Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network
Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greate...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Andrew Filer [verfasserIn] Michael H Weisman [verfasserIn] Judith A James [verfasserIn] Kenneth Kalunian [verfasserIn] Michelle A Petri [verfasserIn] Chaim Putterman [verfasserIn] H Michael Belmont [verfasserIn] Ilfita Sahbudin [verfasserIn] Karim Raza [verfasserIn] Maria Dall'Era [verfasserIn] Jill P Buyon [verfasserIn] Diane L Kamen [verfasserIn] Karen Salomon-Escoto [verfasserIn] Kazuyoshi Ishigaki [verfasserIn] Patrick Dunn [verfasserIn] David Wofsy [verfasserIn] Michele Bombardieri [verfasserIn] Vivian Bykerk [verfasserIn] Myles Lewis [verfasserIn] Ming Wu [verfasserIn] Soumya Raychaudhuri [verfasserIn] Hemant Suryawanshi [verfasserIn] Thomas Tuschl [verfasserIn] Christopher Ritchlin [verfasserIn] Maureen McMahon [verfasserIn] Jennifer Grossman [verfasserIn] Philip M Carlucci [verfasserIn] Alessandra Nerviani [verfasserIn] Peter M Izmirly [verfasserIn] Fan Zhang [verfasserIn] Felice Rivellese [verfasserIn] Joan Bathon [verfasserIn] Zhu Zhu [verfasserIn] Qian Xiao [verfasserIn] Jessica Li [verfasserIn] Holden Maecker [verfasserIn] Nir Hacohen [verfasserIn] Rong Mao [verfasserIn] Jennifer Anolik [verfasserIn] Javier Rangel-Moreno [verfasserIn] Nida Meednu [verfasserIn] Susan Goodman [verfasserIn] Lindsy Forbess [verfasserIn] Mariko Ishimori [verfasserIn] Kevin Deane [verfasserIn] David Hildeman [verfasserIn] Yuhong Li [verfasserIn] Laura Hughes [verfasserIn] Robert Clancy [verfasserIn] ANNE DAVIDSON [verfasserIn] Matthias Kretzler [verfasserIn] Larry Moreland [verfasserIn] Harris Perlman [verfasserIn] Peter Gregersen [verfasserIn] Celine C Berthier [verfasserIn] Andrea Fava [verfasserIn] David Boyle [verfasserIn] Derek M Fine [verfasserIn] Ami Ben-Artzi [verfasserIn] P J Utz [verfasserIn] Melanie Smith [verfasserIn] Beatrice Goilav [verfasserIn] Carla Cuda [verfasserIn] Andrew McDavid [verfasserIn] Deepak A Rao [verfasserIn] Joshua Keegan [verfasserIn] Ilya Korsunsky [verfasserIn] Joel Guthridge [verfasserIn] Kevin Wei [verfasserIn] Arnon Arazi [verfasserIn] Thomas Eisenhaure [verfasserIn] Michael Brenner [verfasserIn] Susan Macwana [verfasserIn] Pavel Morozov [verfasserIn] Manjunath Kustagi [verfasserIn] Gerald Watts [verfasserIn] Kristina K Deonaraine [verfasserIn] Jose Monroy-Trujillo [verfasserIn] Mohamed G Atta [verfasserIn] Kristin Haag [verfasserIn] William Apruzzese [verfasserIn] Sean Connery [verfasserIn] Fernanda Payan-Schober [verfasserIn] Kerry Cho [verfasserIn] Jennifer Goff [verfasserIn] Aparna Nathan [verfasserIn] Joseph Mears [verfasserIn] Nghia Millard [verfasserIn] Kathryn Weinand [verfasserIn] Saori Sakaue [verfasserIn] Bill Robinson [verfasserIn] Wade DeJager [verfasserIn] Louis Bridges [verfasserIn] Laura Donlin [verfasserIn] Edward DiCarlo [verfasserIn] Amit Lakhanpal [verfasserIn] Heather Sherman [verfasserIn] Anvita Singaraju [verfasserIn] Lorien Shakib [verfasserIn] Brendan Boyce [verfasserIn] Darren Tabechian [verfasserIn] Jen Albrecht [verfasserIn] James Lederer [verfasserIn] A Helena Jonsson [verfasserIn] Daimon Simmons [verfasserIn] Gregory Keras [verfasserIn] Adam Chicoine [verfasserIn] Zhihan Jian Li [verfasserIn] Mandy McGeachy [verfasserIn] Gary Firestein [verfasserIn] Arnold Ceponis [verfasserIn] Diane Horowitz [verfasserIn] Salina Dominguez [verfasserIn] Arthur Mandelin [verfasserIn] Anjali Thakrar [verfasserIn] Mike Holers [verfasserIn] Jennifer Seifert [verfasserIn] Constanino Pitzalis [verfasserIn] Ellen Gravallese [verfasserIn] Jennifer Barnas [verfasserIn] Raymond Hsu [verfasserIn] Steven Woodle [verfasserIn] Paul Hoover [verfasserIn] Michael Peters [verfasserIn] Tony Jones [verfasserIn] David Lieb [verfasserIn] Jeffrey Hodgin [verfasserIn] Raji Menon [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Übergeordnetes Werk: |
In: Lupus Science and Medicine - BMJ Publishing Group, 2015, 8(2021), 1 |
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| Übergeordnetes Werk: |
volume:8 ; year:2021 ; number:1 |
| Links: |
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| DOI / URN: |
10.1136/lupus-2021-000522 |
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| Katalog-ID: |
DOAJ070572542 |
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| 245 | 1 | 0 | |a Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network |
