How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR
Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new...
Ausführliche Beschreibung
Autor*in: |
Clara García-Carro [verfasserIn] Ander Vergara [verfasserIn] Sheila Bermejo [verfasserIn] María A. Azancot [verfasserIn] Ana I. Sánchez-Fructuoso [verfasserIn] M. Dolores Sánchez de la Nieta [verfasserIn] Irene Agraz [verfasserIn] María José Soler [verfasserIn] |
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E-Artikel |
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Englisch |
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2021 |
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In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 11, p 2505 |
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Übergeordnetes Werk: |
volume:10 ; year:2021 ; number:11, p 2505 |
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DOI / URN: |
10.3390/jcm10112505 |
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Katalog-ID: |
DOAJ070289220 |
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10.3390/jcm10112505 doi (DE-627)DOAJ070289220 (DE-599)DOAJ1b46cec96c294c8db6c9527b036d58d5 DE-627 ger DE-627 rakwb eng Clara García-Carro verfasserin aut How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way. diabetic kidney disease diabetes mellitus chronic kidney disease Medicine R Ander Vergara verfasserin aut Sheila Bermejo verfasserin aut María A. Azancot verfasserin aut Ana I. Sánchez-Fructuoso verfasserin aut M. Dolores Sánchez de la Nieta verfasserin aut Irene Agraz verfasserin aut María José Soler verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 11, p 2505 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:11, p 2505 https://doi.org/10.3390/jcm10112505 kostenfrei https://doaj.org/article/1b46cec96c294c8db6c9527b036d58d5 kostenfrei https://www.mdpi.com/2077-0383/10/11/2505 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11, p 2505 |
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10.3390/jcm10112505 doi (DE-627)DOAJ070289220 (DE-599)DOAJ1b46cec96c294c8db6c9527b036d58d5 DE-627 ger DE-627 rakwb eng Clara García-Carro verfasserin aut How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way. diabetic kidney disease diabetes mellitus chronic kidney disease Medicine R Ander Vergara verfasserin aut Sheila Bermejo verfasserin aut María A. Azancot verfasserin aut Ana I. Sánchez-Fructuoso verfasserin aut M. Dolores Sánchez de la Nieta verfasserin aut Irene Agraz verfasserin aut María José Soler verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 11, p 2505 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:11, p 2505 https://doi.org/10.3390/jcm10112505 kostenfrei https://doaj.org/article/1b46cec96c294c8db6c9527b036d58d5 kostenfrei https://www.mdpi.com/2077-0383/10/11/2505 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11, p 2505 |
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10.3390/jcm10112505 doi (DE-627)DOAJ070289220 (DE-599)DOAJ1b46cec96c294c8db6c9527b036d58d5 DE-627 ger DE-627 rakwb eng Clara García-Carro verfasserin aut How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way. diabetic kidney disease diabetes mellitus chronic kidney disease Medicine R Ander Vergara verfasserin aut Sheila Bermejo verfasserin aut María A. Azancot verfasserin aut Ana I. Sánchez-Fructuoso verfasserin aut M. Dolores Sánchez de la Nieta verfasserin aut Irene Agraz verfasserin aut María José Soler verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 11, p 2505 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:11, p 2505 https://doi.org/10.3390/jcm10112505 kostenfrei https://doaj.org/article/1b46cec96c294c8db6c9527b036d58d5 kostenfrei https://www.mdpi.com/2077-0383/10/11/2505 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11, p 2505 |
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10.3390/jcm10112505 doi (DE-627)DOAJ070289220 (DE-599)DOAJ1b46cec96c294c8db6c9527b036d58d5 DE-627 ger DE-627 rakwb eng Clara García-Carro verfasserin aut How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way. diabetic kidney disease diabetes mellitus chronic kidney disease Medicine R Ander Vergara verfasserin aut Sheila Bermejo verfasserin aut María A. Azancot verfasserin aut Ana I. Sánchez-Fructuoso verfasserin aut M. Dolores Sánchez de la Nieta verfasserin aut Irene Agraz verfasserin aut María José Soler verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 11, p 2505 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:11, p 2505 https://doi.org/10.3390/jcm10112505 kostenfrei https://doaj.org/article/1b46cec96c294c8db6c9527b036d58d5 kostenfrei https://www.mdpi.com/2077-0383/10/11/2505 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11, p 2505 |
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10.3390/jcm10112505 doi (DE-627)DOAJ070289220 (DE-599)DOAJ1b46cec96c294c8db6c9527b036d58d5 DE-627 ger DE-627 rakwb eng Clara García-Carro verfasserin aut How to Assess Diabetic Kidney Disease Progression? From Albuminuria to GFR 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way. diabetic kidney disease diabetes mellitus chronic kidney disease Medicine R Ander Vergara verfasserin aut Sheila Bermejo verfasserin aut María A. Azancot verfasserin aut Ana I. Sánchez-Fructuoso verfasserin aut M. Dolores Sánchez de la Nieta verfasserin aut Irene Agraz verfasserin aut María José Soler verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 11, p 2505 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:11, p 2505 https://doi.org/10.3390/jcm10112505 kostenfrei https://doaj.org/article/1b46cec96c294c8db6c9527b036d58d5 kostenfrei https://www.mdpi.com/2077-0383/10/11/2505 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 11, p 2505 |
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Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way. |
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Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way. |
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Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes and dramatically increases the cardiovascular risk in these patients. Currently, DKD is severely infra-diagnosed, or its diagnosis is usually made at advanced stages of the disease. During the last decade, new drugs have demonstrated a beneficial effect in terms of cardiovascular and renal protection in type 2 diabetes, supporting the crucial role of an early DKD diagnosis to permit the use of new available therapeutic strategies. Moreover, cardiovascular and renal outcome trials, developed to study these new drugs, are based on diverse cardiovascular and renal simple and composite endpoints, which makes difficult their interpretation and the comparison between them. In this article, DKD diagnosis is reviewed, focusing on albuminuria and the recommendations for glomerular filtration rate measurement. Furthermore, cardiovascular and renal endpoints used in classical and recent cardiovascular outcome trials are assessed in a pragmatic way. |
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