Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance

Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABLO during virus infection (VSV-S). Endogenous Smac in HeLa cel...
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Gespeichert in:

Autor*in:	Weike Li [verfasserIn] Ravi Chakra Turaga [verfasserIn] Xin Li [verfasserIn] Malvika Sharma [verfasserIn] Zahra Enadi [verfasserIn] Sydney Nicole Dunham Tompkins [verfasserIn] Kyle Christian Hardy [verfasserIn] Falguni Mishra [verfasserIn] Jun Tsao [verfasserIn] Zhi-ren Liu [verfasserIn] Daping Fan [verfasserIn] Ming Luo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Molecular Therapy: Oncolytics - Elsevier, 2016, 14(2019), Seite 188-195
Übergeordnetes Werk:	volume:14 ; year:2019 ; pages:188-195

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.omto.2019.05.006

Katalog-ID:	DOAJ070572151

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spelling	10.1016/j.omto.2019.05.006 doi (DE-627)DOAJ070572151 (DE-599)DOAJ01e6204ec62e4f168d3f98b030c1a988 DE-627 ger DE-627 rakwb eng RC254-282 Weike Li verfasserin aut Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABLO during virus infection (VSV-S). Endogenous Smac in HeLa cells was diminished during wtVSV infection, whereas the Smac level was enhanced during VSV-S infection. Apoptosis was readily induced by VSV-S, but not wtVSV, infection. More importantly, the tumor volume was reduced to a larger extent when xenografts of 4T1 cells in BALB/c mice and OV-resistant T-47D cells in nude mice were intratumorally injected with VSV-S. VSV-S represents a novel mechanism to overcome tumor resistance, resulting in more significant tumor regression due to enhanced apoptosis. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ravi Chakra Turaga verfasserin aut Xin Li verfasserin aut Malvika Sharma verfasserin aut Zahra Enadi verfasserin aut Sydney Nicole Dunham Tompkins verfasserin aut Kyle Christian Hardy verfasserin aut Falguni Mishra verfasserin aut Jun Tsao verfasserin aut Zhi-ren Liu verfasserin aut Daping Fan verfasserin aut Ming Luo verfasserin aut In Molecular Therapy: Oncolytics Elsevier, 2016 14(2019), Seite 188-195 (DE-627)843857420 (DE-600)2842549-2 23727705 nnns volume:14 year:2019 pages:188-195 https://doi.org/10.1016/j.omto.2019.05.006 kostenfrei https://doaj.org/article/01e6204ec62e4f168d3f98b030c1a988 kostenfrei http://www.sciencedirect.com/science/article/pii/S2372770519300622 kostenfrei https://doaj.org/toc/2372-7705 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 188-195
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allfieldsSound	10.1016/j.omto.2019.05.006 doi (DE-627)DOAJ070572151 (DE-599)DOAJ01e6204ec62e4f168d3f98b030c1a988 DE-627 ger DE-627 rakwb eng RC254-282 Weike Li verfasserin aut Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABLO during virus infection (VSV-S). Endogenous Smac in HeLa cells was diminished during wtVSV infection, whereas the Smac level was enhanced during VSV-S infection. Apoptosis was readily induced by VSV-S, but not wtVSV, infection. More importantly, the tumor volume was reduced to a larger extent when xenografts of 4T1 cells in BALB/c mice and OV-resistant T-47D cells in nude mice were intratumorally injected with VSV-S. VSV-S represents a novel mechanism to overcome tumor resistance, resulting in more significant tumor regression due to enhanced apoptosis. Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ravi Chakra Turaga verfasserin aut Xin Li verfasserin aut Malvika Sharma verfasserin aut Zahra Enadi verfasserin aut Sydney Nicole Dunham Tompkins verfasserin aut Kyle Christian Hardy verfasserin aut Falguni Mishra verfasserin aut Jun Tsao verfasserin aut Zhi-ren Liu verfasserin aut Daping Fan verfasserin aut Ming Luo verfasserin aut In Molecular Therapy: Oncolytics Elsevier, 2016 14(2019), Seite 188-195 (DE-627)843857420 (DE-600)2842549-2 23727705 nnns volume:14 year:2019 pages:188-195 https://doi.org/10.1016/j.omto.2019.05.006 kostenfrei https://doaj.org/article/01e6204ec62e4f168d3f98b030c1a988 kostenfrei http://www.sciencedirect.com/science/article/pii/S2372770519300622 kostenfrei https://doaj.org/toc/2372-7705 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 188-195
language	English
source	In Molecular Therapy: Oncolytics 14(2019), Seite 188-195 volume:14 year:2019 pages:188-195
sourceStr	In Molecular Therapy: Oncolytics 14(2019), Seite 188-195 volume:14 year:2019 pages:188-195
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Molecular Therapy: Oncolytics
authorswithroles_txt_mv	Weike Li @@aut@@ Ravi Chakra Turaga @@aut@@ Xin Li @@aut@@ Malvika Sharma @@aut@@ Zahra Enadi @@aut@@ Sydney Nicole Dunham Tompkins @@aut@@ Kyle Christian Hardy @@aut@@ Falguni Mishra @@aut@@ Jun Tsao @@aut@@ Zhi-ren Liu @@aut@@ Daping Fan @@aut@@ Ming Luo @@aut@@
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callnumber-first	R - Medicine
author	Weike Li
spellingShingle	Weike Li misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance
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topic_title	RC254-282 Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance
topic	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance
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title_full	Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance
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title_sort	overexpression of smac by an armed vesicular stomatitis virus overcomes tumor resistance
callnumber	RC254-282
title_auth	Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance
abstract	Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABLO during virus infection (VSV-S). Endogenous Smac in HeLa cells was diminished during wtVSV infection, whereas the Smac level was enhanced during VSV-S infection. Apoptosis was readily induced by VSV-S, but not wtVSV, infection. More importantly, the tumor volume was reduced to a larger extent when xenografts of 4T1 cells in BALB/c mice and OV-resistant T-47D cells in nude mice were intratumorally injected with VSV-S. VSV-S represents a novel mechanism to overcome tumor resistance, resulting in more significant tumor regression due to enhanced apoptosis.
abstractGer	Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABLO during virus infection (VSV-S). Endogenous Smac in HeLa cells was diminished during wtVSV infection, whereas the Smac level was enhanced during VSV-S infection. Apoptosis was readily induced by VSV-S, but not wtVSV, infection. More importantly, the tumor volume was reduced to a larger extent when xenografts of 4T1 cells in BALB/c mice and OV-resistant T-47D cells in nude mice were intratumorally injected with VSV-S. VSV-S represents a novel mechanism to overcome tumor resistance, resulting in more significant tumor regression due to enhanced apoptosis.
abstract_unstemmed	Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABLO during virus infection (VSV-S). Endogenous Smac in HeLa cells was diminished during wtVSV infection, whereas the Smac level was enhanced during VSV-S infection. Apoptosis was readily induced by VSV-S, but not wtVSV, infection. More importantly, the tumor volume was reduced to a larger extent when xenografts of 4T1 cells in BALB/c mice and OV-resistant T-47D cells in nude mice were intratumorally injected with VSV-S. VSV-S represents a novel mechanism to overcome tumor resistance, resulting in more significant tumor regression due to enhanced apoptosis.
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title_short	Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance
url	https://doi.org/10.1016/j.omto.2019.05.006 https://doaj.org/article/01e6204ec62e4f168d3f98b030c1a988 http://www.sciencedirect.com/science/article/pii/S2372770519300622 https://doaj.org/toc/2372-7705
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up_date	2024-07-03T15:31:54.970Z
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