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| 520 | |a Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. | ||
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| 700 | 0 | |a Ming Wu |e verfasserin |4 aut | |
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| 700 | 0 | |a Javier Rangel-Moreno |e verfasserin |4 aut | |
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10.1136/lupus-2021-000522 doi (DE-627)DOAJ070572542 (DE-599)DOAJe3722c73b6ce45bba6e56c13af3b5745 DE-627 ger DE-627 rakwb eng RC581-607 Andrew Filer verfasserin aut Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. Immunologic diseases. Allergy Michael H Weisman verfasserin aut Judith A James verfasserin aut Kenneth Kalunian verfasserin aut Michelle A Petri verfasserin aut Chaim Putterman verfasserin aut H Michael Belmont verfasserin aut Ilfita Sahbudin verfasserin aut Karim Raza verfasserin aut Maria Dall'Era verfasserin aut Jill P Buyon verfasserin aut Diane L Kamen verfasserin aut Karen Salomon-Escoto verfasserin aut Kazuyoshi Ishigaki verfasserin aut Patrick Dunn verfasserin aut David Wofsy verfasserin aut Michele Bombardieri verfasserin aut Vivian Bykerk verfasserin aut Myles Lewis verfasserin aut Ming Wu verfasserin aut Soumya Raychaudhuri verfasserin aut Hemant Suryawanshi verfasserin aut Thomas Tuschl verfasserin aut Christopher Ritchlin verfasserin aut Maureen McMahon verfasserin aut Jennifer Grossman verfasserin aut Philip M Carlucci verfasserin aut Alessandra Nerviani verfasserin aut Peter M Izmirly verfasserin aut Fan Zhang verfasserin aut Felice Rivellese verfasserin aut Joan Bathon verfasserin aut Zhu Zhu verfasserin aut Qian Xiao verfasserin aut Jessica Li verfasserin aut Holden Maecker verfasserin aut Nir Hacohen verfasserin aut Rong Mao verfasserin aut Jennifer Anolik verfasserin aut Javier Rangel-Moreno verfasserin aut Nida Meednu verfasserin aut Susan Goodman verfasserin aut Lindsy Forbess verfasserin aut Mariko Ishimori verfasserin aut Kevin Deane verfasserin aut David Hildeman verfasserin aut Yuhong Li verfasserin aut Laura Hughes verfasserin aut Robert Clancy verfasserin aut ANNE DAVIDSON verfasserin aut Matthias Kretzler verfasserin aut Larry Moreland verfasserin aut Harris Perlman verfasserin aut Peter Gregersen verfasserin aut Celine C Berthier verfasserin aut Andrea Fava verfasserin aut David Boyle verfasserin aut Derek M Fine verfasserin aut Ami Ben-Artzi verfasserin aut P J Utz verfasserin aut Melanie Smith verfasserin aut Beatrice Goilav verfasserin aut Carla Cuda verfasserin aut Andrew McDavid verfasserin aut Deepak A Rao verfasserin aut Joshua Keegan verfasserin aut Ilya Korsunsky verfasserin aut Joel Guthridge verfasserin aut Kevin Wei verfasserin aut Arnon Arazi verfasserin aut Thomas Eisenhaure verfasserin aut Michael Brenner verfasserin aut Susan Macwana verfasserin aut Pavel Morozov verfasserin aut Manjunath Kustagi verfasserin aut Gerald Watts verfasserin aut Kristina K Deonaraine verfasserin aut Jose Monroy-Trujillo verfasserin aut Mohamed G Atta verfasserin aut Kristin Haag verfasserin aut William Apruzzese verfasserin aut Sean Connery verfasserin aut Fernanda Payan-Schober verfasserin aut Kerry Cho verfasserin aut Jennifer Goff verfasserin aut Aparna Nathan verfasserin aut Joseph Mears verfasserin aut Nghia Millard verfasserin aut Kathryn Weinand verfasserin aut Saori Sakaue verfasserin aut Bill Robinson verfasserin aut Wade DeJager verfasserin aut Louis Bridges verfasserin aut Laura Donlin verfasserin aut Edward DiCarlo verfasserin aut Amit Lakhanpal verfasserin aut Heather Sherman verfasserin aut Anvita Singaraju verfasserin aut Lorien Shakib verfasserin aut Brendan Boyce verfasserin aut Darren Tabechian verfasserin aut Jen Albrecht verfasserin aut James Lederer verfasserin aut A Helena Jonsson verfasserin aut Daimon Simmons verfasserin aut Gregory Keras verfasserin aut Adam Chicoine verfasserin aut Zhihan Jian Li verfasserin aut Mandy McGeachy verfasserin aut Gary Firestein verfasserin aut Arnold Ceponis verfasserin aut Diane Horowitz verfasserin aut Salina Dominguez verfasserin aut Arthur Mandelin verfasserin aut Anjali Thakrar verfasserin aut Mike Holers verfasserin aut Jennifer Seifert verfasserin aut Constanino Pitzalis verfasserin aut Ellen Gravallese verfasserin aut Jennifer Barnas verfasserin aut Raymond Hsu verfasserin aut Steven Woodle verfasserin aut Paul Hoover verfasserin aut Michael Peters verfasserin aut Tony Jones verfasserin aut David Lieb verfasserin aut Jeffrey Hodgin verfasserin aut Raji Menon verfasserin aut In Lupus Science and Medicine BMJ Publishing Group, 2015 8(2021), 1 (DE-627)792128222 (DE-600)2779620-6 20538790 nnns volume:8 year:2021 number:1 https://doi.org/10.1136/lupus-2021-000522 kostenfrei https://doaj.org/article/e3722c73b6ce45bba6e56c13af3b5745 kostenfrei https://lupus.bmj.com/content/8/1/e000522.full kostenfrei https://doaj.org/toc/2053-8790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 |
