonasal cancer is lacking. A narrative literature review was performed to summarize the current evidence and provide the reader with available data supporting the decision-making process in patients affected by sinonasal squamous cell carcinoma, alongside the authors’ personal opinion on the unsolved issues of this tumor. The review has highlighted several advances in molecular definition of epithelial cancers of the sinonasal tract. Surgery represents the pivot of treatment and is performed through an endoscopic transnasal approach whenever feasible. Open surgery is required for a large proportion of cases. Reconstruction of the defect follows principles of skull base and cranio-maxillo-facial reconstruction. Chemotherapy is given as neoadjuvant treatment or concomitantly to radiotherapy. Photon-based radiation therapy has a crucial role in the adjuvant setting. Particle therapy is providing promising results. Management of the neck should be planned based on the presence of clinically appreciable metastases, primary tumor extension, and need for recipient vessels. Biotherapy and immunotherapy are still underexplored therapeutical modalities. sinonasal cancer nasal cavity paranasal sinuses squamous cell carcinoma diagnosis staging Neoplasms. Tumors. Oncology. Including cancer and carcinogens Stefano Taboni verfasserin aut Andrea Luigi Camillo Carobbio verfasserin aut Enzo Emanuelli verfasserin aut Roberto Maroldi verfasserin aut Paolo Bossi verfasserin aut Piero Nicolai verfasserin aut In Cancers MDPI AG, 2010 13(2021), 11, p 2835 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:13 year:2021 number:11, p 2835 https://doi.org/10.3390/cancers13112835 kostenfrei https://doaj.org/article/c20b0cba18b54fbdb3fc46a5bc155695 kostenfrei https://www.mdpi.com/2072-6694/13/11/2835 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2021 11, p 2835
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callnumber-first	R - Medicine
author	Marco Ferrari
spellingShingle	Marco Ferrari misc RC254-282 misc sinonasal cancer misc nasal cavity misc paranasal sinuses misc squamous cell carcinoma misc diagnosis misc staging misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence
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topic_title	RC254-282 Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence sinonasal cancer nasal cavity paranasal sinuses squamous cell carcinoma diagnosis staging
topic	misc RC254-282 misc sinonasal cancer misc nasal cavity misc paranasal sinuses misc squamous cell carcinoma misc diagnosis misc staging misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc sinonasal cancer misc nasal cavity misc paranasal sinuses misc squamous cell carcinoma misc diagnosis misc staging misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title_sort	sinonasal squamous cell carcinoma, a narrative reappraisal of the current evidence
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title_auth	Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence
abstract	Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this sinonasal cancer is lacking. A narrative literature review was performed to summarize the current evidence and provide the reader with available data supporting the decision-making process in patients affected by sinonasal squamous cell carcinoma, alongside the authors’ personal opinion on the unsolved issues of this tumor. The review has highlighted several advances in molecular definition of epithelial cancers of the sinonasal tract. Surgery represents the pivot of treatment and is performed through an endoscopic transnasal approach whenever feasible. Open surgery is required for a large proportion of cases. Reconstruction of the defect follows principles of skull base and cranio-maxillo-facial reconstruction. Chemotherapy is given as neoadjuvant treatment or concomitantly to radiotherapy. Photon-based radiation therapy has a crucial role in the adjuvant setting. Particle therapy is providing promising results. Management of the neck should be planned based on the presence of clinically appreciable metastases, primary tumor extension, and need for recipient vessels. Biotherapy and immunotherapy are still underexplored therapeutical modalities.
abstractGer	Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this sinonasal cancer is lacking. A narrative literature review was performed to summarize the current evidence and provide the reader with available data supporting the decision-making process in patients affected by sinonasal squamous cell carcinoma, alongside the authors’ personal opinion on the unsolved issues of this tumor. The review has highlighted several advances in molecular definition of epithelial cancers of the sinonasal tract. Surgery represents the pivot of treatment and is performed through an endoscopic transnasal approach whenever feasible. Open surgery is required for a large proportion of cases. Reconstruction of the defect follows principles of skull base and cranio-maxillo-facial reconstruction. Chemotherapy is given as neoadjuvant treatment or concomitantly to radiotherapy. Photon-based radiation therapy has a crucial role in the adjuvant setting. Particle therapy is providing promising results. Management of the neck should be planned based on the presence of clinically appreciable metastases, primary tumor extension, and need for recipient vessels. Biotherapy and immunotherapy are still underexplored therapeutical modalities.
abstract_unstemmed	Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this sinonasal cancer is lacking. A narrative literature review was performed to summarize the current evidence and provide the reader with available data supporting the decision-making process in patients affected by sinonasal squamous cell carcinoma, alongside the authors’ personal opinion on the unsolved issues of this tumor. The review has highlighted several advances in molecular definition of epithelial cancers of the sinonasal tract. Surgery represents the pivot of treatment and is performed through an endoscopic transnasal approach whenever feasible. Open surgery is required for a large proportion of cases. Reconstruction of the defect follows principles of skull base and cranio-maxillo-facial reconstruction. Chemotherapy is given as neoadjuvant treatment or concomitantly to radiotherapy. Photon-based radiation therapy has a crucial role in the adjuvant setting. Particle therapy is providing promising results. Management of the neck should be planned based on the presence of clinically appreciable metastases, primary tumor extension, and need for recipient vessels. Biotherapy and immunotherapy are still underexplored therapeutical modalities.
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title_short	Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence
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Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

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