| spelling |
10.1136/lupus-2021-000522 doi (DE-627)DOAJ070572542 (DE-599)DOAJe3722c73b6ce45bba6e56c13af3b5745 DE-627 ger DE-627 rakwb eng RC581-607 Andrew Filer verfasserin aut Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. Immunologic diseases. Allergy Michael H Weisman verfasserin aut Judith A James verfasserin aut Kenneth Kalunian verfasserin aut Michelle A Petri verfasserin aut Chaim Putterman verfasserin aut H Michael Belmont verfasserin aut Ilfita Sahbudin verfasserin aut Karim Raza verfasserin aut Maria Dall'Era verfasserin aut Jill P Buyon verfasserin aut Diane L Kamen verfasserin aut Karen Salomon-Escoto verfasserin aut Kazuyoshi Ishigaki verfasserin aut Patrick Dunn verfasserin aut David Wofsy verfasserin aut Michele Bombardieri verfasserin aut Vivian Bykerk verfasserin aut Myles Lewis verfasserin aut Ming Wu verfasserin aut Soumya Raychaudhuri verfasserin aut Hemant Suryawanshi verfasserin aut Thomas Tuschl verfasserin aut Christopher Ritchlin verfasserin aut Maureen McMahon verfasserin aut Jennifer Grossman verfasserin aut Philip M Carlucci verfasserin aut Alessandra Nerviani verfasserin aut Peter M Izmirly verfasserin aut Fan Zhang verfasserin aut Felice Rivellese verfasserin aut Joan Bathon verfasserin aut Zhu Zhu verfasserin aut Qian Xiao verfasserin aut Jessica Li verfasserin aut Holden Maecker verfasserin aut Nir Hacohen verfasserin aut Rong Mao verfasserin aut Jennifer Anolik verfasserin aut Javier Rangel-Moreno verfasserin aut Nida Meednu verfasserin aut Susan Goodman verfasserin aut Lindsy Forbess verfasserin aut Mariko Ishimori verfasserin aut Kevin Deane verfasserin aut David Hildeman verfasserin aut Yuhong Li verfasserin aut Laura Hughes verfasserin aut Robert Clancy verfasserin aut ANNE DAVIDSON verfasserin aut Matthias Kretzler verfasserin aut Larry Moreland verfasserin aut Harris Perlman verfasserin aut Peter Gregersen verfasserin aut Celine C Berthier verfasserin aut Andrea Fava verfasserin aut David Boyle verfasserin aut Derek M Fine verfasserin aut Ami Ben-Artzi verfasserin aut P J Utz verfasserin aut Melanie Smith verfasserin aut Beatrice Goilav verfasserin aut Carla Cuda verfasserin aut Andrew McDavid verfasserin aut Deepak A Rao verfasserin aut Joshua Keegan verfasserin aut Ilya Korsunsky verfasserin aut Joel Guthridge verfasserin aut Kevin Wei verfasserin aut Arnon Arazi verfasserin aut Thomas Eisenhaure verfasserin aut Michael Brenner verfasserin aut Susan Macwana verfasserin aut Pavel Morozov verfasserin aut Manjunath Kustagi verfasserin aut Gerald Watts verfasserin aut Kristina K Deonaraine verfasserin aut Jose Monroy-Trujillo verfasserin aut Mohamed G Atta verfasserin aut Kristin Haag verfasserin aut William Apruzzese verfasserin aut Sean Connery verfasserin aut Fernanda Payan-Schober verfasserin aut Kerry Cho verfasserin aut Jennifer Goff verfasserin aut Aparna Nathan verfasserin aut Joseph Mears verfasserin aut Nghia Millard verfasserin aut Kathryn Weinand verfasserin aut Saori Sakaue verfasserin aut Bill Robinson verfasserin aut Wade DeJager verfasserin aut Louis Bridges verfasserin aut Laura Donlin verfasserin aut Edward DiCarlo verfasserin aut Amit Lakhanpal verfasserin aut Heather Sherman verfasserin aut Anvita Singaraju verfasserin aut Lorien Shakib verfasserin aut Brendan Boyce verfasserin aut Darren Tabechian verfasserin aut Jen Albrecht verfasserin aut James Lederer verfasserin aut A Helena Jonsson verfasserin aut Daimon Simmons verfasserin aut Gregory Keras verfasserin aut Adam Chicoine verfasserin aut Zhihan Jian Li verfasserin aut Mandy McGeachy verfasserin aut Gary Firestein verfasserin aut Arnold Ceponis verfasserin aut Diane Horowitz verfasserin aut Salina Dominguez verfasserin aut Arthur Mandelin verfasserin aut Anjali Thakrar verfasserin aut Mike Holers verfasserin aut Jennifer Seifert verfasserin aut Constanino Pitzalis verfasserin aut Ellen Gravallese verfasserin aut Jennifer Barnas verfasserin aut Raymond Hsu verfasserin aut Steven Woodle verfasserin aut Paul Hoover verfasserin aut Michael Peters verfasserin aut Tony Jones verfasserin aut David Lieb verfasserin aut Jeffrey Hodgin verfasserin aut Raji Menon verfasserin aut In Lupus Science and Medicine BMJ Publishing Group, 2015 8(2021), 1 (DE-627)792128222 (DE-600)2779620-6 20538790 nnns volume:8 year:2021 number:1 https://doi.org/10.1136/lupus-2021-000522 kostenfrei https://doaj.org/article/e3722c73b6ce45bba6e56c13af3b5745 kostenfrei https://lupus.bmj.com/content/8/1/e000522.full kostenfrei https://doaj.org/toc/2053-8790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 |
| allfields_unstemmed |
10.1136/lupus-2021-000522 doi (DE-627)DOAJ070572542 (DE-599)DOAJe3722c73b6ce45bba6e56c13af3b5745 DE-627 ger DE-627 rakwb eng RC581-607 Andrew Filer verfasserin aut Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. Immunologic diseases. Allergy Michael H Weisman verfasserin aut Judith A James verfasserin aut Kenneth Kalunian verfasserin aut Michelle A Petri verfasserin aut Chaim Putterman verfasserin aut H Michael Belmont verfasserin aut Ilfita Sahbudin verfasserin aut Karim Raza verfasserin aut Maria Dall'Era verfasserin aut Jill P Buyon verfasserin aut Diane L Kamen verfasserin aut Karen Salomon-Escoto verfasserin aut Kazuyoshi Ishigaki verfasserin aut Patrick Dunn verfasserin aut David Wofsy verfasserin aut Michele Bombardieri verfasserin aut Vivian Bykerk verfasserin aut Myles Lewis verfasserin aut Ming Wu verfasserin aut Soumya Raychaudhuri verfasserin aut Hemant Suryawanshi verfasserin aut Thomas Tuschl verfasserin aut Christopher Ritchlin verfasserin aut Maureen McMahon verfasserin aut Jennifer Grossman verfasserin aut Philip M Carlucci verfasserin aut Alessandra Nerviani verfasserin aut Peter M Izmirly verfasserin aut Fan Zhang verfasserin aut Felice Rivellese verfasserin aut Joan Bathon verfasserin aut Zhu Zhu verfasserin aut Qian Xiao verfasserin aut Jessica Li verfasserin aut Holden Maecker verfasserin aut Nir Hacohen verfasserin aut Rong Mao verfasserin aut Jennifer Anolik verfasserin aut Javier Rangel-Moreno verfasserin aut Nida Meednu verfasserin aut Susan Goodman verfasserin aut Lindsy Forbess verfasserin aut Mariko Ishimori verfasserin aut Kevin Deane verfasserin aut David Hildeman verfasserin aut Yuhong Li verfasserin aut Laura Hughes verfasserin aut Robert Clancy verfasserin aut ANNE DAVIDSON verfasserin aut Matthias Kretzler verfasserin aut Larry Moreland verfasserin aut Harris Perlman verfasserin aut Peter Gregersen verfasserin aut Celine C Berthier verfasserin aut Andrea Fava verfasserin aut David Boyle verfasserin aut Derek M Fine verfasserin aut Ami Ben-Artzi verfasserin aut P J Utz verfasserin aut Melanie Smith verfasserin aut Beatrice Goilav verfasserin aut Carla Cuda verfasserin aut Andrew McDavid verfasserin aut Deepak A Rao verfasserin aut Joshua Keegan verfasserin aut Ilya Korsunsky verfasserin aut Joel Guthridge verfasserin aut Kevin Wei verfasserin aut Arnon Arazi verfasserin aut Thomas Eisenhaure verfasserin aut Michael Brenner verfasserin aut Susan Macwana verfasserin aut Pavel Morozov verfasserin aut Manjunath Kustagi verfasserin aut Gerald Watts verfasserin aut Kristina K Deonaraine verfasserin aut Jose Monroy-Trujillo verfasserin aut Mohamed G Atta verfasserin aut Kristin Haag verfasserin aut William Apruzzese verfasserin aut Sean Connery verfasserin aut Fernanda Payan-Schober verfasserin aut Kerry Cho verfasserin aut Jennifer Goff verfasserin aut Aparna Nathan verfasserin aut Joseph Mears verfasserin aut Nghia Millard verfasserin aut Kathryn Weinand verfasserin aut Saori Sakaue verfasserin aut Bill Robinson verfasserin aut Wade DeJager verfasserin aut Louis Bridges verfasserin aut Laura Donlin verfasserin aut Edward DiCarlo verfasserin aut Amit Lakhanpal verfasserin aut Heather Sherman verfasserin aut Anvita Singaraju verfasserin aut Lorien Shakib verfasserin aut Brendan Boyce verfasserin aut Darren Tabechian verfasserin aut Jen Albrecht verfasserin aut James Lederer verfasserin aut A Helena Jonsson verfasserin aut Daimon Simmons verfasserin aut Gregory Keras verfasserin aut Adam Chicoine verfasserin aut Zhihan Jian Li verfasserin aut Mandy McGeachy verfasserin aut Gary Firestein verfasserin aut Arnold Ceponis verfasserin aut Diane Horowitz verfasserin aut Salina Dominguez verfasserin aut Arthur Mandelin verfasserin aut Anjali Thakrar verfasserin aut Mike Holers verfasserin aut Jennifer Seifert verfasserin aut Constanino Pitzalis verfasserin aut Ellen Gravallese verfasserin aut Jennifer Barnas verfasserin aut Raymond Hsu verfasserin aut Steven Woodle verfasserin aut Paul Hoover verfasserin aut Michael Peters verfasserin aut Tony Jones verfasserin aut David Lieb verfasserin aut Jeffrey Hodgin verfasserin aut Raji Menon verfasserin aut In Lupus Science and Medicine BMJ Publishing Group, 2015 8(2021), 1 (DE-627)792128222 (DE-600)2779620-6 20538790 nnns volume:8 year:2021 number:1 https://doi.org/10.1136/lupus-2021-000522 kostenfrei https://doaj.org/article/e3722c73b6ce45bba6e56c13af3b5745 kostenfrei https://lupus.bmj.com/content/8/1/e000522.full kostenfrei https://doaj.org/toc/2053-8790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 |
| allfieldsGer |
10.1136/lupus-2021-000522 doi (DE-627)DOAJ070572542 (DE-599)DOAJe3722c73b6ce45bba6e56c13af3b5745 DE-627 ger DE-627 rakwb eng RC581-607 Andrew Filer verfasserin aut Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. Immunologic diseases. Allergy Michael H Weisman verfasserin aut Judith A James verfasserin aut Kenneth Kalunian verfasserin aut Michelle A Petri verfasserin aut Chaim Putterman verfasserin aut H Michael Belmont verfasserin aut Ilfita Sahbudin verfasserin aut Karim Raza verfasserin aut Maria Dall'Era verfasserin aut Jill P Buyon verfasserin aut Diane L Kamen verfasserin aut Karen Salomon-Escoto verfasserin aut Kazuyoshi Ishigaki verfasserin aut Patrick Dunn verfasserin aut David Wofsy verfasserin aut Michele Bombardieri verfasserin aut Vivian Bykerk verfasserin aut Myles Lewis verfasserin aut Ming Wu verfasserin aut Soumya Raychaudhuri verfasserin aut Hemant Suryawanshi verfasserin aut Thomas Tuschl verfasserin aut Christopher Ritchlin verfasserin aut Maureen McMahon verfasserin aut Jennifer Grossman verfasserin aut Philip M Carlucci verfasserin aut Alessandra Nerviani verfasserin aut Peter M Izmirly verfasserin aut Fan Zhang verfasserin aut Felice Rivellese verfasserin aut Joan Bathon verfasserin aut Zhu Zhu verfasserin aut Qian Xiao verfasserin aut Jessica Li verfasserin aut Holden Maecker verfasserin aut Nir Hacohen verfasserin aut Rong Mao verfasserin aut Jennifer Anolik verfasserin aut Javier Rangel-Moreno verfasserin aut Nida Meednu verfasserin aut Susan Goodman verfasserin aut Lindsy Forbess verfasserin aut Mariko Ishimori verfasserin aut Kevin Deane verfasserin aut David Hildeman verfasserin aut Yuhong Li verfasserin aut Laura Hughes verfasserin aut Robert Clancy verfasserin aut ANNE DAVIDSON verfasserin aut Matthias Kretzler verfasserin aut Larry Moreland verfasserin aut Harris Perlman verfasserin aut Peter Gregersen verfasserin aut Celine C Berthier verfasserin aut Andrea Fava verfasserin aut David Boyle verfasserin aut Derek M Fine verfasserin aut Ami Ben-Artzi verfasserin aut P J Utz verfasserin aut Melanie Smith verfasserin aut Beatrice Goilav verfasserin aut Carla Cuda verfasserin aut Andrew McDavid verfasserin aut Deepak A Rao verfasserin aut Joshua Keegan verfasserin aut Ilya Korsunsky verfasserin aut Joel Guthridge verfasserin aut Kevin Wei verfasserin aut Arnon Arazi verfasserin aut Thomas Eisenhaure verfasserin aut Michael Brenner verfasserin aut Susan Macwana verfasserin aut Pavel Morozov verfasserin aut Manjunath Kustagi verfasserin aut Gerald Watts verfasserin aut Kristina K Deonaraine verfasserin aut Jose Monroy-Trujillo verfasserin aut Mohamed G Atta verfasserin aut Kristin Haag verfasserin aut William Apruzzese verfasserin aut Sean Connery verfasserin aut Fernanda Payan-Schober verfasserin aut Kerry Cho verfasserin aut Jennifer Goff verfasserin aut Aparna Nathan verfasserin aut Joseph Mears verfasserin aut Nghia Millard verfasserin aut Kathryn Weinand verfasserin aut Saori Sakaue verfasserin aut Bill Robinson verfasserin aut Wade DeJager verfasserin aut Louis Bridges verfasserin aut Laura Donlin verfasserin aut Edward DiCarlo verfasserin aut Amit Lakhanpal verfasserin aut Heather Sherman verfasserin aut Anvita Singaraju verfasserin aut Lorien Shakib verfasserin aut Brendan Boyce verfasserin aut Darren Tabechian verfasserin aut Jen Albrecht verfasserin aut James Lederer verfasserin aut A Helena Jonsson verfasserin aut Daimon Simmons verfasserin aut Gregory Keras verfasserin aut Adam Chicoine verfasserin aut Zhihan Jian Li verfasserin aut Mandy McGeachy verfasserin aut Gary Firestein verfasserin aut Arnold Ceponis verfasserin aut Diane Horowitz verfasserin aut Salina Dominguez verfasserin aut Arthur Mandelin verfasserin aut Anjali Thakrar verfasserin aut Mike Holers verfasserin aut Jennifer Seifert verfasserin aut Constanino Pitzalis verfasserin aut Ellen Gravallese verfasserin aut Jennifer Barnas verfasserin aut Raymond Hsu verfasserin aut Steven Woodle verfasserin aut Paul Hoover verfasserin aut Michael Peters verfasserin aut Tony Jones verfasserin aut David Lieb verfasserin aut Jeffrey Hodgin verfasserin aut Raji Menon verfasserin aut In Lupus Science and Medicine BMJ Publishing Group, 2015 8(2021), 1 (DE-627)792128222 (DE-600)2779620-6 20538790 nnns volume:8 year:2021 number:1 https://doi.org/10.1136/lupus-2021-000522 kostenfrei https://doaj.org/article/e3722c73b6ce45bba6e56c13af3b5745 kostenfrei https://lupus.bmj.com/content/8/1/e000522.full kostenfrei https://doaj.org/toc/2053-8790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 |
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10.1136/lupus-2021-000522 doi (DE-627)DOAJ070572542 (DE-599)DOAJe3722c73b6ce45bba6e56c13af3b5745 DE-627 ger DE-627 rakwb eng RC581-607 Andrew Filer verfasserin aut Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. Immunologic diseases. Allergy Michael H Weisman verfasserin aut Judith A James verfasserin aut Kenneth Kalunian verfasserin aut Michelle A Petri verfasserin aut Chaim Putterman verfasserin aut H Michael Belmont verfasserin aut Ilfita Sahbudin verfasserin aut Karim Raza verfasserin aut Maria Dall'Era verfasserin aut Jill P Buyon verfasserin aut Diane L Kamen verfasserin aut Karen Salomon-Escoto verfasserin aut Kazuyoshi Ishigaki verfasserin aut Patrick Dunn verfasserin aut David Wofsy verfasserin aut Michele Bombardieri verfasserin aut Vivian Bykerk verfasserin aut Myles Lewis verfasserin aut Ming Wu verfasserin aut Soumya Raychaudhuri verfasserin aut Hemant Suryawanshi verfasserin aut Thomas Tuschl verfasserin aut Christopher Ritchlin verfasserin aut Maureen McMahon verfasserin aut Jennifer Grossman verfasserin aut Philip M Carlucci verfasserin aut Alessandra Nerviani verfasserin aut Peter M Izmirly verfasserin aut Fan Zhang verfasserin aut Felice Rivellese verfasserin aut Joan Bathon verfasserin aut Zhu Zhu verfasserin aut Qian Xiao verfasserin aut Jessica Li verfasserin aut Holden Maecker verfasserin aut Nir Hacohen verfasserin aut Rong Mao verfasserin aut Jennifer Anolik verfasserin aut Javier Rangel-Moreno verfasserin aut Nida Meednu verfasserin aut Susan Goodman verfasserin aut Lindsy Forbess verfasserin aut Mariko Ishimori verfasserin aut Kevin Deane verfasserin aut David Hildeman verfasserin aut Yuhong Li verfasserin aut Laura Hughes verfasserin aut Robert Clancy verfasserin aut ANNE DAVIDSON verfasserin aut Matthias Kretzler verfasserin aut Larry Moreland verfasserin aut Harris Perlman verfasserin aut Peter Gregersen verfasserin aut Celine C Berthier verfasserin aut Andrea Fava verfasserin aut David Boyle verfasserin aut Derek M Fine verfasserin aut Ami Ben-Artzi verfasserin aut P J Utz verfasserin aut Melanie Smith verfasserin aut Beatrice Goilav verfasserin aut Carla Cuda verfasserin aut Andrew McDavid verfasserin aut Deepak A Rao verfasserin aut Joshua Keegan verfasserin aut Ilya Korsunsky verfasserin aut Joel Guthridge verfasserin aut Kevin Wei verfasserin aut Arnon Arazi verfasserin aut Thomas Eisenhaure verfasserin aut Michael Brenner verfasserin aut Susan Macwana verfasserin aut Pavel Morozov verfasserin aut Manjunath Kustagi verfasserin aut Gerald Watts verfasserin aut Kristina K Deonaraine verfasserin aut Jose Monroy-Trujillo verfasserin aut Mohamed G Atta verfasserin aut Kristin Haag verfasserin aut William Apruzzese verfasserin aut Sean Connery verfasserin aut Fernanda Payan-Schober verfasserin aut Kerry Cho verfasserin aut Jennifer Goff verfasserin aut Aparna Nathan verfasserin aut Joseph Mears verfasserin aut Nghia Millard verfasserin aut Kathryn Weinand verfasserin aut Saori Sakaue verfasserin aut Bill Robinson verfasserin aut Wade DeJager verfasserin aut Louis Bridges verfasserin aut Laura Donlin verfasserin aut Edward DiCarlo verfasserin aut Amit Lakhanpal verfasserin aut Heather Sherman verfasserin aut Anvita Singaraju verfasserin aut Lorien Shakib verfasserin aut Brendan Boyce verfasserin aut Darren Tabechian verfasserin aut Jen Albrecht verfasserin aut James Lederer verfasserin aut A Helena Jonsson verfasserin aut Daimon Simmons verfasserin aut Gregory Keras verfasserin aut Adam Chicoine verfasserin aut Zhihan Jian Li verfasserin aut Mandy McGeachy verfasserin aut Gary Firestein verfasserin aut Arnold Ceponis verfasserin aut Diane Horowitz verfasserin aut Salina Dominguez verfasserin aut Arthur Mandelin verfasserin aut Anjali Thakrar verfasserin aut Mike Holers verfasserin aut Jennifer Seifert verfasserin aut Constanino Pitzalis verfasserin aut Ellen Gravallese verfasserin aut Jennifer Barnas verfasserin aut Raymond Hsu verfasserin aut Steven Woodle verfasserin aut Paul Hoover verfasserin aut Michael Peters verfasserin aut Tony Jones verfasserin aut David Lieb verfasserin aut Jeffrey Hodgin verfasserin aut Raji Menon verfasserin aut In Lupus Science and Medicine BMJ Publishing Group, 2015 8(2021), 1 (DE-627)792128222 (DE-600)2779620-6 20538790 nnns volume:8 year:2021 number:1 https://doi.org/10.1136/lupus-2021-000522 kostenfrei https://doaj.org/article/e3722c73b6ce45bba6e56c13af3b5745 kostenfrei https://lupus.bmj.com/content/8/1/e000522.full kostenfrei https://doaj.org/toc/2053-8790 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2021 1 |
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Andrew Filer @@aut@@ Michael H Weisman @@aut@@ Judith A James @@aut@@ Kenneth Kalunian @@aut@@ Michelle A Petri @@aut@@ Chaim Putterman @@aut@@ H Michael Belmont @@aut@@ Ilfita Sahbudin @@aut@@ Karim Raza @@aut@@ Maria Dall'Era @@aut@@ Jill P Buyon @@aut@@ Diane L Kamen @@aut@@ Karen Salomon-Escoto @@aut@@ Kazuyoshi Ishigaki @@aut@@ Patrick Dunn @@aut@@ David Wofsy @@aut@@ Michele Bombardieri @@aut@@ Vivian Bykerk @@aut@@ Myles Lewis @@aut@@ Ming Wu @@aut@@ Soumya Raychaudhuri @@aut@@ Hemant Suryawanshi @@aut@@ Thomas Tuschl @@aut@@ Christopher Ritchlin @@aut@@ Maureen McMahon @@aut@@ Jennifer Grossman @@aut@@ Philip M Carlucci @@aut@@ Alessandra Nerviani @@aut@@ Peter M Izmirly @@aut@@ Fan Zhang @@aut@@ Felice Rivellese @@aut@@ Joan Bathon @@aut@@ Zhu Zhu @@aut@@ Qian Xiao @@aut@@ Jessica Li @@aut@@ Holden Maecker @@aut@@ Nir Hacohen @@aut@@ Rong Mao @@aut@@ Jennifer Anolik @@aut@@ Javier Rangel-Moreno @@aut@@ Nida Meednu @@aut@@ Susan Goodman @@aut@@ Lindsy Forbess @@aut@@ Mariko Ishimori @@aut@@ Kevin Deane @@aut@@ David Hildeman @@aut@@ Yuhong Li @@aut@@ Laura Hughes @@aut@@ Robert Clancy @@aut@@ ANNE DAVIDSON @@aut@@ Matthias Kretzler @@aut@@ Larry Moreland @@aut@@ Harris Perlman @@aut@@ Peter Gregersen @@aut@@ Celine C Berthier @@aut@@ Andrea Fava @@aut@@ David Boyle @@aut@@ Derek M Fine @@aut@@ Ami Ben-Artzi @@aut@@ P J Utz @@aut@@ Melanie Smith @@aut@@ Beatrice Goilav @@aut@@ Carla Cuda @@aut@@ Andrew McDavid @@aut@@ Deepak A Rao @@aut@@ Joshua Keegan @@aut@@ Ilya Korsunsky @@aut@@ Joel Guthridge @@aut@@ Kevin Wei @@aut@@ Arnon Arazi @@aut@@ Thomas Eisenhaure @@aut@@ Michael Brenner @@aut@@ Susan Macwana @@aut@@ Pavel Morozov @@aut@@ Manjunath Kustagi @@aut@@ Gerald Watts @@aut@@ Kristina K Deonaraine @@aut@@ Jose Monroy-Trujillo @@aut@@ Mohamed G Atta @@aut@@ Kristin Haag @@aut@@ William Apruzzese @@aut@@ Sean Connery @@aut@@ Fernanda Payan-Schober @@aut@@ Kerry Cho @@aut@@ Jennifer Goff @@aut@@ Aparna Nathan @@aut@@ Joseph Mears @@aut@@ Nghia Millard @@aut@@ Kathryn Weinand @@aut@@ Saori Sakaue @@aut@@ Bill Robinson @@aut@@ Wade DeJager @@aut@@ Louis Bridges @@aut@@ Laura Donlin @@aut@@ Edward DiCarlo @@aut@@ Amit Lakhanpal @@aut@@ Heather Sherman @@aut@@ Anvita Singaraju @@aut@@ Lorien Shakib @@aut@@ Brendan Boyce @@aut@@ Darren Tabechian @@aut@@ Jen Albrecht @@aut@@ James Lederer @@aut@@ A Helena Jonsson @@aut@@ Daimon Simmons @@aut@@ Gregory Keras @@aut@@ Adam Chicoine @@aut@@ Zhihan Jian Li @@aut@@ Mandy McGeachy @@aut@@ Gary Firestein @@aut@@ Arnold Ceponis @@aut@@ Diane Horowitz @@aut@@ Salina Dominguez @@aut@@ Arthur Mandelin @@aut@@ Anjali Thakrar @@aut@@ Mike Holers @@aut@@ Jennifer Seifert @@aut@@ Constanino Pitzalis @@aut@@ Ellen Gravallese @@aut@@ Jennifer Barnas @@aut@@ Raymond Hsu @@aut@@ Steven Woodle @@aut@@ Paul Hoover @@aut@@ Michael Peters @@aut@@ Tony Jones @@aut@@ David Lieb @@aut@@ Jeffrey Hodgin @@aut@@ Raji Menon @@aut@@ |
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RC581-607 Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network |
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Andrew Filer Michael H Weisman Judith A James Kenneth Kalunian Michelle A Petri Chaim Putterman H Michael Belmont Ilfita Sahbudin Karim Raza Maria Dall'Era Jill P Buyon Diane L Kamen Karen Salomon-Escoto Kazuyoshi Ishigaki Patrick Dunn David Wofsy Michele Bombardieri Vivian Bykerk Myles Lewis Ming Wu Soumya Raychaudhuri Hemant Suryawanshi Thomas Tuschl Christopher Ritchlin Maureen McMahon Jennifer Grossman Philip M Carlucci Alessandra Nerviani Peter M Izmirly Fan Zhang Felice Rivellese Joan Bathon Zhu Zhu Qian Xiao Jessica Li Holden Maecker Nir Hacohen Rong Mao Jennifer Anolik Javier Rangel-Moreno Nida Meednu Susan Goodman Lindsy Forbess Mariko Ishimori Kevin Deane David Hildeman Yuhong Li Laura Hughes Robert Clancy ANNE DAVIDSON Matthias Kretzler Larry Moreland Harris Perlman Peter Gregersen Celine C Berthier Andrea Fava David Boyle Derek M Fine Ami Ben-Artzi P J Utz Melanie Smith Beatrice Goilav Carla Cuda Andrew McDavid Deepak A Rao Joshua Keegan Ilya Korsunsky Joel Guthridge Kevin Wei Arnon Arazi Thomas Eisenhaure Michael Brenner Susan Macwana Pavel Morozov Manjunath Kustagi Gerald Watts Kristina K Deonaraine Jose Monroy-Trujillo Mohamed G Atta Kristin Haag William Apruzzese Sean Connery Fernanda Payan-Schober Kerry Cho Jennifer Goff Aparna Nathan Joseph Mears Nghia Millard Kathryn Weinand Saori Sakaue Bill Robinson Wade DeJager Louis Bridges Laura Donlin Edward DiCarlo Amit Lakhanpal Heather Sherman Anvita Singaraju Lorien Shakib Brendan Boyce Darren Tabechian Jen Albrecht James Lederer A Helena Jonsson Daimon Simmons Gregory Keras Adam Chicoine Zhihan Jian Li Mandy McGeachy Gary Firestein Arnold Ceponis Diane Horowitz Salina Dominguez Arthur Mandelin Anjali Thakrar Mike Holers Jennifer Seifert Constanino Pitzalis Ellen Gravallese Jennifer Barnas Raymond Hsu Steven Woodle Paul Hoover Michael Peters Tony Jones David Lieb Jeffrey Hodgin Raji Menon |
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safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the accelerating medicines partnership ra/sle network |
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Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network |
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Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. |
| abstractGer |
Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. |
| abstract_unstemmed |
Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required. |
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Michael H Weisman Judith A James Kenneth Kalunian Michelle A Petri Chaim Putterman H Michael Belmont Ilfita Sahbudin Karim Raza Maria Dall'Era Jill P Buyon Diane L Kamen Karen Salomon-Escoto Kazuyoshi Ishigaki Patrick Dunn David Wofsy Michele Bombardieri Vivian Bykerk Myles Lewis Ming Wu Soumya Raychaudhuri Hemant Suryawanshi Thomas Tuschl Christopher Ritchlin Maureen McMahon Jennifer Grossman Philip M Carlucci Alessandra Nerviani Peter M Izmirly Fan Zhang Felice Rivellese Joan Bathon Zhu Zhu Qian Xiao Jessica Li Holden Maecker Nir Hacohen Rong Mao Jennifer Anolik Javier Rangel-Moreno Nida Meednu Susan Goodman Lindsy Forbess Mariko Ishimori Kevin Deane David Hildeman Yuhong Li Laura Hughes Robert Clancy ANNE DAVIDSON Matthias Kretzler Larry Moreland Harris Perlman Peter Gregersen Celine C Berthier Andrea Fava David Boyle Derek M Fine Ami Ben-Artzi P J Utz Melanie Smith Beatrice Goilav Carla Cuda Andrew McDavid Deepak A Rao Joshua Keegan Ilya Korsunsky Joel Guthridge Kevin Wei Arnon Arazi Thomas Eisenhaure Michael Brenner Susan Macwana Pavel Morozov Manjunath Kustagi Gerald Watts Kristina K Deonaraine Jose Monroy-Trujillo Mohamed G Atta Kristin Haag William Apruzzese Sean Connery Fernanda Payan-Schober Kerry Cho Jennifer Goff Aparna Nathan Joseph Mears Nghia Millard Kathryn Weinand Saori Sakaue Bill Robinson Wade DeJager Louis Bridges Laura Donlin Edward DiCarlo Amit Lakhanpal Heather Sherman Anvita Singaraju Lorien Shakib Brendan Boyce Darren Tabechian Jen Albrecht James Lederer A Helena Jonsson Daimon Simmons Gregory Keras Adam Chicoine Zhihan Jian Li Mandy McGeachy Gary Firestein Arnold Ceponis Diane Horowitz Salina Dominguez Arthur Mandelin Anjali Thakrar Mike Holers Jennifer Seifert Constanino Pitzalis Ellen Gravallese Jennifer Barnas Raymond Hsu Steven Woodle Paul Hoover Michael Peters Tony Jones David Lieb Jeffrey Hodgin Raji Menon |
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